IMPAIRED REGULATORY MECHANISMS OF THE mTOR SIGNALING PATHWAY IN OSTEOARTHROSIS by Elena Vasilyevna Chetina, E A Bratygina, E M Zaitseva, E P Sharapova, A L Alekseyeva, N V Demin, S A Makarov

“…Objective: to study the pattern of impaired regulatory mechanisms of the mammalian target of rapamycin (TOR) signaling pathway, by monitoring gene expression in the blood of patients with osteoarthrosis (OA) at different stages of the disease. …”
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Etiology, antibiotic susceptibility and prognostic factors of pediatric community-acquired sepsis in Addis Ababa, Ethiopia by Abel Abera Negash, Daniel Asrat, Workeabeba Abebe, Tewodros Hailemariam, Andualem Wubete, Abraham Aseffa, Mario Vaneechoutte

“…We sought to determine the etiology, role of Streptococcus pneumoniae, antibiotic susceptibility pattern, and prognostic factors in children with CAS in Addis Ababa, Ethiopia. …”
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Nonlinear association between AST/ALT ratio and 28-day all-cause mortality following ICU admission in critically ill cirrhotic patients: a retrospective cohort study by Zhigang Xu, Baohong Xu

“…Results The study involved 2,090 critically ill liver cirrhosis patients, averaging 59.1 years old, with 65% male and a 28-day post-ICU admission mortality rate of 29%. The AST/ALT ratio was linked to mortality risk (adjusted odds ratio (OR) 1.1, 95% confidence interval (CI) 1.0–1.2; p = 0.015), showing a nonlinear pattern with a critical point at 3.6. …”
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Advances in application of ultrasound in diagnosis of diabetic nephropathy by GUO Juan, YANG Zhifang, JI Ri

“…As the global incidence rate of diabetes continues to rise, the clinical diagnosis and treatment of DN have become increasingly critical. …”
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Hyper-induction of IL-6 after TLR1/2 stimulation in calves with bovine respiratory disease. by Cian Reid, John Donlon, Aude Remot, Emer Kennedy, Giovanna De Matteis, Cliona O'Farrelly, Conor McAloon, Kieran G Meade

“…ROC analysis identified this induced IL-6 response to TLR1/2 stimulation as a potential diagnostic for BRD with a 74% true positive and 5% false positive detection rate for an IL-6 concentration >1780pg/mL. Overall, these results show altered immune responses specifically upon TLR1/2 activation is associated with BRD pathology which may contribute to disease progression. …”
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Assessing genetic redundancy and diversity in Colombian cacao germplasm banks using SNP fingerprinting by Jaime A. Osorio-Guarín, Jhon A. Berdugo-Cely, Gina A. Garzón-Martínez, Deisy Lisseth Toloza-Moreno, Paola Delgadillo-Duran, Eliana Y. Báez-Daza, Lyndel W. Meinhardt, Sunchung Park, Dapeng Zhang, Roxana Yockteng, Roxana Yockteng

“…Our results revealed that both collections exhibit a similar pattern of genetic diversity. However, a medium rate of mislabeling (12.4%) and high genetic redundancy (53.1%) were detected, likely due to errors in collecting, introduction, pre-planting labeling, and the use of rootstocks. …”
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Trypanosoma dionisii in China: ecology and tentative epidemiology by Qin Liu, Mu-xin Chen, Yu-chun Cai, Yuan-yuan Li, Zi-yi Wang, Yun-hai Guo, Yu-wan Hao, Jing-bo Xue, Yi-dan Jing, Fan-na Wei, Yong-bin Wang, Yue-jin Li, Hai-fang Wang, Jun-ling Sun, Ya-li Wang, Gang Wang, Na Wang, Nai-li Guo, Jian-cun Fang, Wei-xiao Chen, Xun-ming Zhou, Yang Yu, Yi Zhang, Jun-hu Chen, Qiang Wang, Shi-zhu Li, Ge Yan, Qun Li

