Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy by Alexander Pil Henriksen, Cristina Leal Rodríguez, Hannah Currant, Ioannis Louloudis, Jorge Hernansanz Biel, Maria Herrero-Zazo, Ewan Birney, Thomas Folkmann Hansen, Gianluca Mazzoni, Amalie Dahl Haue, Henning Bundgaard, Christian Erikstrup, Khoa Manh Dinh, Liam Quinn, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sørensen, Christina Mikkelsen, Michael Schwinn, Ole Birger Vestager Pedersen, Henrik Ullum, Sisse Rye Ostrowski, Karina Banasik, Søren Brunak

“…As populations get older and medicine consumption rises, the rate of concurrent drug use and polypharmacy among patients is increasing. …”
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Paradigm shift of respiratory viruses causing lower respiratory tract infection in children during COVID-19 pandemic in India by Mannat Kang, Subhabrata Sarkar, Suresh Kumar Angurana, Pankaj Singh, Meenakshi Rana, Ishani Bora, Rishi Chetanya, Bharatendu Singh, Jayashree Muralidharan, Radha Kanta Ratho

“…No significant difference in positivity rate of Inf A pdmH1N1, Inf A H3N2 and Inf B was seen. …”
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Epidemiological characterization of chronic myeloid leukaemia patients at an oncologic centre: A retrospective observational study by Ana Maria Meireles, Rita Calisto, Maria José Bento, Pedro Martinho Gouveia, Susana Bizarro, Manuel Teixeira, Cláudia Moreira, Ana Espírito Santo, Mário Mariz

“…At three months, the early molecular response rate was 77 %. At 12 months of treatment, of the 67 patients with response evaluation, 93 % achieved complete cytogenetic response and 49 % major molecular response. …”
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Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies. by Yanina Sguassero, Cristina B Cuesta, Karen N Roberts, Elizabeth Hicks, Daniel Comandé, Agustín Ciapponi, Sergio Sosa-Estani

“…In the long-term, the rate of negativization was between 20% and 45%. The main sources of bias identified across cohort studies were the lack of control for confounding and attrition bias. …”
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Heritability and Genetics of Type 2 Diabetes Mellitus in Sub-Saharan Africa: A Systematic Review and Meta-Analysis by Evans Adu Asamoah, Christian Obirikorang, Emmanuel Acheampong, Max Efui Annani-Akollor, Edwin Ferguson Laing, Eddie-Williams Owiredu, Enoch Odame Anto

“…Sub-Saharan Africa (SSA) is observing an accelerating prevalence rate of type 2 diabetes mellitus (T2DM) influenced by gene-environment interaction of modifiable and nonmodifiable factors. …”
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COVID-19 vaccine evidence monitoring assisted by artificial Intelligence: An emergency system implemented by the Public Health Agency of Canada to capture and describe the trajecto... by Su Hyun Lim, Mona Hersi, Ramya Krishnan, Joshua Montroy, Bonnie Rook, Kelly Farrah, Yung-En Chung, Adrienne Stevens, Joseline Zafack, Eva Wong, Nicole Forbes, April Killikelly, Kelsey Young, Matthew Tunis

“…Analysis of COVID-19 vaccine research patterns supports projections of research volume, type, and rate that will help predict resourcing and information needs to plan future emergency vaccine guidance activities.…”
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Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma by Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

“…Multiple myeloma (MM) is the second most prevalent hematologic malignancy characterized by a high synthesis rate of disulfide bond-rich proteins and chronic oxidative stress. …”
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Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response by Cong Tang, Patrícia Corredeira, Sandra Casimiro, Qi Shi, Qiwei Han, Wesley Sukdao, Ana Cavaco, Cecília Melo-Alvim, Carolina Ochôa Matos, Catarina Abreu, Steven Walsh, Gonçalo Nogueira-Costa, Leonor Ribeiro, Rita Sousa, Ana Lorena Barradas, João Eurico Fonseca, Luís Costa, Emma V. Yates, Gonçalo J. L. Bernardes

“…By measuring the total concentrations of cysteine, free cysteine, lysine, tryptophan, and tyrosine protein-incorporated biomarkers and analyzing the results with supervised machine learning, we identify 78% of cancers with 0% false positive rate (N = 97) with an AUROC of 0.95. The cancer, healthy, and autoimmune/infectious biomarker pattern are statistically significantly different (p < 0.0001). …”
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Discovery and molecular identification of a new orthophasmavirus in the Asian citrus psyllid (Diaphorina citri) by Song Zhang, Song Zhang, Jing Chen, Jing Chen, Luqin Liu, Luqin Liu, Zhipeng Xie, Zhipeng Xie, Jiamei Liang, Jiamei Liang, Fulin Yan, Fulin Yan, Yaqin Song, Xuefeng Wang, Xuefeng Wang, Changyong Zhou, Changyong Zhou, Mengji Cao, Mengji Cao, Jinxiang Liu, Jinxiang Liu

