Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease by Alton Barbehenn, Lei Shi, Junzhe Shao, Rebecca Hoh, Heather M. Hartig, Vivian Pae, Sannidhi Sarvadhavabhatla, Sophia Donaire, Caroline Sheikhzadeh, Jeffrey Milush, Gregory M. Laird, Mignot Mathias, Kristen Ritter, Michael J. Peluso, Jeffrey Martin, Frederick Hecht, Christopher Pilcher, Stephanie E. Cohen, Susan Buchbinder, Diane Havlir, Monica Gandhi, Timothy J. Henrich, Hiroyu Hatano, Jingshen Wang, Steven G. Deeks, Sulggi A. Lee

“…Defective DNA had a similar biphasic pattern, but data were more variable. Predicted intact and defective decay rates were faster for PLWH with earlier timing of ART initiation, higher initial CD4 + T cell count, and lower pre-ART viral load. …”
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Groundwater ammonia-oxidizing bacteria distribution and the correlations between the distribution and environmental factors around livestock lagoons by REN Juan, ZHANG Lei, ZENG Lingzao, WU Laosheng, SHI Jiachun

“…In water nitrate cycle, micro-organisms play a significant role. The first and rate limiting step of nitrification is ammoxidation, and the functional gene is ammonia monooxygenase, which existed in ammonia-oxidizing bacteria and ammonia-oxidizing archaea.However, the factors affecting ammonia-oxidizing bacteria distribution pattern in groundwater and the influence mode are still not clear enough. …”
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Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome by Xiangmei Li, Lei Liu, Xing Li, Long Yang, Li Men

“…KM survival curves showed that higher DII quartiles were associated with lower survival rates (Log-rank P < 0.05). Cox regression results indicated that each unit increase in DII was associated with a higher risk of all-cause mortality (HR = 1.052, 95% CI: 1.006-1.100, P = 0.026) and cardiovascular mortality (HR = 1.157, 95% CI: 1.076–1.244, P < 0.001). …”
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Real-World Evidence of Safety and Efficacy of Carboplatin plus Nanoparticle Albumin-Bound Paclitaxel in Patients with Advanced Non-Small-Cell Lung Cancer and Preexisting Interstiti... by Tomoyuki Araya, Toshiyuki Kita, Tsukasa Ueda, Nanao Terada, Tamami Sakai, Kenta Yamamura, Koji Kurokawa, Yuka Uchida, Takashi Sone, Hideharu Kimura, Kazuo Kasahara

“…The overall response and disease control rates were 77.8% (95% CI, 40.0–97.2) and 88.9% (95% CI, 51.8–97.2), respectively. …”
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The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-eco... by Mengsha Chen, Mengya Yang, Rui Yan, Zhengwei Liu, Can Chen, Rongrong Qu, Wenkai Zhou, Jiaxing Qi, Kexin Cao, Jiani Miao, Xiaoyue Wu, Jiaxin Chen, Qianqian Feng, HuiHui Zhang, Anqi Dai, Yi Yang, Jingtong Zhou, Qin Chen, Jimin Sun, Shigui Yang

“…High-intensity outbreaks were defined as weekly incidence rates above 72.2 per 100,000. Methods This study estimated the incidence of influenza from 2018 to 2023 in Zhejiang Province, China, using influenza weekly surveillance data. …”
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MtDNA copy number enrichment is associated with poor prognosis and eosinophilic morphology in clear cell renal cell carcinoma by Sarah Bellal, Sarah Bellal, Cyrielle Rolley, Jeremy Richard, Nolwenn Bounaix, Vincent Le Corre, Marie-Christine Copin, Odile Blanchet, Pierre Bigot, Pierre Bigot, Vincent Procaccio, Vincent Procaccio, Céline Bris, Céline Bris

