Does Seasonality Affect Peptic Ulcer Perforation? A Single-Center Retrospective Study by Iva Krajnović, Zenon Pogorelić, Iva Perić, Marija Ćavar, Matija Borić

“…Previous studies have suggested a seasonal pattern in the occurrence of symptomatic perforated peptic ulcers. …”
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Multicenter study correlating molecular characteristics and clinical outcomes of cancer cases with patient-derived organoids by Paloma Navarro, Tatiana P. Grazioso, Arantzazu Barquín, Maria Barba, Mónica Yagüe, Carlos Millán, Irene López, Elena Sevillano, Miguel Quiralte, Paloma Fernández, Diego Losada, Eduardo Caleiras, Julia Calzas, Beatriz Jiménez, Sergio Ruiz-Llorente, Juan Justo, Félix Guerrero, Vital Hevia, Raquel Martín, Francisco José Pérez-Rodriguez, Julia Tejerina, Mario Prieto, Paula Comune, Juan Francisco Rodriguez-Moreno, Jesús García-Donás

“…Results From 184 patients (17 tumor types), 249 samples were collected: 149 (59.8%) from tumor tissue, 61 (24.5%) from peritoneal fluids, 39 (15.7%) from peripheral blood. Success rates for PDO establishment were 39.5%, 34.4%, and 25.6%, respectively. …”
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Trends in prescription opioid use in Europe: A DARWIN EU® multinational cohort study including seven European countries by Junqing Xie, Mike Du, Yuchen Guo, Cesar Barboza, James T. Brash, Antonella Delmestri, Talita Duarte-Salles, Talita Duarte-Salles, Jasmine Gratton, Romain Griffier, Raivo Kolde, Wai Yi Man, Núria Mercadé-Besora, Marek Oja, Sarah Seager, Katia Verhamme, Dina Vojinovic, Edward Burn, Daniel Prieto-Alhambra, Daniel Prieto-Alhambra, Martí Català, Annika M. Jödicke

“…Annual period prevalence and incidence rates of opioid prescriptions were estimated, and long-term trends were quantified as the percent change from 2012 to 2019. …”
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Barriers and facilitators to implementing a task-sharing mental health intervention for Sickle Cell Disease populations in low- and middle-income countries: a qualitative analysis... by John Patena, Leah Elster, Tania Hameed, Sumedha Kulkarni, Alden Yuanhong Lai, Annika C. Sweetland, Joyce Gyamfi, Temitope Ojo, Angela Odoms-Young, Charmaine Royal, Emmanuel Peprah

“…BackgroundPeople living with Sickle Cell Disease (SCD) experience higher rates of common mental disorders (CMD). There is an alarming treatment gap in the provision of adequate mental health services for CMDs in low- and middle-income countries (LMIC). …”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…However, relatively little attention has been given to urbanized areas characterized by high rates of population growth and land development. …”
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A longitudinal qualitative study of clinical nurses caring for hospitalized adults during the first fifteen months of COVID-19: lessons in professional survival and leadership by Elizabeth M. Norman, Mildred Ortu Kowalski, Roxanne Sabatini, Carol S. Jones, Wendy Silverstein

“…At the time of this April surge, nurses were exposed to a virus with no standard treatments and high mortality rates. Using a longitudinal qualitative design, the team hoped to answer questions about what compelled these nurses to continue to come to work? …”
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Hydrodynamic Performance and Cavitation Analysis in Bottom Outlets of Dam Using CFD Modelling by Omid Aminoroayaie Yamini, S. Hooman Mousavi, M. R. Kavianpour, Ramin Safari Ghaleh

“…The service gate controls the outlet flow rate, and whenever this gate is out of order, the emergency gate which is located at upstream is utilized. …”
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Groundwater ammonia-oxidizing bacteria distribution and the correlations between the distribution and environmental factors around livestock lagoons by REN Juan, ZHANG Lei, ZENG Lingzao, WU Laosheng, SHI Jiachun

