GEM-CRAP: a fusion architecture for focal seizure detection by Jianwei Shi, Yuanyuan Zhang, Ziang Song, Hang Xu, Yanfeng Yang, Lei Jin, Hengxin Dong, Zhaoying Li, Penghu Wei, Yongzhi Shan, Guoguang Zhao

“…We introduced an average channel deviation rate metric to assess seizure detection accuracy. …”
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Construction and application of copula-based trivariate standardized river disconnection index for seasonal rivers in arid and semi-arid areas by Qingqing Qi, Zipeng Wang, Zezhong Zhang, Hang Yin, Hexin Lai, Yiyang Zhao, Fei Wang, Kai Feng

“…Optimal distribution functions vary across regions, times, and datasets; therefore, using the best monthly distribution functions to compute SRI, SGDI, and SSMI provides a more scientifically robust mathematical and statistical basis. (2) The SSRDI, which combines surface water, groundwater, and soil water, is more consistent with the actual hydrological conditions of Tabu River compared to the three univariate indices. (3) From 2002 to 2020, the SSRDI for Tabu River shows a continuous declining trend, albeit at a slowing rate. The overall pattern exhibits a cyclical trend of worsening followed by improvement, with June being the month of most severe ecological river disconnection. (4) The seasonal component of the SSRDI from 2002 to 2020 displays cyclical changes, with a mutation in June 2004. …”
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Chronic opioid use following surgery for head and neck cancer patients undergoing free flap reconstruction by Ashley Hinther, Alysha Rasool, Steven C. Nakoneshny, Shamir P. Chandarana, Robert Hart, T. Wayne Matthews, Joseph C. Dort

“…Abstract Background Physician opioid-prescribing patterns have significant impacts on the current opioid crisis. …”
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The Effectiveness of the UNAIDS Strategy«90-90-90»in Populations with Different Population Growth by D. A. Neshumaev, E. N. Sukharev, V. L. Stasenko

“…The following parameters were used to describe the epidemic process: population size, birth rate, mortality, HIV prevalence, lethality among patients with HIV/AIDS and probability of HIV transmission. …”
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Transcriptome Profiling Reveals Genetic Basis of Muscle Development and Meat Quality Traits in Chinese Congjiang Xiang and Landrace Pigs by Jiada Yang, Qiaowen Tang, Chunying Sun, Qiuyue Li, Xiaoyu Li, Lu Hou, Yi Yang, Kang Yang

“…RNA sequencing was performed on muscle tissues from ten individuals of each breed, generating 874.5 million raw reads with an average mapping rate of 89.3% to the pig reference genome. (3) Results: Transcriptional profiling revealed distinct expression patterns with 785 genes exclusively expressed in CX pigs and 457 genes unique to LAN pigs, while 7099 co-expressed genes were shared by both breeds. …”
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The cost effectiveness of a multidomain intervention on physical, cognitive, vascular, dietary and psychosocial outcomes among community dwelling older adults with cognitive frailt... by Pavapriya Ponvel, Suzana Shahar, Devinder Kaur Ajit Singh, Arimi Fitri Mat Ludin, Ponnusamy Subramaniam, Norhayati Ibrahim, Hasnah Haron, Aniza Ismail, Chin Ai-Vyrn, Mazlyfarina Mohamad, Hidayah Fadzil, Norhayati Mustafa Khalid, A’isyah Mohammad Safien, Jamilah Mohammad Hanipah, Azyana Ibrahim, Jenni Lehtisalo, Miia Kivipelto, Francesca Mangialasche

“…Despite a 50% dropout rate, adherence among remaining participants was over 50% for all intervention components (range 53%-91%). …”
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Spatiotemporal dynamics and key climatic influences on vegetation resilience in opencast coal mine dumps after restoration by Hui Wang, Chengye Zhang, Yaxin Ding, Feiyue Li, Wanxi Liu, Yan Ma, Yingjie Guo, Bikram Banerjee, Jun Li

“…These findings demonstrate that vegetation resilience captures stage-specific ecological patterns that NDVI alone cannot detect, thereby supporting adaptive restoration and climate-informed management in mining environments.…”
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Characteristics of second primary malignancies following bispecific antibodies therapy by Dan Liu, Tong Li, Liang Wang, Jia Guo, Xinyu Zhou, Hongsheng Zhou, Xiaojie Liang, Baiwei Luo, Bingyu Lin, WeiXiang Lu, Shengyu Tian, Zihong Cai, Zhihao Jin, Keren Chen

