Is pyroptosis a brake or an accelerator in the fate of the tumor? by Yixuan Hou, Wei Li, Jiaying Yang, Haoyang Yu, Congcong Wang, Yanru Li, Shuang Lv, Ling Zhang

“…These interactive therapeutic patterns may catalyze a paradigm shift in oncology. …”
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IMMUNOLOGICAL FEATURES OF SEPSIS PHENOTYPES AND ENDOTYPES by Mariia B. Potapova, Vitaly V. Zverev, Maxim A. Babaev, Ekaterina A. Bogdanova, Oksana O. Grin, Irina B. Semenova, Ekaterina A. Meremianina, Oxana A. Svitich

“…Despite new findings in antimicrobial and intensive care therapy, the incidence and mortality rates of sepsis remain high, which underscores the relevance of further investigation of its pathogenesis. …”
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Implementing a multidimensional faculty promotion matrix at Saint George University of Beirut Faculty of Medicine [version 2; peer review: 1 approved, 2 approved with reservations,... by Carmen El Khoury, Alexandre Nehme, George Karam, Ghewa El Achkar, Marc Jreij, Ziad Tannous, Nadime Cortas

“…The results showed no significant differences in promotion rates among various faculty ranks, highlighting the matrix’s fairness and impartiality. …”
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Machine learning derived development and validation of extracellular matrix related signature for predicting prognosis in adolescents and young adults glioma by Pancheng Wu, Yi Zheng, Wei Wu, Beichen Zhang, Yichang Wang, Mingjing Zhou, Ziyi Liu, Zhao Wang, Maode Wang, Jia Wang

“…Abstract The mortality rates have been increasing for glioma in adolescents and young adults (AYAs, aged 15–39 years). …”
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Predicting and Preventing School Dropout with Business Intelligence: Insights from a Systematic Review by Diana-Margarita Córdova-Esparza, Juan Terven, Julio-Alejandro Romero-González, Karen-Edith Córdova-Esparza, Rocio-Edith López-Martínez, Teresa García-Ramírez, Ricardo Chaparro-Sánchez

“…This review emphasizes the need for ongoing research on integrating ethical AI-driven analytics and scaling BI solutions across diverse educational contexts to reduce dropout rates effectively and sustainably.…”
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Single or multiple climate oscillations? Impacts on the Northwestern Pacific seabream fishery by Sandipan Mondal, Sandipan Mondal, Arpita Ghosh, Alakesh Pradhan, Aratrika Ray, Ipsita Biswas, Jinn-Shing Weng, Ming-An Lee, Ming-An Lee, Ming-An Lee

“…Cross-spectrum analysis was utilised to identify predominant periodicities, whereas wavelet coherence analysis investigated temporal coherence and phase correlations between climate indices and catch rates.ResultsThe Pacific Decadal Oscillation (PDO) was identified as the predominant predictor for all species, with explained deviance between 24.6% and 42.3%. …”
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Spice Defense: Resistance, Capsaicin, and Photosynthesis in Diverse Capsicum Genotypes Under Root-Knot Nematode Stress by Kansiree Jindapunnapat, Pornthip Sroisai, Nichaphat Auangaree, Nawarat Pornsopin, Suchila Techawongstien, Tanyarat Tarinta

“…Physiological assessments revealed variable photosynthetic responses, with some genotypes showing increased photosynthetic rates of post-infection, indicating potential compensatory mechanisms. …”
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Development of oculomotor digital biomarkers using clinical examinations as “Ground Truth” by Brittany Trotter, Melissa Hunfalvay, Melissa Hunfalvay, Nicholas P. Murray, Greg C. Mathews, Frederick Robert Carrick, Frederick Robert Carrick, Frederick Robert Carrick, Frederick Robert Carrick

