Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy by Wei Wu, Qihan Fu, Lulu Liu, Yi Zheng, Hangyu Zhang, Peng Zhao, Weijia Fang, Xuanwen Bao, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Zhou Tong, Fanglong Liu

“…A receiver operating characteristic curve was used to evaluate the accuracy rate of neural network, reaching 100%.Conclusion Our analysis unraveled the difference in the molecular nature and genomic variance in MSI and MSS colon cancer. …”
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Examining the Spatial Disequilibrium and Driving Factors of Population Aging and Elderly Service Resource Allocation in Rural Areas: A Case Study of Wenzhou City by Xiang Xiaoye, Lin Liyue, Xu Shiyu, Huang Tao

“…The results can be summarized as follows: 1) As Wenzhou enters a deeply aging society, the spatial distribution of the elderly population, elderly population density, population aging coefficient, elderly population support ratio, and comprehensive aging index are basically the same, showing a gradually increasing spatial pattern from the municipal district to the peripheral streets of the municipal district to the remote towns; 2) Elderly care service resources in Wenzhou present an asymmetrical and unbalanced north-south spatial distribution pattern with the municipal districts as " diversified supply in municipal streets, basic guarantee in developed coastal towns, and shortage of supply in inland mountainous towns "; 3) The streets of the municipal district have rich elderly care service resources, including Grade 3 general hospitals and comprehensive nursing homes, to provide diversified elderly care services for the elderly in the municipal district; there are many old-age care facilities such as hospitals, clinics, and nursing homes in Ruian, Yueqing City, and central towns such as Hongqiao and Aojiang, which provide basic old-age security for the elderly in and around the area. …”
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Experimental Investigation on Energy Dissipation in Diversion Tunnel at the Head of Canal by ZHONG Kun, YAN Fu-gen, GUO Jian-hua, YI Shun, LI Min-kang

“…Then, based on the hydraulic model test results under different conditions, the downstream flow pressure characteristics, cavitation characteristics of the weir surface behind the operating gate, pressure characteristics of the gradually expanding stilling basin floor and sidewalls, flow connection patterns, and energy dissipation performance were obtained. …”
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Overweight and Helicobacter pylori infection: a correlation in metabolic dysfunction-associated fatty liver disease by Xu Chen, Jiayue Fu, Jiayue Fu, Kejia Jin, Kejia Jin, Zixuan Yang, Zixuan Yang, Yidan Qian, Yidan Qian, Kehan Mei, Yihan Wang, Jialei Min, Yilin Du, Zaisheng Zhu, Zaisheng Zhu, Shengcun Li, Shengcun Li

“…Therefore, eradication of H. pylori infection may have positive implications for reducing the incidence rate of overweight MAFLD.…”
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Multi-source Data-driven Analysis of Deformation and Influencing Factors for Expansive Soil Canal Slopes by ZHANG Yuhan, HU Jiang, LI Xing

“…This approach facilitates a comprehensive analysis of deformation patterns at the slope surface and various subsurface depths, while elucidating the dominant controlling factors governing expansive soil canal slope behavior.Results and Discussions　The study focused on a deep excavated expansive soil canal section (Stake 8+886~12+921) of a major water diversion project, yielding the following key findings: 1) The analysis of 128 Sentinel-1A images from March 2017 to December 2021 revealed that the deformation data obtained through SBAS-InSAR method showed less than 3mm discrepancy with surface vertical displacement measurements at monitoring points (fourth-stage berm at 9+363 and third-stage berm at 11+400), with consistent deformation trends, confirming the reliability of SBAS-InSAR for canal slope deformation monitoring. 2) The study section exhibited LOS deformation rates ranging from -10 to 24 mm/a, demonstrating overall uplift characteristics, with positive LOS deformation showing annual increase. …”
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Epidemiology and genetic characterization of porcine reproductive and respiratory syndrome virus in Fujian Province, China, from 2023 to 2024 by Long-Bin Kang, Long-Bin Kang, Qiu-Yong Chen, Qiu-Yong Chen, Bing He, Bing He, Ren-Jie Wu, Ren-Jie Wu, Jing-Li Qiu, Jing-Li Qiu, Ru-Jing Chen, Ru-Jing Chen, Xue-Min Wu, Xue-Min Wu, Long-Bai Wang, Long-Bai Wang, Lun-Jiang Zhou, Lun-Jiang Zhou

