Decoding stimulus-specific regulation of promoter activity of p53 target genes by Flavia Vigliotti, Nicolai Engelmann, Mark Sinzger-D’Angelo, Heinz Koeppl, Heinz Koeppl, Alexander Loewer, Alexander Loewer

“…Indeed, stimulus-specific stochastic gene expression is predominantly regulated by promoter activation and deactivation rates. Interestingly, we found that in many situations, transcriptional activity was uncoupled from the total amount of p53 and the fraction bound to DNA, highlighting that transcriptional regulation by p53 is a multi-dimensional process. …”
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Is mechanism of injury associated with outcome in spinal trauma? An observational cohort study from Tanzania. by Chibuikem Anthony Ikwuegbuenyi, Julie Woodfield, François Waterkeyn, Scott L Zuckerman, Beverly Cheserem, Andreas Leidinger, Albert Lazaro, Hamisi K Shabani, Roger Härtl, Halinder S Mangat

“…Improved neurological outcomes were associated with incomplete injuries (AIS B-D), while higher mortality rates were linked to cervical injuries and complete (AIS A) injuries.…”
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Direct and Indirect Protection with Pediatric Quadrivalent Live-Attenuated Influenza Vaccination in Europe Estimated by a Dynamic Transmission Model by Laetitia Gerlier, Judith Hackett, Richard Lawson, Sofia Dos Santos Mendes, Catherine Weil-Olivier, Markus Schwehm, Martin Eichner

“… # Conclusions The model highlights direct and indirect protection benefits when vaccinating healthy children with QLAIV in Europe, across a range of demographic structures, contact patterns and vaccination coverage rates.…”
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Century-Long Cycles of Evolution of the Country’s Active Population by A. I. Latysheva

“…The collected factual material allows us to draw a conclusion about the general patterns of creative activity of the population both at the beginning of the last century and in our years. …”
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A Retrospective Analysis of CLL Patients in a Romanian Hematology Center by Ana-Maria IORDAN, Minodora Cezarina ONISAI, Anca RAITARU, Claudia DESPAN, Ionel GELATU, Silvia CIORTAN, Daniela GEORGESCU

“…Time to first treatment (TTFT), treatment patterns, and response rates were evaluated. Statistical tests included MannWhitney U and Fisher’s exact test, with p < 0.05 considered significant. …”
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Impact of COVID-19 on mucormycosis presentation and laboratory values: A comparative analysis. by Sepideh Hejazi, Ali Gholampour Kargar, Sahar Ravanshad, Arash Ziaee, Maryam Emadzadeh, Mona Kabiri, Reza Khoshbakht, Mohammad Hossein Ahmadi, Masoumeh Hosseinpoor, Hamed Khosravi, Imtiaz Ahmed, Mehdi Bakhshaee

“…The study compared patient laboratory studies and presentation symptoms between COVID-19 history-positive and COVID-19 history-negative groups, with a particular focus on mortality rates and associated comorbidities such as diabetes, cancer and immunosuppressive treatment.…”
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Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma by Fenglin Zhang, Kexin Liu, Mengfan Ao, Jiangang Zhao, Xinghe Liao, Ping Li, Hao Chen

“…The elevated-risk cohort, as identified by the risk assessment metric, correlates with poorer survival rates. Additionally, we uncover an association between the risk indicator and the tumor milieu, encompassing immune cell infiltration patterns and drug sensitivity profiles. …”
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Burden and inequality of autism spectrum disorders in global, East asian, and Southeast Asian regions, 1990–2021: result from the global burden of disease study 2021 by Wen Liu, Xinhao Gong, Jinping Ou, Shoulin Chen

“…Abstract Introduction Autism Spectrum Disorders (ASD) represent a range of neurodevelopmental conditions characterized by abnormal behavioral patterns. ASD is frequently comorbid with other neurodevelopmental disorders. …”
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Intramedullary nailing with and without cerclage in subtrochanteric fractures: an updated systematic review and meta-analysis by Ahmed Oun, Omar Abdelaziz, Islam Saeed Elhois, Mohamed Al-Badaineh, Karim Zinhom, George Jabrieh, Hamza S. Al-Himyari, Abdullah A. Nada

“…No significant differences were observed in non-union, infection, or mortality rates. Quality assessment using the Newcastle–Ottawa Scale indicated high quality studies. …”
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INFLUENCE OF THE EVAPORITE FORMATION STRUCTURE ON SALT TECTONICS AND HYDROCARBON TRAPS (BY THE RESULTS OF NUMERICAL SIMULATION OF HALOKINESIS IN THE PRE-CASPIAN) by B. V. Lunev, V. V. Lapkovsky, M. P. Antipov, Y. A. Volozh, I. S. Postnikova

