The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic... by Xu Wang, Chuizhao Xue, Xueying Deng, Qilu Chen, Chunyang Li, Baixue Liu, Ying Wang, Yan Kui, Qingqiu Zuo, Jianhai Yin, Shuai Han, Yujuan Shen, Jianping Cao

“…This dietary diversification correlated with seasonal resource scarcity, driving foxes to exploit alternative prey. The infection rates of Echinococcus in V. ferrilata displayed the U-shaped seasonal patterns. …”
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Fertility intentions among Chinese adults: a cross-sectional study using a national survey by Mingyan Hao, Chenxiao Zhang, Haofeng Fu, Jingting Zhang, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Chen Chen, Yajing Zhou, Jianzhong Zheng, Wei Liu, Lizheng Wang

“…To tackle the challenge of decreasing fertility rates effectively, it is essential that interventions focus on younger women and highlight the advantages of living with multiple generations. …”
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Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China by Ming-Fang Ji, Yong-Qiao He, Min-Zhong Tang, Wen-Qiong Xue, Xia Yu, Hua Diao, Da-Wei Yang, Zhi-Ming Mai, Io Hong Cheong, Zhi-Yang Zhao, Biao-Hua Wu, Fu-Gui Li, Ji-Yun Zhan, Chang-Ling Huang, Hao-Lin Ma, Jun Li, Yan-Cheng Li, Tong-Min Wang, Ying Liao, Xue-Yin Chen, Zhi-Heng Liang, Shi-Feng Lian, Yun Du, Xue-Jun Liang, Zisis Kozlakidis, Jun Ma, Wei-Hua Jia

“…The associations showed an increased dose-response pattern, and keep persistent even up to ten years prior to diagnosis. …”
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Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury by Hong Duo, Yanwei Yang, Jun Luo, Yumeng Cao, Qian Liu, Jiarui Zhang, Siqi Du, Jian You, Guqing Zhang, Qifa Ye, Huaqin Pan

“…Abstract Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. …”
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Differences in the inflammatory response and outcome among hospitalized patients during different waves of the COVID-19 pandemic by Violeta Briciu, Violeta Briciu, Daniel-Corneliu Leucuta, Monica Muntean, Monica Muntean, Amanda Radulescu, Amanda Radulescu, Cristina Cismaru, Cristina Cismaru, Adriana Topan, Adriana Topan, Lucia Herbel, Melinda Horvat, Melinda Horvat, Mirela Flonta, Mihai Calin, Roxana Dobrota, Mihaela Lupse, Mihaela Lupse

“…Systemic inflammatory indexes like neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-platelet ratio (NPR), Systemic Immune-Inflammation Index (SII), and systemic inflammation response index (SIRI) were calculated.ResultsThe Delta wave, characterized by the longest hospitalizations and the highest rates of severe cases and mortality, showed significant elevations in inflammatory biomarkers. …”
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Mapping Antimicrobial Resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights by Nawal AL Shizawi, Zaaima AL Jabri, Fatima Khan, Hiba Sami, Turkiya AL Siyabi, Zakariya AL Muharrmi, Srinivasa Rao Sirasanagandla, Meher Rizvi

“…In comparison, susceptibility rates of <i>K. pneumoniae</i> were far lower: nitrofurantoin (38%), fosfomycin (89%), aminoglycosides (82%), piperacillin-tazobactam (72%), and carbapenems (83%). …”
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Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort by Dai C, Tang G, Yang H, Wu F, Deng Z, Zheng Y, Zhao N, Lu L, Wan Q, Wang Z, Peng J, Wu X, Zhou K, Cai G, Xiao S, Wen X, Yang C, Chen S, Yu S, Sun R, Zhou Y, Ran P

“…Furthermore, the prevalence of PRISm varied from 2.0% to 12.5% depending on the definitions and predicted equations, with the Chinese equation, LLN definition in Chinese equation and fixed definition in GLI equation yielding higher prevalence rates.Conclusion: Our findings highlight concerns about the comparability of studies and the interchangeability of various definitions and reference equations for PRISm.Keywords: PRISm, definitions, clinical features, prevalence, reference equations…”
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Tratamento de sequelas de queimadura de face com laser de CO2 fracionado em pacientes com fototipos III a VI Treatment of facial burn sequelae using fractional CO2 lasers in patien... by Alessandra Grassi Salles, Adelina Fátima do Nascimento Remigio, Valéria Berton Liguori Zacchi, Marcus Castro Ferreira

“…CONCLUSIONS: The treatment with CO2F laser with mild parameters was well tolerated and resulted in high satisfaction rates for patients with facial burn sequelae as well as improved skin texture, distensibility, and surface irregularities. …”
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Investigation of Population Changes and Determination of the Bean Pod Borer Helicoverpa armigera (Lepidoptera:Noctuidae) Peak in Bean Phaseolus vulgaris Linnaeus Fields by Pheromon... by Sedighe Ashtari

