Long-term outcomes of dupilumab therapy in severe asthma: A retrospective, multicenter, real-world study by Carlo Mümmler, MD, Alexandra Lenoir, MD, Jeremias Götschke, MD, Michael Gerckens, MD, Merle Kaiser, MD, Moritz Kayser, MD, Nora Drick, MD, Hendrik Suhling, MD, Leonie Biener, MD, Carmen Pizarro, MD, Dirk Skowasch, MD, Nikolaus Kneidinger, MD, PhD, Jürgen Behr, MD, Katrin Milger, MD

“…Data on asthma control, medication, lung function, and annualized exacerbation rates were collected at baseline and 3, 12, and 36 months after initiation of dupilumab therapy. …”
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Decentralized Immunization Monitoring: Lessons Learnt from a Pilot Implementation in Kumbotso LGA, Kano State, Nigeria by Adam Attahiru, Yahaya Mohammed, Fiyidi Mikailu, Hyelshilni Waziri, Ndadilnasiya Endie Waziri, Mustapha Tukur, Bashir Sunusi, Mohammed Nasir Mahmoud, Nancy Vollmer, William Vargas, Yusuf Yusufari, Gustavo Corrêa, Heidi W. Reynolds, Teemar Fisseha, Talatu Buba Bello, Moreen Kamateeka, Adefisoye Oluwaseun Adewole, Musa Bello, Imam Wada Bello, Sulaiman Etamesor, Joseph J. Valadez, Patrick Nguku

“…To enable a better understanding of contextual factors towards increasing uptake, we piloted a Decentralized Immunization Monitoring (DIM) approach in the Kumbotso local government area (LGA) of Kano state, Nigeria, to identify wards with low vaccination rates and understand why this is happening. The findings were used to improve routine immunization (RI) programs and reduce the number of unvaccinated children and children yet to receive their first dose of diphtheria–pertussis–tetanus (DPT) vaccine, referred to as Zero-Dose children (ZD). …”
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Ultrahigh-throughput single-pixel complex-field microscopy with frequency-comb acousto-optic coherent encoding (FACE) by Daixuan Wu, Yuecheng Shen, Zhongzheng Zhu, Tijian Li, Jiawei Luo, Zhengyang Wang, Jiaming Liang, Zhiling Zhang, Yunhua Yao, Dalong Qi, Lianzhong Deng, Zhenrong Sun, Meng Liu, Zhi-Chao Luo, Shian Zhang

“…However, limitations such as slow pattern projection rates and time-consuming reconstruction algorithms hinder its throughput for real-time imaging. …”
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Phylogeochemistry: exploring evolutionary constraints on belemnite rostrum element composition by A. Pohle, K. Stevens, R. Hoffmann, A. Immenhauser, A. Immenhauser

“…We used comparative Bayesian phylogenetic tools to reconstruct ancestral states and phenotypic evolutionary rates of these geochemical data based on trees inferred from morphological data. …”
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Distribution and extended triage of high-risk human papillomavirus genotyping based on vaginal self-sampling by Ling Li, Yun Zhao, Rong Liu, Chen Yao, Zhijun Zhang, Yingying Hu, Ruifang Wu, Ruifang An, Hui Du, Xinfeng Qu, Lihui Wei, Bei Lin, Mingzhu Li, Chao Zhao, Jingran Li, Zhixin Lin, Jihong Deng, Songling Zhang

“…Different HPV subtypes have different detection rates for CIN2+, and combining HPV16/18/33 significantly improved the sensitivity for detecting CIN2+.…”
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The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners by Rossella Roncoroni, Denisa Baci, Martina Cucchiara, Annarosaria de Vito, Matteo Gallazzi, Maria Teresa Palano, Francesca Olmeo, Cristian Rubuano, Alessandra Giannatiempo, Laura Monti, Raffaella Bombelli, Daniele Mercatelli, Giovanna Finzi, Francesca Franzi, Stefano La Rosa, Douglas M. Noonan, Barbara Bassani, Lorenzo Mortara, Antonino Bruno, Francesco Acquati

“…Here, we investigated the effects of the human RNASET2 alarmin in two different human PCa cell lines focusing on cell proliferation, colony formation, adhesion, migration rates, and release of soluble immune-modulatory factors. …”
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Red cell distribution width-to-platelet ratio (RPR) as a predictor of prolonged stay at hospital for COVID-19 inpatients by Martha Fors, Santiago J. Ballaz

