Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: result... by Forrest L. Baker, Forrest L. Baker, Forrest L. Baker, Jessica Stokes, Megan J. Cracchiolo, Dan Davini, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis

“…Multi-parameter flow cytometry and TCR β sequencing of genomic DNA was performed on isolated PBMCs on PT days +30, +60, +100, +180, and +365.ResultsOverall, the PT-CY/BEN (n=14) regimen was associated with earlier neutrophil and platelet engraftment, reduced transfusion requirements, and comparable clinical outcomes to PT-CY (n=10), including survival and relapse rates. PT-CY/BEN patients exhibited distinct immune reconstitution patterns, characterized by earlier CD4+ T-cell recovery, impaired CD8+ T-cell engraftment, and reduced NK-cell counts. …”
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Epidemiological and Socioeconomic Disparities in the 1742–1743 Epidemic: A Comparative Analysis of Urban Centers and Indigenous Populations Along the Royal Road by Jorge Hugo Villafañe

“…This study assessed excess mortality and socio-economic consequences across different population groups and settlement types. Results: Mortality rates increased dramatically—up to twelve times the pre-epidemic average in Cordova (Córdoba) and by 45% in Santa Fe—disproportionately affecting Indigenous and enslaved populations. …”
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Unraveling the Mechanistic Links Between Species Diversity and Infection Risk From Zoonotic Pathogens With Direct Transmission Among Reservoir Hosts: Rodent‐Orthohantavirus Systems... by Andreas Eleftheriou, Angela D. Luis

“…Although host regulation likely functions via density‐dependent transmission, and can thus change contact rates among hosts, consequences to other mechanisms have been neglected. …”
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A Data-Driven Analysis of Engineering Contract Risk Characterization Based on Judicial Cases of Disputes by Yongcheng Zhang, Ziyi Wu, Chaohua Xiong, Jianwei Wang, Maxwell Fordjour Antwi-Afari

“…The research identifies contractual risk characteristics across dimensions such as regional distribution, dispute terminology, legal citation patterns, and appellate role transitions. The key findings include the following: (1) Primary risks involve payment disputes, quality assurance failures, contractual validity issues, and schedule compliance challenges. (2) Litigation patterns reveal complex interdependencies between contracting parties and stakeholders, posing significant risk management challenges. (3) High second-instance modification rates stem from procedural irregularities, new evidence, improper legal application, and factual errors in initial trials. …”
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Multimorbidity frailty index and clinical outcomes among 42,989 older heart failure patients directly discharged from emergency departments: A nationwide retrospective cohort study by Wan-Ju Liao, Hsi-Yu Lai, Liang-Yi Lin, Cheng-Hsueh Wu, Fei-Yuan Hsiao, Liang-Kung Chen

“…Readmission rates showed similar patterns. The severely frail group had higher risks of mortality (aHR 1.44, 95 % CI 1.33–1.55), all-cause readmissions (sHR 1.69, 95 % CI 1.62–1.76), and HF-related readmissions (sHR 1.59, 95 % CI 1.48–1.71). …”
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Farm households’ livelihood adaptive capacity under multiple pressures of small watershed management by Yaru Sun, Yilin Gan, Jing Luo, Tingting Han, Hafo Wang, Ruirui Yang, Lingling Tian

“…However, the FHLAC remains predominantly low to moderate in the small watershed. The contribution rates of livelihood pressure, livelihood capital, and willingness to adapt to FHLAC are 22.24 %, 28.69 %, and 49.07 %, respectively. …”
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Geospatial analysis of cholera outbreak in Lusaka, Zambia, between 2023 and 2024 by William Ngosa, Tadatsugu Imamura, Nyuma Mbewe, Joseph Seriki, Oscar Nzila, Fred Mfune, Godfrey Zulu, Chomba Mulando, Tizha Chiluba, Luo Miyanda, Agness Phiri, Lucy Sichone, Galion Mwape, Kapambwe Mulenga, Charles Chileshe, Nawa Mabuku, Dabwiso Banda, Fangyu Yan, Taro Kamigaki, Roma Chilengi, Nyambe Sinyange

“…Results Over the study period, 4,591 suspected cholera cases with geocoordinate data were identified, with incidence rates varying across the constituencies. Median cholera incidence (IQR) was 0.55 (0.27–1.44) in Lusaka, with higher incidence rates observed in unplanned residential areas. …”
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Molecular and genomic investigation of an urban outbreak of dengue virus serotype 2 in Angola, 2017-2019. by Zoraima Neto, Pedro A Martinez, Sarah C Hill, Domingos Jandondo, Julien Thézé, Marinela Mirandela, Renato Santana Aguiar, Joilson Xavier, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Filipa Vaz, Gisel Reyes Castro, Joana Paula Paixão, Nicholas J Loman, Philippe Lemey, Oliver G Pybus, Jocelyne Vasconcelos, Nuno Rodrigues Faria, Joana de Morais

“…<h4>Background</h4>The transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remain poorly understood. …”
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Dynamic parking space allocation at urban scale: Problem formulation and resolution by Hanae Errousso, Jihane El Ouadi, El Arbi Abdellaoui Alaoui, Siham Benhadou

