Biomechanical stability and stress distribution before talus prosthesis design: effects of ligament removal and cartilage overlay thickness using finite element analysis by Gang Zeng, Yujun Sun, Min Liang, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Taolue Zhou, Huiying Zhao, Weidong Song, Yue Ding

“…Recent advancements, including patient-specific implants and improved biomaterials, show promise in enhancing long-term outcomes and reducing complication rates. Aim This study investigates the mechanical stability and stress distribution changes in a talus prosthesis after the sequential removal of surrounding ligaments and the application of varying thicknesses of cartilage overlays. …”
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Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, indi... by Emmanuel Bottieau, Achilleas Tsoumanis, Yven Van Herrewege, Diana Arango, Christophe Burm, Badara Cisse, Souleymane Mboup, Clémentine Roucher, Isabel Brosius, Moustapha Mbow, Babacar Thiendella Faye, Annelies De Hondt, Bart Smekens, Linda Paredis, Idzi Potters, Katja Polman

“…The trial’s primary endpoints are the efficacy (cure rate (CR), assessed by microscopy) and safety (frequency and pattern of drug-related adverse events) of one AM course versus PZQ at 4 weeks after treatment. …”
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Spatiotemporal Change in Climate Variables and Resources of Wind， Solar Radiation and Precipitation in Qinghai Province from 1961 to 2021 by Meixia DUAN, Miaoni GAO, Han JIANG, Runhong XU, buda SU, Tong JIANG

“…In order to evaluate the potential of wind， solar radiation and precipitation in guaranteeing the development of clean energy comprehensively， this study analyzed the temporal and spatial changes in climate variables and resources of wind speed， solar radiation and precipitation in Qinghai Province throughout the year and four seasons from 1961 to 2021 based on the observation data of daily 10-meter-height wind speed， sunshine duration and precipitation at 51 meteorological stations.The results are as follows： （1） The annual average wind speed， solar radiation and precipitation in Qinghai Province are 2.67 m·s-1， 6084.2 MJ·m-2， and 299.7 mm， respectively.Wind speed tends to be higher in the western regions and lower in the east， which exceeds 3 m/s and reaches the standard for wind energy resource development in western Qinghai.The annual solar radiation in the entire Province exceeds 5040 MJ·m-2， and reaches the "very rich" level according to China Solar energy GB Standards.The solar radiation of Qaidam Basin is at its highest abundance level， which is ideal for solar energy resource development.Precipitation generally decreases from southeast to northwest.The resources of wind， solar radiation， and precipitation in Qinghai Province exhibits seasonal complementarity， characterized by a pattern of “strong winds， good sunlight， and less water in spring， whereas weak winds， good sunlight， and abundant water in summer”.（2） Under climate change， the annual average wind speed and total solar radiation in Qinghai Province show a significant decrease at rates of 0.16 m·s-1·10a-1and 29.04 MJ·m-2·（10a）-1， respectively.The western and central parts of Haixi are most affected by these changes， but the wind speed and solar radiation still remain within the acceptable range for wind energy and photovoltaic resource development.Meanwhile， precipitation increases significantly at a rate of 8.85 mm·（10a）-1， with the largest increase observed in western Yushu， eastern Haixi and northern Guoluo.The most significant decrease in wind speed is observed in spring， while summer solar radiation decreases at the fastest rate but with a substantial increase in precipitation.The changes in solar radiation and precipitation could be ascribed to the increased cloud cover in this region.（3） The changes in the areas where wind speed and solar radiation meet suitable development standards in Qinghai Province are not significant with reduced variabilities， which could ensure the stable development of clean energy.Wind energy resources in western Qinghai （such as Tanggula Mountains）， solar energy resources in the Qaidam Basin， and water energy resources in the three major river basins of the Yangtze River， Yellow River， and Lancang River have great potential for development.Overall， the results provide a theoretical foundation for the development of a balanced clean energy system encompassing wind， solar and hydropower.This contributes to achieving national "dual carbon" goals and enhancing the high-quality development of Qinghai Province.…”
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Release Behavior and Bioaccumulation Characteristics of Organophosphate Esters from Plastics in Marine Aquaculture by Zhi YANG, Dongni LIU, Shengnan HUANG, Xuetian DAI, Wei QIAN, Xiaoshan ZHU

