Conversational AI agent for precision oncology: AI-HOPE-WNT integrates clinical and genomic data to investigate WNT pathway dysregulation in colorectal cancer by Ei-Wen Yang, Brigette Waldrup, Enrique Velazquez-Villarreal, Enrique Velazquez-Villarreal

“…Exploratory queries further assessed treatment response, co-mutation patterns, and population-specific trends.ResultsIn recapitulation analyses, AI-HOPE-WNT reproduced key trends from prior work, including improved survival in WNT-altered EOCRC and higher RNF43 mutation rates in Hispanic/Latino (H/L) populations compared to non-Hispanic White (NHW) people. …”
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Estimating the burden of disease attributable to non-assisted suicide in Switzerland from 2009 to 2021: a secondary data analysis by Annora Mack, Sarah Rajkumar, Jacob Kofler, Kaspar Wyss

“…The stark sex disparity in suicide rates further underscores the need for sex-sensitive approaches. …”
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Heterogeneity of Candida bloodstream isolates in an academic medical center and affiliated hospitals by Nancy E. Scott, Elizabeth Wash, Christopher Zajac, Serin E. Erayil, Susan E. Kline, Anna Selmecki

“…Phenotypic data, including patterns of antifungal drug resistance, are limited. …”
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Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study by Lucia Libanez Bessa Campelo Braga, Helio De Almeida Nobre Junior, Jorg Heukelbach, Anderson Fuentes Ferreira, Ana Suzete Lopes, Edson Luiz de Oliveira, Vitor de Sousa Tomé, Taynara Lais Silva, Daniele Calheiros Campelo Maia, Alberto Novaes Ramos Júnior

“…The highest mortality rates were found in the southern parts of the state and around a northern major urban center. …”
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Genomic data suggest parallel dental vestigialization within the xenarthran radiation by Emerling, Christopher A, Gibb, Gillian C, Tilak, Marie-Ka, Hughes, Jonathan J, Kuch, Melanie, Duggan, Ana T, Poinar, Hendrik N, Nachman, Michael W, Delsuc, Frédéric

“…These genomic data provide evidence for multiple pathways and rates of anatomical regression, and underscore the utility of using pseudogenes to reconstruct evolutionary history when fossils are sparse. …”
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Development of prediction models for screening depression and anxiety using smartphone and wearable-based digital phenotyping: protocol for the Smartphone and Wearable Assessment f... by Sujin Kim, Ah Young Kim, Yu-Bin Shin, Seonmin Kim, Min-Sup Shin, Jinhwa Choi, Kyung Lyun Lee, Jisu Lee, Sangwon Byun, Heon-Jeong Lee, Chul-Hyun Cho

“…However, their detection and diagnosis rates remain low owing to the limitations of the current screening methods. …”
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Characteristics and Outcomes of People With COPD Who Experience Exacerbations While on Inhaled Triple Therapy: Results of the SIRIUS I Cohort Study in the US (2015–2019) by Nordon C, Carstens D, Fagerås M, Müllerová H, Veeranki PS, Alves JA, Germack HD, Barnes TL, McCormack MC

“…Baseline characteristics and treatment patterns, crude incidence rates (IRs) for exacerbations and mortality (per 100 person-years [PYs]; variable follow-up), and HCRU and costs (12-month follow-up) were summarized descriptively.Results: Of 4,920 patients in the TT cohort, mean (SD) age was 62.3 (9.7) years, 60.9% were female, and 68.0% were white; 46.5% of TT cohort patients with a history of smoking were current smokers. …”
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The impact of COVID-19 pandemic on mortality among adults receiving care for chronic health conditions in rural South Africa: findings from Agincourt health and socio-demographic s... by Daniel Ohene-Kwofie, Cyril Chironda, Jean Bashingwa, Tshegofatso Seabi, Audry Dube, Beth Tippett-Barr, Francesc Xavier Gómez-Olivé, Kathleen Kahn, Stephen Tollman, Chodziwadziwa W. Kabudula

“…Mortality rate among persons with HIV, and diabetes or hypertension increased by up to 26% and 70%, respectively during the COVID-19 pandemic period, particularly among women. …”
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The resurgence of Lassa fever in Nigeria: economic impact, challenges, and strategic public health interventions by Stanley Chinedu Eneh, Stanley Chinedu Eneh, Stanley Chinedu Eneh, Chidera Gabriel Obi, Chidera Gabriel Obi, Udokang Ephraim Ikpongifono, Udokang Ephraim Ikpongifono, Zakariya’u Dauda, Zakariya’u Dauda, Samson Adiaetok Udoewah, Samson Adiaetok Udoewah, Collins Chibueze Anokwuru, Collins Chibueze Anokwuru, Francisca Ogochukwu Onukansi, Francisca Ogochukwu Onukansi, Ogechi Vinaprisca Ikhuoria, Ogechi Vinaprisca Ikhuoria, Temitope Olumuyiwa Ojo, Chukwuocha Uchechukwu Madukaku, Ibuchukwu Nkeonyenasoya Orabueze, Ibuchukwu Nkeonyenasoya Orabueze, Amara Frances Chizoba

“…Recent data from the Nigeria Centre for Disease Control and Prevention (NCDC) indicates 1,171 suspected cases, 290 confirmed cases, and 53 deaths between January 6 to 26, 2025, with a case fatality rate of 18.3%. Lassa fever transmission is highly seasonal, peaking during the dry months when food scarcity drives rodent-human interactions. …”
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Development of approaches to the evaluation of pharmacotherapy effectiveness for chronic hepatitis C by I. A. Narkevich, E. A. Tsitlionok

