Epidemiological investigation of venomous snakebites in Yunnan Province by Qinfen Gao, Yajun Teng, Chao Xiao, Rui Zeng, Bin Han, Hong Gao, Jianhai Wang, Xiaoyan Li, Canju Yang, Jianneng Dai, Chunxi Li, Qunyan Huang, Zengzheng Li, Wei Zhang

“…Subsequently, the effect of different therapeutic measures on these patients’ hospital stays was analyzed.ResultsA total of 2,112 venomous snakebite cases were recorded, with incidence rates rising annually: 406/46.73 million in 2022, 825/46.73 million in 2023, and 886/46.73 million in 2024. …”
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Associations between perceived stress profiles, social connection and work engagement in clinical registered nurses: a mediation analysis and generalized additive models by Yuan Liao, Miaochun Huang, Zhimin Gu, Chun Li, Yan Yu, Qimei Zhang, Xiangyu Lai, Jialin Liu, Kang He, Huiyun Chu, Yao Zhao, Xinyu Wu, Lihua Wu, Yu Li, Sujuan Fang

“…Nursing leaders should promptly identify the stress patterns of nurses, implement appropriate stress management strategies, enhance group cohesion through social networks, and promote the nurses’ mental health and occupational well-being, which in turn can decrease nurse turnover rates and enhance the quality of clinical nursing care. …”
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Shedding light on pharmacoepidemiology of eye diseases: a cohort study in Western Iran by Zeinab Mousavi, Masood Bagheri, Farid Najafi, Mahsa Yavari, Omid Bahiraee, Mehdi Moradinazar

“…The overall eye disease prevalence in males was 26.33% and 34.02% in females, thus pointing to the greater incidence in women who exhibit higher rates for most of the ophthalmopathies, excluding uveitis. …”
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Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis. by Anna L McNaughton, José Lourenço, Phillip Armand Bester, Jolynne Mokaya, Sheila F Lumley, Uri Obolski, Donall Forde, Tongai G Maponga, Kenneth R Katumba, Dominique Goedhals, Sunetra Gupta, Janet Seeley, Robert Newton, Ponsiano Ocama, Philippa C Matthews

“…Region-specific differences were present, with estimated CHB prevalence in Northern Africa typically 30% to 40% lower (p = 0.007) than in Southern Africa for statistically similar exposure rates, demonstrating the need for intervention strategies to be tailored to individual settings. …”
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Developing self-efficacy and ‘communities of practice’ between community and institutional partners to prevent suicide and increase mental health in under-resourced communities: ex... by Lisa Wexler, Lauren White, Joel Ginn, Tara Schmidt, Suzanne Rataj, Caroline C. Wells, Katie Schultz, Eleni A. Kapoulea, Diane McEachern, Patrick Habecker, Holly Laws

“…Abstract Background Suicide is a serious and growing health inequity for Alaska Native (AN) youth (ages 15–24), who experience suicide rates significantly higher than the general U.S. youth population. …”
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Distinct Roles of HHLA2 and PD-L1 in the Immune Cell and Prognosis of Hepatocellular Carcinoma by Wang CH, Chen SL, Yang X, Wu T, Liu LL, Yun JP

“…Hematoxylin and eosin (H&E) staining was utilized to quantify TILs (percentage/area), while IHC was used to measure the densities of CD3+, CD4+, and CD8+ TILs (cells/mm²).Results: HHLA2 and PD-L1 exhibited similar positivity rates. HHLA2 positivity was associated with older age, lower alpha-fetoprotein (AFP) levels, well-differentiated tumors, and improved overall survival (OS). …”
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Long‐Term Trends in Incidence and Risk Factors for Hemorrhagic Stroke Subtypes Over 24 Years: The South London Stroke Register by Xianqi Li, Lu Liu, Ajay Bhalla, Matthew D. L. O'Connell, Charles D. A. Wolfe, Yanzhong Wang

“…Methods We used 1995 to 2018 data from the South London Stroke Register. The annual incidence rates of HS, ICH, and SAH were standardized to the 2011 England and Wales population and stratified by age, sex, and race or ethnicity. …”
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Multicenter Study Examining Temporal Trends in Traumatic Intracranial Hemorrhage Over Six Years Using Joinpoint Regression by Timbre Backen, Kristin Salottolo, David Acuna, Carlos H. Palacio, Gina Berg, Andrea Tsoris, Robert Madayag, Kaysie Banton, David Bar-Or