“…Chlorinated OPEs exhibited the highest dissolution rates, with TCEP showing a dissolution rate of 40.6%. …”
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Exploring the profile and risk factors associated with self-harm ideation and behaviors in adolescents with high psychoticism by Xiao-Ming Xu, Ru-Hong Jiang, Yu-Shuang Han, Wo Wang, Ming Ai, Jian-Mei Chen, Jun Cao, Xiao-Rong Chen, Zhen Lv, He-Yan Xu, Da-Qin Ding, Su Hong, Jing-Lan He, Qi Zhang, Lei Shi, Ning Du, Jin-Hui Hu, Li Kuang

“…Actual self-harm rates were 4.7% (lifetime), 1.64% (past year), and 0.37% (past month). …”
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Timing matters! Academic assessment changes throughout the day by Carmelo M. Vicario, Michael A. Nitsche, Chiara Lucifora, Pietro Perconti, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Francesco Tomaiuolo, Simona Massimino, Alessio Avenanti, Alessio Avenanti, Massimo Mucciardi

“…Our results demonstrate a Gaussian distribution of passing rates throughout the day, with a significant peak at midday. …”
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Planned Liver Stereotactic Body Radiotherapy for Residual Colorectal Cancer Liver Metastases After Surgery: A Single-Arm Retrospective Study by Sixuan Li, Dezuo Dong, Xuan Zheng, Hongzhi Wang, Kun Wang, Baocai Xing, Weihu Wang

“…The 1-, and 2-year cumulative incidence rates of LF after SBRT were 7.7%, and 9.6%, respectively. …”
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Clinical features of patients with dysthymia in a large cohort of Han Chinese women with recurrent major depression. by Wenqing Wu, Zhoubing Wang, Yan Wei, Guanghua Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jianguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Ying Liu, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Chunmei Hu, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S Kendler, Jonathan Flint, Zhen Zhang

“…<h4>Conclusions</h4>There are increased rates of stressful life events in MDD with dysthymia, but the impact of life events on susceptibility to dysthymia with MDD differs from that seen for MDD alone. …”
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Toxicokinetics, tissue distribution, and toxic potency of PFOS alternative OBS in adult zebrafish (Danio rerio) based on flow-through exposure system by Yilong Zou, Yu Zhou, Xianglian Wang, Guiqing Gao, Gang Chen, Zhanmeng Liu, Mi Deng, Xueping Huang, Yongming Wu

“…Our findings indicate that OBS accumulated rapidly in zebrafish, with log kinetic bioconcentration factor (logBCFk) values ranging from 2.48 to 2.70 and slow elimination rates (ke = 0.0490–0.0643 d−1). The blood, liver, and muscle were responsible for over 50 % of the total body burden of OBS, with tissue concentrations decreasing in the following order: blood > liver > intestine > gills > gonad > brain > muscle, suggesting a tissue-specific accumulation pattern. …”
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Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…Conversely, <i>GmNAC35</i> showed an inverse pattern, indicating negative regulation by miR164. …”
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An integrated high-resolution bathymetric model for the Danube Delta system by L. Alaerts, L. Alaerts, J. Lambrechts, N. R. Randresihaja, N. R. Randresihaja, L. Vandenbulcke, O. Gourgue, E. Hanert, E. Hanert, M. Grégoire

“…These error rates are comparable to those observed in bathymetry interpolation in rivers with similar source datasets. …”
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Biomechanical evaluation of novel construct for stabilizing subcapital femoral neck fractures: a synthetic bone model by Anjan R. Shah, Miguel A. Diaz, Douglas L. Cerynik, Blake Schultz

“…Abstract Background High complication rates continue to be reported for femoral neck fractures, where moderate to severe shortening has been associated with pain and inferior functional outcomes. …”
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Preoperative Bowel Preparation in Minimally Invasive and Vaginal Gynecologic Surgery by Michail Diakosavvas, Nikolaos Thomakos, Alexandros Psarris, Zacharias Fasoulakis, Marianna Theodora, Dimitrios Haidopoulos, Alexandros Rodolakis

