Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…Quality findings from the early-stage, interim-stage, and conclusion-stage QC rounds of clinical trials were rated by using 3 severity grades (minor, major, or critical) and classified into 5 categories (with 4 taxonomy levels under each category). …”
Get full text

Criminal legal penalties, substance use, and overdose: a concept mapping study examining Colorado’s criminal legal penalties by Katherine LeMasters, Samantha K. Nall, Cole Jurecka, Betsy Craft, Paul J. Christine, Ryan Goodman, Jessie Henderson, Robert Haywood-James, Angela Williams, Grace Wittner, Joshua A. Barocas

“…Participants — recruited from community-based organizations — identified, rated, sorted, and categorized factors affecting criminal legal involvement, substance use, and/or overdose in their community. …”
Get full text

Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia by Novick D, Montgomery W, Haro JM, Moneta MV, Zhu G, Yue L, Hong J, Duenas H, Brugnoli R

“…Depression severity was assessed using the 16-item Quick Inventory of Depressive Symptomatology-Self Report. PPS were rated using the modified Somatic Symptom Inventory. …”
Get full text

Effect of maize-soybean intercropping on quality of vegetable soybean by FANG Ping, LIU Weiguo, LIU Xiaode, LIU Ting, CHI Xiaoyu, XU Yan, PANG Ting, PENG Xiao, CAI Ling, YANG Wenyu

“…Because the appearance quality of vegetable soybean is affected by cropping pattern and the nutrition are affected by pattern and variety, we should screen out well adaptability and good quality varieties. …”
Get full text

Estimating Future Surface Water Availability Through an Integrated Climate‐Hydrology‐Management Modeling Framework at a Basin Scale Under CMIP6 Scenarios by Manqing Shao, Nelun Fernando, John Zhu, Gang Zhao, Shih‐Chieh Kao, Bingjie Zhao, Elizabeth Roberts, Huilin Gao

“…Finally, the DHSVM simulated naturalized streamflow and reservoir evaporation rate are input to WAM to simulate reservoir FY. A new term—“Ratio of Firm Yield” (RFY)—is created to compare how much FY changes under different climate scenarios. …”
Get full text

Annual variation of temperature and mass balance of first-year and second-year land-fast sea ice in Prydz Bay, East Antarctica by Dinglong Zhao, Bin Cheng, Matti Leppäranta, Jingkai Ma, Xuejing Chen, Jiechen Zhao

“…The evolution of the temperature and mass balance of first-year (FYI: Site S1) and second-year (SYI: Site S2) land-fast sea ice (LFSI) in May–November were investigated using high-resolution thermistor-string-based ice mass balance buoys, borehole measurements and a numerical sea ice model. In May, the growth rate of a 0.55 m FYI ice floe (9.2 mm day−1) was twice that of 1.08 m SYI (4.7 mm day−1) in snow-free conditions. …”
Get full text

Transarterial chemoembolization for advanced hepatocellular carcinoma after failure of first-line systemic treatment: a single-center case series by Qingyu Xu, Bin Leng, Ran You, Lingfeng Diao, Chendong Wang, Zeyu Yu, Guowen Yin

“…The most common progression pattern was the development of new intrahepatic lesions. …”
Get full text

Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response by Cong Tang, Patrícia Corredeira, Sandra Casimiro, Qi Shi, Qiwei Han, Wesley Sukdao, Ana Cavaco, Cecília Melo-Alvim, Carolina Ochôa Matos, Catarina Abreu, Steven Walsh, Gonçalo Nogueira-Costa, Leonor Ribeiro, Rita Sousa, Ana Lorena Barradas, João Eurico Fonseca, Luís Costa, Emma V. Yates, Gonçalo J. L. Bernardes

“…By measuring the total concentrations of cysteine, free cysteine, lysine, tryptophan, and tyrosine protein-incorporated biomarkers and analyzing the results with supervised machine learning, we identify 78% of cancers with 0% false positive rate (N = 97) with an AUROC of 0.95. The cancer, healthy, and autoimmune/infectious biomarker pattern are statistically significantly different (p < 0.0001). …”
Get full text

The Stabilization Mechanism of a Stable Landslide Dam on the Eastern Margin of the Tibetan Plateau, China: Insights from Field Investigation and Numerical Simulation by Liang Song, Yanjun Shang, Yunsheng Wang, Tong Li, Zhuolin Xiao, Yuchao Zhao, Tao Tang, Shicheng Liu

“…Additionally, the step-pool system formed in the spillway of the Conaxue Co landslide dam contributes to the protection of the dam structure by dissipating 68% of the river’s energy (energy dissipation rate η = 0.68). Understanding the formation mechanisms of the Conaxue Co landslide dam can provide critical insights into managing future landslide dams that may form in the QTP, both in emergency response and long-term strategies.…”
Get full text

An interpretable XAI deep EEG model for schizophrenia diagnosis using feature selection and attention mechanisms by Ahmad Almadhor, Stephen Ojo, Thomas I. Nathaniel, Shtwai Alsubai, Abdullah Alharthi, Abdullah Al Hejaili, Gabriel Avelino Sampedro

