Exploring the interplay between LDHA and ABCC1 in breast cancer using computational approach by Bader Alshehri

“…Abstract Background Drug resistance is the major cause of the high death rates in Breast cancer (BC), which continues to be the most frequent disease among women. …”
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Secretory carcinoma of breast with predominant microcystic morphology： report of two cases and literature review by WEI Jingjing, YIN Haoqiang, WANG Yanwen, ZHANG Xiaoyun

“…The results showed expression rates of S100, pan-TRK, and GATA3 at 97%, 95%, and 100%, respectively. …”
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Seaward expansion of salt marshes on the largest uninhabited island in Changjiang Estuary over the past two decades by Yaying Lou, Zhijun Dai, Xuefei Mei, Huabing Shi, Hui Dong, Jinping Cheng

“…The results reveal that salt marshes on JiuDuan Shoal underwent substantial seaward expansion, averaging 3.66 km2/yr, with vertical accretion rates of 0.15 m/yr. Conversely, bare flats shifted from slight deposition (0.01 m/yr from 2002 to 2014) to erosion (0.07 m/yr from 2014 to 2022). …”
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Reducing locomotive maintenance costs with intelligent software by Valeria A. Butusova, Yuriy A. Davydov, Alexey S. Kushniruk, Denis Yu. Drogolov

“…The core methodology is based on the statistical analysis of reliability indicators, including failure rates and the time between failures for individual components. …”
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Vitamin A and D deficiencies in Tibetan vs. non-Tibetan children: roles of altitude, gender, and season in Sichuan Province by Ping Huang, Yanan Zhao, Dong Wang, Yanru Huang, Zheng Peng, Huiye Chen, Xiangyu Zeng, Xinmei Lin

“…Results Tibetan children showed significantly higher rates of vitamin A (47.7% vs. 21.0%) and D (19.8% vs. 10.7%) deficiency compared to non-Tibetan children. …”
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Chronic Obstructive Pulmonary Disease in People with HIV: an Evidence-Based Review by Read AT, Akodu J, Barber TJ, Brown JP, Burns FM, Hurst JR, Miller RF, Lipman MCI

“…Consequently, people with HIV develop COPD younger, more often, and with faster rates of lung function decline compared to seronegative individuals. …”
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KDFE: Robust KNN-Driven Fusion Estimator for LEO-SoOP Under Multi-Beam Phased-Array Dynamics by Jiaqi Yin, Ruidan Luo, Xiao Chen, Linhui Zhao, Hong Yuan, Guang Yang

“…This decision model overcomes the accuracy-robustness trade-off by matching algorithmic strengths to beam-specific dynamics, ensuring optimal performance during abrupt SNR transitions and high Doppler rates. Both simulations and field tests demonstrate KDFE’s dual superiority: Doppler estimation errors were reduced by 26.3% (vs. …”
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Partial Order Ranking of the Key Drivers of Grassland Conversion in the Urban–Grassland Interface: A Case Study of the Hohhot–Baotou–Ordos Region by Xuemei Li, Chang An, Batunacun, Yu Feng, Kaixin Liu, Yong Mei

“…The results show that (1) transitions between grasslands and other land-use types became more frequent across the two periods. Specifically, the rates of grassland conversion out and conversion increased from 2.1% and 3.5% during the period 2000–2010 to 4.7% and 4.8% during the period 2010–2020, respectively. (2) Urbanization was the primary driver of grassland conversion in 11 and 10 of the 18 counties during the first and second periods, respectively, followed by factors related to weather variables. (3) In the future, the eastern region of the study area needs to prioritize mitigating the impacts of urban development, while the western region should focus on enhancing ecological construction projects. …”
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Effects of long-term maize/peanut intercropping and phosphorus application on soil surface electrochemical properties and crop yield by Rentian Ma, Ning Yu, Shiwei Zhao, Shiwei Zhao, Taiji Kou, Nianyuan Jiao

“…This study took the soil under the maize-peanut intercropping system which has been planted for 12 years as the research object, the physical, chemical, and electrochemical properties of soil, and crop yield under different planting patterns [sole-crop maize (SM), sole-crop peanut (SP), and maize-peanut intercropping (M/P)] and phosphorus application rates [P application (180 kg P2O5 ha−1) and no P application (0 kg P2O5 ha−1)] were studied. …”
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Analysis of Tumor and Tumor-Like Entities Tested on the Orthopaedic In-Training Examination From 2012 to 2023 by Sean Kelly, MD, Braden Goldberg, MD, Eli Bryk, MD, FAAOS, FAOA, FACS, Vincent Vigorita, MD

“…Emphasizing highyield topics and adapting to evolving question patterns can optimize educational outcomes and improve board pass rates.…”
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Epigenetic Regulation of Neutrophils in ARDS by Jordan E. Williams, Zannatul Mauya, Virginia Walkup, Shaquria Adderley, Colin Evans, Kiesha Wilson