“…Although no evidence of a high risk for human epidemic was found, the widespread presence of this parasites in bat species and a relatively high infection rate observed in the surveyed cats and dogs emphasize the emerging threat it poses to human health. …”
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A Robust Framework for Bamboo Forest AGB Estimation by Integrating Geostatistical Prediction and Ensemble Learning by Lianjin Fu, Qingtai Shu, Cuifen Xia, Zeyu Li, Hailing He, Zhengying Li, Shaoyang Ma, Chaoguan Qin, Rong Wei, Qin Xiang, Xiao Zhang, Yiran Zhang, Huashi Cai

“…Furthermore, SHAP analysis provided mechanistic insights, identifying the canopy photon rate as the dominant predictor and quantifying the ecological thresholds governing AGB distribution. …”
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Kevlar/Basalt and Kevlar/Glass Intra‐Ply Reinforced Hybrid Composites: Influence of Basket Weave Fabric Structure on Thermal Properties, Flammability, and Impact Performance by Mahdi Hosseini, Milan Gaff, Petr Konvalinka, Haitao Li, Hynek Maňák, Jensin Joshua, Ahmad Hosseini, Krishna Teja, S. Yogeswari, Pritam Ghosh, M. Chandrasekar

“…Flammability tests showed that all composites had a burn rate below 10 mm/min, meeting standard safety criteria. …”
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Prevalence and sequence of chronic conditions in older people with dementia: a multi-province, population-based cohort study by Susan E. Bronskill, Azmina Artani, Laura C. Maclagan, Xuesong Wang, Hannah Chung, J. Michael Paterson, Andrea Gruneir, Karen A. Phillips, Rasaq Ojasanya, Xibiao Ye, Kayla McLean, Fernanda Ewerling, Claire Godard-Sebillotte, Victoria Massamba, Louis Rochette, Isabelle Vedel, Larry Shaver, Catherine Pelletier, Colleen J. Maxwell

“…MethodsWe analyzed data from the 2019 Canadian Community Health Survey on the self-rated ability of adults and youth (N = 60 643; 12+ years) to cope with unexpected or difficult problems and day-to-day demands along with three PMH outcomes: selfrated mental health (SRMH), happiness and life satisfaction. …”
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Functional Reproductive and Developmental Traits Differences Between Two Macrocystis Ecomorphs: Importance of Neutral Lipids by Camilo Rodríguez‐Villegas, Alejandro H. Buschmann, Mayra A. Barrios, Sandra Pereda, Carolina Camus, Pamela Fernández, María C. Hérnandez‐González, Ángela M. Baldrich, Cynthia Urrutia, Ailen M. Poza, Karina Villegas, Camila Martínez, Jaime Vargas

“…Further, we have seen a highly consistent pattern of a higher zoospore production, germination rate, sexual reproductive success, and early developmental performance (growth and survival) of juvenile sporophytes of “pyrifera” compared to “integrifolia.” …”
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Anthropogenic Activities Dominate Vegetation Improvement in Arid Areas of China by Yu Guo, Xinwei Wang, Hongying Cao, Qin Peng, Yunshe Dong, Yunchun Qi, Jian Liu, Ning Lv, Feihu Yin, Xiujin Yuan, Mei Zeng

“…The results indicated that (1) overall vegetation cover was low (averaged peak FVC = 0.191), showing a spatial pattern of higher values in the northwest and lower values in the southeast; high FVC values were primarily observed in mountainous areas and river corridors; (2) the annual peak FVC increased significantly at a rate of 0.0508 yr⁻¹, with 33.72% of the region showing significant improvements and 5.49% degradation; (3) the spatial pattern of FVC was shaped by the distribution of land use types (59.46%), while the temporal dynamics of FVC were driven by land use changes (16.37%) and the land use intensity (37.56%); (4) both the spatial pattern and the temporal dynamics were limited by the environmental conditions. …”
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The Effectiveness of Fiscal Decentralization in Alleviating Poverty from An Sharia Economic Perspective in Kebumen, Indonesia by Muyassarah Muyassarah, Abdul Ghofur, Ali Mutadho, Maizatul Saadiah binti Mohamad, Mansur Mansur