“…In water nitrate cycle, micro-organisms play a significant role. The first and rate limiting step of nitrification is ammoxidation, and the functional gene is ammonia monooxygenase, which existed in ammonia-oxidizing bacteria and ammonia-oxidizing archaea.However, the factors affecting ammonia-oxidizing bacteria distribution pattern in groundwater and the influence mode are still not clear enough. …”
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Development technologies and models of different types of gas reservoirs in Ordos Basin, NW China by Ailin JIA, Dewei MENG, Guoting WANG, Guang JI, Zhi GUO, Naichao FENG, Ruohan LIU, Suqi HUANG, Shuai ZHENG, Tong XU

“…Four key directions of future research and technological breakthroughs are proposed: (1) Utilizing dual-porosity (fracture-matrix) modeling techniques in low-permeability carbonate reservoirs to delineate the volume and distribution of remaining gas in secondary pay zones, supporting well pattern optimization and production enhancement of existing wells. (2) Integrating well-log and seismic data to characterize reservoir spatial distribution of successive strata, enhancing drilling success rates in low-permeability sandstone reservoirs. (3) Utilizing the advantages of horizontal wells to penetrate effective reservoirs laterally, achieving meter-scale quantification of small-scale single sand bodies in tight gas reservoirs, and applying high-resolution 3D geological models to clarify the distribution of remaining gas and guide well placement optimization. (4) Further strengthening the evaluation of deep coal-rock gas in terms of resource potential, well type and pattern, reservoir stimulation, single-well performance, and economic viability.…”
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Specialized insectivores drive differences in avian community composition between primary and secondary forest in Central Africa by Eleanor M. Barrie, Eleanor M. Barrie, Billi A. Krochuk, Billi A. Krochuk, Crinan Jarrett, Crinan Jarrett, Crinan Jarrett, Diogo F. Ferreira, Diogo F. Ferreira, Diogo F. Ferreira, Patricia F. Rodrigues, Patricia F. Rodrigues, Patricia F. Rodrigues, Patricia F. Rodrigues, Susana Lin Mufumu, Susana Lin Mufumu, Silvestre Esteban Malanza, Silvestre Esteban Malanza, Agustin Ebana Nsue Akele, Agustin Ebana Nsue Akele, Cayetano Ebana Ebana Alene, Cayetano Ebana Ebana Alene, Kristin E. Brzeski, Kristin E. Brzeski, Jacob. C. Cooper, Jacob. C. Cooper, Jacob. C. Cooper, Jared D. Wolfe, Jared D. Wolfe, Luke L. Powell, Luke L. Powell, Luke L. Powell, Luke L. Powell

“…Notably, few species disappeared entirely in secondary forest (unlike patterns seen in the Neotropics); rather, capture rates of 12 of 30 species (40%) were significantly reduced relative to primary forest. …”
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Global burden trends and future predictions of ischemic heart disease attributable to air pollution in people aged 60 years and older, 1990–2021 by Yuanqin Zhao, Yuanqin Zhao, Lihui Liu, Lihui Liu, Wei Fan, Wei Fan, Man Qi, Man Qi, Bin Liao, Bin Liao

“…Therefore, it is of utmost significance to investigate the impact of AP on IHD burden, especially on vulnerable populations such as older individuals.MethodologyGlobal Burden of Disease (GBD) Study 2021 data was used to analyze and quantify contemporary global burden of IHD in individuals aged 60 and above due to AP and for trends for the time period between 1990 and 2021 using disease burden indicators such as deaths, DALYs, YLDs, YLLs and corresponding age-standardized rates (ASRs). Specifically, we are in patterns of disease burden of IHD in various subgroups stratified by age, sex, Sociodemographic Index (SDI), and GBD regions and countries. …”
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Burden of six common sexually transmitted infections groups in North Africa and Middle East Region from 1990 to 2021: A systematic analysis of global burden of diseases by Amirhossein Shahsavand, Leonardo Oliveira Reis, Ali Golestani, Alireza Namazi Shabestari, Ziba Aghsaeifard, Ozra Tabatabaei-Malazy, Iman Menbari Oskouie, Bagher Larijani, Seyed Mohammad Kazem Aghamir

