Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes by Tobias Brünger, Alina Ivaniuk, Eduardo Pérez-Palma, Ludovica Montanucci, Stacey Cohen, Lacey Smith, Shridhar Parthasarathy, Ingo Helbig, Michael Nothnagel, Patrick May, Dennis Lal

“…For the gene family of voltage-gated sodium channels, where variants and expert-curated clinical phenotypes are available, we also assess whether phenotype patterns of multiple disorders for each gene are conserved across variant positions within the gene family. …”
Get full text

Estimating Future Surface Water Availability Through an Integrated Climate‐Hydrology‐Management Modeling Framework at a Basin Scale Under CMIP6 Scenarios by Manqing Shao, Nelun Fernando, John Zhu, Gang Zhao, Shih‐Chieh Kao, Bingjie Zhao, Elizabeth Roberts, Huilin Gao

“…Finally, the DHSVM simulated naturalized streamflow and reservoir evaporation rate are input to WAM to simulate reservoir FY. A new term—“Ratio of Firm Yield” (RFY)—is created to compare how much FY changes under different climate scenarios. …”
Get full text

Annual variation of temperature and mass balance of first-year and second-year land-fast sea ice in Prydz Bay, East Antarctica by Dinglong Zhao, Bin Cheng, Matti Leppäranta, Jingkai Ma, Xuejing Chen, Jiechen Zhao

“…The evolution of the temperature and mass balance of first-year (FYI: Site S1) and second-year (SYI: Site S2) land-fast sea ice (LFSI) in May–November were investigated using high-resolution thermistor-string-based ice mass balance buoys, borehole measurements and a numerical sea ice model. In May, the growth rate of a 0.55 m FYI ice floe (9.2 mm day−1) was twice that of 1.08 m SYI (4.7 mm day−1) in snow-free conditions. …”
Get full text

Transarterial chemoembolization for advanced hepatocellular carcinoma after failure of first-line systemic treatment: a single-center case series by Qingyu Xu, Bin Leng, Ran You, Lingfeng Diao, Chendong Wang, Zeyu Yu, Guowen Yin

“…The most common progression pattern was the development of new intrahepatic lesions. …”
Get full text

Malware-SeqGuard: An Approach Utilizing LSTM and GRU for Effective Detection of Evolving Malware in Android Environments by Muhammad Usama Tanveer, Kashif Munir, Abdulatif Alabdulatif, Anas R. Najdawi, Rutvij H. Jhaveri

“…In this study, we introduce a state-of-the-art scheme for Android malware detection that combines the strengths of Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU) networks. These advanced deep learning architectures are particularly adept at capturing sequential dependencies within data making them well-suited for analyzing complex time-series information, such as user behaviour patterns system logs and network traffic. …”
Get full text

The Stabilization Mechanism of a Stable Landslide Dam on the Eastern Margin of the Tibetan Plateau, China: Insights from Field Investigation and Numerical Simulation by Liang Song, Yanjun Shang, Yunsheng Wang, Tong Li, Zhuolin Xiao, Yuchao Zhao, Tao Tang, Shicheng Liu

“…Additionally, the step-pool system formed in the spillway of the Conaxue Co landslide dam contributes to the protection of the dam structure by dissipating 68% of the river’s energy (energy dissipation rate η = 0.68). Understanding the formation mechanisms of the Conaxue Co landslide dam can provide critical insights into managing future landslide dams that may form in the QTP, both in emergency response and long-term strategies.…”
Get full text

Dual smart sensor data-based deep learning network for premature infant hypoglycemia detection by Muhammad Shafiq, J. Kavitha, Dhruva R. Rinku, N. K. Senthil Kumar, Kamal Poon, Amar Y. Jaffar, V. Saravanan

“…Based on features, the sorted-out data gets evaluated through a GRU-LSTM (Gated Recurrent Unit - Long Short-Term Memory) network to identify the state of the infant as usual and suggestive of hypoglycemia—blood glucose below 70 mg/dL, pale complexion, profuse perspiration. …”
Get full text

Transfer learning for securing electric vehicle charging infrastructure from cyber-physical attacks by Ahmad Almadhor, Shtwai Alsubai, Imen Bouazzi, Vincent Karovic, Monika Davidekova, Abdullah Al Hejaili, Gabriel Avelino Sampedro

“…The study also provides a comparison with different DL models such as Long Short-Term Memory (LSTM), Recurrent Neural Networks (RNN), Long Short-Term Memory-Recurrent Neural Networks (LSTM-RNN), and Gated Recurrent Unit (GRU). The CICEVSE2024 (EVSE-A and EVSE-B) datasets are used to assess the framework, where one dataset is used to train and store weights, and the second is used to evaluate the learned patterns using transfer learning. …”
Get full text

Kinetics of silicon extraction into alloy from a mixture of amorphous rocks by V.M. Shevko, N.M. Mirkayev, A.D. Badikova