“…The results revealed that the overall prevalence rate of PRRSV was 16.79% (44/262), PRRSV-1 and PRRSV-2 genotypes were co-prevalent in Fujian. …”
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CONCOMITANT CARDIOVASCULAR DISEASES AND ANTIHYPERTENSIVE TREATMENT IN OUTPATIENT PRACTICE (BY THE RECVASA REGISTRY DATA) by M. M. Loukianov, S. A. Boytsov, S. S. Yakushin, S. Yu. Martsevich, A. N. Vorobyev, A. V. Zagrebelnyy, N. N. Nikulina, K. G. Pereverzeva, E. A. Pravkina, A. D. Deev, E. V. Kudryashov, E. N. Belova

“…The mean number of prescribed AHDs was 1.73. The mean incidence rate of target blood pressure achievement was 26.1%. …”
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Selenium + Vitamin E Supplementation in Anestrus Goats: A Strategy to Enhance Reproductive Outcomes Under a Semi-Arid Production System by Raquel Santos-Silva, Cesar A. Meza-Herrera, Brenda Castro-Roque, Guadalupe Calderón-Leyva, Cayetano Navarrete-Molina, Oscar Angel-García, Jessica M. Flores-Salas, Angeles De Santiago-Miramontes, Fernando Arellano-Rodriguez, Cesar A. Rosales-Nieto

“…The response variables included estrus induction (EI), ovulatory rate (OR), corpus luteum diameter (CLD), left and right ovary diameters (LOD and ROD), embryo implantation (EMBRYO), and pregnancy rates (PREG). …”
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Dietary supplementation with L-carnitine elevates intracellular carnitine levels and affects gene expression of SLC25A20 and COX4I1, as well as non-mitochondrial respiration of bov... by Leonie Seemann, Susanne Kersten, Susanne Bühler, Fabian Billenkamp, Ulrich Meyer, Christian Visscher, Korinna Huber, Erika Most, Klaus Eder, Sven Dänicke, Jana Frahm

“…The same applied for PBMC mitochondrial functionality and metabolic activity as assessed by ex vivo approaches, whereas non-mitochondrial respiration rate was significantly affected by L-carnitine supplementation over time. …”
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Clinical and radiographical analysis of percutaneous kyphoplasty with multi-point cement anchoring technique for preventing bone cement displacement in Kümmell’s disease of stage I... by Heng Wu, Xiao Dai, Hao Liu, Xiang Yang, Shenao Liu, Shuang Xu, Hao Chi, Yuquan Chen, Song Wang

“…The operation time, volume of cement, VAS score, ODI score, cement distribution pattern and score, bone cement leakage, adjacent vertebra fracture, and bone cement displacement were compared between the two groups. …”
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hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA by Xin-bo Huang, Yue Zhang, Jing-wen Fan, Xin-yu Yu, Yun-lan Fang, Jin-xin Ren, Bin-yan Liu

“…However, it remains largely unclear whether A2B1 could function as a nucleic acid pattern-recognition receptor during cytoplasmic RNA virus infection. …”
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The optimal strategy for seasonal influenza vaccination to prevent high-intensity level of influenza epidemics in Zhejiang, China: an integrated transmission-dynamic and health-eco... by Mengsha Chen, Mengya Yang, Rui Yan, Zhengwei Liu, Can Chen, Rongrong Qu, Wenkai Zhou, Jiaxing Qi, Kexin Cao, Jiani Miao, Xiaoyue Wu, Jiaxin Chen, Qianqian Feng, HuiHui Zhang, Anqi Dai, Yi Yang, Jingtong Zhou, Qin Chen, Jimin Sun, Shigui Yang

“…Results Between 2018 and 2020, influenza incidence in Zhejiang Province followed typical seasonal patterns. However, during the COVID-19 pandemic, these patterns became irregular, culminating in a high-intensity influenza season in 2022–2023. …”
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Three‒Dimensional Numerical Simulation of the Breaching Process of Landslide Dams with Heterogeneous Structures by HU Xianrui, PENG Ming, FU Xiaoli, YANG Ge, ZHU Yan, SHI Zhenming, ZHANG Gongding

“…The middle layer (V2) governed vertical incision rates: fine-grained layers accelerated downward erosion, whereas coarse layers formed headcuts that restricted further deepening. …”
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Impact of Calcium and Potassium Currents on Spiral Wave Dynamics in the LR1 Model by Xiaoping Yuan, Qianqian Zheng

