Lignin Unlocks Stealth Carbon Sinks in Cold Seeps via Microbial Enzymatic Gatekeeping by Jialing Li, Jingchun Feng, Pandeng Wang, Mengzhuo Zhu, Yongji Huang, Ying Wu, Junning Fan, Junlin Hu, Xiyang Dong, Yingli Zhou, Xuanyu Tao, Si Zhang

“…Our findings establish 3 paradigm shifts: (a) The turnover rates of terrestrial organic carbon are likely underestimated in deep-sea ecosystems; (b) microbial consortia employ combinatorial enzymatic strategies distinct from terrestrial decomposition regimes; (c) methyl shunting from lignin breakdown primes methanogenic precursors, revealing cryptic linkages between refractory carbon cycling and greenhouse gas reservoirs.…”
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The Use of 3D Convolutional Autoencoder in Fault and Fracture Network Characterization by Feng Xu, Zhiyong Li, Bo Wen, Youhui Huang, Yaojun Wang

“…Conventional pattern recognition methods directly use 1D poststack data or 2D prestack data for the statistical pattern recognition of fault and fracture network, thereby ignoring the spatial structure information in 3D seismic data. …”
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Prevalence of Moraxella Catarrhalis as a Nasal Flora among Healthy Kindergarten Children in Bhaktapur, Nepal by Neetu Amatya, Govinda Paudel, Bhuvan Saud, Sunita Wagle, Vikram Shrestha, Bibhav Adhikari

“…Using bivariate and multivariate analysis, the associated risk factors with significantly high carriage rates were age group of 3–4 years, classroom occupancy with 15–30 children, and antibiotic consumption within 6 months, with a p value of ≤0.05 in each of the cases. …”
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Nutritional status, dietary inflammatory potential, and risk of osteosarcopenia: the Bushehr Elderly Health (BEH) program by Gita Shafiee, Mehrad Nasiri, Zhaleh Shadman, Mehdi Ebrahimi, Narges Zargar Balajam, Ramin Abdi Dezfouli, Iraj Nabipour, Ramin Heshmat

“…Abstract Background Osteosarcopenia is a growingly approved geriatric condition with a significant prevalence that contributes to higher rates of illness and death. Chronic inflammation and inadequate nutrition are key risk factors for numerous age-related diseases. …”
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Ultrasound-activated miR-195-5p/shikonin nanobubbles remodel immunosuppressive microenvironment via immunogenic cell death to potentiate PD-1/PD-L1 blockade in hepatocellular carci... by Yandi Tan, Qiao Xu, Yezi Chen, Yun Liu, Chaoqi Liu, Xinwu Cui, Yun Zhao

“…Despite the transformative clinical impact of programmed cell death ligand 1/programmed death 1 (PD-1/PD-L1) blockade in hepatocellular carcinoma (HCC), therapeutic efficacy remains limited by the tumor immunosuppressive microenvironment (TIME), with objective response rates persistently below 20 %. To address this critical clinical challenge, we engineered ultrasound (US)-responsive lipid nanobubbles (NBs) co-encapsulating microRNA (miR)-195-5p and shikonin (SK) (designated miR-195-5p/SK-NBs), a dual-functional platform designed to synergize PD-L1 suppression with immunogenic cell death (ICD). …”
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Machine Learning-Based Intrusion Detection Systems for the Internet of Drones: A Systematic Literature Review by Mostafa Ogab, Sofiane Zaidi, Abdelhabib Bourouis, Carlos T. Calafate

“…Existing Intrusion Detection Systems (IDS) for IoD face several limitations, including high false positive rates, resource constraints of drones, limited adaptability to evolving attack patterns, and a lack of standardized datasets for benchmarking, despite ongoing research efforts. …”
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Global collaboration and innovation in malignant cerebral edema research: a bibliometric perspective by Xinhua Peng, Xinhua Peng, Rongrong Zhu, Ke Zhang, Jianghong Ji, Chuanguo Lv, Feng Feng, Feng Feng

“…AimMalignant cerebral edema (MCE) is a life-threatening complication of acute brain injuries, with mortality rates exceeding 80% in the absence of treatment. …”
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Profiles and kinetics of PgRNA and clinical characteristics in pregnant, postpartum, and non-pregnant women with chronic HBV infection by Genju Wang, Yandan Wu, Ziyue Zhang, Qiuchen Wu, Juan Tang, Ying Ji, Yan Wang, Guanlun Zhou, Minmin Yu

“…Moreover, the detection rates of pgRNA, DNA, and HBeAg varied significantly across the three stages and different treatment regimens in CHB women. pgRNA was highly correlated with HBeAg, and a moderate correlation was found between pgRNA and HBV DNA levels. …”
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The Risk of Vestibular Disorders with Semaglutide and Tirzepatide: Findings from a Large Real-World Cohort by Eman A. Toraih, Awwad Alenezy, Mohammad H. Hussein, Shahmeer Hashmat, Saitej Mummadi, Nawaf Farhan Alrawili, Ahmed Abdelmaksoud, Manal S. Fawzy

“…Tirzepatide users demonstrated similar patterns but lower absolute rates (0.10% at 6 months to 0.19% at 3 years vs. controls 0.04% to 0.15%), with hazard ratios from 3.19 (95% CI: 2.11–4.81) to 4.55 (95% CI: 3.43–6.03). …”
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Analyzing the Contents of a Large, Public Online Peer Support Forum for Obsessive-Compulsive Disorder: Thematic Analysis by Nora Yanyi Sun, Christopher Pittenger, Terence Ching