“…One exemption was the red cell distribution width-to-platelet ratio (RPR) index, which can increase the probability of a longer hospital stay by up to ten times (HR(IC95%) = 0.092(0.03-0.29); p < 0.001).Conclusion The most effective biomarker to identify COVID-19 patients at high risk for extended hospital stay was RPR.Highlights IntroductionDetermining hospital Length of Stay (LoS) is vital for resource management, especially for future COVID-19 outbreaks.Previous studies have primarily focused on sociodemographic and clinical attributes, along with resource availability, but have not accounted for other factors like routine laboratory tests, which can significantly impact LoS predictions.This study examines novel hematology scores as predictors of LoS, emphasizing their importance in resource-limited settings like Ecuador.MethodsThis retrospective cohort study analyzed 2,930 COVID-19 patients admitted to Hospital IESS Quito Sur in Ecuador focusing on confirmed cases with complete blood count (CBC) values to assess LoS.The study explored various hematological ratios, such as the neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width-to-lymphocyte ratio (RLR), as potential predictors of LoS and in-hospital outcomes for COVID-19 patients, using a combination of univariate and multivariable Cox proportional hazards regression models.Kaplan-Meier survival estimates and log-rank tests were used to analyze survival and discharge probabilities over time, highlighting sex-dependent effects and the significant association between selected hematological indices and patient outcomes.ResultsThe mean LoS for survivors was significantly shorter compared to those who died (p < 0.001), indicating that longer hospitalization was associated with higher mortality risk.Women had a shorter average LoS (with lower mortality risk (p < 0.001), suggesting an asymmetrical hospitalization pattern based on sex.While most hematological markers had minimal clinical relevance for LoS, the red cell distribution width-to-platelet ratio (RPR) stood out, increasing the likelihood of a longer hospital stay by up to tenfold, making it a critical factor in predicting prolonged hospitalization.DiscussionMen had longer hospital stays and higher mortality rates than women, likely due to differing inflammatory responses, though hyperinflammation markers like NLR, PLR, and Leu-CPR had minimal clinical impact.RPR had the strongest link to longer hospital stays, indicating a higher risk of extended hospitalization in severe COVID-19 cases.Elevated RPR is tied to oxidative stress and coagulation issues, suggesting early identification could help reduce prolonged stays and complications.ConclusionResearch generally points to clinical complications from COVID-19 as the main factor behind prolonged hospitalizations, underlining the importance of early identification and management of these issues.…”
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Biogeochemical responses to water management: Insights from the regulated Geum River, Korea by Min-Young Lee, Tae-Hoon Kim, Yongwon Kim, Hyebin Kim, Tae-Woo Kang, Sung-Eun Park

“…We compared conditions during August 2021 (gate-closing) and August 2022 (gate-opening), periods with starkly different residence times (3.5 vs. 0.5 days) that resulted in distinct biogeochemical dynamics. …”
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Seasonal population dynamics and dietary switching of Vulpes spp. amplify Echinococcus spp. transmission in the Eastern Tibetan plateau: implications for wildlife-mediated zoonotic... by Xu Wang, Chuizhao Xue, Xueying Deng, Qilu Chen, Chunyang Li, Baixue Liu, Ying Wang, Yan Kui, Qingqiu Zuo, Jianhai Yin, Shuai Han, Yujuan Shen, Jianping Cao

“…This dietary diversification correlated with seasonal resource scarcity, driving foxes to exploit alternative prey. The infection rates of Echinococcus in V. ferrilata displayed the U-shaped seasonal patterns. …”
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Fertility intentions among Chinese adults: a cross-sectional study using a national survey by Mingyan Hao, Chenxiao Zhang, Haofeng Fu, Jingting Zhang, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Chen Chen, Yajing Zhou, Jianzhong Zheng, Wei Liu, Lizheng Wang

“…To tackle the challenge of decreasing fertility rates effectively, it is essential that interventions focus on younger women and highlight the advantages of living with multiple generations. …”
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Experimental Investigation on Energy Dissipation in Diversion Tunnel at the Head of Canal by ZHONG Kun, YAN Fu-gen, GUO Jian-hua, YI Shun, LI Min-kang

“…Then, based on the hydraulic model test results under different conditions, the downstream flow pressure characteristics, cavitation characteristics of the weir surface behind the operating gate, pressure characteristics of the gradually expanding stilling basin floor and sidewalls, flow connection patterns, and energy dissipation performance were obtained. …”
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Epstein Barr virus antibody and cancer risk in two prospective cohorts in Southern China by Ming-Fang Ji, Yong-Qiao He, Min-Zhong Tang, Wen-Qiong Xue, Xia Yu, Hua Diao, Da-Wei Yang, Zhi-Ming Mai, Io Hong Cheong, Zhi-Yang Zhao, Biao-Hua Wu, Fu-Gui Li, Ji-Yun Zhan, Chang-Ling Huang, Hao-Lin Ma, Jun Li, Yan-Cheng Li, Tong-Min Wang, Ying Liao, Xue-Yin Chen, Zhi-Heng Liang, Shi-Feng Lian, Yun Du, Xue-Jun Liang, Zisis Kozlakidis, Jun Ma, Wei-Hua Jia

