Development of approaches to the evaluation of pharmacotherapy effectiveness for chronic hepatitis C by I. A. Narkevich, E. A. Tsitlionok

“…Objective: to analyse the consumption pattern of antiviral therapy (AVT) for chronic hepatitis C on the example of an infectious hospital.Material and methods. …”
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Radiological features of gait phenotypes in patients with idiopathic normal pressure hydrocephalus by Silvia Nicolosi, Silvia Nicolosi, Massimiliano Todisco, Massimiliano Todisco, Matteo Paoletti, Eduardo Caverzasi, Eduardo Caverzasi, Francesco Tarantino, Elena Ballante, Francesca Valentino, Roberta Zangaglia, Silvia Figini, Silvia Figini, Giuseppe Cosentino, Giuseppe Cosentino, Claudio Pacchetti, Anna Pichiecchio, Anna Pichiecchio

“…We compared the iNPH subtypes assessing differences in eight linear radiological indexes and their clinical correlates.ResultsThe Height of the third ventricle was the only radiological feature that differed between the two motor phenotypes (p < 0.05), being higher in the parkinsonian subtype and showing a trend of correlation with the motor score of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale and with the continence score of the iNPH Rating Scale. …”
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Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes by Tobias Brünger, Alina Ivaniuk, Eduardo Pérez-Palma, Ludovica Montanucci, Stacey Cohen, Lacey Smith, Shridhar Parthasarathy, Ingo Helbig, Michael Nothnagel, Patrick May, Dennis Lal

“…For the gene family of voltage-gated sodium channels, where variants and expert-curated clinical phenotypes are available, we also assess whether phenotype patterns of multiple disorders for each gene are conserved across variant positions within the gene family. …”
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Avaliação comparativa e evolutiva dos protocolos de atendimento dos pacientes fissurados Comparative and evolutive evaluation of attendance protocols of patients with clef lip and... by Nivaldo Alonso, Daniela Yukie Sakai Tanikawa, Jonas Eraldo de Lima Junior, Marcus Castro Ferreira

“…Eight surgical categories were related, palate repair (35.18%) was the most utilized one, followed by lip repair (unilateral and bilateral), keeping the same distribution pattern. Secondary procedures had persisted with high rates (approximately 30%), however the number of complications decreased (no fistulae). …”
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Clinical characteristics of obsessive-compulsive disorder comorbid with obsessive -compulsive personality disorder: subtype implications by Ayse Dondu, Levent Sevincok

“…The severity of current OC symptoms was assessed using the Yale–Brown Obsessive Compulsive Scale (Y-BOCS), while depressive symptoms were measured with the Hamilton Depression Rating Scale (HDRS). Anxiety symptoms were also evaluated using the Hamilton Anxiety Rating Scale (HARS).ResultsAmong 148 OCD patients, 58.8% met the diagnostic criteria for OCPD. …”
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An interpretable XAI deep EEG model for schizophrenia diagnosis using feature selection and attention mechanisms by Ahmad Almadhor, Stephen Ojo, Thomas I. Nathaniel, Shtwai Alsubai, Abdullah Alharthi, Abdullah Al Hejaili, Gabriel Avelino Sampedro

“…The study proposes a novel automated technique for diagnosing Schizophrenia based on electroencephalogram (EEG) sensor data, aiming to enhance interpretability and prediction performance.MethodsThis research utilizes Deep Learning (DL) models, including the Deep Neural Network (DNN), Bi-Directional Long Short-Term Memory-Gated Recurrent Unit (BiLSTM- GRU), and BiLSTM with Attention, for the detection of Schizophrenia based on EEG data. …”
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Disentangling the roles of natural variability and climate change in Canada’s 2023 fire season by Clair Barnes, Piyush Jain, Theodore R Keeping, Nathan Gillett, Jonathan Boucher, Philippe Gachon, Dorothy Heinrich, Megan Kirchmeier-Young, Yan Boulanger

“…We find that the annual accumulated daily severity rating (DSR), a measure of weather-related fire risk) is increasing in most ecozones in response to global warming, with the largest increases in the early months of the fire season; although temperatures are increasing everywhere, this effect is offset in some regions by increased precipitation. …”
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Coping and positive mental health in Canada among youth and adults: findings from a population-based nationally representative survey by Mihojana Jhumi, Laura L. Ooi, Karen C. Roberts, Melanie Varin

“…MethodsWe analyzed data from the 2019 Canadian Community Health Survey on the self-rated ability of adults and youth (N = 60 643; 12+ years) to cope with unexpected or difficult problems and day-to-day demands along with three PMH outcomes: selfrated mental health (SRMH), happiness and life satisfaction. …”
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Evaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial by Abhishek Abhishek, Sameer Akram Gohir, Paul Greenhaff, Ana M. Valdes

“…The participants will be assessed using a Numerical Rating Scale, the Western Ontario and McMaster Universities Osteoarthritis Index, the Arthritis Research UK Musculoskeletal Health Questionnaire, the Pittsburgh Sleep Quality Index, 30 s sit to stand test, timed up and go test, quantitative sensory testing, musculoskeletal ultrasound scan, muscle thickness assessment of the vastus lateralis, and quadriceps muscles force generation during an isokinetic maximum voluntary contraction (MVC). …”
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Subjective Performance Expectations From and Demographic and Categorical Differences in the Acceptance of Virtual Reality or AI Technologies in Rehabilitation Programs: Cross-Secti... by Guido Waldmann, Dominik Raab

