Preparation and Evaluation of Alpha-2-Macroglobulin Hydrogel for Drug Release Kinetics and Biocompatibility on Human Gingival Fibroblasts: An In-vitro Study by Poulami Chakraborty, ND Jayakumar, S Raghunandhakumar

“…Aim: This study investigates the preparation, drug release pattern, and biocompatibility of Alpha-2-Macroglobulin (A2M) hydrogel for use as a Local Drug Delivery (LDD) agent in the management of periodontitis. …”
Get full text

Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury by Hong Duo, Yanwei Yang, Jun Luo, Yumeng Cao, Qian Liu, Jiarui Zhang, Siqi Du, Jian You, Guqing Zhang, Qifa Ye, Huaqin Pan

“…Abstract Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. …”
Get full text

Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstiti... by Tomoyuki Araya, Toshiyuki Kita, Tsukasa Ueda, Nanao Terada, Tamami Sakai, Kenta Yamamura, Koji Kurokawa, Yuka Uchida, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

“…The overall response and disease control rates were 77.8% (95% CI, 40.0–97.2) and 88.9% (95% CI, 51.8–97.2), respectively. …”
Get full text

Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…Conversely, <i>GmNAC35</i> showed an inverse pattern, indicating negative regulation by miR164. …”
Get full text

An integrated high-resolution bathymetric model for the Danube Delta system by L. Alaerts, L. Alaerts, J. Lambrechts, N. R. Randresihaja, N. R. Randresihaja, L. Vandenbulcke, O. Gourgue, E. Hanert, E. Hanert, M. Grégoire

“…These error rates are comparable to those observed in bathymetry interpolation in rivers with similar source datasets. …”
Get full text

Combined alverine citrate and simeticonein preparation in the treatment of irritable bowel syndrome by Ye. A. Poluektova, S. Yu. Kuchumova, V. T. Ivashkin

“…Thirteen patients had clinical pattern of diarrhea predominance (IBS-D), 17 – predominance of constipation (IBS-С). …”
Get full text

Biomechanical evaluation of novel construct for stabilizing subcapital femoral neck fractures: a synthetic bone model by Anjan R. Shah, Miguel A. Diaz, Douglas L. Cerynik, Blake Schultz

“…Abstract Background High complication rates continue to be reported for femoral neck fractures, where moderate to severe shortening has been associated with pain and inferior functional outcomes. …”
Get full text

Preoperative Bowel Preparation in Minimally Invasive and Vaginal Gynecologic Surgery by Michail Diakosavvas, Nikolaos Thomakos, Alexandros Psarris, Zacharias Fasoulakis, Marianna Theodora, Dimitrios Haidopoulos, Alexandros Rodolakis

“…Taking into consideration the fact that in most gynecologic cases there is minimal probability of bowel intraluminal entry and, thus, low surgical site infection rates, most scientific societies have issued guidelines against the use of any bowel preparation regimen before laparoscopic or vaginal surgery. …”
Get full text

Copper and Temperature Interactions Induce Differential Physiological and Metal Exclusion Responses in the Model Brown Macroalga <i>Ectocarpus</i> by Alex Santillán-Sarmiento, Paula S. M. Celis-Plá, A. John Moody, Claudio A. Saez, Murray T. Brown

“…In this study, we exposed the model brown seaweed <i>Ectocarpus</i> to different Cu concentrations (0, 0.8, 1.6, and 3.2 μM) at two different temperatures (15 and 25 °C). Relative growth rates decreased at 25 °C for the two highest Cu concentrations after 8 days of exposure, but a contrasting pattern was observed in the photosynthetic maximum quantum yield (<i>F_v</i>/<i>F_m</i>) and photosynthetic efficiency (<i>α</i>), where reductions were observed at 15 °C for the same Cu concentrations. …”
Get full text

Systemic Immunomodulatory Therapy in Uveitis Related to Beh&amp;ccedil;et&amp;rsquo;s Disease: A 10-year Profile by Almeida M, Ferreira AM, Araújo JR, Figueira L

“…The median treatment duration was 63.5 months, significantly reducing relapse rates from 2 ± 2.0 to 1 ± 1.2 per year (p &lt; 0.001). …”
Get full text

Antimicrobial Resistance Profile and Biofilm Formation of <i>Listeria monocytogenes</i> Isolated from Meat by Joana Paiva, Vanessa Silva, Patrícia Poeta, Cristina Saraiva

“…Introduction: <i>Listeria monocytogenes</i> is the causative agent of listeriosis, a serious infectious disease with one of the highest case fatality rates among foodborne diseases affecting humans. …”
Get full text

