Overcoming therapeutic resistance in driver-negative NSCLC: Immunomodulatory mechanisms and clinical efficacy of Camrelizumab-chemotherapy combination in a real-world cohort by Yan Ge, Yang Zhao

“…Progression-free survival (PFS) was the primary endpoint, with objective response rate (ORR), resistance patterns, and treatment-related adverse events as secondary outcomes. …”
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Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study by Dina A. Hammouda, Alaa M. Mansour, Ahmed R. Zaher, Mohammed E. Grawish

“…This study aimed to evaluate the effect of DPCs-sEVs on the proliferation rate, migration capability, and expression pattern of DPCs for osteo/odontogenic gene markers in comparison with mineral trioxide aggregate (MTA). …”
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GEM-CRAP: a fusion architecture for focal seizure detection by Jianwei Shi, Yuanyuan Zhang, Ziang Song, Hang Xu, Yanfeng Yang, Lei Jin, Hengxin Dong, Zhaoying Li, Penghu Wei, Yongzhi Shan, Guoguang Zhao

“…We introduced an average channel deviation rate metric to assess seizure detection accuracy. …”
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Construction and application of copula-based trivariate standardized river disconnection index for seasonal rivers in arid and semi-arid areas by Qingqing Qi, Zipeng Wang, Zezhong Zhang, Hang Yin, Hexin Lai, Yiyang Zhao, Fei Wang, Kai Feng

“…Optimal distribution functions vary across regions, times, and datasets; therefore, using the best monthly distribution functions to compute SRI, SGDI, and SSMI provides a more scientifically robust mathematical and statistical basis. (2) The SSRDI, which combines surface water, groundwater, and soil water, is more consistent with the actual hydrological conditions of Tabu River compared to the three univariate indices. (3) From 2002 to 2020, the SSRDI for Tabu River shows a continuous declining trend, albeit at a slowing rate. The overall pattern exhibits a cyclical trend of worsening followed by improvement, with June being the month of most severe ecological river disconnection. (4) The seasonal component of the SSRDI from 2002 to 2020 displays cyclical changes, with a mutation in June 2004. …”
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Chronic opioid use following surgery for head and neck cancer patients undergoing free flap reconstruction by Ashley Hinther, Alysha Rasool, Steven C. Nakoneshny, Shamir P. Chandarana, Robert Hart, T. Wayne Matthews, Joseph C. Dort

“…Abstract Background Physician opioid-prescribing patterns have significant impacts on the current opioid crisis. …”
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The Effectiveness of the UNAIDS Strategy«90-90-90»in Populations with Different Population Growth by D. A. Neshumaev, E. N. Sukharev, V. L. Stasenko

“…The following parameters were used to describe the epidemic process: population size, birth rate, mortality, HIV prevalence, lethality among patients with HIV/AIDS and probability of HIV transmission. …”
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Transcriptome Profiling Reveals Genetic Basis of Muscle Development and Meat Quality Traits in Chinese Congjiang Xiang and Landrace Pigs by Jiada Yang, Qiaowen Tang, Chunying Sun, Qiuyue Li, Xiaoyu Li, Lu Hou, Yi Yang, Kang Yang

“…RNA sequencing was performed on muscle tissues from ten individuals of each breed, generating 874.5 million raw reads with an average mapping rate of 89.3% to the pig reference genome. (3) Results: Transcriptional profiling revealed distinct expression patterns with 785 genes exclusively expressed in CX pigs and 457 genes unique to LAN pigs, while 7099 co-expressed genes were shared by both breeds. …”
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Integration Method with Backpropagation by Nidhal AL-Assady, Jamal Majeed, Shahbaa Khaleel

“…In this research, a new method is discovered (combined method) to accelerate the backpropagation network by using the expected values of source units for updating weights, we mean the expected value of unit by the sum of the output of the unit and its error term multiplied by the factor Beta to accelerate the algorithm and also adjust the value of learning coefficient continuously if the value of energy function E decreases the learning rate is increased by a factor , if the value of the energy function E increases , the value of the learning rate is decreased by a factor . …”
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Assessing the implementation of ESG criteria in the frontrunners insurance companies in the Spanish market by Albert Marti, Ramon Bastida-Vialcanet, Frederic Marimon

“…Originality/value: This study contributes to the academic literature and managerial practice by offering a robust framework, model, and methodology for ESG assessment, as well as identifying patterns in ESG adoption. Additionally, the article explores how the combination of outstanding PSI principles achievements influences the ESG rating performance of insurance companies. …”
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A personalized reinforcement learning recommendation algorithm using bi-clustering techniques. by Muhammad Waqar, Mubbashir Ayub

“…Moreover, we introduced a novel strategy to predict item ratings within the RL framework. The validity of the proposed algorithm is evaluated on three datasets of movies domain, namely, ML100K, ML-latest-small and FilmTrust. …”
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Excessive or reduced rest-day sleep compensation linked to depression in Chinese adults by Yanliqing Song, Long Wang, Yue Liu

“…These findings highlight the importance of maintaining stable sleep patterns during special periods and provide scientific evidence for the development of targeted public health interventions.…”
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The Nature of Attachment Relationships and Grief Responses in Older Adults: An Attachment Path Model of Grief. by Yan Kho, Robert T Kane, Lynn Priddis, Josephine Hudson

