The role of hypoxia-senescence co-related molecular subtypes and prognostic characteristics in hepatocellular carcinoma by Fuqing Chen, Yifan Cai, Xiangmei Chen, Changzhou Chen, Qinliang Fang, Jianming Liu, Yibin Zhang, Jianyin Zhou

“…Abstract Hepatocellular carcinoma (HCC) is known for its high invasiveness, high fatality rate. Both hypoxia and senescence play crucial roles in the initiation and progression of cancer, yet their prognostic implications in HCC are yet to be fully understood. …”
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Endoscopic management of large laterally spreading colorectal tumors (LSTs): a comparative study of techniques and outcomes by V. S. Tkachov, O. M. Kiosov, A. V. Klymenko

“…To compare EMR, pEMR, ESD, and hybrid ESD with respect to complication rates (bleeding, perforation), recurrence, and influencing factors. …”
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An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits by Ellen M. Howerton, Valerie Morrill, Rose Schrott, Jason Daniels, Ashley Y. Song, Kelly Benke, Heather Volk, Homayoon Farzadegan, Aimee Anido Alexander, Amanda L. Tapia, Gabriel S. Dichter, Lisa A. Croen, Lisa Wiggins, Genevieve Wojcik, M. Daniele Fallin, Christine Ladd-Acosta

“…We sought to identify DNA methylation patterns in child blood associated with Social Responsiveness Scale score, Second Edition (SRS). …”
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Metal–organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy by Tao Jiang, Zixiang Tang, Shumiao Tian, Haitian Tang, Zhekun Jia, Fangjian Li, Chenyue Qiu, Lin Deng, Lang Ke, Pan He, Gang Liu, Chengchao Chu, Yongfu Xiong

“…Remarkably, ultrasound irradiation induced substantial oxidative stress and immunogenic cell death, promoting the release of damage-associated molecular patterns (DAMPs), which elevated the maturation rate of tumor-infiltrating dendritic cells (DCs) and significantly increased the proportion of CD8⁺ T cells. …”
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Deep learning and genomic best linear unbiased prediction integration: An approach to identify potential nonlinear genetic relationships between traits by F. Shokor, P. Croiseau, H. Gangloff, R. Saintilan, T. Tribout, T. Mary-Huard, B.C.D. Cuyabano

“…Deep learning (DL) offers a promising alternative for capturing nonlinear genetic relationships due to its ability to identify complex patterns without prior assumptions about the data structure. …”
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Longitudinal Digital Phenotyping of Multiple Sclerosis Severity Using Passively Sensed Behaviors and Ecological Momentary Assessments: Real-World Evaluation by Zongqi Xia, Prerna Chikersal, Shruthi Venkatesh, Elizabeth Walker, Anind K Dey, Mayank Goel

“…Smartphone sensors recorded call activity, location, and screen use, while fitness trackers captured heart rate, sleep patterns, and step count. We extracted patient-level behavioral features and categorized them into 2 feature sets: one from the prediction period (called action) and one from the preceding period (called context). …”
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Population immunity to SARS-CoV-2 virus in residents of the Irkutsk Region in the dynamics of the epidemic by S. V. Balakhonov, V. I. Dubrovina, M. V. Chesnokova, D. D. Bryukhova, N. O. Kiseleva, A. B. Pyatidesyatnikova, K. M. Korytov, V. V. Voitkova, A. N. Perezhogin, T. A. Gavrilova, A. A. Seledtsov

“…In this regard, the study of the manifestations of the epidemic process of the new coronavirus infection COVID-19 and the patterns of its development are an urgent area of research. …”
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Groundwater rebound and seepage characteristics and water quality evolution in a sealed mining area in North China type coalfield by Huiyong YIN, Dehui SUN, Fangying DONG, Fanhua WANG, Lifeng ZHANG, Tao WU, Chao LIU, Yifan ZENG

“…After the goaf sealing, water-rock interactions persisted during the reinjection of the accumulated water, but the cation exchange rate slowed down. The mineral phases showed similar but weakened variation trends compared to the water inrush stage. …”
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The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis by Shaoyu Zheng, Zexuan Zhou, Guangzhou Du, Qingzi Chen, Shaoqi Chen, Jianqun Lin, Shijian Hu, Weijin Zhang, Kedi Zheng, Jinghua Zhuang, Meigan Huang, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Marco Matucci-Cerinic, Daniel E. Furst, Yukai Wang

“…Sonographic ILD was detected in 76 patients who underwent LUS examination. The concordance rate between two modalities was 83.33% (Kappa value = 0.64, 95% CI 0.50–0.78). …”
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Dynamics of changes in population immunity to the SARS-CоV-2 virus in residents the Irkutsk region in the context of the COVID-19 pandemic by S. V. Balakhonov, V. I. Dubrovina, A. B. Pyatidesyatnikova, D. D. Briukhova, N. O. Kiseleva, K. M. Korytov, V. V. Voitkova, A. N. Perezhogin, M. V. Chesnokova, T. A. Gavrilova, A. A. Seledtcov

“…A comprehensive study of the patterns of development and manifestations of the epidemic process of the new coronavirus infection COVID-19 is an urgent line of research. …”
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The impact of referral workload on cardiology registrars in a high-volume district general hospital: implications for workforce well-being and service efficiency by Md Imran Hossain, Jaymin Shantilal Shah