“… Abstract BackgroundObsessive-compulsive disorder (OCD) is a debilitating chronic anxiety disorder with low rates of remission. r/OCD is a peer support forum hosted by the Reddit website with over 180,000 users and 100‐200 new posts daily. …”
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Immunohistochemical analysis of IDH1, ATRX, p53, and Ki-67 in glioblastoma and diffuse infiltrative glioma: Therapeutic and prognostic correlation by Hasbay Bermal, Kayaselçuk Fazilet, Süner Halil İbrahim, Tufan Kadir

“…Kaplan-Meier method and Cox proportional regression model (forward model) were used to estimate the mean and median survival times, failure rates, and hazard ratios. Results. In the study, 115 (56.1%) patients were male and 90 (43.9%) were female. …”
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Dietary strategies for preventing and managing obesity through evidence-based nutritional interventions by Stephen Olaide Aremu, Blessing Akute, Dorcas Oluwakemi Aremu, Caleb Zando, Esther Damilola Aremu, Omagu Julia Nwachukwu, Mary Omolola Omosebi, Victoria Oluwatosin Akute, Stephen Tokunbo Oluwole, Abdillahi Abdi Barkhadle, Matthew Olaleke Aremu

“…This crisis is driven by multifaceted factors, including sedentary lifestyles, urbanization, dietary transitions, and behavioral influences. As obesity rates continue to rise, dietary interventions emerge as crucial and modifiable strategies for prevention and management. …”
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Development of a PPP1R14B-associated immune prognostic model for hepatocellular carcinoma by Ligang Zhao, Xiaoling Jin, Qiushi Yu, Yigang He, Facai Yang, Weihu Ma, Zhengqing Lei, Jiahua Zhou

“…Results PPP1R14B levels were substantially elevated in HCC specimens versus normal tissues, and elevated expression independently linked to diminished survival rates. PPP1R14B levels exhibited notable associations with various immune cells, including memory B lymphocytes, M1/M2 macrophage populations, CD8-positive T lymphocytes, and T follicular helper cells. …”
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Global trends and hotspots of adolescent eating disorders: a bibliometric study and visual analysis by Qian Ye, Qian Ye, Yiling Yang, Yue Qi, Jiale Li, Huijuan Lei, Lina Sun, Jie Zhang

“…BackgroundAdolescent eating disorders represent a category of mental illness, marked by elevated mortality and morbidity rates and a significant adverse impact on the quality of life of both patients and their families. …”
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Molecular Epidemiology and Genetic Context of <i>optrA</i>-Carrying Linezolid-Resistant Enterococci from Humans and Animals in South Korea by Younggwon On, Sung Young Lee, Jung Sik Yoo, Jung Wook Kim

“…<i>optrA</i>-positive linezolid-resistant isolates were less frequent, with rates of 0.1%, 1.4%, 0.9%, and 1.0%, respectively. …”
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Global burden and trend of substance use disorders, self-harm, and interpersonal violence from 1990 to 2021, with projection to 2040 by Jia An, Qiang Wang, Zihao Bai, Xueying Du, Di Yu, Xuming Mo

“…Abstract Background Alcohol use disorders (AUD), drug use disorders (DUD), interpersonal violence, and self-harm are a major public health concern globally, with high rates of disability, morbidity, and mortality associated with this. …”
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The changes in health service utilisation in Malawi during the COVID-19 pandemic. by Bingling She, Tara D Mangal, Anna Y Adjabeng, Tim Colbourn, Joseph H Collins, Eva Janoušková, Ines Li Lin, Emmanuel Mnjowe, Sakshi Mohan, Margherita Molaro, Andrew N Phillips, Paul Revill, Robert Manning Smith, Pakwanja D Twea, Dominic Nkhoma, Gerald Manthalu, Timothy B Hallett

“…Two datasets were prepared: unadjusted and adjusted; for the latter, unreported monthly data entries for a facility were filled in through systematic rules based on reported mean values of that facility or facility type and considering both reporting rates and comparability with published data. Using statistical descriptive methods, we first described the patterns of service utilisation in pre-pandemic years (2015-2019). …”
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An explorative study on movement detection using wearable sensors in acute care hospital patients by Joris Kirchberger, Dominik Kunz, Guido Perrot, Sven Hirsch, Maren Leifke, Bianca Hölz, Lukas Geissmann, Miro Käch, Samuel Wehrli, Jens Eckstein

“…Abstract Insufficient physical activity during hospitalization correlates with decreased physical functionality, prolonged stays, and higher readmission rates among the elderly population. Wearable systems provide an approach for monitoring patients’ physical activity, data to set achievable goals and motivation for patients to stay active. …”
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Harnessing an Artificial Intelligence–Based Large Language Model With Personal Health Record Capability for Personalized Information Support in Postsurgery Myocardial Infarction: D... by Ting-ting Yang, Hong-xia Zheng, Sha Cao, Mei-ling Jing, Ju Hu, Yan Zuo, Qing-yong Chen, Jian-jun Zhang

“…Although postsurgical cardiac interventions have improved survival rates, effective management during recovery remains challenging. …”
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Identification of Immune-Related Risk Signatures for the Prognostic Prediction in Oral Squamous Cell Carcinoma by Chen Zou, Dahong Huang, Haigang Wei, Siyuan Wu, Jing Song, Zhe Tang, Xia Li, Yilong Ai

“…The two groups (high and low risk) stratified by the immune-related risk scores had significantly different OS and mortality rates. The gene expression patterns and prognostic values of these immune-related signatures were also verified in two independent validation cohorts. …”
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