An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits by Ellen M. Howerton, Valerie Morrill, Rose Schrott, Jason Daniels, Ashley Y. Song, Kelly Benke, Heather Volk, Homayoon Farzadegan, Aimee Anido Alexander, Amanda L. Tapia, Gabriel S. Dichter, Lisa A. Croen, Lisa Wiggins, Genevieve Wojcik, M. Daniele Fallin, Christine Ladd-Acosta

“…We sought to identify DNA methylation patterns in child blood associated with Social Responsiveness Scale score, Second Edition (SRS). …”
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Metal–organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy by Tao Jiang, Zixiang Tang, Shumiao Tian, Haitian Tang, Zhekun Jia, Fangjian Li, Chenyue Qiu, Lin Deng, Lang Ke, Pan He, Gang Liu, Chengchao Chu, Yongfu Xiong

“…Remarkably, ultrasound irradiation induced substantial oxidative stress and immunogenic cell death, promoting the release of damage-associated molecular patterns (DAMPs), which elevated the maturation rate of tumor-infiltrating dendritic cells (DCs) and significantly increased the proportion of CD8⁺ T cells. …”
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Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…Deep learning (DL) offers a promising alternative for capturing nonlinear genetic relationships due to its ability to identify complex patterns without prior assumptions about the data structure. …”
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Population immunity to SARS-CoV-2 virus in residents of the Irkutsk Region in the dynamics of the epidemic by S. V. Balakhonov, V. I. Dubrovina, M. V. Chesnokova, D. D. Bryukhova, N. O. Kiseleva, A. B. Pyatidesyatnikova, K. M. Korytov, V. V. Voitkova, A. N. Perezhogin, T. A. Gavrilova, A. A. Seledtsov

“…In this regard, the study of the manifestations of the epidemic process of the new coronavirus infection COVID-19 and the patterns of its development are an urgent area of research. …”
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Groundwater rebound and seepage characteristics and water quality evolution in a sealed mining area in North China type coalfield by Huiyong YIN, Dehui SUN, Fangying DONG, Fanhua WANG, Lifeng ZHANG, Tao WU, Chao LIU, Yifan ZENG

“…After the goaf sealing, water-rock interactions persisted during the reinjection of the accumulated water, but the cation exchange rate slowed down. The mineral phases showed similar but weakened variation trends compared to the water inrush stage. …”
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The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis by Shaoyu Zheng, Zexuan Zhou, Guangzhou Du, Qingzi Chen, Shaoqi Chen, Jianqun Lin, Shijian Hu, Weijin Zhang, Kedi Zheng, Jinghua Zhuang, Meigan Huang, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Marco Matucci-Cerinic, Daniel E. Furst, Yukai Wang

“…Sonographic ILD was detected in 76 patients who underwent LUS examination. The concordance rate between two modalities was 83.33% (Kappa value = 0.64, 95% CI 0.50–0.78). …”
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Dynamics of changes in population immunity to the SARS-CоV-2 virus in residents the Irkutsk region in the context of the COVID-19 pandemic by S. V. Balakhonov, V. I. Dubrovina, A. B. Pyatidesyatnikova, D. D. Briukhova, N. O. Kiseleva, K. M. Korytov, V. V. Voitkova, A. N. Perezhogin, M. V. Chesnokova, T. A. Gavrilova, A. A. Seledtcov

“…A comprehensive study of the patterns of development and manifestations of the epidemic process of the new coronavirus infection COVID-19 is an urgent line of research. …”
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The impact of referral workload on cardiology registrars in a high-volume district general hospital: implications for workforce well-being and service efficiency by Md Imran Hossain, Jaymin Shantilal Shah

“…All inpatient cardiology referrals were audited for total referral volume, weekday versus weekend patterns and referral method (electronic vs bleep-based). …”
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A mobile app to improve adherence to colorectal cancer screening and post polypectomy surveillance guidelines by María A. Casas, Francisco Schlottmann, Leandro Steinberg, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Sonia Torres, Antoni Castells, Francesc Balaguer, Jaume Grau, Lisandro Pereyra, María Pellisé

“…Users’ characteristics, consultation types, and patient data were analyzed to assess app’s implementation, usage patterns, and impact on CRC screening and surveillance outcomes. …”
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Sex disparities in alcohol-associated liver disease and subtype differences in alcohol-attributable cancers in the United States by Pojsakorn Danpanichkul, Yanfang Pang, Tanuj Mahendru, Primrose Tothanarungroj, Luis Antonio Díaz, Juan Pablo Arab, Pimtawan Jatupornpakdee, Mark D. Muthiah, Kwanjit Duangsonk, Won-Mook Choi, Daniel Q. Huang, Donghee Kim, Mazen Noureddin, Karn Wijarnpreecha, Suthat Liangpunsakul, Amit G. Singal, Ju Dong Yang

“…The age-standardized incidence and death rate of ALD rose disproportionately among females compared to males. …”
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A first large study of whole-exome sequencing (WES) in 489 patients with suspected rare genetic disorders at a tertiary centre in Malaysia by Lip Hen Moey, Go Hun Seo, Boon Eu Cheah, Wee Teik Keng, Hane Lee, Gaik Siew Ch’ng