“…A board-certified neurologist with 16 years of experience also conducted an oculomotor examination to mirror eye movement patterns.ResultsData analysis included a series of single-block logistic regressions to examine the scoring of the six eye-tracking tests (RightEye, LLC) to predict clinician-rated eye movement classifications (i.e., normal or abnormal). …”
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Magnetohydrodynamic control of Falkner–Skan nanofluid transport around a wedge-shaped geometry for advanced thermal solutions: Applications in medical skin patches by Abdul Kareem Abdul Jawwad, Ali B.M. Ali, A. Divya, Narinderjit Singh Sawaran Singh, Muhammad Jawad, Hakim AL Garalleh, Ibrahim Mahariq

“…Binary processes have direct impact on heat generation and dissipation, fluid flow patterns and thermal properties. For example, depending on the specific active dynamics of such reactions heat and mass transfer rates may be either speeded-up or impeded. …”
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Exploring the longitudinal relationships between non-suicidal self-injury and depressive symptoms in adolescents: a cross-lagged panel network analysis by Qiannan Jia, Zhongying Wu, Bin Liu, Yuting Feng, Wei Liang, Danxia Liu, Lei Song, Caina Li, Qun Yang

“…Therefore, this study aimed to explore the comorbidity patterns of NSSI and depressive symptoms and provide valuable insights for future interventions. …”
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Relevance of Cellular Homeostasis-Related Gene Expression Signatures in Distinct Molecular Subtypes of Breast Cancer by Sharda P. Singh, Chathurika S. Dhanasekara, Michael W. Melkus, Chhanda Bose, Sonia Y. Khan, Flavia Sardela de Miranda, Maria F. Mahecha, Prrishti J. Gukhool, Sahil S. Tonk, Se-Ran Jun, Sahra Uygun, Rakhshanda Layeequr Rahman

“…This study aimed to identify the gene expression patterns and biomarkers associated with breast cancer risk and progression by integrating transcriptomic and clinical data. …”
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Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Nomogram-based risk stratification effectively predicted biologic treatment responses across multiple therapeutic classes using four independent treatment datasets (GSE16879, GSE92415, GSE73661, GSE206285): low-risk patients demonstrated superior response rates to golimumab (63.3%), infliximab (54.8%), and vedolizumab (29% vs. 15% in high-risk group). …”
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Global psychiatrists' opinions about hikikomori from biopsychosocial perspectives: International case vignette survey by Marcus P. J. Tan, Kohei Hayakawa, Yukako Nakagami, Victor Pereira‐Sanchez, Seon Cheol Park, Yong Chon Park, Seok Woo Moon, Tae Young Choi, Yu‐Tao Xiang, Kang Sim, Toru Horinouchi, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Yugesh Rai, Mohammadreza Shalbafan, Pavita Chongsuksiri, Pichet Udomratn, Samudra T. Kathriarachchi, Afzal Javed, Mian‐Yoon Chong, Tan Chay‐Hoon, Toshiya Inada, Toshiya Murai, Tomohiro Nakao, Shigenobu Kanba, Shih‐Ku Lin, Norman Sartorius, Naotaka Shinfuku, Takahiro A. Kato

“…Most respondents felt the case could be treated by an outpatient visit, while others preferred hospitalization. Psychotherapy was rated highly as an intervention; Iran, South Korea, and “others” also rated pharmacotherapy highly. …”
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Monitoring and Evaluation of Fish Passage Effectiveness in Nature-like Fishway of Sanghe River Secondary Hydropower Station by SHEN Chun-ying, WANG Jing-chao, QIN Xin, CHEN Yu-bin, XUE Ru-zhan

“…[Objective] With the continuous expansion of China’s water conservancy infrastructure, hydraulic structures such as dams and sluice gates have obstructed fish migration routes and altered hydrological regimes both upstream and downstream. …”
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Disentangling the roles of natural variability and climate change in Canada’s 2023 fire season by Clair Barnes, Piyush Jain, Theodore R Keeping, Nathan Gillett, Jonathan Boucher, Philippe Gachon, Dorothy Heinrich, Megan Kirchmeier-Young, Yan Boulanger

