Evaluation of Cerebrospinal Fluid Pressure by a Formula and Its Role in the Pathogenesis of Glaucoma by Laura Landi, Federica Casciaro, Serena Telani, Carlo E. Traverso, Alon Harris, Alice C. Verticchio Vercellin, Lauren Saint, Michele Iester

“…Weight and height were measured to calculate body mass index (BMI), along with blood pressure, heart rate, visual acuity, and IOP. Biometrics exam, corneal pachymetry, peripapillary retinal nerve fiber layer (RNFL) thickness, and macular thickness were assessed. …”
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Experimental study on nonlinear hygroscopic and strength behavior of mudstone under coupled temperature and humidity conditions for underground engineering by Weisheng Zhao, Lijun Han, Shuai Yan, Wei He

“…The results indicated that the equilibrium water content (EWC) exhibited a three-stage growth pattern with increasing humidity: rapid growth (0‒20% RH), slow growth (20‒60% RH), and accelerated growth (60‒100% RH), whereas it decreased with increasing temperature, although the rate of decrease slowed progressively. …”
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Elderly patients undergoing laparoscopic radical cystectomy benefit from dynamic D-dimer measurement in combination with vascular ultrasonography: reduction of VTE risk and improve... by Wenbo Gao, Haihong Ye, Yangkai Xu

“…The incidence of VTE event, major postoperative complications, major bleeding rate, and evaluation of activities of daily living within 30 days postoperatively were compared.ResultsThe preoperative and intraoperative parameters were similar between the two groups. …”
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Impact of Caspase3/GSDME-Mediated Pyroptosis on Tumor Immune Microenvironment and Clinical Prognosis Across Multiple Cancers by Huang Y, Liu J, Lin C, Zhu Q, Wu L

“…Its uncontrolled growth pattern and metastasis characteristics are the fundamental reasons for the high mortality rate of cancer and its current incurability. …”
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IMPAIRED REGULATORY MECHANISMS OF THE mTOR SIGNALING PATHWAY IN OSTEOARTHROSIS by Elena Vasilyevna Chetina, E A Bratygina, E M Zaitseva, E P Sharapova, A L Alekseyeva, N V Demin, S A Makarov

“…Objective: to study the pattern of impaired regulatory mechanisms of the mammalian target of rapamycin (TOR) signaling pathway, by monitoring gene expression in the blood of patients with osteoarthrosis (OA) at different stages of the disease. …”
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Etiology, antibiotic susceptibility and prognostic factors of pediatric community-acquired sepsis in Addis Ababa, Ethiopia by Abel Abera Negash, Daniel Asrat, Workeabeba Abebe, Tewodros Hailemariam, Andualem Wubete, Abraham Aseffa, Mario Vaneechoutte

“…We sought to determine the etiology, role of Streptococcus pneumoniae, antibiotic susceptibility pattern, and prognostic factors in children with CAS in Addis Ababa, Ethiopia. …”
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Nonlinear association between AST/ALT ratio and 28-day all-cause mortality following ICU admission in critically ill cirrhotic patients: a retrospective cohort study by Zhigang Xu, Baohong Xu

“…Results The study involved 2,090 critically ill liver cirrhosis patients, averaging 59.1 years old, with 65% male and a 28-day post-ICU admission mortality rate of 29%. The AST/ALT ratio was linked to mortality risk (adjusted odds ratio (OR) 1.1, 95% confidence interval (CI) 1.0–1.2; p = 0.015), showing a nonlinear pattern with a critical point at 3.6. …”
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Advances in application of ultrasound in diagnosis of diabetic nephropathy by GUO Juan, YANG Zhifang, JI Ri

“…As the global incidence rate of diabetes continues to rise, the clinical diagnosis and treatment of DN have become increasingly critical. …”
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Hyper-induction of IL-6 after TLR1/2 stimulation in calves with bovine respiratory disease. by Cian Reid, John Donlon, Aude Remot, Emer Kennedy, Giovanna De Matteis, Cliona O'Farrelly, Conor McAloon, Kieran G Meade

