Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Finally, in vivo targeting and anticancer studies demonstrated that FOL-RSV-LPHNCs selectively internalized to the cancerous region and suppressed the tumor volume with an 8.66-fold higher rate in the xenograft mouse model. The folate receptor-mediated uptake mainly facilitates this superior therapeutic response which was further confirmed by in silico molecular docking and dynamic simulation. …”
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Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis by Xinwan Zhang, Shijie Luo, Xiali Ye, Lin Liu, Xinxin Jia, Deyuan Jiang, Weiwei Wen

“…Compared to 0 mM Al treatment, low Al concentrations (0.4 mM) enhanced root vitality by 8.91%, while higher Al concentrations (10 and 100 mM) reduced root vigor by 19.31% and 76.81%, respectively. In a similar pattern, the electron transfer rate in leaves remained stable under low Al levels but significantly decreased under high Al conditions. …”
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Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa by Josephine Wambani, Patrick Okoth

“…However, in certain areas, the rate of decline has slowed or even reversed the gains made so far. …”
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Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…Abstract Background Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. …”
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Dr Papineau Meets Dr Masquelet—Management of Open Calcaneal Fractures, Combining Two Techniques: A Case Report by Shuvendu P Roy, Yogendra Gupta, Gurinder Bedi, Vishwadeep Sharma

“…Aim and background: Open fractures of the calcaneum are often the source of significant morbidity due to the high rate of wound infection and significant morbidity, ranging from malunion to amputation. …”
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Fluid–solid coupling productivity analysis of multi-stage fractured horizontal wells in shale reservoirs by Qian QI, Ming YUE, Weiyao ZHU, Wenjiang MA

“…The simulation results of the model align with actual field data, showing that gas production follows an “L-shaped” decline pattern with a coincidence rate exceeding 70%, verifying the model’s accuracy.…”
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Safety and efficacy of prone position ventilation in patients with severe pneumonia in neurosurgical intensive care units by CHENG Longyang，LI Jun，LI Shaoya，LI Chuanqing，XU Manman，WANG Rong，ZHAO Penglai

“…Changes in blood gas analysis［pH，arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2），oxygenation index］and hemodynamics［heart rate（HR），mean arterial pressure（MAP）］were compared before prone positioning，and at 1 day，3 days，5 days，and 7 days after resuming supine position following prone position treatment. …”
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Clinical characteristics and outcomes of non-tuberculous mycobacterial pulmonary infections after hematopoietic stem cell transplantation: A retrospective cohort study by Zahia Esber, Hamza Salam, Shefali Godara, Ayman Soubani

“…Conclusion: Outcomes vary significantly among non-tuberculous mycobacterial pulmonary infections based on mycobacterial species, rate of colonization and degree of immunosuppression. …”
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Cutis verticis gyrata in a Patient with Familial presenile sebaceous hyperplasia Presenting as “Leonine facies”: A Rare Case by Sutedja EK, Sutedja E, Ruchiatan K, Faldian Y, Yogya Y, Dwiyana RF, Maharani RH, Budiarsa M

“…Isotretinoin, with its sebocyte-suppressing effect, may reduce gland size but has a high recurrence rate upon discontinuation. Early recognition and a multidisciplinary approach are crucial to prevent further progression, particularly in older patients.Keywords: cutis verticis gyrata, familial presenile sebaceous hyperplasia, leonine facies…”
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Isokinetic knee strength as a predictor of cardiorespiratory responses during loaded aerobic capacity test in elite athletes by Bekir Çar, Ahmet Kurtoğlu, Özdemir Atar, Musa Türkmen, Özgür Eken, Mehmet Soyler, Monira I. Aldhahi

“…Cardiorespiratory parameters—average breath volume (ABV), average breath frequency (ABF), auxiliary oxygen density (AOD), and heart rate (HR)—were recorded during the Bruce Protocol conducted under two conditions: unloaded and with a 10 kg loaded vest. …”
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Energy Dissipation and Failure Characteristics of Layered Composite Rocks under Impact Load by Wenjie Liu, Ke Yang, Wei Zhen, Xiaolou Chi, Rijie Xu, Xin Lv

“…The energy dissipation pattern of composite rock had an obvious strain rate effect. …”
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Neuroendocrine tumors of the digestive system: pathologic and molecular characteristics by V. V. Delektorskaya

