Immunohistochemical analysis of IDH1, ATRX, p53, and Ki-67 in glioblastoma and diffuse infiltrative glioma: Therapeutic and prognostic correlation by Hasbay Bermal, Kayaselçuk Fazilet, Süner Halil İbrahim, Tufan Kadir

“…Kaplan-Meier method and Cox proportional regression model (forward model) were used to estimate the mean and median survival times, failure rates, and hazard ratios. Results. In the study, 115 (56.1%) patients were male and 90 (43.9%) were female. …”
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Definitive urine drug testing in emergency medicine: Recreational and psychiatric drug findings by Thomas G. Rosano, S.M.Touhidul Islam, John M. Rumberger, Robert M. Konetchy, Jr., Michelle Wood, Joseph A. Sorce, Karl A. Robstad, Heather Long

“…Forty percent of patients were also positive for antidepressants and 24% positive for antipsychotics. Significant patterns of co-drug use were found for cocaine, fentanyl, morphine and nicotine. …”
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Dietary strategies for preventing and managing obesity through evidence-based nutritional interventions by Stephen Olaide Aremu, Blessing Akute, Dorcas Oluwakemi Aremu, Caleb Zando, Esther Damilola Aremu, Omagu Julia Nwachukwu, Mary Omolola Omosebi, Victoria Oluwatosin Akute, Stephen Tokunbo Oluwole, Abdillahi Abdi Barkhadle, Matthew Olaleke Aremu

“…This crisis is driven by multifaceted factors, including sedentary lifestyles, urbanization, dietary transitions, and behavioral influences. As obesity rates continue to rise, dietary interventions emerge as crucial and modifiable strategies for prevention and management. …”
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Real-world effectiveness and safety of CDK4/6i in elderly and BIPOC patients with HR+/HER2- advanced/metastatic breast cancer: an updated systematic literature review by Nadia Harbeck, Adam Brufsky, Chloe Grace Rose, Beata Korytowsky, Connie Chen, Krista Tantakoun, Endri Jazexhi, Do Hoang Vien Nguyen, Meaghan Bartlett, Imtiaz A. Samjoo, Timothy Pluard

“…Key outcomes for synthesis were effectiveness, treatment patterns, and safety.ResultsThis review included 23 unique studies. …”
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Ultrasound-activated miR-195-5p/shikonin nanobubbles remodel immunosuppressive microenvironment via immunogenic cell death to potentiate PD-1/PD-L1 blockade in hepatocellular carci... by Yandi Tan, Qiao Xu, Yezi Chen, Yun Liu, Chaoqi Liu, Xinwu Cui, Yun Zhao

“…Concurrently, SK—a naphthoquinone compound repurposed as a potent ICD inducer—overcame the systemic toxicity and solubility limitations through NBs-mediated delivery, triggering robust release of damage-associated molecular patterns, including adenosine triphosphate, surface-exposed calreticulin, and secreted high-mobility group box 1 protein. …”
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Development of a PPP1R14B-associated immune prognostic model for hepatocellular carcinoma by Ligang Zhao, Xiaoling Jin, Qiushi Yu, Yigang He, Facai Yang, Weihu Ma, Zhengqing Lei, Jiahua Zhou

“…The analysis revealed distinct variations in immune scores and multiple immune cell enrichment patterns between elevated and reduced PPP1R14B expression categories, suggesting immune status connections. …”
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Antitumor power of oncolytic HSV engineered with IL-12 and IL-15 by Lei Zhang, Yanbin Zhu, Kunpeng Zheng, Xinyu Zhang, Chunxue Fu, Dan Wang, Xinqiang Zhang, Tong Wu, Shuxin Han, Zhenghai Ma

“…The engineered oHSV-1 demonstrated growth patterns comparable to wild-type HSV-1. The viral titers exhibited consistency within the same tumor cells. …”
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Deep learning enhanced road traffic analysis: Scalable vehicle detection and velocity estimation using PlanetScope imagery by Maciej Adamiak, Yulia Grinblat, Julian Psotta, Nir Fulman, Himshikhar Mazumdar, Shiyu Tang, Alexander Zipf

“…Satellite-based approaches provide broad spatial coverage, but face challenges, including high costs, low frame rates, and difficulty detecting small vehicles in medium-resolution imagery. …”
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Global trends and hotspots of adolescent eating disorders: a bibliometric study and visual analysis by Qian Ye, Qian Ye, Yiling Yang, Yue Qi, Jiale Li, Huijuan Lei, Lina Sun, Jie Zhang

“…BackgroundAdolescent eating disorders represent a category of mental illness, marked by elevated mortality and morbidity rates and a significant adverse impact on the quality of life of both patients and their families. …”
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Improvement of Oral Anticoagulant Prescription and Long‐Term Clinical Outcomes of Patients With Atrial Fibrillation After Implementation of a Clinical Decision Support System in Ou... by Po‐Tseng Lee, Mu‐Hsiang Huang, Ting‐Chun Huang, Pi‐Shan Sung, Chi‐Hui Hsu, Ya‐Ling Huang, Sheng‐Hsian Lin, Ping‐Yen Liu