“…Since halokinesis is the main factor controlling the migration and accumulation of hydrocarbons in the Preaspian region, background and aim of prospecting and exploration require identifying the specifics of the formation of various types of salt structures and the relationship between their location patterns and halokinesis process.Numerical simulation shows that, depending on the instable layer thickness and its relationship with the total thickness of the overlying layers, the instability development occurs at different rates, forming different types of structures. …”
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The tsunami of antibiotic resistance as a global health crisis in otorhinolaryngology patients; a cross-sectional study by Peter Milad, Ossama Ibrahim Mansour, Mohammed Shehata Taha, Tarek Ashmawy, Heba Mahmoud Abdelmageed, Samia Abdou Girgis, Azza Omran, Anas Askoura, Omar Yassin, Amr Hamed, Mena Maher Nassif

“…Objective Due to the desperate need for sustainable access to effective antibiotic the patterns of antimicrobial resistance among ORL patients in Egypt were studied and the implications for clinical management and public health were assessed. …”
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Do older parents do better? Relationships between parental age, chick body condition and migratory behaviour in a colonial‐breeding waterbird by Hugo R. S. Ferreira, Jocelyn Champagnon, Thomas Blanchon, Tamar Lok, José A. Alves

“…In differential migration systems, low‐quality or socially subordinate individuals may be constrained to sub‐optimal migratory behaviours associated with lower demographic rates. Therefore, producing high‐quality chicks may enhance the survival of offspring. …”
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RiverBedDynamics v1.0: a Landlab component for computing two-dimensional sediment transport and river bed evolution by A. D. Monsalve, S. R. Anderson, N. M. Gasparini, E. M. Yager

“…By dynamically coupling RiverBedDynamics with Landlab's hydrodynamic flow solver, OverlandFlow, we created a new LEM capable of simulating the dynamics of local shear stresses, bed load transport rates, and grain size distributions. Comparisons of our LEM results with analytical and previously reported solutions demonstrate its ability to accurately predict time-varying local changes in bed surface elevation, including erosion and deposition, as well as grain size distribution. …”
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Prevalence and determinants of apparent treatment-resistant hypertension among patients in South African primary care: a single-centre observational study by Kellicia Courtney Govender, Mergan Naidoo

“…South Africa, like other low-middle-income countries, faces a disproportionate burden due to the increasing prevalence of hypertension, exacerbated by low awareness, treatment, and control rates. Treatment-resistant hypertension (TRH) is a complex clinical entity and poses significant obstacles to achieving therapeutic goals. …”
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Building a dynamic web calculator for individualized conditional survival estimation in brainstem ependymoma by Hua Huang, Regina Chizi Tunje, Jiajie Xia, Zhihao Yang

“…CS analysis was performed to assess changes in survival probability over time. Annual hazard rates were calculated to identify high-risk periods. …”
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SmartTrust: a hybrid deep learning framework for real-time threat detection in cloud environments using Zero-Trust Architecture by Umesh Kumar Lilhore, Sarita Simaiya, Roobaea Alroobaea, Abdullah M. Baqasah, Majed Alsafyani, Afnan Alhazmi, Md Monish Khan

“…The model achieved detection rates of 99.19% for insider threats, 98.23% for privilege escalation, and 99.27% for data breaches while reducing false positives by over 40% compared to existing approaches. …”
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Impact of Climate Variability on Coffee Production in Kambuga Sub-County Kanungu District. by Tumutegyerize, Vicent

“…The findings showed that climatic factors that have affected coffee production in Kambuga sub-county, Kanungu district include; Temperature, Rainfall Patterns, Pests and Diseases, Rainfall, Humidity, and Climate Extremes. …”
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Global burden and trends of self-harm from 1990 to 2021, with predictions to 2050 by Li Xie, Liangchen Tang, Yixin Liu, Zhenchao Dong, Xiaojun Zhang

“…Globally, the burden of self-harm was higher for males than for females. DALYs rates were highest among adolescents and young adults (20-29 years), whereas mortality rates showed a predominantly age-progressive pattern with the highest burden observed in middle-aged and older populations, albeit with a modest decline in the oldest age groups. …”
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Gene expression in uterine leiomyoma from tumors likely to be growing (from black women over 35) and tumors likely to be non-growing (from white women over 35). by Barbara J Davis, John I Risinger, Gadisetti V R Chandramouli, Pierre R Bushel, Donna Day Baird, Shyamal D Peddada

“…Growth rates for leiomyoma were on average much higher from older black women than for older white women, and we now report gene expression pattern differences in tumors from these two groups of study participants. …”
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Economic Clues to Crime: Insights from Mongolia by Dagvasuren Ganbold, Enkhbayar Jamsranjav, Young-Rae Kim, Erdenechuluun Jargalsaikhan

“…The empirical findings reveal that detection rates exert a statistically significant deterrent effect on robbery in the short term, while incarceration rates are effective in reducing theft. …”
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