“…The aging US population has altered the epidemiology of traumatic injury, but there are few studies examining changing patterns of traumatic intracranial hemorrhage (tICH). …”
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Post-marketing safety surveillance of pneumococcal vaccines: a real-world pharmacovigilance study using the U.S. vaccine adverse event reporting system (VAERS) database by Xinkuo Zheng, Meishen Liu, Aili Ding, Shihong Zhang, Ling Wu, Fanli Kong, Weijia Sun, Yuchen Peng, Yalin Xi

“…Females showed higher AE reporting rates (54.29%) compared to males (36.88%), with the majority of cases (38.20%) occurring in individuals aged < 18 years. …”
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Biomechanical stability and stress distribution before talus prosthesis design: effects of ligament removal and cartilage overlay thickness using finite element analysis by Gang Zeng, Yujun Sun, Min Liang, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Taolue Zhou, Huiying Zhao, Weidong Song, Yue Ding

“…Recent advancements, including patient-specific implants and improved biomaterials, show promise in enhancing long-term outcomes and reducing complication rates. Aim This study investigates the mechanical stability and stress distribution changes in a talus prosthesis after the sequential removal of surrounding ligaments and the application of varying thicknesses of cartilage overlays. …”
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Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, indi... by Emmanuel Bottieau, Achilleas Tsoumanis, Yven Van Herrewege, Diana Arango, Christophe Burm, Badara Cisse, Souleymane Mboup, Clémentine Roucher, Isabel Brosius, Moustapha Mbow, Babacar Thiendella Faye, Annelies De Hondt, Bart Smekens, Linda Paredis, Idzi Potters, Katja Polman

“…The trial’s primary endpoints are the efficacy (cure rate (CR), assessed by microscopy) and safety (frequency and pattern of drug-related adverse events) of one AM course versus PZQ at 4 weeks after treatment. …”
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Spatiotemporal Change in Climate Variables and Resources of Wind， Solar Radiation and Precipitation in Qinghai Province from 1961 to 2021 by Meixia DUAN, Miaoni GAO, Han JIANG, Runhong XU, buda SU, Tong JIANG

“…In order to evaluate the potential of wind， solar radiation and precipitation in guaranteeing the development of clean energy comprehensively， this study analyzed the temporal and spatial changes in climate variables and resources of wind speed， solar radiation and precipitation in Qinghai Province throughout the year and four seasons from 1961 to 2021 based on the observation data of daily 10-meter-height wind speed， sunshine duration and precipitation at 51 meteorological stations.The results are as follows： （1） The annual average wind speed， solar radiation and precipitation in Qinghai Province are 2.67 m·s-1， 6084.2 MJ·m-2， and 299.7 mm， respectively.Wind speed tends to be higher in the western regions and lower in the east， which exceeds 3 m/s and reaches the standard for wind energy resource development in western Qinghai.The annual solar radiation in the entire Province exceeds 5040 MJ·m-2， and reaches the "very rich" level according to China Solar energy GB Standards.The solar radiation of Qaidam Basin is at its highest abundance level， which is ideal for solar energy resource development.Precipitation generally decreases from southeast to northwest.The resources of wind， solar radiation， and precipitation in Qinghai Province exhibits seasonal complementarity， characterized by a pattern of “strong winds， good sunlight， and less water in spring， whereas weak winds， good sunlight， and abundant water in summer”.（2） Under climate change， the annual average wind speed and total solar radiation in Qinghai Province show a significant decrease at rates of 0.16 m·s-1·10a-1and 29.04 MJ·m-2·（10a）-1， respectively.The western and central parts of Haixi are most affected by these changes， but the wind speed and solar radiation still remain within the acceptable range for wind energy and photovoltaic resource development.Meanwhile， precipitation increases significantly at a rate of 8.85 mm·（10a）-1， with the largest increase observed in western Yushu， eastern Haixi and northern Guoluo.The most significant decrease in wind speed is observed in spring， while summer solar radiation decreases at the fastest rate but with a substantial increase in precipitation.The changes in solar radiation and precipitation could be ascribed to the increased cloud cover in this region.（3） The changes in the areas where wind speed and solar radiation meet suitable development standards in Qinghai Province are not significant with reduced variabilities， which could ensure the stable development of clean energy.Wind energy resources in western Qinghai （such as Tanggula Mountains）， solar energy resources in the Qaidam Basin， and water energy resources in the three major river basins of the Yangtze River， Yellow River， and Lancang River have great potential for development.Overall， the results provide a theoretical foundation for the development of a balanced clean energy system encompassing wind， solar and hydropower.This contributes to achieving national "dual carbon" goals and enhancing the high-quality development of Qinghai Province.…”
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Release Behavior and Bioaccumulation Characteristics of Organophosphate Esters from Plastics in Marine Aquaculture by Zhi YANG, Dongni LIU, Shengnan HUANG, Xuetian DAI, Wei QIAN, Xiaoshan ZHU