Treatment for Paget’s disease: surgical approaches by E. Yu. Fetisova, A. D. Zikiryakhodzhaev, N. N. Volchenko

“…Breast cancer (BC) ranks first in the pattern of female malignancies (20.7 %) and remains the top cancer among women. …”
Get full text

Socioeconomic inequalities in non-communicable diseases prevalence in India: disparities between self-reported diagnoses and standardized measures. by Sukumar Vellakkal, Sukumar Vellakkal, S V Subramanian, Christopher Millett, Sanjay Basu, David Stuckler, Shah Ebrahim

“…<h4>Methods</h4>We calculated age-adjusted prevalence rates of common NCDs from the Study on Global Ageing and Adult Health, a nationally representative cross-sectional survey. …”
Get full text

Ten-year outcomes of IMRT with chemotherapy versus IMRT alone for stage II–IVa nasopharyngeal carcinoma: a retrospective study by Xiao-li Wang, Da-qing Sun, Hui Yang, Yang Li, Xiu-feng Li, Xiao-long Chang, Xiang-di Meng, Ya-nan Zhang, Yun-xiang Zhang, Fu-rong Hao, Jian-wen Li

“…The 10-year OS, PFS, LRFS, and DMFS rates were 66.6%, 75.3%, 91.9%, and 81.2%, respectively. …”
Get full text

The Friendship Questionnaire, autism, and gender differences: a study revisited by Felicity Sedgewick, Jenni Leppanen, Kate Tchanturia

“…On the URCS, we took the data from those who rated specific close relationships and found that autistic people scored this relationship more highly than non-autistic adults did. …”
Get full text

Development technologies and models of different types of gas reservoirs in Ordos Basin, NW China by Ailin JIA, Dewei MENG, Guoting WANG, Guang JI, Zhi GUO, Naichao FENG, Ruohan LIU, Suqi HUANG, Shuai ZHENG, Tong XU

“…Four key directions of future research and technological breakthroughs are proposed: (1) Utilizing dual-porosity (fracture-matrix) modeling techniques in low-permeability carbonate reservoirs to delineate the volume and distribution of remaining gas in secondary pay zones, supporting well pattern optimization and production enhancement of existing wells. (2) Integrating well-log and seismic data to characterize reservoir spatial distribution of successive strata, enhancing drilling success rates in low-permeability sandstone reservoirs. (3) Utilizing the advantages of horizontal wells to penetrate effective reservoirs laterally, achieving meter-scale quantification of small-scale single sand bodies in tight gas reservoirs, and applying high-resolution 3D geological models to clarify the distribution of remaining gas and guide well placement optimization. (4) Further strengthening the evaluation of deep coal-rock gas in terms of resource potential, well type and pattern, reservoir stimulation, single-well performance, and economic viability.…”
Get full text

Clinical Characteristics of the Premature Ejaculation Sufferers in Aegean Region of the Turkey: A Multicentre, Observational Study by Ahmet Cihan, Ömer Demir, Ali Şahin, Fatih Zeren, Deniz Bolat, Burak Özçift, Abdulkadir Pektaş, Ertan Can, Bilal Gümüş, Tahir Turan, Ahmet Bölükbaşı, Haluk Erol, Ahmet Adil Esen

“…Subjects in the PE group gave poor ratings than non-PE subjects. Partner responses were similar pattern. …”
Get full text

Stem introducer designs and surgical technique play a significant role in achieving the optimal implant-cement interface by Bernard H. van Duren, Kevin Ilo, Sophie Walker, Mark Higgins, Benjamin V. Bloch, Andrew R. Manktelow, Hemant G. Pandit

“…A significant variation exists between PTS stem designs, associated fractured rates among them, and the design of introducers used. …”
Get full text

Impact of oral hygiene on the development of oropharyngeal neoplasms by D. G. Kiparisova, Yu. S. Kiparisov, N. S. Nurieva

“…The patient hygiene performance (PHP) index (Podshadley, Haley, 1968) was used to estimate his/her baseline ability. The rates of initial visits made by patients with oropharyngeal tumors to physicians of different specialties were also analyzed.Results. …”
Get full text

Meningitis caused by Aspergillus fumigatus: a case report by Yifei Zhang, Yu Ma, Rushuang Yue, Yuan Meng, Yue Jin, Chengwei Yin, Qianmei Zhou, Rong Shi

“…Briefly, DNBs are arrayed on a patterned flow cell, where DNA polymerase catalyzes the incorporation of fluorescently labeled nucleotides during sequencing-by-synthesis. …”
Get full text