“…Blocking circulation patterns are likewise associated with increased DSR, with the strongest responses in May and September. …”
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Impact of post-transplant cyclophosphamide with bendamustine on immune reconstitution in young patients undergoing T-cell replete haploidentical bone marrow transplantation: result... by Forrest L. Baker, Forrest L. Baker, Forrest L. Baker, Jessica Stokes, Megan J. Cracchiolo, Dan Davini, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis

“…Multi-parameter flow cytometry and TCR β sequencing of genomic DNA was performed on isolated PBMCs on PT days +30, +60, +100, +180, and +365.ResultsOverall, the PT-CY/BEN (n=14) regimen was associated with earlier neutrophil and platelet engraftment, reduced transfusion requirements, and comparable clinical outcomes to PT-CY (n=10), including survival and relapse rates. PT-CY/BEN patients exhibited distinct immune reconstitution patterns, characterized by earlier CD4+ T-cell recovery, impaired CD8+ T-cell engraftment, and reduced NK-cell counts. …”
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Specialized insectivores drive differences in avian community composition between primary and secondary forest in Central Africa by Eleanor M. Barrie, Eleanor M. Barrie, Billi A. Krochuk, Billi A. Krochuk, Crinan Jarrett, Crinan Jarrett, Crinan Jarrett, Diogo F. Ferreira, Diogo F. Ferreira, Diogo F. Ferreira, Patricia F. Rodrigues, Patricia F. Rodrigues, Patricia F. Rodrigues, Patricia F. Rodrigues, Susana Lin Mufumu, Susana Lin Mufumu, Silvestre Esteban Malanza, Silvestre Esteban Malanza, Agustin Ebana Nsue Akele, Agustin Ebana Nsue Akele, Cayetano Ebana Ebana Alene, Cayetano Ebana Ebana Alene, Kristin E. Brzeski, Kristin E. Brzeski, Jacob. C. Cooper, Jacob. C. Cooper, Jacob. C. Cooper, Jared D. Wolfe, Jared D. Wolfe, Luke L. Powell, Luke L. Powell, Luke L. Powell, Luke L. Powell

“…Notably, few species disappeared entirely in secondary forest (unlike patterns seen in the Neotropics); rather, capture rates of 12 of 30 species (40%) were significantly reduced relative to primary forest. …”
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Oxidative stress, DAMPs, and immune cells in acute pancreatitis: molecular mechanisms and therapeutic prospects by Hanwen Chen, Hanwen Chen, Yanhong Wang, Maddalena Zippi, Sirio Fiorino, Wandong Hong

“…Acute pancreatitis (AP) is a gastrointestinal disease characterized by inflammation of the pancreas and is associated with high rates of morbidity and mortality. The pathogenesis of AP involves a complex interplay of cellular and molecular mechanisms, including oxidative stress, damage-associated molecular patterns (DAMPs), and the infiltration of various immune cells. …”
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Clinical Manifestations of Nontyphoid Salmonellosis in Children Younger than 2 Years Old—Experiences of a Tertiary Hospital in Southern Taiwan by I-Fei Huang, Chih-Hsiang Kao, Wei-Yang Lee, Ming-Fang Chang, Yao-Shen Chen, Kuan-Sheng Wu, Hong-Hsiang Hu, Kai-Sheng Hsieh, Christine C. Chiou

“…Local susceptibility patterns could serve as a guide for the prescription of antibiotics by clinicians.…”
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Steroid and illicit drug abuse in the health and fitness community: A systematic review of evidence by Abdullah Al Hamid, Latifah Alomani, Alhanoof Aljuresan, Wasan Alahmad, Zainab Alluwaim

“…AAS use was prevalent across various regions and demographics, with rates ranging from 6.4 % to 29.3 % globally among gym participants, depending on the population and setting. …”
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