“…Results OAC prescription rates increased from 47.3% to 67.5% after CDSS implementation. …”
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Molecular Epidemiology and Genetic Context of <i>optrA</i>-Carrying Linezolid-Resistant Enterococci from Humans and Animals in South Korea by Younggwon On, Sung Young Lee, Jung Sik Yoo, Jung Wook Kim

“…<i>optrA</i>-positive linezolid-resistant isolates were less frequent, with rates of 0.1%, 1.4%, 0.9%, and 1.0%, respectively. …”
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Global burden and trend of substance use disorders, self-harm, and interpersonal violence from 1990 to 2021, with projection to 2040 by Jia An, Qiang Wang, Zihao Bai, Xueying Du, Di Yu, Xuming Mo

“…Abstract Background Alcohol use disorders (AUD), drug use disorders (DUD), interpersonal violence, and self-harm are a major public health concern globally, with high rates of disability, morbidity, and mortality associated with this. …”
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The changes in health service utilisation in Malawi during the COVID-19 pandemic. by Bingling She, Tara D Mangal, Anna Y Adjabeng, Tim Colbourn, Joseph H Collins, Eva Janoušková, Ines Li Lin, Emmanuel Mnjowe, Sakshi Mohan, Margherita Molaro, Andrew N Phillips, Paul Revill, Robert Manning Smith, Pakwanja D Twea, Dominic Nkhoma, Gerald Manthalu, Timothy B Hallett

“…Two datasets were prepared: unadjusted and adjusted; for the latter, unreported monthly data entries for a facility were filled in through systematic rules based on reported mean values of that facility or facility type and considering both reporting rates and comparability with published data. Using statistical descriptive methods, we first described the patterns of service utilisation in pre-pandemic years (2015-2019). …”
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Antidepressant use in the Canary Islands (Spain): a retrospective study of provincial, island and municipal trends and associated factors by Alexis Oliva, Vanessa Moreno, Mariana Sapino, Sandra Dévora, Susana Abdala-Kuri

“…This provided total overall dispensation of AD and its rate of change for each island, as well as differences in dispensation at the island and municipal level.ResultsOver the study period, prescription rates increased steadily at all population levels, although the level of dispensing and the rate of variation varied between island and municipalities but no between provinces. …”
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Impact of Extracorporeal Detoxification on the Serum Levels of Microbial Aromatic Acid Metabolites in Sepsis by S. E. Khoroshilov, N. V. Beloborodova, A. V. Nikulin, A. Yu. Bedova

“…In sepsis associated renal failure, the clearance rate of microbial aromatic acid metabolites (p HPAA and p HPLA) is promising potential biomarker to evaluate the efficiency of extracorporeal detoxification methods.…”
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An explorative study on movement detection using wearable sensors in acute care hospital patients by Joris Kirchberger, Dominik Kunz, Guido Perrot, Sven Hirsch, Maren Leifke, Bianca Hölz, Lukas Geissmann, Miro Käch, Samuel Wehrli, Jens Eckstein

“…However, elderly patients often present distinct gait patterns due to walking aids or co-morbidities, and most existing monitoring solutions are trained on data from healthy individuals. …”
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Exploring mobility data for enhancing HIV care engagement in Black/African American and Hispanic/Latinx individuals: a longitudinal observational study protocol by Katherine P Theall, Lisa Hightow-Weidman, Xiaoming Li, Sean Young, Lidia Flores, Seungjun Kim, Maryam Hassani, Cristina De Haro, Mohamed Emish, Zeyad Kelani, Dominic Arjuna Ugarte, Amanda Castel

“…We seek to study the relationship between mobility patterns and HIV care engagement.Ethics and dissemination Ethical approval has been obtained from the Institutional Review Board of the University of California, Irvine (#20205923). …”
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Harnessing an Artificial Intelligence–Based Large Language Model With Personal Health Record Capability for Personalized Information Support in Postsurgery Myocardial Infarction: D... by Ting-ting Yang, Hong-xia Zheng, Sha Cao, Mei-ling Jing, Ju Hu, Yan Zuo, Qing-yong Chen, Jian-jun Zhang

“…Although postsurgical cardiac interventions have improved survival rates, effective management during recovery remains challenging. …”
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Identification of Immune-Related Risk Signatures for the Prognostic Prediction in Oral Squamous Cell Carcinoma by Chen Zou, Dahong Huang, Haigang Wei, Siyuan Wu, Jing Song, Zhe Tang, Xia Li, Yilong Ai

“…The two groups (high and low risk) stratified by the immune-related risk scores had significantly different OS and mortality rates. The gene expression patterns and prognostic values of these immune-related signatures were also verified in two independent validation cohorts. …”
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<i>SHROOM3</i> Deficiency Aggravates Adriamycin-Induced Nephropathy Accompanied by Focal Adhesion Disassembly and Stress Fiber Disorganization by Li-Nan Xu, Ying-Ying Sun, Yan-Feng Tan, Xin-Yue Zhou, Tian-Chao Xiang, Ye Fang, Fei Li, Qian Shen, Hong Xu, Jia Rao

“…Clinically, the glomerular <i>SHROOM3</i> expression positively correlated with glomerular filtration rates in focal segmental glomerulosclerosis patients. …”
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