“…Chlorinated OPEs exhibited the highest dissolution rates, with TCEP showing a dissolution rate of 40.6%. …”
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Exploring the profile and risk factors associated with self-harm ideation and behaviors in adolescents with high psychoticism by Xiao-Ming Xu, Ru-Hong Jiang, Yu-Shuang Han, Wo Wang, Ming Ai, Jian-Mei Chen, Jun Cao, Xiao-Rong Chen, Zhen Lv, He-Yan Xu, Da-Qin Ding, Su Hong, Jing-Lan He, Qi Zhang, Lei Shi, Ning Du, Jin-Hui Hu, Li Kuang

“…Actual self-harm rates were 4.7% (lifetime), 1.64% (past year), and 0.37% (past month). …”
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Timing matters! Academic assessment changes throughout the day by Carmelo M. Vicario, Michael A. Nitsche, Chiara Lucifora, Pietro Perconti, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Mohammad A. Salehinejad, Francesco Tomaiuolo, Simona Massimino, Alessio Avenanti, Alessio Avenanti, Massimo Mucciardi

“…Our results demonstrate a Gaussian distribution of passing rates throughout the day, with a significant peak at midday. …”
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Planned Liver Stereotactic Body Radiotherapy for Residual Colorectal Cancer Liver Metastases After Surgery: A Single-Arm Retrospective Study by Sixuan Li, Dezuo Dong, Xuan Zheng, Hongzhi Wang, Kun Wang, Baocai Xing, Weihu Wang

“…The 1-, and 2-year cumulative incidence rates of LF after SBRT were 7.7%, and 9.6%, respectively. …”
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Clinical features of patients with dysthymia in a large cohort of Han Chinese women with recurrent major depression. by Wenqing Wu, Zhoubing Wang, Yan Wei, Guanghua Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jianguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Ying Liu, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Chunmei Hu, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S Kendler, Jonathan Flint, Zhen Zhang

“…<h4>Conclusions</h4>There are increased rates of stressful life events in MDD with dysthymia, but the impact of life events on susceptibility to dysthymia with MDD differs from that seen for MDD alone. …”
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Toxicokinetics, tissue distribution, and toxic potency of PFOS alternative OBS in adult zebrafish (Danio rerio) based on flow-through exposure system by Yilong Zou, Yu Zhou, Xianglian Wang, Guiqing Gao, Gang Chen, Zhanmeng Liu, Mi Deng, Xueping Huang, Yongming Wu

“…Our findings indicate that OBS accumulated rapidly in zebrafish, with log kinetic bioconcentration factor (logBCFk) values ranging from 2.48 to 2.70 and slow elimination rates (ke = 0.0490–0.0643 d−1). The blood, liver, and muscle were responsible for over 50 % of the total body burden of OBS, with tissue concentrations decreasing in the following order: blood > liver > intestine > gills > gonad > brain > muscle, suggesting a tissue-specific accumulation pattern. …”
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Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…Conversely, <i>GmNAC35</i> showed an inverse pattern, indicating negative regulation by miR164. …”
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An integrated high-resolution bathymetric model for the Danube Delta system by L. Alaerts, L. Alaerts, J. Lambrechts, N. R. Randresihaja, N. R. Randresihaja, L. Vandenbulcke, O. Gourgue, E. Hanert, E. Hanert, M. Grégoire

“…These error rates are comparable to those observed in bathymetry interpolation in rivers with similar source datasets. …”
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