“…CSS was significantly reduced in the “HIGH” than in the “LOW” group with respective 5-year survival rates: 78.7% (CI 95: 64.8–95.5) and 95.5% (CI 95 87.1–100.0) (Hazard Ratio: 7.4 (CI 95: 1.9–29.9, p = 0.027*) in multivariate analysis, including pathological classification, tumor size, International Society of Urological Pathology grade, lymphovascular invasion, dedifferentiated pattern, necrosis and adjuvant therapy. …”
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Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. by Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, John Rek, Maato Zedi, Catherine Maiteki-Sebuguzi, Jimmy Opigo, Sarah G Staedke, Ambrose Oruni, Martin J Donnelly, Bryan Greenhouse, Jessica Briggs, Paul J Krezanoski, Teun Bousema, Philip J Rosenthal, Peter Olwoch, Prasanna Jagannathan, Isabel Rodriguez-Barraquer, Grant Dorsey

“…In Busia, An. gambiae s.s. remained the primary vector throughout the observation period. Sporozoite rates were approximately 50% higher among An. funestus compared to the other common malaria vectors. …”
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Treatment of total hip arthroplasty between two surgical access routes associated chronic pain, function and biomechanical parameters in older after osteoporotic femur fracture: co... by Marco Antônio Leite Pereira Pinto, Giovanna Truyts Biscardi Pinto, Mariana Afonso Ribeiro Sarquis Ude, Claudia Aparecida de Morais, Ana Paula Ribeiro

“…Conclusion Total hip arthroplasty via the posterolateral approach proved to be more successful when associated with reducing chronic pain, improving functional parameters and hip joint mobility, as well as facilitating a more efficient gait pattern with lower rates of plantar overload and enhanced body balance in older adults undergoing total hip arthroplasty after osteoporotic femur fracture. …”
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Dynamic Effects of Sodium Selenite on the Rhizospheric Microenvironment, Growth, and Antioxidative Responses of Wheat (<i>Triticum aestivum</i> L.) by Fang Qin, Han Zhang, Feiyan Zhang, Xiangrui Zhu, Hongji Li, Yuefeng Xu

“…Soil selenium (Se) speciation characteristics and their influence on the Se enrichment pattern and physiological characteristics of wheat are poorly understood. …”
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Double fluorescence-guided surgery with 5-ALA and fluorescein sodium in grade 2 and grade 3 adult-type diffuse gliomas: retrospective analysis of 112 cases by Andrea Bianconi, Marta Bonada, Pietro Zeppa, Francesco Bruno, Pietro La Cava, Flavio Panico, Roberta Rudà, Antonio Melcarne, Diego Garbossa, Fabio Cofano

“…Fluorescence positive rate and pattern have been reported both for 5-ALA and for fluoresceine. …”
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Dynamic gas supply mechanism and theoretical production modes of free gas-rich deep coal reservoirs by Shida CHEN, Taiyuan ZHANG, Dazhen TANG, Hao XU, Shu TAO, Song LI, Shuling TANG

“…Furthermore, the first priority for commercial production capacity construction of deep CBM is determining rational production capacity targets and required well-controlled areas for varying deep geological units and synergistically optimizing well completion methods, well pattern density, fracturing parameters, production allocation rates, and production cycles under the guidance of geological and engineering integration.…”
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Multi-source Data-driven Analysis of Deformation and Influencing Factors for Expansive Soil Canal Slopes by ZHANG Yuhan, HU Jiang, LI Xing

