Optimization of bovine oocyte cryopreservation: membrane fusion competence and cell death of linoleic acid-in vitro matured oocytes subjected to vitrification by Glenda L. Ríos, María Florencia Suqueli García, María Florencia Suqueli García, Rodrigo J. Manrique, Jorgelina Buschiazzo

“…Zona pellucida-free oocytes co-incubated with sperm demonstrated that 43 μM LA better preserved the original sperm adhesion and fusion pattern post-vitrification, although fertilization rate was not improved. …”
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Dynamic brain-heart-gut coupling during sleep: a continuous physiological signal analysis by Guojing Wang, Guojing Wang, Guojing Wang, Hongyun Liu, Hongyun Liu, Shijing Wu, Shijing Wu, Xiaohua Yu, Xiaohua Yu, Weidong Wang, Weidong Wang

“…In terms of heart-gut coupling (HGC), the coupling strength between the very low frequency (VLF) band of heart rate variability (HRV) and all BS-derived power sequences was significantly lower than other HRV frequency bands. …”
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Laryngeal recurrence sites in patients previously treated with transoral laser microsurgery for squamous cell carcinoma by P. Horwich, M. H. Rigby, C. MacKay, J. Melong, B. Williams, M. Bullock, R. Hart, J. Trites, S. M. Taylor

“…Treatment with TLM does not predispose patients to a lower rate of locoregional control and overall survival after total laryngectomy and salvage outcomes are consistent with literature values.…”
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Aberrant Histone Methylation in Patients with Graves’ Disease by Ni Yan, Kaida Mu, Xiao-fei An, Ling Li, Qiu Qin, Rong-hua Song, Qiu-ming Yao, Xiao-qing Shao, Jin-an Zhang

“…The rate (degree) of H3K4 and H3K9 methylation and the expressions of histone-modifying genes were investigated. …”
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Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. by Wenbo Tang, Matthew Kowgier, Daan W Loth, María Soler Artigas, Bonnie R Joubert, Emily Hodge, Sina A Gharib, Albert V Smith, Ingo Ruczinski, Vilmundur Gudnason, Rasika A Mathias, Tamara B Harris, Nadia N Hansel, Lenore J Launer, Kathleen C Barnes, Joyanna G Hansen, Eva Albrecht, Melinda C Aldrich, Michael Allerhand, R Graham Barr, Guy G Brusselle, David J Couper, Ivan Curjuric, Gail Davies, Ian J Deary, Josée Dupuis, Tove Fall, Millennia Foy, Nora Franceschini, Wei Gao, Sven Gläser, Xiangjun Gu, Dana B Hancock, Joachim Heinrich, Albert Hofman, Medea Imboden, Erik Ingelsson, Alan James, Stefan Karrasch, Beate Koch, Stephen B Kritchevsky, Ashish Kumar, Lies Lahousse, Guo Li, Lars Lind, Cecilia Lindgren, Yongmei Liu, Kurt Lohman, Thomas Lumley, Wendy L McArdle, Bernd Meibohm, Andrew P Morris, Alanna C Morrison, Bill Musk, Kari E North, Lyle J Palmer, Nicole M Probst-Hensch, Bruce M Psaty, Fernando Rivadeneira, Jerome I Rotter, Holger Schulz, Lewis J Smith, Akshay Sood, John M Starr, David P Strachan, Alexander Teumer, André G Uitterlinden, Henry Völzke, Arend Voorman, Louise V Wain, Martin T Wells, Jemma B Wilk, O Dale Williams, Susan R Heckbert, Bruno H Stricker, Stephanie J London, Myriam Fornage, Martin D Tobin, George T O'Connor, Ian P Hall, Patricia A Cassano

“…As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.…”
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Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study by Yuan Fang, Jiachen Chen, Jesse Mez, Jesse Mez, Jesse Mez, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Michael L. Alosco, Michael L. Alosco, Michael L. Alosco, Wei Qiao Qiu, Wei Qiao Qiu, Wei Qiao Qiu, Margaret F. Doyle, Joanne M. Murabito, Joanne M. Murabito, Joanne M. Murabito, Kathryn L. Lunetta

