Genome-wide associations spanning 194 in-hospital drug dosage change phenotypes highlight diverse genetic backgrounds in concurrent drug therapy by Alexander Pil Henriksen, Cristina Leal Rodríguez, Hannah Currant, Ioannis Louloudis, Jorge Hernansanz Biel, Maria Herrero-Zazo, Ewan Birney, Thomas Folkmann Hansen, Gianluca Mazzoni, Amalie Dahl Haue, Henning Bundgaard, Christian Erikstrup, Khoa Manh Dinh, Liam Quinn, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sørensen, Christina Mikkelsen, Michael Schwinn, Ole Birger Vestager Pedersen, Henrik Ullum, Sisse Rye Ostrowski, Karina Banasik, Søren Brunak

“…As populations get older and medicine consumption rises, the rate of concurrent drug use and polypharmacy among patients is increasing. …”
Get full text

Glycogen depletion in astrocytes induces sex-dimorphic remodeling of astrocytic and synaptic structures with concomitant anxiety-like behaviors and maternal care deficits by Xiaotong Shi, Yuanyuan Zhu, Zhaoyichun Zhang, Ningcan Ma, Danyi He, You Wu, Ziyi Dai, Xinyan Qin, Yingyi Chen, Youyi Zhao, Haopeng Zhang, Jing Huang, Hui Zhang, Ze Fan

“…Maternal care was analyzed through pup retrieval assays and nest-building behavior, while offspring development was tracked via survival rates and ultrasonic vocalizations. Expression of hormonal receptors was identified via qPCR and immunofluorescence staining. …”
Get full text

Estimation of long-term gridded cloud radiative kernel and radiative effects based on cloud fraction by X. Liu, T. He, Q. Wang, X. Xiao, Y. Ma, Y. Wang, S. Luo, L. Du, Z. Wu, Z. Wu

“…The GCF-CRKs exhibit similar signs and patterns and enhanced stability compared to existing kernels. …”
Get full text

Epidemiological characterization of chronic myeloid leukaemia patients at an oncologic centre: A retrospective observational study by Ana Maria Meireles, Rita Calisto, Maria José Bento, Pedro Martinho Gouveia, Susana Bizarro, Manuel Teixeira, Cláudia Moreira, Ana Espírito Santo, Mário Mariz

“…Background: The chronic myeloid leukaemia population, treatment patterns and responses in Portugal are unknown. The aim of this study is to describe these features in a Portuguese reference centre. …”
Get full text

Multi-omics analysis of Taiwanofungus gaoligongensis: effects of different cultivation methods on secondary metabolites by Tingwen He, Tingwen He, Tingwen He, Xiaolong Yuan, Liangjun Xiao, Tanggeran Hu, Yi Wang, Xiaolei Zhao, Xiaolei Zhao, Xiaolei Zhao, Lu Li, Lu Li, Chengbo Peng, Chengbo Peng, Chengbo Peng, Hongling Zhang, Hongling Zhang, Hongling Zhang, Yuan Zheng, Yuan Zheng, Yuan Zheng, Yuan Zheng

“…This study compared the metabolite profiles and gene expression patterns of the fruiting bodies of T. gaoligongensis with those of three types of cultivated mycelia. …”
Get full text

The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-eco... by Mengsha Chen, Mengya Yang, Rui Yan, Zhengwei Liu, Can Chen, Rongrong Qu, Wenkai Zhou, Jiaxing Qi, Kexin Cao, Jiani Miao, Xiaoyue Wu, Jiaxin Chen, Qianqian Feng, HuiHui Zhang, Anqi Dai, Yi Yang, Jingtong Zhou, Qin Chen, Jimin Sun, Shigui Yang

“…Results Between 2018 and 2020, influenza incidence in Zhejiang Province followed typical seasonal patterns. However, during the COVID-19 pandemic, these patterns became irregular, culminating in a high-intensity influenza season in 2022–2023. …”
Get full text

Three‒Dimensional Numerical Simulation of the Breaching Process of Landslide Dams with Heterogeneous Structures by HU Xianrui, PENG Ming, FU Xiaoli, YANG Ge, ZHU Yan, SHI Zhenming, ZHANG Gongding

“…The middle layer (V2) governed vertical incision rates: fine-grained layers accelerated downward erosion, whereas coarse layers formed headcuts that restricted further deepening. …”
Get full text

Therapeutic Effects of Forest Bathing on Human Health: A Systematic Review by Adrianna Samoraj, Jakub Zajączkowski, Paulina Krzeszowska, Kacper Stępniak, Karolina Marrodán-Wojtczak, Jan Wilk, Jakub Jarmołowicz, Aleksandra Kujawa, Karolina Krochmal, Radosław Kuźma

“…Specifically, a reduction in heart rate, as well as systolic and diastolic blood pressure, was observed in individuals who participated in forest excursions.  …”
Get full text

Clinical Presentation, Pathological Spectrum, and Outcomes of Alcoholic Cirrhosis-Related Immunoglobulin A Nephropathy by Charles Ronsin, Pierre Braud, Christine Kandel-Aznar, Amaury Dujardin, Clémence Petit, David Larmet, Claire Garandeau, Clément Deltombe, Alice Le Clech, Claire Leman, Gilles Blancho, Juliet Schurder, Grégoire Couvrat-Desvergnes, Simon Ville

“…The cumulative mortality rate in cirrhosis-IgAN was 26% and 46% at 1-year and 3-years, respectively. …”
Get full text