“…Taking into consideration the fact that in most gynecologic cases there is minimal probability of bowel intraluminal entry and, thus, low surgical site infection rates, most scientific societies have issued guidelines against the use of any bowel preparation regimen before laparoscopic or vaginal surgery. …”
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Copper and Temperature Interactions Induce Differential Physiological and Metal Exclusion Responses in the Model Brown Macroalga <i>Ectocarpus</i> by Alex Santillán-Sarmiento, Paula S. M. Celis-Plá, A. John Moody, Claudio A. Saez, Murray T. Brown

“…In this study, we exposed the model brown seaweed <i>Ectocarpus</i> to different Cu concentrations (0, 0.8, 1.6, and 3.2 μM) at two different temperatures (15 and 25 °C). Relative growth rates decreased at 25 °C for the two highest Cu concentrations after 8 days of exposure, but a contrasting pattern was observed in the photosynthetic maximum quantum yield (<i>F_v</i>/<i>F_m</i>) and photosynthetic efficiency (<i>α</i>), where reductions were observed at 15 °C for the same Cu concentrations. …”
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Systemic Immunomodulatory Therapy in Uveitis Related to Beh&amp;ccedil;et&amp;rsquo;s Disease: A 10-year Profile by Almeida M, Ferreira AM, Araújo JR, Figueira L

“…The median treatment duration was 63.5 months, significantly reducing relapse rates from 2 ± 2.0 to 1 ± 1.2 per year (p &lt; 0.001). …”
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Antimicrobial Resistance Profile and Biofilm Formation of <i>Listeria monocytogenes</i> Isolated from Meat by Joana Paiva, Vanessa Silva, Patrícia Poeta, Cristina Saraiva

“…Introduction: <i>Listeria monocytogenes</i> is the causative agent of listeriosis, a serious infectious disease with one of the highest case fatality rates among foodborne diseases affecting humans. …”
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Treatment for Paget’s disease: surgical approaches by E. Yu. Fetisova, A. D. Zikiryakhodzhaev, N. N. Volchenko

“…Breast cancer (BC) ranks first in the pattern of female malignancies (20.7 %) and remains the top cancer among women. …”
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Socioeconomic inequalities in non-communicable diseases prevalence in India: disparities between self-reported diagnoses and standardized measures. by Sukumar Vellakkal, Sukumar Vellakkal, S V Subramanian, Christopher Millett, Sanjay Basu, David Stuckler, Shah Ebrahim

“…<h4>Methods</h4>We calculated age-adjusted prevalence rates of common NCDs from the Study on Global Ageing and Adult Health, a nationally representative cross-sectional survey. …”
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Ten-year outcomes of IMRT with chemotherapy versus IMRT alone for stage II–IVa nasopharyngeal carcinoma: a retrospective study by Xiao-li Wang, Da-qing Sun, Hui Yang, Yang Li, Xiu-feng Li, Xiao-long Chang, Xiang-di Meng, Ya-nan Zhang, Yun-xiang Zhang, Fu-rong Hao, Jian-wen Li

“…The 10-year OS, PFS, LRFS, and DMFS rates were 66.6%, 75.3%, 91.9%, and 81.2%, respectively. …”
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The system of atmosphere, land, ice and ocean in the region near the 79N Glacier in northeast Greenland: synthesis and key findings from the Greenland Ice Sheet–Ocean Interaction (... by T. Kanzow, T. Kanzow, A. Humbert, A. Humbert, T. Mölg, M. Scheinert, M. Braun, H. Burchard, F. Doglioni, P. Hochreuther, M. Horwath, O. Huhn, M. Kappelsberger, J. Kusche, E. Loebel, K. Lutz, B. Marzeion, B. Marzeion, R. McPherson, M. Mohammadi-Aragh, M. Mohammadi-Aragh, M. Möller, M. Möller, C. Pickler, M. Reinert, M. Rhein, M. Rhein, M. Rückamp, M. Rückamp, J. Schaffer, J. Schaffer, M. Shafeeque, M. Shafeeque, S. Stolzenberger, R. Timmermann, J. Turton, J. Turton, C. Wekerle, O. Zeising

“…Observations and models employed in this study are consistent in terms of melt rates occurring below the floating ice tongue. Our results suggest that the multidecadal warming of Atlantic Intermediate Water flowing into the cavity below the ice tongue – supplied by the recirculating branch of the West Spitsbergen Current in Fram Strait – is the main driver of the recent major increase in basal melt rates. …”
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