“…IntroductionThe prevalence of cognitive impairment in the population is growing; however, there is substantial heterogeneity in the rate of decline across different cognitive domains. …”
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Data-Driven Insights into LEED Certification Trends: Saudi Arabia's Path to Sustainability by Hala Sirror, Zeinab Alhassan, Malathe Hamid

“…It analyzes trends over the past decade, focusing on certification growth, building types, rating levels (Certified, Silver, Gold, Platinum), and regional distribution. …”
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Artificial Ventilation-Induced Acute Lung Lesion: Experimental, Morphological Study by A. M. Golubev, V. V. Moroz, D. V. Lysenko, A. N. Kuzovlev, D. A. Ostapchenko

“…Objective: to elucidate the pattern of morphological changes in the lung during artificial ventilation.Materials and methods. …”
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Genetic diversity of Mycobacterium tuberculosis using 24-locus MIRU-VNTR typing and Spoligotyping in Upper Myanmar by Waing Waing Moe Sann, Wises Namwat, Kiatichai Faksri, Thyn Lei Swe, Kyi Kyi Swe, Thandar Thwin, Arunnee Sangka

“…The usage and analysis of 24-locus MIRU-VNTR typing might prove useful for our broader understanding of TB outbreaks and epidemiology than spoligotyping. The genotypic pattern of this combined method suggests that the lower transmission rate may be due to a higher possibility of reactivation cases in Upper Myanmar. …”
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Survival prognostic factors and molecular aspects in extremity soft tissue sarcoma by Bogdan Serban, Eugen Radu, Adrian Cursaru, Bogdan Stefan Cretu, Sergiu Andrei Iordache, Madalina Cîrnu, Cosmin Florentin Niculae, Cătălin Florin Cîrstoiu

“…Significant prognostic factors for the likelihood of a lower survival and death rate are tumor size, tumor depth, histology type, and vascular invasion. …”
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A bibliometric analysis of research trends in mesenchymal stem cell therapy for neonatal bronchopulmonary dysplasia: 2004–2024 by Lu Bai, Yue Xin

“…Time-series analysis revealed a significant acceleration in publication output after 2015 (p < 0.01), with a compound annual growth rate of 18.2%. The United States was the leading contributor (131 publications, 37.1%), followed by China (72 publications, 20.4%) and Canada (54 publications, 15.3%). …”
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Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial. by Xinlei Ma, Fan Yang, Jinzhi Wu, Bei Xu, Mengdi Jiang, Yiduo Sun, Chuanying Sun, Ye Yu, Danyi Xu, Lanlan Xiao, Chunyun Ren, Chunyan Chen, Zi Ye, Junyu Liang, Jin Lin, Weiqian Chen

“…Secondary endpoints: PMR-AS score, c-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) at weeks 12 and 24. Thirty-nine patients with newly diagnosed PMR received tofacitinib, and 37 patients received glucocorticoid. …”
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Estimation of duration and its changes in Lagrangian observations relying on ice floes in the Arctic Ocean utilizing a sea ice motion product by F. Zhang, F. Zhang, R. Lei, R. Lei, M. Qu, N. Li, Y. Chen, X. Pang

“…In particular, the autumn east–west surface air pressure gradient across the central Arctic and the Arctic dipole anomaly indices significantly influenced the terminal points of ice trajectories after 9 months, and their extreme positive phases were found to expand the ideal deployment areas. The rate of increase in near-surface air temperatures in autumn–spring along the trajectories was more pronounced in the TPD region than that in the BG region. …”
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Clinical Findings and Related Factors with the Final Outcome in Hospitalized COVID-19 Patients: An Evidence Based Cross-Sectional Study by Samad EJ Golzari, Nasim Hajipoor kashgsaray, Ehsan Sarbazi, Zahra Taghavi, Saber Ghaffari Fam, Alireza Ala, Ali Ostadi, Robab Mehdizadeh Esfanjani, Sonia Sedghian, Hassan Soleimanpour