“…The grade (G) is based on the proliferative activity of the tumor assessed by the mitotic rate or by Ki-67 immunohistochemistry. Several markers are useful in the identification of a primary organ of NETs in metastatic lesions are also discussed. …”
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Network meta-analysis of erlotinib, gefitinib, afatinib and icotinib in patients with advanced non-small-cell lung cancer harboring EGFR mutations. by Wenhua Liang, Xuan Wu, Wenfeng Fang, Yuanyuan Zhao, Yunpeng Yang, Zhihuang Hu, Cong Xue, Jing Zhang, Jianwei Zhang, Yuxiang Ma, Ting Zhou, Yue Yan, Xue Hou, Tao Qin, Xiaoxiao Dinglin, Ying Tian, Peiyu Huang, Yan Huang, Hongyun Zhao, Li Zhang

“…Pooled data on objective response rate (ORR), progression free survival (PFS), overall survival (OS) were calculated. …”
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Demographic and clinical characteristics of patients with benign bone tumors: Evidence of bimodal age distribution in a Hispanic population by Blake C. Martin, Mohammad Khalil, Juan Lopez-Alvarenga, Michael Sander

“…This indicates an incidence rate of 0.00018 per person-year. The average age was 38.8 years (SD 24.0), with females representing 58 % of the sample. …”
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Reduced Inter-Element Interference mmWave MIMO Antenna and Its Application in WBAN by Jawad Ahmad, Mohammad Hashmi

“…A specific absorption rate (SAR) analysis confirmed that the design complies with safety standards for both 1g and 10g tissue models. …”
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Early Recurrence of Hepatocellular Carcinoma in Patients without Microscopic Vascular Invasion: Clinicopathological Characteristics and Risk Factors by Ngo HTT, Nguyen DD, Dang MX, Doan TTP, Thai TT

“…Microscopic features of both tumor and non-tumor liver tissue were assessed using Hematoxylin-Eosin-stained slides.Results: The majority of patients were male (78.3%) and had cirrhosis (72.5%). The early recurrence rate was 31.9%, with most recurrences occurring between 6- and 18-month post-surgery. …”
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Factors associated with interstitial lung disease in patients with rheumatoid arthritis by Benyapa Suppa-Udom, Supparerk Disayabutr, Suwimon Wonglaksanapimon, Krittachat Butnian, Wanruchada Katchamart

“…Patients exhibited low disease activity [mean Disease Activity Score 28-erythrocyte sedimentation rate score (SD) 2.69 (0.90)] and mild functional impairment [median Health Assessment Questionnaire score (range) 0.25 (0–0.63)]. …”
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Comparative analysis of START and CAVI arterial stiffness scores in hypertensive patients by A. N. Sumin, A. V. Shcheglova, I. B. Bakholdin

“…Parameters were associated with age (r=0,412 for CAVI and r=0,355 for START; p<0,001), smoking duration (r=0,390 and r=0,361; p<0,001), glomerular filtration rate (r=-0,317 and r= -0,318; p<0,001), body mass index (r=-0,176 and r=-0,185; p=0,001). …”
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Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response by Cong Tang, Patrícia Corredeira, Sandra Casimiro, Qi Shi, Qiwei Han, Wesley Sukdao, Ana Cavaco, Cecília Melo-Alvim, Carolina Ochôa Matos, Catarina Abreu, Steven Walsh, Gonçalo Nogueira-Costa, Leonor Ribeiro, Rita Sousa, Ana Lorena Barradas, João Eurico Fonseca, Luís Costa, Emma V. Yates, Gonçalo J. L. Bernardes

“…By measuring the total concentrations of cysteine, free cysteine, lysine, tryptophan, and tyrosine protein-incorporated biomarkers and analyzing the results with supervised machine learning, we identify 78% of cancers with 0% false positive rate (N = 97) with an AUROC of 0.95. The cancer, healthy, and autoimmune/infectious biomarker pattern are statistically significantly different (p < 0.0001). …”
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MIR155HG promotes metastasis and cisplatin resistance of cervical cancer cells by regulating the miR-409-3p and ZEB1 axis by Yanxia Chen, Jing Wang, Youqiang Heng, Yu Guo, Ka Ding, Cailing Ma

“…Overexpression of MIR155HG (MIR155HG-OE) demonstrated higher proliferation and migration levels in HeLa cells, while MIR155HG inhibited the apoptosis rate of HeLa cells. Meanwhile, we found MIR155HG can reduce the effect of cisplatin sensitivity on HeLa cells. …”
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