“…The incidence risk of SPMs was stable over the past 8 years, accounting for 1–2% of all adverse events, with a case fatality rate of 29.63% among the SPM cases. Myeloid leukemias and non-Hodgkin’s lymphoma were more frequent in blinatumomab recipients, while solid malignancies predominated in those treated with teclistamab. …”
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Analysis of epigenetic biomarkers for diagnosis and assessment of severity in rheumatoid arthritis: a cross-sectional study by Arkaitz Mucientes, Gracia María Martín Núñez, Natalia Mena-Vázquez, Jose Manuel Lisbona-Montañez, Sara Manrique-Arija, Andrés González-Jiménez, Patricia Ruiz-Limón, Aimara Garcia-Studer, Fernando Ortiz-Márquez, Laura Cano-García, Antonio Fernández-Nebro

“…This study aims to analyze methylation patterns in RA patients and controls to identify diagnostic and prognostic epigenetic biomarkers. …”
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GPC3: a novel mutated gene in pleuropulmonary blastoma by Jiahang Zeng, Xinying Wang, Yingyi Xu, Qinglin Yang, Junzheng Peng, Fenghua Wang, Jue Tang, Dongmei Huang, Jiachi Liao, Yunyu He, Lin Huang, Jianhua Liang, Le Li, Zefeng Lin

“…Survival analysis revealed that patients with high GPC3 expression (GPC3+++) exhibited a markedly lower two-year survival rate (30%) compared to moderate (GPC3++, 75%) and low (GPC3+, 90.9%) expression groups (p = 0.0035). …”
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Clinical benefit of tafasitamab plus lenalidomide in relapsed or refractory diffuse large Bcell lymphoma: real-world data from the EarlyMIND study by Gabriel Brisou, Jérôme Paillassa, Sophie Bernard, Olivier Tournilhac, Luc-Matthieu Fornecker, Frédéric Maloisel, Lauris Gastaud, Eric Durot, Adrian Tempescul, Thorsten Braun, Vadim Ivanov, Brieuc Cherel, Caroline Serrier, Jeremy Delage, Abderrazak El Yamani, Baptiste Delapierre, Laure Lebras, Elsa Lestang, Camille Villesuzanne, Philippe Agape, Guillaume Escure, Ludovic Fouillet, Christophe Nicol, Gaëlle Olivier, Anthony Levy, Anne-Sophie Le Bris, Ophélie Cassuto, Laura Jacquemelle, Corinne Haioun, Charles Herbaux

“…Approval was based on the L-MIND study, which demonstrated a 57.5% overall response rate (ORR), 41.3% complete response (CR) rate, 12.1 months median progression-free survival (PFS), and 33.5 months median overall survival (OS) at five years. …”
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Real-world effectiveness of post-trastuzumab emtansine treatment for human epidermal growth factor receptor 2-positive metastatic breast cancer: a multicenter, matched cohort analy... by C. Courtinard, V. Barbet, R. Schiappa, F. Pilleul, S. Michiels, S. Dabakuyo, S. Gourgou, A. Jaffre, B. Asselain, L. Bosquet, K. Dunton, M. Rosenlund, Z. Liang, J. Cathcart, S. Delaloge

“…Patients and methods: Patients from the French Epidemiology Strategy and Medical Economics (ESME) mBC database who initiated treatment for HER2+ mBC between 1 January 2008 and 31 December 2016, and received one or more treatment lines following T-DM1 were propensity score matched 1 : 1 to patients from DESTINY-Breast01 to create an ESME DB-01 matched cohort. Treatment patterns, real-world best overall response, real-world objective response rate (rwORR), real-world disease control rate (rwDCR), real-world progression-free survival (rwPFS), and overall survival (OS) were estimated, including by prior pertuzumab exposure and de novo/relapsed mBC status. …”
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[Translated article] Fixation of adult femoral neck fractures: Retrospective comparison between cannulated screws and femoral neck system (FNS) by E. Guillén Botaya, Á. Soler García, J.L. Aparicio Martínez, A. Tejeda Gómez, F. Segura Llopis, A. Silvestre Muñoz