“…ROC analysis identified this induced IL-6 response to TLR1/2 stimulation as a potential diagnostic for BRD with a 74% true positive and 5% false positive detection rate for an IL-6 concentration >1780pg/mL. Overall, these results show altered immune responses specifically upon TLR1/2 activation is associated with BRD pathology which may contribute to disease progression. …”
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Multi-source Data-driven Analysis of Deformation and Influencing Factors for Expansive Soil Canal Slopes by ZHANG Yuhan, HU Jiang, LI Xing

“…This approach facilitates a comprehensive analysis of deformation patterns at the slope surface and various subsurface depths, while elucidating the dominant controlling factors governing expansive soil canal slope behavior.Results and Discussions　The study focused on a deep excavated expansive soil canal section (Stake 8+886~12+921) of a major water diversion project, yielding the following key findings: 1) The analysis of 128 Sentinel-1A images from March 2017 to December 2021 revealed that the deformation data obtained through SBAS-InSAR method showed less than 3mm discrepancy with surface vertical displacement measurements at monitoring points (fourth-stage berm at 9+363 and third-stage berm at 11+400), with consistent deformation trends, confirming the reliability of SBAS-InSAR for canal slope deformation monitoring. 2) The study section exhibited LOS deformation rates ranging from -10 to 24 mm/a, demonstrating overall uplift characteristics, with positive LOS deformation showing annual increase. …”
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Nitrogen reduction with supplemental irrigation enhances yield by delaying leaf senescence and optimizing grain-filling process for ridge-furrow film mulching winter wheat by Xiaobo Gu, Yang Xu, Tongtong Zhao, Yadan Du, Yuanling Zhang, Yuyu Tian, Zhikai Cheng, Huanjie Cai, Zhandong Liu

“…However, the optimal supplemental irrigation rate to further increase the yield of winter wheat under RFM remains unclear. …”
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The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-eco... by Mengsha Chen, Mengya Yang, Rui Yan, Zhengwei Liu, Can Chen, Rongrong Qu, Wenkai Zhou, Jiaxing Qi, Kexin Cao, Jiani Miao, Xiaoyue Wu, Jiaxin Chen, Qianqian Feng, HuiHui Zhang, Anqi Dai, Yi Yang, Jingtong Zhou, Qin Chen, Jimin Sun, Shigui Yang

“…High-intensity outbreaks were defined as weekly incidence rates above 72.2 per 100,000. Methods This study estimated the incidence of influenza from 2018 to 2023 in Zhejiang Province, China, using influenza weekly surveillance data. …”
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Global stroke burden attributable to household air pollution: Insights from GBD 2021 and projections to 2040. by Manqing Li, Shicheng Liao, Chao Wang, Haojia Ma, Xiumei Xing, Jianhui Yuan, Jie Jiang, Zhuoying Zeng

“…From 1990-2021, age-standardized death rates (EAPC = -0.37), DALY rates (EAPC = -0.20), and YLL rates (EAPC = -0.30) decreased, while YLD rates increased (EAPC = 1.11). …”
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Extranodal diffuse large B‐cell lymphoma: Clinical and molecular insights with survival outcomes from the multicenter EXPECT study by Si‐Yuan Chen, Peng‐Peng Xu, Ru Feng, Guo‐Hui Cui, Li Wang, Shu Cheng, Rong‐Ji Mu, Hui‐Lai Zhang, Xiao‐Lei Wei, Yong‐Ping Song, Kai‐Yang Ding, Li‐Hua Dong, Zun‐Min Zhu, Shen‐Miao Yang, Xin Wang, Ting‐Bo Liu, Jian‐Da Hu, Xiao‐Yun Zheng, Ou Bai, Jing‐Yan Xu, Liang Huang, Wei Sang, Ke‐Qian Shi, Fan Zhou, Fei Li, Ai‐Bin Liang, Hui Zhou, Si‐Guo Hao, Hong‐Hui Huang, Bin Xu, Wen‐Bin Qian, Cai‐Xia Li, Zhi‐Ming Li, Chong‐Yang Wu, Xiao‐Bo Wang, Wen‐Yu Shi, Shu‐Ye Wang, Yu‐Yang Tian, Xi Zhang, Ke‐Shu Zhou, Li‐Juan Cui, Hui Liu, Huo Tan, Qing Leng, Dong‐Lu Zhao, Ting Niu, Wei‐Li Zhao