“…The research objective is to determine the effectiveness of fiscal independence in poverty alleviation based on economic principles, efficiency, effectiveness, independence, and the pattern of regional and central relations. This research uses a qualitative approach, secondary data from the 2019-2021 APBD, and interviews by looking at the economic formula, efficiency, and effectiveness, as well as the independence of regional financial management and analysis techniques with an Islamic economic approach.Kebumen's financial management has not been able to reduce the poverty rate because of its low self-support because it still needs a budget injection from the province/central. …”
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<i>Helicobacter pylori</i> Persistence in Patients with Peptic Ulcer Disease and Chronic Gastritis in the Treatment with Antibiotics and Acid-Suppressive Agents by E. V. Golubkina

“…Acid production was significantly higher in the patients with peptic ulcer disease than in those with chronic pancreatits and concomitant gastritis; the former patients show a statistically significant predominance of virulent strains; the latter patients had nonvirulent strains (at the same rate of Helicobacter pylori detection).Conclusion. …”
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Interobserver Agreement and Reliability of Intrapartum Nonreassuring Cardiotocography and Prediction of Neonatal Acidemia by Zhuyu Li, Yan Wang, Jian Cai, Peizhen Zhao, Hanqing Chen, Haiyan Liu, Lixia Shen, Lian Chen, Shufang Li, Yangyu Zhao, Zilian Wang, Yang Pan

“…Six obstetricians from two hospitals with three levels of experience (junior, medium, and senior) reviewed 100 nonreassuring fetal heart rate (FHR) tracings from 1 hour before the onset of abnormalities until delivery. …”
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Perceptions of using herbal medicines for managing menopausal symptoms: a web-based survey of Korean medicine doctors by Ji Hee Jun, Hye Won Lee, Jiae Choi, Tae-Young Choi, Ju Ah Lee, Ho-Yeon Go, Myeong Soo Lee

“…Results: Out of the 497 KMDs, we received responses from 48 doctors, a response rate of 9.7%. The most common symptoms of menopausal disorder perceived by responded KMDs were hot flashes (22.9%), sleep disorders (18.2%), systemic fatigue (12.5%), and sweating (12.0%). …”
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Estimating Future Surface Water Availability Through an Integrated Climate‐Hydrology‐Management Modeling Framework at a Basin Scale Under CMIP6 Scenarios by Manqing Shao, Nelun Fernando, John Zhu, Gang Zhao, Shih‐Chieh Kao, Bingjie Zhao, Elizabeth Roberts, Huilin Gao

“…Finally, the DHSVM simulated naturalized streamflow and reservoir evaporation rate are input to WAM to simulate reservoir FY. A new term—“Ratio of Firm Yield” (RFY)—is created to compare how much FY changes under different climate scenarios. …”
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Annual variation of temperature and mass balance of first-year and second-year land-fast sea ice in Prydz Bay, East Antarctica by Dinglong Zhao, Bin Cheng, Matti Leppäranta, Jingkai Ma, Xuejing Chen, Jiechen Zhao

“…The evolution of the temperature and mass balance of first-year (FYI: Site S1) and second-year (SYI: Site S2) land-fast sea ice (LFSI) in May–November were investigated using high-resolution thermistor-string-based ice mass balance buoys, borehole measurements and a numerical sea ice model. In May, the growth rate of a 0.55 m FYI ice floe (9.2 mm day−1) was twice that of 1.08 m SYI (4.7 mm day−1) in snow-free conditions. …”
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Transarterial chemoembolization for advanced hepatocellular carcinoma after failure of first-line systemic treatment: a single-center case series by Qingyu Xu, Bin Leng, Ran You, Lingfeng Diao, Chendong Wang, Zeyu Yu, Guowen Yin

“…The most common progression pattern was the development of new intrahepatic lesions. …”
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Simultaneous Observation of Equatorial Plasma Bubbles and Traveling Ionospheric Disturbances Over Indonesia Following the 15 January 2022 Tonga Volcano Eruption by Asnawi Husin, Varuliantor Dear, Agri Faturahman, Sefria Anggarani, Annis Siradj Mardiani, Adi Purwono, Jiyo Harjosuwito, Rezy Pradipta

“…There were enhancements in the rate‐of‐TEC index (ROTI) and S4 scintillation index, indicating the presence of ionospheric density irregularities. …”
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