Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database by Xinkuo Zheng, Meishen Liu, Aili Ding, Shihong Zhang, Ling Wu, Fanli Kong, Weijia Sun, Yuchen Peng, Yalin Xi

“…Females showed higher AE reporting rates (54.29%) compared to males (36.88%), with the majority of cases (38.20%) occurring in individuals aged < 18 years. …”
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Palliative Radiotherapy Near the End of Life: An Analysis of Factors Influencing the Administration of Radiotherapy in Advanced Tumor Disease by Nguyen-Son Le, Asli Zeybek, Klaus Hackner, Cornelia Gallauner, Josef Singer, Felix Schragel, Petra Georg, Sandra Gottsauner-Wolf, Martin Pecherstorfer, Gudrun Kreye

“…Furthermore, RT near the EOL was more likely administered at multiple sites (OR, 2.08 [95% CI, 1.00 to 4.29]) and with ≤5 fractions (OR, 2.37 [95% CI, 1.23 to 4.57]), while being associated with lower response rates (OR, 0.43 [95% CI, 0.21 to 0.86]) and increased therapy discontinuation (OR, 4.40 [95% CI, 1.45 to 13.37]).CONCLUSIONThese findings highlight varying RT patterns influenced by specific factors, demonstrating the complexity of EOL treatment decisions in advanced cancer care. …”
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Biomechanical stability and stress distribution before talus prosthesis design: effects of ligament removal and cartilage overlay thickness using finite element analysis by Gang Zeng, Yujun Sun, Min Liang, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Taolue Zhou, Huiying Zhao, Weidong Song, Yue Ding

“…Recent advancements, including patient-specific implants and improved biomaterials, show promise in enhancing long-term outcomes and reducing complication rates. Aim This study investigates the mechanical stability and stress distribution changes in a talus prosthesis after the sequential removal of surrounding ligaments and the application of varying thicknesses of cartilage overlays. …”
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Changes in influenza-associated excess mortality in China between 2012–2019 and 2020–2021: a population-based statistical modelling study by Xiaowei Deng, Jiangmei Liu, Minghan Wang, Nana Chen, Feiran Hao, Juan Yang, Maigeng Zhou, Hongjie Yu

“…Distinct pattern was observed for the AC and P&I outcomes. …”
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Development of approaches to the evaluation of pharmacotherapy effectiveness for chronic hepatitis C by I. A. Narkevich, E. A. Tsitlionok

“…Objective: to analyse the consumption pattern of antiviral therapy (AVT) for chronic hepatitis C on the example of an infectious hospital.Material and methods. …”
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Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, indi... by Emmanuel Bottieau, Achilleas Tsoumanis, Yven Van Herrewege, Diana Arango, Christophe Burm, Badara Cisse, Souleymane Mboup, Clémentine Roucher, Isabel Brosius, Moustapha Mbow, Babacar Thiendella Faye, Annelies De Hondt, Bart Smekens, Linda Paredis, Idzi Potters, Katja Polman

“…The trial’s primary endpoints are the efficacy (cure rate (CR), assessed by microscopy) and safety (frequency and pattern of drug-related adverse events) of one AM course versus PZQ at 4 weeks after treatment. …”
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Spatiotemporal Change in Climate Variables and Resources of Wind， Solar Radiation and Precipitation in Qinghai Province from 1961 to 2021 by Meixia DUAN, Miaoni GAO, Han JIANG, Runhong XU, buda SU, Tong JIANG