“…This approach facilitates a comprehensive analysis of deformation patterns at the slope surface and various subsurface depths, while elucidating the dominant controlling factors governing expansive soil canal slope behavior.Results and Discussions　The study focused on a deep excavated expansive soil canal section (Stake 8+886~12+921) of a major water diversion project, yielding the following key findings: 1) The analysis of 128 Sentinel-1A images from March 2017 to December 2021 revealed that the deformation data obtained through SBAS-InSAR method showed less than 3mm discrepancy with surface vertical displacement measurements at monitoring points (fourth-stage berm at 9+363 and third-stage berm at 11+400), with consistent deformation trends, confirming the reliability of SBAS-InSAR for canal slope deformation monitoring. 2) The study section exhibited LOS deformation rates ranging from -10 to 24 mm/a, demonstrating overall uplift characteristics, with positive LOS deformation showing annual increase. …”
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Specialized insectivores drive differences in avian community composition between primary and secondary forest in Central Africa by Eleanor M. Barrie, Eleanor M. Barrie, Billi A. Krochuk, Billi A. Krochuk, Crinan Jarrett, Crinan Jarrett, Crinan Jarrett, Diogo F. Ferreira, Diogo F. Ferreira, Diogo F. Ferreira, Patricia F. Rodrigues, Patricia F. Rodrigues, Patricia F. Rodrigues, Patricia F. Rodrigues, Susana Lin Mufumu, Susana Lin Mufumu, Silvestre Esteban Malanza, Silvestre Esteban Malanza, Agustin Ebana Nsue Akele, Agustin Ebana Nsue Akele, Cayetano Ebana Ebana Alene, Cayetano Ebana Ebana Alene, Kristin E. Brzeski, Kristin E. Brzeski, Jacob. C. Cooper, Jacob. C. Cooper, Jacob. C. Cooper, Jared D. Wolfe, Jared D. Wolfe, Luke L. Powell, Luke L. Powell, Luke L. Powell, Luke L. Powell

“…Notably, few species disappeared entirely in secondary forest (unlike patterns seen in the Neotropics); rather, capture rates of 12 of 30 species (40%) were significantly reduced relative to primary forest. …”
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Global burden trends and future predictions of ischemic heart disease attributable to air pollution in people aged 60 years and older, 1990–2021 by Yuanqin Zhao, Yuanqin Zhao, Lihui Liu, Lihui Liu, Wei Fan, Wei Fan, Man Qi, Man Qi, Bin Liao, Bin Liao

“…Therefore, it is of utmost significance to investigate the impact of AP on IHD burden, especially on vulnerable populations such as older individuals.MethodologyGlobal Burden of Disease (GBD) Study 2021 data was used to analyze and quantify contemporary global burden of IHD in individuals aged 60 and above due to AP and for trends for the time period between 1990 and 2021 using disease burden indicators such as deaths, DALYs, YLDs, YLLs and corresponding age-standardized rates (ASRs). Specifically, we are in patterns of disease burden of IHD in various subgroups stratified by age, sex, Sociodemographic Index (SDI), and GBD regions and countries. …”
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Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE) by Daixuan Wu, Yuecheng Shen, Zhongzheng Zhu, Tijian Li, Jiawei Luo, Zhengyang Wang, Jiaming Liang, Zhiling Zhang, Yunhua Yao, Dalong Qi, Lianzhong Deng, Zhenrong Sun, Meng Liu, Zhi-Chao Luo, Shian Zhang

“…However, limitations such as slow pattern projection rates and time-consuming reconstruction algorithms hinder its throughput for real-time imaging. …”
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Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling by Ling Li, Yun Zhao, Rong Liu, Chen Yao, Zhijun Zhang, Yingying Hu, Ruifang Wu, Ruifang An, Hui Du, Xinfeng Qu, Lihui Wei, Bei Lin, Mingzhu Li, Chao Zhao, Jingran Li, Zhixin Lin, Jihong Deng, Songling Zhang

“…Different HPV subtypes have different detection rates for CIN2+, and combining HPV16/18/33 significantly improved the sensitivity for detecting CIN2+.…”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study by Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD

“…Data on asthma control, medication, lung function, and annualized exacerbation rates were collected at baseline and 3, 12, and 36 months after initiation of dupilumab therapy. …”
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Phylogeochemistry: exploring evolutionary constraints on belemnite rostrum element composition by A. Pohle, K. Stevens, R. Hoffmann, A. Immenhauser, A. Immenhauser

“…We used comparative Bayesian phylogenetic tools to reconstruct ancestral states and phenotypic evolutionary rates of these geochemical data based on trees inferred from morphological data. …”
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