“…To do this, we consider both solicitation rates in these areas and coverage ratios of received parking demands. …”
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The characteristics of new-onset myasthenia gravis after COVID-19 outbreak: a cross-sectional study by Yanzhen Huang, Yu Wu, Shaodan Zhou, Xianting Que, Ailing Jiang, Danli Shi, Ting Lu, Yanlan Chen, Ziqun Lin, Chao Liu, Yishuang Wen, Shuyi Zhang, Wen Huang

“…After COVID-19 outbreak, there was an increase in new-onset MG patients, with more cases occurring within the first three months. The rates of pulmonary inflammation (40.28%), COVID-19 vaccination (88.14%), and treatment with tacrolimus (15.98%) and MG duration (15 weeks, IQR: 5.75, 32) were higher, while rates of thymectomy (13.92%), baseline MG-ADL (3, IQR: 3, 6), and QMGS (7, IQR: 5,8) were lower compared to new-onset MG patients before COVID-19 outbreak. …”
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Nitrogen reduction with supplemental irrigation enhances yield by delaying leaf senescence and optimizing grain-filling process for ridge-furrow film mulching winter wheat by Xiaobo Gu, Yang Xu, Tongtong Zhao, Yadan Du, Yuanling Zhang, Yuyu Tian, Zhikai Cheng, Huanjie Cai, Zhandong Liu

“…However, the optimal supplemental irrigation rate to further increase the yield of winter wheat under RFM remains unclear. …”
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Paclitaxel resistance development is associated with biphasic changes in reactive oxygen species, mitochondrial membrane potential and autophagy with elevated energy production cap... by Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Nabanita Das, Sib Sankar Roy, Gopal Chakrabarti

“…Increase in extracellular acidification rates and oxygen consumption rates was found to be directly correlated with acquisition of resistance. …”
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A Real-World Case Study Towards Net Zero: EV Charger and Heat Pump Integration in End-User Residential Distribution Networks by Thet Paing Tun, Oguzhan Ceylan, Ioana Pisica

“…Based on the outcome of power flow calculation, the transformer loadings and voltage levels were assessed for existing and projected heat pump and EV adoption rates, in line with national policy targets. Findings highlight that varied consumer density and diverse usage patterns significantly influence upgrade requirements.…”
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Innovative deep learning classifiers for breast cancer detection through hybrid feature extraction techniques by S. Vijayalakshmi, Binay Kumar Pandey, Digvijay Pandey, Mesfin Esayas Lelisho

“…Abstract Breast cancer remains a major cause of mortality among women, where early and accurate detection is critical to improving survival rates. This study presents a hybrid classification approach for mammogram analysis by combining handcrafted statistical features and deep learning techniques. …”
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Recent advances in tumor targeted polymeric nanoparticles for HNC treatment: Enhancing therapeutic efficacy via engineered and biocompatible drug delivery systems by Manoj Kumar Srinivasan, Monisha Prasad

“…Head and neck cancer (HNC) represents a heterogeneous group of malignancies with high global incidence and mortality rates. Traditional treatments for advanced HNC, such as combined radiotherapy and chemotherapy, often lead to debilitating long-term side effects that significantly affect patients quality of life. …”
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A novel design for continuous measurement of CO2 from deep remineralization of petrogenic organic carbon by Wan‐Yin Lien, Rick Chen, Jui‐Fen Tsai, Jhen‐Nien Chen, Li‐Hung Lin, Pei‐Ling Wang

“…Measurements in the passive mode yielded stepwise CO2 releases in the fractured zone and steady accumulation in the pulverized zone at rates (18.9–132 mgC m−2 day−1) resembling those for other active orogens. …”
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Prexion: Probabilistic Matching-Based Compression to Mitigate Compression Side Channel Attacks Against HTTPS by Hyoungshick Kim, Sangwon Hyun

“…Furthermore, Prexion ensures robust security, with attack success rates consistently below 5% under recommended configurations.…”
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Employing Data Mining Techniques and Machine Learning Models in Classification of Students’ Academic Performance. by Hussein, Alkattan, Alhumaima, Ali Subhi, Oluwaseun, Adelaja A., Abotaleb, Mostafa, Mijwil, Maad M., Pradeep, Mishra, Sekiwu, Denis, Bamwerinde, Wilson, Turyasingura, Benson

“…The results showed that the use of decision trees can effectively classify students' performance and determine the success and failure rates. The cruel outright mistakes, RMS errors, and relative supreme mistakes all showed 0% whereas the kappa esteem obtained from the analysis extended between 0.991 and 1.00 which significantly concurs with most statistical values.…”
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Big Data Analytics Framework for Decision-Making in Sports Performance Optimization by Dan Cristian Mănescu

“…Key results include a 12% reduction in hamstring injury rates in football, a 16% improvement in clutch decision-making accuracy in basketball, and an 8% decrease in 100 m sprint times among athletes. …”
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Astrocyte–microglia crosstalk in subarachnoid hemorrhage: mechanisms and treatments by Kaibo Yu, Ding Wang, Wenhua Yu

“…Subarachnoid hemorrhage (SAH) is a frequently encountered critical emergency characterized by the rupturing of an unhealthy blood vessel, resulting in high mortality and disability rates. Alterations in the neurovascular unit (NVU) are closely related to the pathogenesis of SAH. …”
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