“…Gene panel sequencing was performed on 1,050 patients to discern molecular patterns according to ENI. Results The 2‐year overall survival (OS) rate was 76.2% [95% confidence interval (CI), 74.0%‐78.2%], and the 5‐year OS rate was 67.9% (95% CI, 65.2%‐70.4%). …”
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The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailt... by Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

“…Despite a 50% dropout rate, adherence among remaining participants was over 50% for all intervention components (range 53%-91%). …”
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Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study by Yuan Fang, Jiachen Chen, Jesse Mez, Jesse Mez, Jesse Mez, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Michael L. Alosco, Michael L. Alosco, Michael L. Alosco, Wei Qiao Qiu, Wei Qiao Qiu, Wei Qiao Qiu, Margaret F. Doyle, Joanne M. Murabito, Joanne M. Murabito, Joanne M. Murabito, Kathryn L. Lunetta

“…IntroductionThe prevalence of cognitive impairment in the population is growing; however, there is substantial heterogeneity in the rate of decline across different cognitive domains. …”
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Temperature-VPD-evapotranspiration interactions modulated asynchronous dynamics of vegetation photosynthesis and net ecosystem production in Eurasia by Rui Yang, Hao Yuan, Ruohua Du, Litao Zhou, Jianjun Wu, Liang Gao, Ting Mao

“…The results showed that the rate of increase in NEP standardized anomalies (0.004 yr−1, p < 0.05) lagged behind NDVI/SIF/GPP standardized anomalies (0.009 − 0.014 yr−1, p < 0.01), particularly after 2000, and it was more pronounced in drylands. …”
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Links between self-monitoring data collected through smartphones and smartwatches and the individual disease trajectories of adult patients with depressive disorders: Study protoco... by Hanna Reich, Simon Schreynemackers, Rebeka Amin, Sascha Ludwig, Jil Zippelius, Johannes Leimhofer, Tobias Dunker, Elisabeth Schriewer, Angela Carell, Yvonne Weber, Ulrich Hegerl

“…Participants will (a) attend three in-person appointments (at baseline, 6 months, and 12 months), (b) self-report daily and weekly depressive symptoms, (c) continuously collect sensor data via the “iTrackDepression” app on their Android smartphone (app usage, phone calls, phonetic parameters from voice recordings), and (d) wear a Samsung Galaxy Watch 5® to record data from the accelerometer, step sensor, light sensor, and heart rate sensor. We will apply multilevel correlations, vector-autoregressive models, and Machine Learning approaches to identify individual patterns in the data, particularly in the relationships between biosensor data and self-reported depressive symptoms.Enhancing the understanding of individual disease trajectories through data from smartphones and smartwatches could allow for classical, digital, and self-management interventions for depression to be delivered in a manner and at a time specifically tailored to the individual's needs.Clinical trial registration number: DRKS00032618 (https://drks.de/search/en/trial/DRKS00032618)…”
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Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents by Yifan Chang, Yue Xuan, Ruinan Zhang, Xuemei Ding, Qiufeng Zeng, Jianping Wang, Shiping Bai, Shanshan Li, Yan Liu, Yuchuan Chen, Keying Zhang

“…The objective of this experiment is to investigate the effects of SAP or SAO as ω-3 PUFA raw materials on production performance, egg quality, serum immunity, serum lipids, and fatty acid deposition patterns in the eggs of laying quails. Chinese yellow-feathered quails served as the experimental subjects. …”
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Variations in the clinical practice of blood pressure and sedo-analgesia management for intracerebral hemorrhage: a case-based survey of Chinese healthcare workers by Rui Dong, Jianwei Li, Qiming Chen, Jiehua Zhang, Zeli Zhang, Yunxing Cao, Mingbiao Yang, Ming Zhang, Kangyue Lin, Yuan Shi, Xiaopeng Li, Xinyu Du, Wenjin Chen, Fen Li, Hong Yang

“…Results Between December 2021 and February 2022, 263 practitioners from the China Neurocritical Study Group were invited to participate, with 220 valid questionnaires returned, yielding an 83.7% response rate. Respondents included 123 doctors (55.9%) and 97 nurses (44.1%). …”
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