“…It was also detected in progeny of infected ACPs and in the leaves fed upon by infected individuals. The infection rate of CLas was reduced in ACPs infected with DcBV2, and vice versa.DiscussionDcBV2 was fully sequenced and represents a new Orthophasmavirus species. …”
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Widespread geographic distribution of filarioid nematodes in caribou (Rangifer tarandus sspp.) in Canada by Aparna Mariyam Thomas, Guilherme G. Verocai, John Soghigian, Fabien Mavrot, Naima Jutha, Jan Adamczewski, Tracy Davison, Gwen Duytschaever, Arthur Fernandes, Allicia Kelly, Matthew R. Kulpa, Eve Lamontagne, Lisa-Marie Leclerc, Sara McCarthy, Ashley McLaren, Amanda D. Melin, Susan J. Kutz

“…The Arctic is currently experiencing an unprecedented rate of climate change, including warming temperatures and altered patterns of precipitation. …”
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An Examination of Water‐Related Melt Processes in Arctic Snow on Tundra and Sea‐Ice by Anika Pinzner, Matthew Sturm, Jennifer S. Delamere, Andrew R. Mahoney

“…In both years meltout dates varied by up to 25 days between sites, and more than 20 days within sites, with melt rates at locations only meters apart differing by up to a factor of seven. …”
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Modeling Riding and Stopping Behaviors at Motorcycle Box Intersections: A Case Study in Chiang Mai City, Thailand by Wachira Wichitphongsa, Nopadon Kronprasert, Moe Sandi Zaw, Pongthep Pisetsit, Thaned Satiennam

“…This research aims to evaluate the traffic performance of motorcycle boxes with respect to motorcycle departure times, headway intervals, lane-filtering rates, and vehicle movement patterns at 12 signalized urban intersections in Chiang Mai, Thailand. …”
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Evaluation of urinary tract infection agents in intensive care unit patients and monitoring of antimicrobial profile in Gram-negative bacteria by Nazife Akman, Pelin Özmen

“…Due to high resistance rates, the use of carbapenems and quinolones should be avoided in the treatment of A. baumannii. …”
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Modeling nitric oxide diffusion and plasticity modulation in cerebellar learning by Alessandra Maria Trapani, Carlo Andrea Sartori, Benedetta Gambosi, Alessandra Pedrocchi, Alberto Antonietti

“…The results demonstrate that NO diffusion significantly affects synaptic plasticity, dynamically adjusting learning rates based on synaptic activity patterns. This metaplasticity mechanism enhances the cerebellum's capacity to prioritize relevant inputs and mitigate learning interference, selectively modulating synaptic efficacy. …”
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An approach to using stranding data to monitor cetacean population trends and guide conservation strategies by Rachel L. Lennon, Rosie S. Williams, Kathryn J. Allan, Mariel T.I. ten Doeschate, Nicholas J. Davison, Simon A. Babayan, Andrew C. Brownlow

“…Species were clustered into broad ecological groups - baleen whales, short-beaked common dolphins, deep divers, harbour porpoises and pelagic dolphins - for spatiotemporal analysis of stranding patterns. All groups showed increases in annual stranding rates over the study period, with common dolphins and baleen whales exhibiting exponential increases, suggesting these species may be facing heightened pressures. …”
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Investigating antibiotic use in Gaza Strip hospitals: A retrospective cross-sectional analysis by Hala ZI Alagha, Maha Jebreel Al Telbani

“… Introduction: Rates of antimicrobial resistance in the Gaza Strip are rising while regulations on antibiotics use are weakly implemented. …”
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Integrated Platform for Bio-Image Processing and Identification of Cervical Cancer by Larisa-Dalina LAZĂR, Diogen BABUC, Todor IVAŞCU

“…The integration of artificial intelligence in medical imaging can contribute to early detection and contribute to reduction of mortality rates associated with this disease. A future direction is to explore the applications of Vision Transformers, which have demonstrated excellent performance in capturing complex patterns in image data, to further improve data preprocessing and classification accuracy. …”
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Mortality trends in Kazakhstan: insights from a million of deaths from 2014 to 2022 by Temirgali Aimyshev, Gulnur Zhakhina, Sauran Yerdessov, Ruslan Akhmedullin, Dinara Galiyeva, Kuanysh Yergaliyev, Antonio Sarria-Santamera, Yuliya Semenova, Abduzhappar Gaipov

“…COVID-19 significantly disrupted mortality patterns in 2020–2021. Mortality rates were consistently higher in males across most age groups, with a sharp increase after age 55, while “other disorders of the brain” emerged as a leading cause of premature mortality. …”
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Examining changes in social care referrals during the 2021 Winter Storm Uri in the Unite Texas network by Zackery White, Amanda Terry, Gillian Feldmeth, Alyssa Altstaedter, Halima Ahmadi-Montecalvo

“…Following the storm, case rates returned to pre-storm levels, with increased case resolution and reduced time to case closure. …”
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Prevalence and factors associated with Babesia bigemina infection in Crioula Lageana cattle breed by Mariana da Silva Casa, Julio de Mattos Vettori, Ketriane Mota de Souza, Paulo Ricardo Benetti Todeschini, Luiz Cláudio Miletti, Carla Ivane Ganz Vogel, André Luís Ferreira Lima, Joandes Henrique Fonteque

“…Males showed significantly higher infection rates (79%; 49/62) compared to females (55%; 137/249; OR=3.36, p<0.001). …”
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