“…<h4>Design</h4>Men (N = 21) and women (N = 68) aged 60 years and above who had lost a partner within the last 12 to 72 months were invited to participate. Participants rated their levels of yearning thoughts about the deceased, emotions and non-acceptance on the Texas Revised Inventory of Grief (TRIG-Present), and their type and level of general romantic attachment on the Experiences In Close Relationship questionnaire (ECR).…”
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Droplet-based high-throughput single microbe RNA sequencing by smRandom-seq by Ziye Xu, Yuting Wang, Kuanwei Sheng, Raoul Rosenthal, Nan Liu, Xiaoting Hua, Tianyu Zhang, Jiaye Chen, Mengdi Song, Yuexiao Lv, Shunji Zhang, Yingjuan Huang, Zhaolun Wang, Ting Cao, Yifei Shen, Yan Jiang, Yunsong Yu, Yu Chen, Guoji Guo, Peng Yin, David A. Weitz, Yongcheng Wang

“…Here, we report a droplet-based high-throughput single-microbe RNA-seq assay (smRandom-seq), using random primers for in situ cDNA generation, droplets for single-microbe barcoding, and CRISPR-based rRNA depletion for mRNA enrichment. smRandom-seq showed a high species specificity (99%), a minor doublet rate (1.6%), a reduced rRNA percentage (32%), and a sensitive gene detection (a median of ~1000 genes per single E. coli). …”
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Emotional Interactive Simulation System of English Speech Recognition in Virtual Context by Dan Li

“…The experiments of feature extraction and pattern recognition of speech samples prove that Hidden Markovian has higher recognition rate and better recognition effect in speech emotion recognition. …”
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Prevention of fetal brain injury in category II tracings by Masahiro Nakao, Michael G. Ross, Shoichi Magawa, Satoshi Toyokawa, Kiyotake Ichizuka, Naohiro Kanayama, Shoji Satoh, Nanako Tamiya, Akihito Nakai, Keiya Fujimori, Tsugio Maeda, Akira Oka, Hideaki Suzuki, Mitsutoshi Iwashita, Tomoaki Ikeda

“…Cases included those presumed to have an intrapartum onset of hypoxic–ischemic insult based on the fetal heart rate pattern evolution from reassuring to an abnormal pattern during delivery, in association with category II tracings marked by recurrent decelerations and an umbilical arterial BDecf ≥ 12 mEq/L. …”
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Systematic Review of Hospital Readmissions in Stroke Patients by Ahsan Rao, Emily Barrow, Sabine Vuik, Ara Darzi, Paul Aylin

“…Common risk factors associated with the change of readmission rate were also examined. Methods. The literature search was conducted from 15 February to 15 March 2016 using various databases, such as Medline, Embase, and Web of Science. …”
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Lymphatic system is the mainstream for breast cancer dissemination and metastasis revealed by single-cell lineage tracing by Kai Miao, Aiping Zhang, Xiaodan Yang, Yipeng Zhang, Anqi Lin, Lijian Wang, Xin Zhang, Heng Sun, Jun Xu, Jingyao Zhang, Yuzhao Feng, Fangyuan Shao, Sen Guo, Zhihui Weng, Peng Luo, Dong Wang, Shuai Gao, Xiao-Yang Zhao, Xiaoling Xu, Chu-Xia Deng

“…In this study, we applied a barcoding system based single-cell lineage tracing approach to study the metastasis rate and route of breast cancer cells and their interactions with the tumor microenvironment (TME) during metastasis. …”
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Intelligent prediction of thyroid cancer in China based on GBD data and hospital electronic medical records: disease burden analysis combined with multiple machine learning models by Lina Yang, Shixia Zhang, Xinguo Wang, Jianjun Yang, Mengya Chen

“…It comprehensively reveals the disease burden trend of thyroid cancer in China, predicts the mortality rate of thyroid cancer in China, and emphasizes the causal role of high BMI as an important controllable risk factor. …”
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Unmasking insider threats using a robust hybrid optimized generative pretrained neural network approach by P. Lavanya, H. Anila Glory, Manuj Aggarwal, V. S. Shankar Sriram

“…The structure of the proposed approach involves three phases: (1) Chebyshev Graph Laplacian Eigenmaps solver (CGLE) for selecting the user-designated samples by reducing the dimensionality of the data and Insider State clustering via Density-Based Spatial Clustering of Applications with Noise (IS-DBSCAN) (2) The EHI of multi-objective Bayesian optimization for optimizing the sensitive learning rate hyperparameter to ensure the stability of the Adabelief optimized WGAN and improve the quality of the generated adversarial samples. (3) The L2-SP regularization technique effectively fine-tunes the pretrained AGCN, which identifies the user behavioural pattern to detect the insiders. …”
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A STUDY TO ASSESS THE DISTRIBUTION OF SUSPECTED ADVERSE EVENTS FOLLOWING IMMUNISATION REPORTED IN A METROPOLITAN CITY IN INDIA by Sophie Simon, Shalini Rawat, Rohan Sangam, G D Velhal

“…Results: The AEFI reporting rate was calculated as 5.8 per 100000 doses administered per year. …”
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