“…There was a statistically significant correlation between blood group type and mortality among the studies patients. The highest rate of the mortality was amongst patients with blood group type A+ and O+ P <0.0001. …”
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Loss of Reduction in Pediatric Distal Radius Fractures: Risk Factors From a Prospective Multicenter Registry by Apurva S. Shah, MD, MBA, Zoe E. Belardo, BA, Mark L. Miller, MD, Michael C. Willey, MD, Susan T. Mahan, MD, MPH, Divya Talwar, PhD, MPH, Donald S. Bae, MD

“…The majority of subjects sustained bicortical metaphyseal distal radius fractures (68%), followed by Salter-Harris II physeal fractures (26%). The rate of radiographic LOR was 44% (271/616), and 11% (70/616) of fractures shifted ≥20°. …”
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Analysis of influencing factors for primary membranous nephropathy complicated with atherosclerotic cardiovascular disease and establishment of a nomogram prediction model by Mirixiatijiang· Maimaiti, Zhu Guo-qiang, Su Ming-jie, Halinuer· Shadekejiang, Zhang Xue-qin, Lu Chen

“…They also had significantly higher systolic blood pressure ［130（120， 142） mmHg（1 mmHg=0.133 kPa） <italic>vs</italic> 122.0（113.5， 135.5） mmHg］， higher diastolic blood pressure ［80 （75， 90） mmHg <italic>vs</italic> 80（70， 85.5） mmHg］， higher prevalence of hypertension［142（64.8%） <italic>vs</italic> 67 （32.7%）］， and higher proportion of manual workers［60（27.4%） <italic>vs</italic> 28（13.7%）］ Additionally， lymphocyte count （LYM）， platelet count （PLT）， blood sodium concentration （Na）， blood urea nitrogen （BUN）， blood creatinine （Cr）， estimated glomerular filtration rate （eGFR）， 24-hour quantitative urine protein， glutamic transaminase， urinary occult blood， number of urinary hyaline and pathological tubular patterns， C-reactive protein （CRP）， complement C4， plasma fibrinogen， D-dimer， and centrocyte-lymphocyte ratio were all significantly different between the two groups （<italic>P</italic>&lt;0.05）. …”
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A data-driven approach to forest health assessment through multivariate analysis and machine learning techniques by Raja Waqar Ahmed Khan, Hamayun Shaheen, Muhammad Ejaz Ul Islam Dar, Tariq Habib, Muhammad Manzoor, Syed Waseem Gillani, Abeer Al-Andal, John Oluwafemi Ayoola, Muhammad Waheed

“…RF-based feature importance analysis showed tree DBH, height, regeneration rate, soil erosion, and tree density as key ecological drivers of forest health. …”
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Malaria prevalence, transmission potential and efficacy of artemisinin-based combination therapy in the Kenyan Central highlands: a zone previously characterized as malaria-free by Francis T. Kimani, Kelvin K. Thiongó, Maureen A. Otinga, Lewis K. Mbabu, Mary N. Ombati, Stanley K. Kitur, Sarah A. Ochieng’, Lucy N. Wachira, Damaris K. Matoke-Muhia, Luna Kamau

“…Conclusion The Plasmodium infections positivity rate observed in the study site was very low but significant. …”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…An in-depth investigation focused on SLC16A3, encoding the high-affinity lactate transporter MCT4, revealed disruptions in extracellular acidification rate and lactate concentration with age. Microglial purine sensing and motility capacities, regulated by P2RY12/P2RY13, displayed age-related alterations. …”
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Digital learning resource use among Swedish medical students: insights from a nationwide survey by Martin F. Bjurström, Emma Lundkvist, Louise W. Sturesson, Ola Borgquist, Robin Lundén, Malin Jonsson Fagerlund, Miklós Lipcsey, Thomas Kander

“…Results One thousand seven hundred sixty-six students responded to the survey, with an average response rate of 20.2% across sites. The five most frequently used digital resources were (percentage using at least on a weekly basis): University study platform (75.3%), videos (68.0%), flashcards (66.4%), student notes (53.4%) and external study platforms (47.3%). …”
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