“…Both age-standardized rates (ASRs) and total numbers were evaluated across 21 NAME countries, with breakdowns by sex, age, and sociodemographic index (SDI). …”
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Postoperative liver dysfunction in gastric cancer patients following early enhanced nutritional protocols: a retrospective observational study by Kazuo Kobayashi, Satoshi Ida, Masanari Tsuji, Arisa Nawa, Takeshi Aoyama, Takashi Yokokawa, Yoshikazu Tateai, Shuichi Watabe, Hisanori Shimizu, Souya Nunobe, Masakazu Yamaguchi

“…The incidence rates of Grade 1 or higher elevations were 51.8% for AST and 39.4% for ALT on POD 1, and 47.9% for AST and 42.0% for ALT on POD 7. …”
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Double fluorescence-guided surgery with 5-ALA and fluorescein sodium in grade 2 and grade 3 adult-type diffuse gliomas: retrospective analysis of 112 cases by Andrea Bianconi, Marta Bonada, Pietro Zeppa, Francesco Bruno, Pietro La Cava, Flavio Panico, Roberta Rudà, Antonio Melcarne, Diego Garbossa, Fabio Cofano

“…Fluorescence positive rate and pattern have been reported both for 5-ALA and for fluoresceine. …”
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Dynamic gas supply mechanism and theoretical production modes of free gas-rich deep coal reservoirs by Shida CHEN, Taiyuan ZHANG, Dazhen TANG, Hao XU, Shu TAO, Song LI, Shuling TANG

“…Furthermore, the first priority for commercial production capacity construction of deep CBM is determining rational production capacity targets and required well-controlled areas for varying deep geological units and synergistically optimizing well completion methods, well pattern density, fracturing parameters, production allocation rates, and production cycles under the guidance of geological and engineering integration.…”
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Genetic tendency and correlation analysis of fruit traits in the F1 population of Cuiyu × Doyenne du Comice pear by DU Chenfei, WEI Chunyan, LI Wenjue, CAI Danying, WANG Yuezhi, SHI Zebin, GAO Yongbin, DAI Meisong

“…The heritability of single fruit weight was 79.75%, with a separation range of 82.8-430.0 g, a coefficient of variation of 33.31%, a super-high parent rate of 12.50%, and a low parent rate of 69.85%. …”
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Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease by Alton Barbehenn, Lei Shi, Junzhe Shao, Rebecca Hoh, Heather M. Hartig, Vivian Pae, Sannidhi Sarvadhavabhatla, Sophia Donaire, Caroline Sheikhzadeh, Jeffrey Milush, Gregory M. Laird, Mignot Mathias, Kristen Ritter, Michael J. Peluso, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Stephanie E. Cohen, Susan Buchbinder, Diane Havlir, Monica Gandhi, Timothy J. Henrich, Hiroyu Hatano, Jingshen Wang, Steven G. Deeks, Sulggi A. Lee

“…Defective DNA had a similar biphasic pattern, but data were more variable. Predicted intact and defective decay rates were faster for PLWH with earlier timing of ART initiation, higher initial CD4 + T cell count, and lower pre-ART viral load. …”
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Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study by Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD

“…Data on asthma control, medication, lung function, and annualized exacerbation rates were collected at baseline and 3, 12, and 36 months after initiation of dupilumab therapy. …”
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Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome by Xiangmei Li, Lei Liu, Xing Li, Long Yang, Li Men

“…KM survival curves showed that higher DII quartiles were associated with lower survival rates (Log-rank P < 0.05). Cox regression results indicated that each unit increase in DII was associated with a higher risk of all-cause mortality (HR = 1.052, 95% CI: 1.006-1.100, P = 0.026) and cardiovascular mortality (HR = 1.157, 95% CI: 1.076–1.244, P < 0.001). …”
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Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstiti... by Tomoyuki Araya, Toshiyuki Kita, Tsukasa Ueda, Nanao Terada, Tamami Sakai, Kenta Yamamura, Koji Kurokawa, Yuka Uchida, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

“…The overall response and disease control rates were 77.8% (95% CI, 40.0–97.2) and 88.9% (95% CI, 51.8–97.2), respectively. …”
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