“…Introduction: Rare genetic disorders occur at a rate of 40–82 per 1000 live births worldwide. Identifying the molecular cause of rare genetic disorders is beneficial because it allows early diagnosis, facilitates treatment planning and provision of accurate genetic counselling. …”
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<i>Helicobacter pylori</i> Persistence in Patients with Peptic Ulcer Disease and Chronic Gastritis in the Treatment with Antibiotics and Acid-Suppressive Agents by E. V. Golubkina

“…In the latter patients, the differences between the background bacteriological pattern and the pattern observed after 1.5–2 months had a high degree of significance; in these follow-up periods, in contrast to the control immediately after therapy, the number of eradications increased and the number of cagA-containing strains decreased due to the change of strains. …”
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Early-stage endometrioid carcinoma with MSH6 protein deficiency: pitfalls in the diagnostic interpretation of microsatellite instability by Cheng Wang, Cheng Wang, Dongni Liang, Dongni Liang, Wei Wang, Wei Wang, Wei Kuang, Wei Kuang, Juan Zou, Juan Zou, Jing Zeng, Jing Zeng, Min Feng, Min Feng

“…This atypical MSI pattern is often overlooked, potentially increasing the risk of underdiagnosis of LS.…”
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East Asian aerosol cleanup has likely contributed to the recent acceleration in global warming by Bjørn H. Samset, Laura J. Wilcox, Robert J. Allen, Camilla W. Stjern, Marianne T. Lund, Sharar Ahmadi, Annica Ekman, Maxwell T. Elling, Luke Fraser-Leach, Paul Griffiths, James Keeble, Tsuyoshi Koshiro, Paul Kushner, Anna Lewinschal, Risto Makkonen, Joonas Merikanto, Pierre Nabat, Larissa Narazenko, Declan O’Donnell, Naga Oshima, Steven T. Rumbold, Toshihiko Takemura, Kostas Tsigaridis, Daniel M. Westervelt

“…Here we show, using a large set of simulations from eight Earth System Models, how a time-evolving 75% reduction in East Asian sulfate emissions partially unmasks greenhouse gas-driven warming and influences the spatial pattern of surface temperature change. We find a rapidly evolving global, annual mean warming of 0.07 ± 0.05 °C, sufficient to be a main driver of the uptick in global warming rate since 2010. …”
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A Robust Framework for Bamboo Forest AGB Estimation by Integrating Geostatistical Prediction and Ensemble Learning by Lianjin Fu, Qingtai Shu, Cuifen Xia, Zeyu Li, Hailing He, Zhengying Li, Shaoyang Ma, Chaoguan Qin, Rong Wei, Qin Xiang, Xiao Zhang, Yiran Zhang, Huashi Cai

“…The mean AGB density was 71.8 ± 21.9 Mg ha⁻¹, with its spatial pattern influenced by elevation and human settlements. …”
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Estimating Future Surface Water Availability Through an Integrated Climate‐Hydrology‐Management Modeling Framework at a Basin Scale Under CMIP6 Scenarios by Manqing Shao, Nelun Fernando, John Zhu, Gang Zhao, Shih‐Chieh Kao, Bingjie Zhao, Elizabeth Roberts, Huilin Gao

“…Finally, the DHSVM simulated naturalized streamflow and reservoir evaporation rate are input to WAM to simulate reservoir FY. A new term—“Ratio of Firm Yield” (RFY)—is created to compare how much FY changes under different climate scenarios. …”
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Annual variation of temperature and mass balance of first-year and second-year land-fast sea ice in Prydz Bay, East Antarctica by Dinglong Zhao, Bin Cheng, Matti Leppäranta, Jingkai Ma, Xuejing Chen, Jiechen Zhao

“…Snow–ice and superimposed ice formation were most sensitive to the precipitation pattern, followed by the initial snow depth and initial ice thickness. …”
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Transarterial chemoembolization for advanced hepatocellular carcinoma after failure of first-line systemic treatment: a single-center case series by Qingyu Xu, Bin Leng, Ran You, Lingfeng Diao, Chendong Wang, Zeyu Yu, Guowen Yin

“…The most common progression pattern was the development of new intrahepatic lesions. …”
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The Stabilization Mechanism of a Stable Landslide Dam on the Eastern Margin of the Tibetan Plateau, China: Insights from Field Investigation and Numerical Simulation by Liang Song, Yanjun Shang, Yunsheng Wang, Tong Li, Zhuolin Xiao, Yuchao Zhao, Tao Tang, Shicheng Liu

“…Field investigation shows that the Conaxue Co landslide dam was formed by a high-speed long-runout landslide blocking the river, with its structure exhibiting a typical inverse grading pattern characterized by coarse-grained rock overlying fine-grained layers. …”
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Kinetics of silicon extraction into alloy from a mixture of amorphous rocks by V.M. Shevko, N.M. Mirkayev, A.D. Badikova

“…It was established that when the melting the amorphous rocks, with an increase in the degree of silicon extraction into the alloy, the apparent activation energy decreases, that is a manifestation of diffusion processes, obviously associated with the formation of a silicon carbide layer on the coke surface. The rate of silicon extraction into the alloy when the melting the amorphous rocks is higher than when the melting quartzite. …”
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