Influence of the extent of cervical lymph node dissection and lymph nodes metastases on prognosis in a cohort of dogs with oral malignant melanoma treated by surgical resection and... by Davide Giacobino, Matteo Olimpo, Erica Ilaria Ferraris, Greta Martinelli, Lorella Maniscalco, Mariateresa Camerino, Federica Riccardo, Federica Cavallo, Lidia Tarone, Marzia Cino, Alfredo Dentini, Selina Iussich, Elena Lardone, Luca Manassero, Raffaella De Maria, Paolo Buracco, Emanuela Morello

“…The overall LN metastatic rate was 31%; metastasis was found mostly in the mandibular lymph center (83%). …”
Get full text

Monitoring and Evaluation of Fish Passage Effectiveness in Nature-like Fishway of Sanghe River Secondary Hydropower Station by SHEN Chun-ying, WANG Jing-chao, QIN Xin, CHEN Yu-bin, XUE Ru-zhan

“…[Objective] With the continuous expansion of China’s water conservancy infrastructure, hydraulic structures such as dams and sluice gates have obstructed fish migration routes and altered hydrological regimes both upstream and downstream. …”
Get full text

Multiscale Water Cycle Mechanisms and Return Flow Utilization in Paddy Fields of Plain Irrigation Districts by Jie Zhang, Yujiang Xiong, Peihua Jiang, Niannian Yuan, Fengli Liu

“…We propose an integrated optimization strategy combining tillering-stage irrigation/drainage control, multiscale hydraulic interception (control gates and pond weirs), and dynamic watershed storage scheduling. …”
Get full text

Prolyl 4-hydroxylase subunit alpha-2 acts as a TRIM21 ubiquitination substrate to promote papillary thyroid cancer progression via the glycolytic pathway by Fengping Wu, Qian Liu, Jinkang Zhang, Dongkun Xu, Xue Jiang, Kun Zhang, YaZheng Chen, Xuliang Xia, Zhiqiang Jiang, Yuhong Shi, Wenling Tu

“…This study explored the expression pattern, functional role, and underlying molecular mechanism of P4HA2 in PTC. …”
Get full text

Diagnostic work-up of anemia and associated health outcomes in people with heart failure by Guobin Su, Ruowei Xiao, Dongze Ji, Kaiyu He, Anna Hallert, Gianluigi Savarese, Lars H. Lund, Yang Xu, Juan Jesus Carrero

“…Time-varying Cox regression explored associations between developing anemia and rate of major adverse cardiovascular events (MACE), HF hospitalization, cancer, and death. …”
Get full text

Path to full immunisation coverage, role of each vaccine and their importance in the immunisation programme: a cross-sectional analytical study of India by Gunjan Taneja, Pawan Kumar, Disha Agarwal, Ajay Kumar Verma, Pritu Dhalaria, Sanjay Kapur, Ajeet Kumar Singh, Bhupendra Tripathi

“…The prevalence of absolute zero-dose children, antigen-wise zero dose, co-coverage rates and cascade levels for vaccine combinations are assessed. …”
Get full text

An Iterative Pixel-Based Dimensional Voting Model for High Spatial-Resolution Image Classification by Muhamad Asyraf Mohd Pouzi, Haza Nuzly Abdull Hamed, Muhammad Razib Othman, Hishammuddin Asmuni, Mohd Adham Isa, Husni Ruslai

Get full text

Analysis of Age-related Changes of Characteristics and High Frequency Symptoms in Pre-elderly and Elderly Inpatients by YUE Xiao, WANG Mei

“…Origin was used to plot scatter plots and graphs to describe the pattern of change in the incidence of inpatient symptoms with age. …”
Get full text

Comparison of impact of various application methods for the blood plasm, enriched by the thrombocytes, on healing of the burn and scalped wounds in experiment by G. V. Terehov, O. A. Hyndych, І. M. Savytska, M. V. Kostylev, E. V. Symulyk, M. V. Chukhraiev

“…To the investigation Group II animals the electrophoresis in accordance to own procedure through napkin, soaked in the blood plasm, enriched by thrombocytes, was performed with the same rate. The blood plasm, enriched by thrombocytes, was prepared from the whole venous blood of human Group A(0), using centrifugation for achievement of targeted quantity of thrombocytes 850 000 in 1 ml. …”
Get full text

Sociodemographic and regional differences in neonatal and infant mortality in Switzerland in 2011–2018: the Swiss National Cohort by Veronika W. Skrivankova, Leonie D. Schreck, Claudia Berlin, Radoslaw Panczak, Kaspar Staub, Marcel Zwahlen, Sven M. Schulzke, Matthias Egger, Claudia E. Kuehni

“… BACKGROUND AND AIMS: Despite a well-funded healthcare system with universal insurance coverage, Switzerland has one of the highest neonatal and infant mortality rates among high-income countries. Identifying avoidable risk factors targeted by evidence-based policies is a public health priority. …”
Get full text

Miotonia congênita: relato de sete pacientes Congenital myotonia: report of seven patients by Helga C. A. Azevedo, Lúcia I. Z. Mendonça, Paulo N. B. Salum, Mary S. Carvalho, Sueli K. Nagahashi-Marie, Alzira A. Siqueira-Carvalho, Maria A. Cerqueira, Umbertina C. Reed, José A. Levy

“…<br>Myotonia is the phenomenon of decrease of muscular relaxation rate, after either a contraction or a mechanical or electrical stimulus. …”
Get full text