“…In order to evaluate the potential of wind， solar radiation and precipitation in guaranteeing the development of clean energy comprehensively， this study analyzed the temporal and spatial changes in climate variables and resources of wind speed， solar radiation and precipitation in Qinghai Province throughout the year and four seasons from 1961 to 2021 based on the observation data of daily 10-meter-height wind speed， sunshine duration and precipitation at 51 meteorological stations.The results are as follows： （1） The annual average wind speed， solar radiation and precipitation in Qinghai Province are 2.67 m·s-1， 6084.2 MJ·m-2， and 299.7 mm， respectively.Wind speed tends to be higher in the western regions and lower in the east， which exceeds 3 m/s and reaches the standard for wind energy resource development in western Qinghai.The annual solar radiation in the entire Province exceeds 5040 MJ·m-2， and reaches the "very rich" level according to China Solar energy GB Standards.The solar radiation of Qaidam Basin is at its highest abundance level， which is ideal for solar energy resource development.Precipitation generally decreases from southeast to northwest.The resources of wind， solar radiation， and precipitation in Qinghai Province exhibits seasonal complementarity， characterized by a pattern of “strong winds， good sunlight， and less water in spring， whereas weak winds， good sunlight， and abundant water in summer”.（2） Under climate change， the annual average wind speed and total solar radiation in Qinghai Province show a significant decrease at rates of 0.16 m·s-1·10a-1and 29.04 MJ·m-2·（10a）-1， respectively.The western and central parts of Haixi are most affected by these changes， but the wind speed and solar radiation still remain within the acceptable range for wind energy and photovoltaic resource development.Meanwhile， precipitation increases significantly at a rate of 8.85 mm·（10a）-1， with the largest increase observed in western Yushu， eastern Haixi and northern Guoluo.The most significant decrease in wind speed is observed in spring， while summer solar radiation decreases at the fastest rate but with a substantial increase in precipitation.The changes in solar radiation and precipitation could be ascribed to the increased cloud cover in this region.（3） The changes in the areas where wind speed and solar radiation meet suitable development standards in Qinghai Province are not significant with reduced variabilities， which could ensure the stable development of clean energy.Wind energy resources in western Qinghai （such as Tanggula Mountains）， solar energy resources in the Qaidam Basin， and water energy resources in the three major river basins of the Yangtze River， Yellow River， and Lancang River have great potential for development.Overall， the results provide a theoretical foundation for the development of a balanced clean energy system encompassing wind， solar and hydropower.This contributes to achieving national "dual carbon" goals and enhancing the high-quality development of Qinghai Province.…”
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Influence of SCD and FABP3 genetic markers on carcass traits and meat quality in Aberdeen Angus bulls by Sena Ardicli, Nursen Senturk, Tugce Necla Selvi, Sena Yonga, Rumeysa Celik, Beyza Karalar, Aleyna Ozdeniz, Madina Aliyeva, Havvanur Aydin, Ozgur Toprak Ay, Ozge Ardicli, Muhammed Emin Sari, Berkay Bozkurt, Oliva Giannelli Viscardi, Huseyn Babayev, Hakan Ustuner

“…The results suggest a notable impact of the FABP3 rs210042291 gene on growth rates. These findings highlight the complexity of genetic influences on meat quality traits.…”
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Supershear source model of the 2025 M7.8 Myanmar earthquake and paleoseismology of the Sagaing Fault: regions of significant overlap with past earthquakes by Diego Melgar, Ray Weldon, Yu Wang, Mary Grace Bato, Lin Thu Aung, Xuhua Shi, Weerachat Wiwegwing, Saw Ngwe Khaing, Soe Min, Myo Thant, Cole Speed, Robert Zinke, Eric Fielding, Aron Meltzner, Timothy Dawson

“…Given the exceptional exposure to earthquakes and high strain rates, our findings underscore the need for urgent attention to earthquake preparedness and infrastructure resilience in central Myanmar. …”
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Valley-filling Potential Evaluation of Urban Public Charging Stations Based on Price Incentive by Dawei SU, Yihui FAN, Tianhui ZHAO, Hongjin PAN, Youhui HUANG, Gang WANG, Yongyong JIA

“…Then, the typical load characteristic indicators including valley-period and flat-period load rates are proposed, and the charging load valley-filling potential evaluation parameters are introduced to carry out valley-filling potential evaluation of urban public charging stations. …”
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Gut Microbiota Contribute to Heterosis for Growth Trait and Muscle Nutrient Composition in Hybrid Largemouth Bass (<i>Micropterus salmoides</i>) by Jixiang Hua, Qingchun Wang, Yifan Tao, Hui Sun, Siqi Lu, Yan Zhuge, Wenhua Chen, Kai Liu, Jie He, Jun Qiang

“…Growth, digestive enzyme activity, and muscle nutrient composition were compared between the hybrid groups (NC and CN) and the purebred groups (NN and CC), and the gut microbiota was investigated. The heterosis rates of body length, body height, and body thickness in hybrid largemouth bass were statistically significant. …”
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Deeply revealing the coupled formation mechanism of inclusions and precipitates in 654NMo ingot by Hongchun Zhu, Xinbo Yan, Huabing Li, Zhiyu He, Zhuowen Ni, Hao Feng, Shucai Zhang, Zhouhua Jiang, Pengchong Lu