“…Acute respiratory distress syndrome (ARDS) is an inflammatory pulmonary condition that remains at alarming rates of fatality, with neutrophils playing a vital role in its pathogenesis. …”
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Impact of the agri-geographical transformation of rural settlements on the geospatial dynamics of soil erosion intensity in municipalities of Central Serbia by Srejić Tanja, Manojlović Sanja, Sibinović Mikica, Lukić Tin, Kričković Emina, Durlević Uroš

“…Cluster analysis (CA) was used to differentiate rural areas of municipalities based on selected indicators. The highest rates of soil erosion intensity reduction were found in the regressive and dominantly regressive types (average specific gross erosion 1971: Ws1 = 980 m3/km2/year; 2011: Ws2 = 587 m3/km2/year). …”
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In silico and in vitro assessment of TP53, ATM, RAD51, and BAX genes in gastric cancer and their contribution to radiotherapy resistance by Junwei Zhang, Pengtao He

“…Mutational analysis showed that TP53 was altered in 88% of gastric cancer samples, while ATM, RAD51, and BAX exhibited lower mutation rates. Survival analysis suggested that elevated expression of TP53, RAD51, and BAX may be linked to poorer survival outcomes, while reduced ATM expression appeared to associate with decreased overall survival. …”
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Decoding stimulus-specific regulation of promoter activity of p53 target genes by Flavia Vigliotti, Nicolai Engelmann, Mark Sinzger-D’Angelo, Heinz Koeppl, Heinz Koeppl, Alexander Loewer, Alexander Loewer

“…Indeed, stimulus-specific stochastic gene expression is predominantly regulated by promoter activation and deactivation rates. Interestingly, we found that in many situations, transcriptional activity was uncoupled from the total amount of p53 and the fraction bound to DNA, highlighting that transcriptional regulation by p53 is a multi-dimensional process. …”
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Is mechanism of injury associated with outcome in spinal trauma? An observational cohort study from Tanzania. by Chibuikem Anthony Ikwuegbuenyi, Julie Woodfield, François Waterkeyn, Scott L Zuckerman, Beverly Cheserem, Andreas Leidinger, Albert Lazaro, Hamisi K Shabani, Roger Härtl, Halinder S Mangat

“…Improved neurological outcomes were associated with incomplete injuries (AIS B-D), while higher mortality rates were linked to cervical injuries and complete (AIS A) injuries.…”
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Direct and Indirect Protection with Pediatric Quadrivalent Live-Attenuated Influenza Vaccination in Europe Estimated by a Dynamic Transmission Model by Laetitia Gerlier, Judith Hackett, Richard Lawson, Sofia Dos Santos Mendes, Catherine Weil-Olivier, Markus Schwehm, Martin Eichner

“… # Conclusions The model highlights direct and indirect protection benefits when vaccinating healthy children with QLAIV in Europe, across a range of demographic structures, contact patterns and vaccination coverage rates.…”
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Century-Long Cycles of Evolution of the Country’s Active Population by A. I. Latysheva

“…The collected factual material allows us to draw a conclusion about the general patterns of creative activity of the population both at the beginning of the last century and in our years. …”
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A Retrospective Analysis of CLL Patients in a Romanian Hematology Center by Ana-Maria IORDAN, Minodora Cezarina ONISAI, Anca RAITARU, Claudia DESPAN, Ionel GELATU, Silvia CIORTAN, Daniela GEORGESCU

“…Time to first treatment (TTFT), treatment patterns, and response rates were evaluated. Statistical tests included MannWhitney U and Fisher’s exact test, with p < 0.05 considered significant. …”
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Impact of COVID-19 on mucormycosis presentation and laboratory values: A comparative analysis. by Sepideh Hejazi, Ali Gholampour Kargar, Sahar Ravanshad, Arash Ziaee, Maryam Emadzadeh, Mona Kabiri, Reza Khoshbakht, Mohammad Hossein Ahmadi, Masoumeh Hosseinpoor, Hamed Khosravi, Imtiaz Ahmed, Mehdi Bakhshaee

“…The study compared patient laboratory studies and presentation symptoms between COVID-19 history-positive and COVID-19 history-negative groups, with a particular focus on mortality rates and associated comorbidities such as diabetes, cancer and immunosuppressive treatment.…”
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Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma by Fenglin Zhang, Kexin Liu, Mengfan Ao, Jiangang Zhao, Xinghe Liao, Ping Li, Hao Chen

“…The elevated-risk cohort, as identified by the risk assessment metric, correlates with poorer survival rates. Additionally, we uncover an association between the risk indicator and the tumor milieu, encompassing immune cell infiltration patterns and drug sensitivity profiles. …”
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