“…All inpatient cardiology referrals were audited for total referral volume, weekday versus weekend patterns and referral method (electronic vs bleep-based). …”
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A mobile app to improve adherence to colorectal cancer screening and post polypectomy surveillance guidelines by María A. Casas, Francisco Schlottmann, Leandro Steinberg, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Sonia Torres, Antoni Castells, Francesc Balaguer, Jaume Grau, Lisandro Pereyra, María Pellisé

“…Users’ characteristics, consultation types, and patient data were analyzed to assess app’s implementation, usage patterns, and impact on CRC screening and surveillance outcomes. …”
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Sex disparities in alcohol-associated liver disease and subtype differences in alcohol-attributable cancers in the United States by Pojsakorn Danpanichkul, Yanfang Pang, Tanuj Mahendru, Primrose Tothanarungroj, Luis Antonio Díaz, Juan Pablo Arab, Pimtawan Jatupornpakdee, Mark D. Muthiah, Kwanjit Duangsonk, Won-Mook Choi, Daniel Q. Huang, Donghee Kim, Mazen Noureddin, Karn Wijarnpreecha, Suthat Liangpunsakul, Amit G. Singal, Ju Dong Yang

“…The age-standardized incidence and death rate of ALD rose disproportionately among females compared to males. …”
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A first large study of whole-exome sequencing (WES) in 489 patients with suspected rare genetic disorders at a tertiary centre in Malaysia by Lip Hen Moey, Go Hun Seo, Boon Eu Cheah, Wee Teik Keng, Hane Lee, Gaik Siew Ch’ng

“…Introduction: Rare genetic disorders occur at a rate of 40–82 per 1000 live births worldwide. Identifying the molecular cause of rare genetic disorders is beneficial because it allows early diagnosis, facilitates treatment planning and provision of accurate genetic counselling. …”
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Treatment of unacceptable bleeding in long-term users of 52-mg levonorgestrel intrauterine device: a prospective observational studyAJOG Global Reports at a Glance by Patty A.H.H. van der Heijden, MD, Karlijn A. Röttgering, Tamara J. Oderkerk, MD, Jeanne P. Dieleman, Arianne C. Lim, PhD, Marlies Y. Bongers, PhD, Peggy M.A.J. Geomini, PhD

“…The secondary outcomes included the number of bleeding days 12 months after the start of medication, bleeding patterns, discontinuation rate of the 52-mg levonorgestrel intrauterine device, side effects, adverse events, and patient satisfaction at 3 and 12 months of follow-up. …”
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Early-stage endometrioid carcinoma with MSH6 protein deficiency: pitfalls in the diagnostic interpretation of microsatellite instability by Cheng Wang, Cheng Wang, Dongni Liang, Dongni Liang, Wei Wang, Wei Wang, Wei Kuang, Wei Kuang, Juan Zou, Juan Zou, Jing Zeng, Jing Zeng, Min Feng, Min Feng

“…This atypical MSI pattern is often overlooked, potentially increasing the risk of underdiagnosis of LS.…”
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Effect of maize-soybean intercropping on quality of vegetable soybean by FANG Ping, LIU Weiguo, LIU Xiaode, LIU Ting, CHI Xiaoyu, XU Yan, PANG Ting, PENG Xiao, CAI Ling, YANG Wenyu

“…Because the appearance quality of vegetable soybean is affected by cropping pattern and the nutrition are affected by pattern and variety, we should screen out well adaptability and good quality varieties. …”
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MIR155HG promotes metastasis and cisplatin resistance of cervical cancer cells by regulating the miR-409-3p and ZEB1 axis by Yanxia Chen, Jing Wang, Youqiang Heng, Yu Guo, Ka Ding, Cailing Ma

“…We analyzed the expression pattern of MIR155HG in CC patients using public database TCGA, and overexpressed its expression in HeLa cells to explore its cellular functions. …”
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A Method for Fitting Full Raindrop Size Distribution Based on Generalized Gamma Model by Zhao Xin, Wang Gaili, Wen Jiaqi, Li Ran, Guo Zaihua

“…The raindrop number concentration N(D), generalized diameter parameter D'm and rain rate obtained are shown to be closer to observations than those fitted by standard Gamma model, and it can be used to describe the drizzle pattern, the precipitation pattern, and the region between them simultaneously. …”
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The influence of the molecular weight of hyaluronic acid on the mangiferin release kinetics from the polymer matrix by P. P. Snetkov, R. O. Shaikenov, V. I. Klimshina, Yu. E. Generalova, S. N. Morozkina

“…Mangiferin release kinetic from a polymer matrix based on hyaluronic acid has a release sigmoidal pattern. The release mechanism has a complex nature of the Super Case II transport type, with the exception of a sample with a low content of mangiferin and hyaluronic acid with molecular weight equal to 1.3 MDa, for which an abnormal release pattern is detected (non-Fickian diffusion), due to the hydrophilic nature of hyaluronic acid, the rapid swelling of the polymer matrix, as well as a significant leading in the diffusion of mangiferin compared to the relaxation rate of the polymer. …”
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