“…We demonstrate that reducing gate variables accelerates wave propagation, thins spiral arms, and shortens action potential duration, ultimately inducing dynamic instability. …”
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Mechanism of atrazine migration and diffusion control in soil by clay matrix composites by Xiangyu Wang, Qiang Fu, Tianxiao Li, Renjie Hou, Mo Li, Dong Liu, Fanying Kong, Mingxuan Liu, Shuqi Dong

“…Sep/BC increased the saturated hydraulic conductivity of the soil by 42.89 % and porosity by 2.81 %, which resulted in a reduction of the ATZ leaching rate by 49 %. The composites had a maximum adsorption capacity of 160.08 mg/g after FC activation, combining iron-catalyzed degradation with competitive resistance to organic matter. …”
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Mental Health in the Age of Hyperconnectivity: A Crisis Hidden in Plain Sight by Sitara Ejaz, Hafiz Muhammad Haseeb Khaliq

“…Young people are experiencing increasing levels of anxiety, depression, and loneliness at an alarming rate. Serious damage to emotional health stems from the pervasive information overload and social envy people experience through their constant online connection 3. …”
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Genetic evolution, epidemic trends, and recombination dynamics of PRRSV-1 in China by Chengzhen Weng, Chengzhen Weng, Chengzhen Weng, Xinxin Huang, Xinxin Huang, Xinxin Huang, Zhian Chen, Zhian Chen, Minjia He, Minjia He, Minjia He, Beiwen Zhang, Beiwen Zhang, Beiwen Zhang, Hongxi Li, Hongxi Li, Hongxi Li, Jingrui Xie, Jingrui Xie, Meichun Chen, Meichun Chen, Meichun Chen, Longxin Qiu, Longxin Qiu, Xiaobing Li, Xiaobing Li, Chong Cao, Chong Cao, Hongbo Chen, Hongbo Chen

“…The persistent threat of porcine reproductive and respiratory syndrome virus (PRRSV) to the global swine industry is exacerbated by the virus’s high mutation rate and frequent recombination events. In China, the emergence of new PRRSV-1 strains in recent years has posed a significant challenge to the sustainability of pork production. …”
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The Gaseous Blowout of the 30 Doradus Starburst Region in the LMC by Suraj Poudel, April Horton, Jo Vazquez, Kathleen A. Barger, Frances H. Cashman, Andrew J. Fox, Nicolas Lehner, Scott Lucchini, Dhanesh Krishnarao, N. M. McClure-Griffiths, Elena D’Onghia, Jason Tumlinson, Ananya Goon Tuli, Lauren Sdun, Stone Gebhart, Katherine Anthony, Bryce Cole, Jacco Th. van Loon, Julia Roman-Duval, Yik Ki Ma, Callum Lynn, Min-Young Lee, Denis Leahy

“…We estimate an outflow mass of M _outflow, Si _ii  ≈ (5.7–8.6)  × 10 ^5 M _⊙ , outflow rate of ${\dot{M}}_{{\rm{outflow}}}\gtrsim 0.02{M}_{\odot }\,{\,\rm{yr}\,}^{-1}$ , and mass loading factor of η  ≳ 0.10 within Δ θ  ≲ 0 $\mathop{.}…”
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Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential by Rita Costa, Rita Costa, Rita Costa, Rita Costa, Rita Costa, Carolina Ferreira, Carolina Ferreira, Carolina Ferreira, André Alves, André Alves, André Alves, Sara Nunes, Sara Nunes, Sara Nunes, Sara Nunes, Sara Nunes, Flávio Reis, Flávio Reis, Flávio Reis, João Malva, João Malva, João Malva, Sofia Viana, Sofia Viana, Sofia Viana, Sofia Viana, Sofia Viana

“…BackgroundLifestyle modifications, particularly the adoption of healthy dietary patterns such as the Mediterranean Diet (MedDiet), are foundational in any treatment plan, including for patients prescribed first-line statin therapy for hypercholesterolemia. …”
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Shear Strength Characteristics of Soft Soil in Nansha District of Guangzhou by WANG Wei-qi, LIAN Chang-jiang, LI Jian-ping, CHEN Zhi-yong, CHENG Dong-hai, CAI Wei-long, TANG Kai, LI Chao

“…Certain anomalies and unconventional patterns are observed in the dataset, including the opposite variation trends in the consolidated quick shear strength of both silt and silty soil with increasing depth, as well as the difference in the rate of strength change for silt at depths of 10 m≤h<20 m under consolidated quick shear compared to direct shear conditions. …”
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