“…The investigation of the distribution and damage level of bean pod borer in important bean-growing areas of Markazi province over two years in five bean-growing regions (Arak, Khomain, Shazand, Milajerd, and Khondab) showed that Khomain and Khondab had the highest and lowest infestation rates, respectively. Red pods showed more sensitivity to this pest compared to green and white pods. …”
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Numerical Simulation Study on the Dynamic Processes and Evolution Laws of Multiple Granular Flows in a Gully by LEI Ming, ZHANG Liang, YE Chen, WANG Xiekang

“…Compared with the first granular flow, subsequent ones feature shorter durations and higher energy dissipation rates. The velocity and displacement of base granules increase significantly as the friction coefficient decreases and the secondary slope increases. …”
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Classification of finger movements through optimal EEG channel and feature selection by Murside Degirmenci, Yilmaz Kemal Yuce, Matjaž Perc, Matjaž Perc, Matjaž Perc, Matjaž Perc, Matjaž Perc, Yalcin Isler

“…This study design may result in an increasing number of false positives and a significant decrease in the prediction rates and classification performance. Moreover, recent studies have focused on improving prediction performance using complex feature extraction and machine learning algorithms while ignoring comprehensive EEG channels and feature investigation in the prediction of finger movements from EEGs. …”
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Effect of Different Treatments on the Structure Sequence and Digestive Characteristics of Oyster Hypoglycemic Peptides by Hua WANG, Xiaojie SU, Zhongqin CHEN, Wenhong CAO, Jialong GAO, Guoping ZHU, Haisheng LIN

“…Moreover, the retention rates of OHPs' inhibitory activity against α-amylase and α-glucosidase were enhanced by alcohol precipitation and activated carbon adsorption treatments. …”
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Renal prognostic value of serum monoclonal immunoglobulin in cryoglobulinemic glomerulonephritis by Lei Ma, Yuanyuan Xia, Yun Fan, Dan Zhou, Xinchen Yao, Yongzhong Zhong, Fan Yang, Feng Xu, Shaoshan Liang, Yujie Wang, Xiaodong Zhu, Dacheng Chen, Rong Tan, Zhengyun Zhu, Dandan Liang, Caihong Zeng

“…The MIg group had significantly lower eGFR levels, higher cryoglobulin levels, and higher rates of abnormal serum-free light chain ratios than the MIg/HBV/HCV negative group. …”
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Calculation Model of Multi-roll Straightening Process Based on Bilinear Hardening and Power Hardening by ZHU Xiaoyu, CHENG Zixing, WANG Xiaogang, HAN Peisheng

“…To evaluate the applicability of different material models, five straightening schemes were designed, corresponding to plasticity rates of 33.4%, 50.0%, 66.7%, 75.0%, and 80.0%. The influence of various hardening coefficients on curvature and plasticity during straightening was investigated. …”
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Strain-Specific developmental cardiovascular physiology landmarks of embryonic red jungle fowl and black Sumatran bantam chickens (Gallus gallus) by Dane A. Crossley, II, Kent Thornburg

“…Collectively our data suggest that timing of functional cholinergic tone on heart rate is strain dependent, while beta adrenergic tone on heart rate was functional on similar days of incubation.…”
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Microstructures and Crystal Size Distribution (CSD) of Chromites from Gysian Silvana Ophiolite Serpentinites, Urmia, Iran by monir modjarrad

“…The first type is a linear steady-state pattern with a nucleation rate/growth rate (J/G) of about 12 and Gt=1.28; the second type has a non-linear concave downtrend which is the result of annealing or Ostwald ripening at a small size part with J/G=13-15 and Gt=1.33. …”
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Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping by Xiaoxi Zhu, Huiling Zheng, Xue Wan, Hang Duan, Ying Qi, Weijia Tang, Fan Yang, Fan Yang, Limei Yu, Limei Yu

“…This advancement substantially enhances the diagnostic rates of genetic etiology in patients experiencing RSA. …”
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Loss aversion and evidence accumulation in short-video addiction: A behavioral and neuroimaging investigation by Chang Liu, Jinlian Wang, Hanbing Li, Qianyi Shangguan, Weipeng Jin, Wenwei Zhu, Pinchun Wang, Xuyi Chen, Qiang Wang

“…Mediation analyses further demonstrated that functional activation patterns in the motor network mediated the relationships between inter-subject variations in SVA symptoms and both loss-aversion and psychological processing patterns (e.g., decision threshold, drift rate, and non-decision time). …”
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