“…Objective: to analyse the consumption pattern of antiviral therapy (AVT) for chronic hepatitis C on the example of an infectious hospital.Material and methods. …”
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Influence of SCD and FABP3 genetic markers on carcass traits and meat quality in Aberdeen Angus bulls by Sena Ardicli, Nursen Senturk, Tugce Necla Selvi, Sena Yonga, Rumeysa Celik, Beyza Karalar, Aleyna Ozdeniz, Madina Aliyeva, Havvanur Aydin, Ozgur Toprak Ay, Ozge Ardicli, Muhammed Emin Sari, Berkay Bozkurt, Oliva Giannelli Viscardi, Huseyn Babayev, Hakan Ustuner

“…The results suggest a notable impact of the FABP3 rs210042291 gene on growth rates. These findings highlight the complexity of genetic influences on meat quality traits.…”
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Supershear source model of the 2025 M7.8 Myanmar earthquake and paleoseismology of the Sagaing Fault: regions of significant overlap with past earthquakes by Diego Melgar, Ray Weldon, Yu Wang, Mary Grace Bato, Lin Thu Aung, Xuhua Shi, Weerachat Wiwegwing, Saw Ngwe Khaing, Soe Min, Myo Thant, Cole Speed, Robert Zinke, Eric Fielding, Aron Meltzner, Timothy Dawson

“…Given the exceptional exposure to earthquakes and high strain rates, our findings underscore the need for urgent attention to earthquake preparedness and infrastructure resilience in central Myanmar. …”
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Valley-filling Potential Evaluation of Urban Public Charging Stations Based on Price Incentive by Dawei SU, Yihui FAN, Tianhui ZHAO, Hongjin PAN, Youhui HUANG, Gang WANG, Yongyong JIA

“…Then, the typical load characteristic indicators including valley-period and flat-period load rates are proposed, and the charging load valley-filling potential evaluation parameters are introduced to carry out valley-filling potential evaluation of urban public charging stations. …”
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Gut Microbiota Contribute to Heterosis for Growth Trait and Muscle Nutrient Composition in Hybrid Largemouth Bass (<i>Micropterus salmoides</i>) by Jixiang Hua, Qingchun Wang, Yifan Tao, Hui Sun, Siqi Lu, Yan Zhuge, Wenhua Chen, Kai Liu, Jie He, Jun Qiang

“…Growth, digestive enzyme activity, and muscle nutrient composition were compared between the hybrid groups (NC and CN) and the purebred groups (NN and CC), and the gut microbiota was investigated. The heterosis rates of body length, body height, and body thickness in hybrid largemouth bass were statistically significant. …”
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Deeply revealing the coupled formation mechanism of inclusions and precipitates in 654NMo ingot by Hongchun Zhu, Xinbo Yan, Huabing Li, Zhiyu He, Zhuowen Ni, Hao Feng, Shucai Zhang, Zhouhua Jiang, Pengchong Lu

“…The inclusion number density is significantly higher at the ingot edge compared to the center, while the bottom zone exhibits a greater density than the top and middle. This distribution pattern is attributed to the higher solidification rates at the edge and bottom. …”
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Multiyear Baleen Endocrine Profiles Suggest a Longer Estimated Gestation in Southern Right Whales (Eubalaena australis) by Loraine Shuttleworth, Andre Ganswindt, Kathleen E. Hunt, Alejandro Fernández Ajó, Estefan Pieterse, S. Mduduzi Seakamela, Chantel Schoeman, Els Vermeulen

“…ABSTRACT Gestation length is a key reproductive parameter influencing fecundity, population growth rates, and the recovery potential of baleen whales. …”
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Using optimization tools to explore stratospheric aerosol injection strategies by E. Brody, Y. Zhang, D. G. MacMartin, D. Visioni, B. Kravitz, B. Kravitz, E. M. Bednarz, E. M. Bednarz, E. M. Bednarz

“…However, the outcomes will depend on how it is deployed: not just how much but also the latitudes of injection and the distribution of injection rates across those latitudes. Different such strategies have been proposed, for example, managing up to three climate metrics simultaneously by injecting at multiple latitudes. …”
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A Detailed Analysis of the Milky Way Warp Based on Classical Cepheids by Xiaoyue Zhou, Xiaodian Chen, Licai Deng, Shu Wang, Jiyu Wang, Jianxing Zhang

“…We analyze the impact of the adopted solar vertical velocity on the inferred warp precession rate and confirm the reliability of the measured precession rate. …”
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SERPINA3 predicts long-term neurological outcomes and mortality in patients with intracerebral hemorrhage by Pei Zheng, Zhihui Qi, Bin Gao, Yang Yao, Jingshan Chen, Hengri Cong, Yue Huang, Fu-Dong Shi

“…Abstract Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability rates, and long-term outcomes among survivors remain unpredictable due to the lack of reliable biomarkers. …”
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Review of Epidemiological Situation on Rickettsioses in the Russian Federation in 2022 as Compared with 2013–2021, Forecast for 2023 by N. A. Pen’evskaya, N. V. Rudakov, S. N. Shpynov, A. I. Blokh, D. V. Trankvilevsky, D. A. Savel’ev, S. V. Shtrek, A. V. Sannikov

“…The aim of the review was to characterize the epidemiological situation on tick-borne rickettsioses (TR) in the Russian Federation in 2022 in comparison with the pandemic years of 2020–2021 and the pre-pandemic period of 2013–2019, to give the forecast for 2023. During 2013–2022, a pattern was observed in the incidence of rickettsiosis of the tick-borne spotted fever group (with the exception of Astrakhan spotted fever – ASF), that is also characteristic of most other natural focal infections (NFIs): a sharp decrease in registered incidence rates in 2020–2021 with the subsequent increase in 2022 almost up to pre-pandemic levels or even exceedance in some regions. …”
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