“…The study proposes a novel automated technique for diagnosing Schizophrenia based on electroencephalogram (EEG) sensor data, aiming to enhance interpretability and prediction performance.MethodsThis research utilizes Deep Learning (DL) models, including the Deep Neural Network (DNN), Bi-Directional Long Short-Term Memory-Gated Recurrent Unit (BiLSTM- GRU), and BiLSTM with Attention, for the detection of Schizophrenia based on EEG data. …”
Get full text

Kinetics of silicon extraction into alloy from a mixture of amorphous rocks by V.M. Shevko, N.M. Mirkayev, A.D. Badikova

“…It was established that when the melting the amorphous rocks, with an increase in the degree of silicon extraction into the alloy, the apparent activation energy decreases, that is a manifestation of diffusion processes, obviously associated with the formation of a silicon carbide layer on the coke surface. The rate of silicon extraction into the alloy when the melting the amorphous rocks is higher than when the melting quartzite. …”
Get full text

Early Dynamics of Circulating Tumor DNA Following Curative Hypofractionated Radiotherapy Related to Disease Control in Lung Cancer by Kyungmi Yang, Jae Myoung Noh, Yeon Jeong Kim, Hongryull Pyo

“…The Dmax showed better disease control rate with marginal significance (<i>p</i> = 0.081). …”
Get full text

Breaking barriers: targeted delivery of resveratrol in lung cancer using folate-integrated and pH-responsive hybrid nanocarriers by Sanjoy Das, Malay K. Das, Taison Jamatia, Nayan Ranjan Ghose Bishwas, Dhritiman Roy, Emdormi Rymbai

“…Finally, in vivo targeting and anticancer studies demonstrated that FOL-RSV-LPHNCs selectively internalized to the cancerous region and suppressed the tumor volume with an 8.66-fold higher rate in the xenograft mouse model. The folate receptor-mediated uptake mainly facilitates this superior therapeutic response which was further confirmed by in silico molecular docking and dynamic simulation. …”
Get full text

Physiological insights into the responses of tea plants to aluminum through an integrated transcriptomic and metabolomic analysis by Xinwan Zhang, Shijie Luo, Xiali Ye, Lin Liu, Xinxin Jia, Deyuan Jiang, Weiwei Wen

“…Compared to 0 mM Al treatment, low Al concentrations (0.4 mM) enhanced root vitality by 8.91%, while higher Al concentrations (10 and 100 mM) reduced root vigor by 19.31% and 76.81%, respectively. In a similar pattern, the electron transfer rate in leaves remained stable under low Al levels but significantly decreased under high Al conditions. …”
Get full text

Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa by Josephine Wambani, Patrick Okoth

“…However, in certain areas, the rate of decline has slowed or even reversed the gains made so far. …”
Get full text

Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis by Xu Yingkai, Jiang Jianfeng, Hu Zhiyong, Zhou Zhifeng, Wang Lei

“…Abstract Background Osteosarcoma (OS) is the most common primary malignant bone tumor characterized by a high rate of metastasis. The clinical efficacy of current targeted drugs for OS is limited, highlighting the urgent need to identify novel therapeutic targets. …”
Get full text

Dr Papineau Meets Dr Masquelet—Management of Open Calcaneal Fractures, Combining Two Techniques: A Case Report by Shuvendu P Roy, Yogendra Gupta, Gurinder Bedi, Vishwadeep Sharma

“…Aim and background: Open fractures of the calcaneum are often the source of significant morbidity due to the high rate of wound infection and significant morbidity, ranging from malunion to amputation. …”
Get full text

Fluid–solid coupling productivity analysis of multi-stage fractured horizontal wells in shale reservoirs by Qian QI, Ming YUE, Weiyao ZHU, Wenjiang MA

“…The simulation results of the model align with actual field data, showing that gas production follows an “L-shaped” decline pattern with a coincidence rate exceeding 70%, verifying the model’s accuracy.…”
Get full text

Safety and efficacy of prone position ventilation in patients with severe pneumonia in neurosurgical intensive care units by CHENG Longyang，LI Jun，LI Shaoya，LI Chuanqing，XU Manman，WANG Rong，ZHAO Penglai

“…Changes in blood gas analysis［pH，arterial partial pressure of oxygen（PaO2），arterial partial pressure of carbon dioxide（PaCO2），oxygenation index］and hemodynamics［heart rate（HR），mean arterial pressure（MAP）］were compared before prone positioning，and at 1 day，3 days，5 days，and 7 days after resuming supine position following prone position treatment. …”
Get full text

Clinical characteristics and outcomes of non-tuberculous mycobacterial pulmonary infections after hematopoietic stem cell transplantation: A retrospective cohort study by Zahia Esber, Hamza Salam, Shefali Godara, Ayman Soubani

“…Conclusion: Outcomes vary significantly among non-tuberculous mycobacterial pulmonary infections based on mycobacterial species, rate of colonization and degree of immunosuppression. …”
Get full text