“…It was established that when the melting the amorphous rocks, with an increase in the degree of silicon extraction into the alloy, the apparent activation energy decreases, that is a manifestation of diffusion processes, obviously associated with the formation of a silicon carbide layer on the coke surface. The rate of silicon extraction into the alloy when the melting the amorphous rocks is higher than when the melting quartzite. …”
Get full text

Early Dynamics of Circulating Tumor DNA Following Curative Hypofractionated Radiotherapy Related to Disease Control in Lung Cancer by Kyungmi Yang, Jae Myoung Noh, Yeon Jeong Kim, Hongryull Pyo

“…The Dmax showed better disease control rate with marginal significance (<i>p</i> = 0.081). …”
Get full text

Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Finally, in vivo targeting and anticancer studies demonstrated that FOL-RSV-LPHNCs selectively internalized to the cancerous region and suppressed the tumor volume with an 8.66-fold higher rate in the xenograft mouse model. The folate receptor-mediated uptake mainly facilitates this superior therapeutic response which was further confirmed by in silico molecular docking and dynamic simulation. …”
Get full text

Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis by Xinwan Zhang, Shijie Luo, Xiali Ye, Lin Liu, Xinxin Jia, Deyuan Jiang, Weiwei Wen

“…Compared to 0 mM Al treatment, low Al concentrations (0.4 mM) enhanced root vitality by 8.91%, while higher Al concentrations (10 and 100 mM) reduced root vigor by 19.31% and 76.81%, respectively. In a similar pattern, the electron transfer rate in leaves remained stable under low Al levels but significantly decreased under high Al conditions. …”
Get full text

Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa by Josephine Wambani, Patrick Okoth

“…However, in certain areas, the rate of decline has slowed or even reversed the gains made so far. …”
Get full text

Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…Abstract Background Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. …”
Get full text

Dr Papineau Meets Dr Masquelet—Management of Open Calcaneal Fractures, Combining Two Techniques: A Case Report by Shuvendu P Roy, Yogendra Gupta, Gurinder Bedi, Vishwadeep Sharma

“…Aim and background: Open fractures of the calcaneum are often the source of significant morbidity due to the high rate of wound infection and significant morbidity, ranging from malunion to amputation. …”
Get full text

Fluid–solid coupling productivity analysis of multi-stage fractured horizontal wells in shale reservoirs by Qian QI, Ming YUE, Weiyao ZHU, Wenjiang MA

“…The simulation results of the model align with actual field data, showing that gas production follows an “L-shaped” decline pattern with a coincidence rate exceeding 70%, verifying the model’s accuracy.…”
Get full text

Safety and efficacy of prone position ventilation in patients with severe pneumonia in neurosurgical intensive care units by CHENG Longyang，LI Jun，LI Shaoya，LI Chuanqing，XU Manman，WANG Rong，ZHAO Penglai

“…Changes in blood gas analysis［pH，arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2），oxygenation index］and hemodynamics［heart rate（HR），mean arterial pressure（MAP）］were compared before prone positioning，and at 1 day，3 days，5 days，and 7 days after resuming supine position following prone position treatment. …”
Get full text

Clinical characteristics and outcomes of non-tuberculous mycobacterial pulmonary infections after hematopoietic stem cell transplantation: A retrospective cohort study by Zahia Esber, Hamza Salam, Shefali Godara, Ayman Soubani

“…Conclusion: Outcomes vary significantly among non-tuberculous mycobacterial pulmonary infections based on mycobacterial species, rate of colonization and degree of immunosuppression. …”
Get full text

Cutis verticis gyrata in a Patient with Familial presenile sebaceous hyperplasia Presenting as &amp;ldquo;Leonine facies&amp;rdquo;: A Rare Case by Sutedja EK, Sutedja E, Ruchiatan K, Faldian Y, Yogya Y, Dwiyana RF, Maharani RH, Budiarsa M

“…Isotretinoin, with its sebocyte-suppressing effect, may reduce gland size but has a high recurrence rate upon discontinuation. Early recognition and a multidisciplinary approach are crucial to prevent further progression, particularly in older patients.Keywords: cutis verticis gyrata, familial presenile sebaceous hyperplasia, leonine facies…”
Get full text

Isokinetic knee strength as a predictor of cardiorespiratory responses during loaded aerobic capacity test in elite athletes by Bekir Çar, Ahmet Kurtoğlu, Özdemir Atar, Musa Türkmen, Özgür Eken, Mehmet Soyler, Monira I. Aldhahi

“…Cardiorespiratory parameters—average breath volume (ABV), average breath frequency (ABF), auxiliary oxygen density (AOD), and heart rate (HR)—were recorded during the Bruce Protocol conducted under two conditions: unloaded and with a 10 kg loaded vest. …”
Get full text