“…The associations showed an increased dose-response pattern, and keep persistent even up to ten years prior to diagnosis. …”
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Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury by Hong Duo, Yanwei Yang, Jun Luo, Yumeng Cao, Qian Liu, Jiarui Zhang, Siqi Du, Jian You, Guqing Zhang, Qifa Ye, Huaqin Pan

“…Abstract Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. …”
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Impact of Calcium and Potassium Currents on Spiral Wave Dynamics in the LR1 Model by Xiaoping Yuan, Qianqian Zheng

“…We demonstrate that reducing gate variables accelerates wave propagation, thins spiral arms, and shortens action potential duration, ultimately inducing dynamic instability. …”
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Differences in the inflammatory response and outcome among hospitalized patients during different waves of the COVID-19 pandemic by Violeta Briciu, Violeta Briciu, Daniel-Corneliu Leucuta, Monica Muntean, Monica Muntean, Amanda Radulescu, Amanda Radulescu, Cristina Cismaru, Cristina Cismaru, Adriana Topan, Adriana Topan, Lucia Herbel, Melinda Horvat, Melinda Horvat, Mirela Flonta, Mihai Calin, Roxana Dobrota, Mihaela Lupse, Mihaela Lupse

“…Systemic inflammatory indexes like neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-platelet ratio (NPR), Systemic Immune-Inflammation Index (SII), and systemic inflammation response index (SIRI) were calculated.ResultsThe Delta wave, characterized by the longest hospitalizations and the highest rates of severe cases and mortality, showed significant elevations in inflammatory biomarkers. …”
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Mapping Antimicrobial Resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> from Complicated Urinary Tract Infections in Oman: Phenotypic and Genotypic Insights by Nawal AL Shizawi, Zaaima AL Jabri, Fatima Khan, Hiba Sami, Turkiya AL Siyabi, Zakariya AL Muharrmi, Srinivasa Rao Sirasanagandla, Meher Rizvi

“…In comparison, susceptibility rates of <i>K. pneumoniae</i> were far lower: nitrofurantoin (38%), fosfomycin (89%), aminoglycosides (82%), piperacillin-tazobactam (72%), and carbapenems (83%). …”
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Assessment of Preserved Ratio Impaired Spirometry (PRISm) Based on Different Definitions in the Early COPD Cohort by Dai C, Tang G, Yang H, Wu F, Deng Z, Zheng Y, Zhao N, Lu L, Wan Q, Wang Z, Peng J, Wu X, Zhou K, Cai G, Xiao S, Wen X, Yang C, Chen S, Yu S, Sun R, Zhou Y, Ran P

“…Furthermore, the prevalence of PRISm varied from 2.0% to 12.5% depending on the definitions and predicted equations, with the Chinese equation, LLN definition in Chinese equation and fixed definition in GLI equation yielding higher prevalence rates.Conclusion: Our findings highlight concerns about the comparability of studies and the interchangeability of various definitions and reference equations for PRISm.Keywords: PRISm, definitions, clinical features, prevalence, reference equations…”
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Tratamento de sequelas de queimadura de face com laser de CO2 fracionado em pacientes com fototipos III a VI Treatment of facial burn sequelae using fractional CO2 lasers in patien... by Alessandra Grassi Salles, Adelina Fátima do Nascimento Remigio, Valéria Berton Liguori Zacchi, Marcus Castro Ferreira

“…CONCLUSIONS: The treatment with CO2F laser with mild parameters was well tolerated and resulted in high satisfaction rates for patients with facial burn sequelae as well as improved skin texture, distensibility, and surface irregularities. …”
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Investigation of Population Changes and Determination of the Bean Pod Borer Helicoverpa armigera (Lepidoptera:Noctuidae) Peak in Bean Phaseolus vulgaris Linnaeus Fields by Pheromon... by Sedighe Ashtari

“…The investigation of the distribution and damage level of bean pod borer in important bean-growing areas of Markazi province over two years in five bean-growing regions (Arak, Khomain, Shazand, Milajerd, and Khondab) showed that Khomain and Khondab had the highest and lowest infestation rates, respectively. Red pods showed more sensitivity to this pest compared to green and white pods. …”
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Numerical Simulation Study on the Dynamic Processes and Evolution Laws of Multiple Granular Flows in a Gully by LEI Ming, ZHANG Liang, YE Chen, WANG Xiekang

“…Compared with the first granular flow, subsequent ones feature shorter durations and higher energy dissipation rates. The velocity and displacement of base granules increase significantly as the friction coefficient decreases and the secondary slope increases. …”
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