“…A significant rank correlation was observed for 103 out of 105 pairwise comparisons of the therapeutic fields, with distinct patterns of effects sizes within the chosen categories. …”
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Deeply revealing the coupled formation mechanism of inclusions and precipitates in 654NMo ingot by Hongchun Zhu, Xinbo Yan, Huabing Li, Zhiyu He, Zhuowen Ni, Hao Feng, Shucai Zhang, Zhouhua Jiang, Pengchong Lu

“…The inclusion number density is significantly higher at the ingot edge compared to the center, while the bottom zone exhibits a greater density than the top and middle. This distribution pattern is attributed to the higher solidification rates at the edge and bottom. …”
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Multiyear Baleen Endocrine Profiles Suggest a Longer Estimated Gestation in Southern Right Whales (Eubalaena australis) by Loraine Shuttleworth, Andre Ganswindt, Kathleen E. Hunt, Alejandro Fernández Ajó, Estefan Pieterse, S. Mduduzi Seakamela, Chantel Schoeman, Els Vermeulen

“…ABSTRACT Gestation length is a key reproductive parameter influencing fecundity, population growth rates, and the recovery potential of baleen whales. …”
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Using optimization tools to explore stratospheric aerosol injection strategies by E. Brody, Y. Zhang, D. G. MacMartin, D. Visioni, B. Kravitz, B. Kravitz, E. M. Bednarz, E. M. Bednarz, E. M. Bednarz

“…However, the outcomes will depend on how it is deployed: not just how much but also the latitudes of injection and the distribution of injection rates across those latitudes. Different such strategies have been proposed, for example, managing up to three climate metrics simultaneously by injecting at multiple latitudes. …”
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Phylogeochemistry: exploring evolutionary constraints on belemnite rostrum element composition by A. Pohle, K. Stevens, R. Hoffmann, A. Immenhauser, A. Immenhauser

“…We used comparative Bayesian phylogenetic tools to reconstruct ancestral states and phenotypic evolutionary rates of these geochemical data based on trees inferred from morphological data. …”
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SERPINA3 predicts long-term neurological outcomes and mortality in patients with intracerebral hemorrhage by Pei Zheng, Zhihui Qi, Bin Gao, Yang Yao, Jingshan Chen, Hengri Cong, Yue Huang, Fu-Dong Shi

“…Abstract Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, and long-term outcomes among survivors remain unpredictable due to the lack of reliable biomarkers. …”
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Review of Epidemiological Situation on Rickettsioses in the Russian Federation in 2022 as Compared with 2013–2021, Forecast for 2023 by N. A. Pen’evskaya, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, D. A. Savel’ev, S. V. Shtrek, A. V. Sannikov

“…The aim of the review was to characterize the epidemiological situation on tick-borne rickettsioses (TR) in the Russian Federation in 2022 in comparison with the pandemic years of 2020–2021 and the pre-pandemic period of 2013–2019, to give the forecast for 2023. During 2013–2022, a pattern was observed in the incidence of rickettsiosis of the tick-borne spotted fever group (with the exception of Astrakhan spotted fever – ASF), that is also characteristic of most other natural focal infections (NFIs): a sharp decrease in registered incidence rates in 2020–2021 with the subsequent increase in 2022 almost up to pre-pandemic levels or even exceedance in some regions. …”
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Psychiatric comorbidities and smoking behavior in chronic obstructive pulmonary disease: A case–control study from a north Indian tertiary Center by Rohit Pathak, Abhishek Pathak, Manish Singh

“…Results: Cases exhibited significantly higher rates of smoking, with regular smokers constituting 51.1% compared to 14.0% of controls (P=0.0001). …”
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Global psychiatrists' opinions about hikikomori from biopsychosocial perspectives: International case vignette survey by Marcus P. J. Tan, Kohei Hayakawa, Yukako Nakagami, Victor Pereira‐Sanchez, Seon Cheol Park, Yong Chon Park, Seok Woo Moon, Tae Young Choi, Yu‐Tao Xiang, Kang Sim, Toru Horinouchi, Ajit Avasthi, Sandeep Grover, Roy Abraham Kallivayalil, Yugesh Rai, Mohammadreza Shalbafan, Pavita Chongsuksiri, Pichet Udomratn, Samudra T. Kathriarachchi, Afzal Javed, Mian‐Yoon Chong, Tan Chay‐Hoon, Toshiya Inada, Toshiya Murai, Tomohiro Nakao, Shigenobu Kanba, Shih‐Ku Lin, Norman Sartorius, Naotaka Shinfuku, Takahiro A. Kato

“…Most respondents felt the case could be treated by an outpatient visit, while others preferred hospitalization. Psychotherapy was rated highly as an intervention; Iran, South Korea, and “others” also rated pharmacotherapy highly. …”
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IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. by Helen M Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S Suthar, Albert Huang, Sarah C Vick, Lisa Clepper, Larissa Thackray, Margaret M Brassil, Herbert W Virgin, Janko Nikolich-Zugich, Ashlee V Moses, Michael Gale, Klaus Früh, Michael S Diamond

“…In pathogenesis studies with two unrelated positive-sense RNA viruses (West Nile virus (WNV) and murine norovirus), TKO mice succumbed at rates greater than DKO mice and equal to or approaching those of mice lacking the type I IFN receptor (Ifnar(-/-)). …”
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In Silico Designed Multi-Epitope Vaccine Based on the Conserved Fragments in Viral Proteins for Broad-Spectrum Protection Against Porcine Reproductive and Respiratory Syndrome Viru... by Shaukat Ullah, Hikmat Ullah, Kainat Fatima, Tan Lei

“…This virus includes two major genotypes, PRRSV1 and PRRSV2, both characterized by high mutation rates and genetic variability, complicating the development of a universally effective vaccine and disease control. …”
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