“…Results: No significant differences were found in age (p-value 0.32), fracture patterns (p-value 0.77), surgical delay (p-value 0.28), surgical time (p-value 0.226), length of hospital stay (p-value 0.921) and blood loss (p-value 0.086) between the two groups.A significantly higher overall complication rate was observed in the group treated with cannulated screws (p-value 0.004). …”
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Differential Cortical Responses of Functional and Sensory Electrical Stimulation in Closed-Loop Tremor Suppression for Parkinson’s Disease by Xiaoqi Zhao, Tinglan Huang, Mengyue Jin, Hongbo Zhao, Yu Shi, Yanlin Wang, Xiao Shen, Zhen Li, Qingqing Shi, Xiaodong Zhu, Lin Meng

“…Both FES and SES significantly reduced tremor amplitude, with FES showing overall greater suppression (hand suppression rate: 60.72% vs. 48.31%, p >0.05; forearm suppression rate: 62.25% vs. 54.41%, p >0.05) where substantial inter-individual variability was observed. …”
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Timing of Surgery and Preoperative Predictors of Surgical Site Infections for Patients with Depressed Skull Fractures in a Sub-Saharan Tertiary Hospital: A Prospective Cohort Study by Hervé Monka Lekuya, Jelle Vandersteene, Larrey Kasereka Kamabu, Rose Nantambi, Ronald Mbiine, Anthony Kirabira, Fredrick Makumbi, Stephen Cose, David Patrick Kateete, Mark Kaddumukasa, Edward Baert, Moses Galukande, Jean-Pierre Okito Kalala

“…The outcome variables were the incidence risk of SSI, types of SSI, microbial culture patterns of wound isolates, and hospital length of stay. …”
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Annual dialysis data report 2022, Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry by Norio Hanafusa, Masanori Abe, Nobuhiko Joki, Junichi Hoshino, Masatomo Taniguchi, Kan Kikuchi, Takeshi Hasegawa, Shunsuke Goto, Tetsuya Ogawa, Eiichiro Kanda, Shigeru Nakai, Toshihide Naganuma, Kenichiro Miura, Atsushi Wada, Yoshiaki Takemoto

“…The results obtained for each condition provide evidence for developing more clinically effective practice patterns for these conditions.…”
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Effects of licorice extract on Paraclostridium bifermentans spore growth and quality changes in ready-to-eat chicken breast during storage by Jichao Huang, Zimu Li, Mengmeng Song, Yang Lei, Kairan Sheng, Tianran Huang, Kaichen Zhang, Ming Huang

“…Furthermore, the Gompertz and Logistic models demonstrated a strong fit (R² > 0.98) with the growth patterns of P. bifermentans spores at 15, 20, and 25 °C. …”
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Multi-modal remote sensory learning for multi-objects over autonomous devices by Aysha Naseer, Naif Almudawi, Hanan Aljuaid, Abdulwahab Alazeb, Yahay AlQahtani, Asaad Algarni, Ahmad Jalal, Ahmad Jalal, Hui Liu, Hui Liu, Hui Liu

“…The assessment findings show a remarkable recognition rate of around 97.90% and 98.90%, on the AID and the UC Merced Land datasets, respectively.…”
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Immune-related adverse events of neoadjuvant immunotherapy in patients with perioperative cancer: a machine-learning-driven, decade-long informatics investigation by Yuan Meng, Rong Hu, Song-Bin Guo, Deng-Yao Liu, Zhen-Zhong Zhou, Hai-Long Li, Wei-Juan Huang, Xiao-Peng Tian

“…During the past decade, the amount of research in the field of NAI safety has displayed a positive trend (annual growth rate: 30.2%), and it has achieved good global collaboration (international coauthorship: 17.43%). …”
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Lipidomic analyses reveal the dysregulation of oxidized fatty acids (OxFAs) and acyl-carnitines (CARs) in major depressive disorder: a case-control study by Lei He, Na Duan, Chong Wang, Ru Shan, Jing Li, Lin Wang, Qiuli Liu, Junwei Tao, Li Liu, Xiaoliang Ma, Bing Cao

“…Results Based on the filtering criteria of false discovery rate (FDR) -adjusted P < 0.05, variable importance in projection (VIP) > 1.5, and fold change (FC) > 2.0 or < 0.5, a total of 40 lipids were identified as significantly different. …”
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