“…The inclusion number density is significantly higher at the ingot edge compared to the center, while the bottom zone exhibits a greater density than the top and middle. This distribution pattern is attributed to the higher solidification rates at the edge and bottom. …”
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Multiyear Baleen Endocrine Profiles Suggest a Longer Estimated Gestation in Southern Right Whales (Eubalaena australis) by Loraine Shuttleworth, Andre Ganswindt, Kathleen E. Hunt, Alejandro Fernández Ajó, Estefan Pieterse, S. Mduduzi Seakamela, Chantel Schoeman, Els Vermeulen

“…ABSTRACT Gestation length is a key reproductive parameter influencing fecundity, population growth rates, and the recovery potential of baleen whales. …”
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Using optimization tools to explore stratospheric aerosol injection strategies by E. Brody, Y. Zhang, D. G. MacMartin, D. Visioni, B. Kravitz, B. Kravitz, E. M. Bednarz, E. M. Bednarz, E. M. Bednarz

“…However, the outcomes will depend on how it is deployed: not just how much but also the latitudes of injection and the distribution of injection rates across those latitudes. Different such strategies have been proposed, for example, managing up to three climate metrics simultaneously by injecting at multiple latitudes. …”
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SERPINA3 predicts long-term neurological outcomes and mortality in patients with intracerebral hemorrhage by Pei Zheng, Zhihui Qi, Bin Gao, Yang Yao, Jingshan Chen, Hengri Cong, Yue Huang, Fu-Dong Shi

“…Abstract Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, and long-term outcomes among survivors remain unpredictable due to the lack of reliable biomarkers. …”
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Review of Epidemiological Situation on Rickettsioses in the Russian Federation in 2022 as Compared with 2013–2021, Forecast for 2023 by N. A. Pen’evskaya, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, D. A. Savel’ev, S. V. Shtrek, A. V. Sannikov

“…The aim of the review was to characterize the epidemiological situation on tick-borne rickettsioses (TR) in the Russian Federation in 2022 in comparison with the pandemic years of 2020–2021 and the pre-pandemic period of 2013–2019, to give the forecast for 2023. During 2013–2022, a pattern was observed in the incidence of rickettsiosis of the tick-borne spotted fever group (with the exception of Astrakhan spotted fever – ASF), that is also characteristic of most other natural focal infections (NFIs): a sharp decrease in registered incidence rates in 2020–2021 with the subsequent increase in 2022 almost up to pre-pandemic levels or even exceedance in some regions. …”
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Psychiatric comorbidities and smoking behavior in chronic obstructive pulmonary disease: A case–control study from a north Indian tertiary Center by Rohit Pathak, Abhishek Pathak, Manish Singh

“…Results: Cases exhibited significantly higher rates of smoking, with regular smokers constituting 51.1% compared to 14.0% of controls (P=0.0001). …”
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IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. by Helen M Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S Suthar, Albert Huang, Sarah C Vick, Lisa Clepper, Larissa Thackray, Margaret M Brassil, Herbert W Virgin, Janko Nikolich-Zugich, Ashlee V Moses, Michael Gale, Klaus Früh, Michael S Diamond

“…In pathogenesis studies with two unrelated positive-sense RNA viruses (West Nile virus (WNV) and murine norovirus), TKO mice succumbed at rates greater than DKO mice and equal to or approaching those of mice lacking the type I IFN receptor (Ifnar(-/-)). …”
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Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis by Rebeka Bustamante Rocha, Fernanda Ferreira Bomtempo, Gabriela Borges Nager, Giulia Isadora Cenci, João Paulo Mota Telles

“…Concerning TST, an apparent dose-dependent pattern was noticed, with higher doses relating to a longer TST. …”
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In Silico Designed Multi-Epitope Vaccine Based on the Conserved Fragments in Viral Proteins for Broad-Spectrum Protection Against Porcine Reproductive and Respiratory Syndrome Viru... by Shaukat Ullah, Hikmat Ullah, Kainat Fatima, Tan Lei

“…This virus includes two major genotypes, PRRSV1 and PRRSV2, both characterized by high mutation rates and genetic variability, complicating the development of a universally effective vaccine and disease control. …”
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