Impact of Caspase3/GSDME-Mediated Pyroptosis on Tumor Immune Microenvironment and Clinical Prognosis Across Multiple Cancers by Huang Y, Liu J, Lin C, Zhu Q, Wu L

“…Its uncontrolled growth pattern and metastasis characteristics are the fundamental reasons for the high mortality rate of cancer and its current incurability. …”
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IMPAIRED REGULATORY MECHANISMS OF THE mTOR SIGNALING PATHWAY IN OSTEOARTHROSIS by Elena Vasilyevna Chetina, E A Bratygina, E M Zaitseva, E P Sharapova, A L Alekseyeva, N V Demin, S A Makarov

“…Objective: to study the pattern of impaired regulatory mechanisms of the mammalian target of rapamycin (TOR) signaling pathway, by monitoring gene expression in the blood of patients with osteoarthrosis (OA) at different stages of the disease. …”
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Etiology, antibiotic susceptibility and prognostic factors of pediatric community-acquired sepsis in Addis Ababa, Ethiopia by Abel Abera Negash, Daniel Asrat, Workeabeba Abebe, Tewodros Hailemariam, Andualem Wubete, Abraham Aseffa, Mario Vaneechoutte

“…We sought to determine the etiology, role of Streptococcus pneumoniae, antibiotic susceptibility pattern, and prognostic factors in children with CAS in Addis Ababa, Ethiopia. …”
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Nonlinear association between AST/ALT ratio and 28-day all-cause mortality following ICU admission in critically ill cirrhotic patients: a retrospective cohort study by Zhigang Xu, Baohong Xu

“…Results The study involved 2,090 critically ill liver cirrhosis patients, averaging 59.1 years old, with 65% male and a 28-day post-ICU admission mortality rate of 29%. The AST/ALT ratio was linked to mortality risk (adjusted odds ratio (OR) 1.1, 95% confidence interval (CI) 1.0–1.2; p = 0.015), showing a nonlinear pattern with a critical point at 3.6. …”
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Advances in application of ultrasound in diagnosis of diabetic nephropathy by GUO Juan, YANG Zhifang, JI Ri

“…As the global incidence rate of diabetes continues to rise, the clinical diagnosis and treatment of DN have become increasingly critical. …”
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Hyper-induction of IL-6 after TLR1/2 stimulation in calves with bovine respiratory disease. by Cian Reid, John Donlon, Aude Remot, Emer Kennedy, Giovanna De Matteis, Cliona O'Farrelly, Conor McAloon, Kieran G Meade

“…ROC analysis identified this induced IL-6 response to TLR1/2 stimulation as a potential diagnostic for BRD with a 74% true positive and 5% false positive detection rate for an IL-6 concentration >1780pg/mL. Overall, these results show altered immune responses specifically upon TLR1/2 activation is associated with BRD pathology which may contribute to disease progression. …”
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Biogeochemical responses to water management: Insights from the regulated Geum River, Korea by Min-Young Lee, Tae-Hoon Kim, Yongwon Kim, Hyebin Kim, Tae-Woo Kang, Sung-Eun Park

“…We compared conditions during August 2021 (gate-closing) and August 2022 (gate-opening), periods with starkly different residence times (3.5 vs. 0.5 days) that resulted in distinct biogeochemical dynamics. …”
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Clinicopathological Evaluation of Rhabdomyosarcoma with Emphasis on Myogenin Expression and FOXO1 Gene Fusion in Various Morphological Subtypes: A Cohort Study by Sindhu Ramamurthy, Ahwini Nargund, Geeta V Patil Okaly, Usha Amirtham, Arun Kumar, Ahok Kumar

“…Among the four histomorphological subtypes of RMS, distinguishing the dense pattern of Embryonal RMS (ERMS) from the solid pattern of Alveolar RMS (ARMS) solely based on morphology is challenging and necessitates ancillary techniques. …”
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Metal–organic nanostructures based on sono/chemo-nanodynamic synergy of TixOy/Ru reaction units: for ultrasound-induced dynamic cancer therapy by Tao Jiang, Zixiang Tang, Shumiao Tian, Haitian Tang, Zhekun Jia, Fangjian Li, Chenyue Qiu, Lin Deng, Lang Ke, Pan He, Gang Liu, Chengchao Chu, Yongfu Xiong

“…Remarkably, ultrasound irradiation induced substantial oxidative stress and immunogenic cell death, promoting the release of damage-associated molecular patterns (DAMPs), which elevated the maturation rate of tumor-infiltrating dendritic cells (DCs) and significantly increased the proportion of CD8⁺ T cells. …”
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The role of hypoxia-senescence co-related molecular subtypes and prognostic characteristics in hepatocellular carcinoma by Fuqing Chen, Yifan Cai, Xiangmei Chen, Changzhou Chen, Qinliang Fang, Jianming Liu, Yibin Zhang, Jianyin Zhou

“…Abstract Hepatocellular carcinoma (HCC) is known for its high invasiveness, high fatality rate. Both hypoxia and senescence play crucial roles in the initiation and progression of cancer, yet their prognostic implications in HCC are yet to be fully understood. …”
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An epigenome-wide association study in the case-control study to explore early development identifies differential DNA methylation near ZFP57 as associated with autistic traits by Ellen M. Howerton, Valerie Morrill, Rose Schrott, Jason Daniels, Ashley Y. Song, Kelly Benke, Heather Volk, Homayoon Farzadegan, Aimee Anido Alexander, Amanda L. Tapia, Gabriel S. Dichter, Lisa A. Croen, Lisa Wiggins, Genevieve Wojcik, M. Daniele Fallin, Christine Ladd-Acosta

“…Results We identified a region about 3.5 kb upstream of ZFP57 on chromosome 6 as differentially methylated (family-wise error rate [fwer] < 0.1) by continuous SRS T-score in the full sample (N = 857; fwer = 0.074) and among ASD cases only (N = 390; fwer = 0.021). …”
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Intra-familial transmission of Hepatitis B virus in a peri-urban community from the Democratic Republic of the Congo by Florence Cindibu Kalonji, Yu Nakagama, Evariste Tshibangu-Kabamba, Nadine Kayiba Kalenda, Shun Nakagama, Sachie Nakagama, Pathy Kamanga Nkolongo, Nestor Kalala-Tshituka, Alphonse Lufuluabu Mpemba, Faustin Ndjibu Mpoji, André Kabongu Kalala, Benjamin Muamba Mpoyi, Dieudonné Mumba Ngoyi, Natsuko Kaku, Yusuke Shimakawa, Ghislain Tumba Disashi, Yasutoshi Kido

“…The overall HBsAg prevalence was 3.8% [95% CI 2.6–5.7], with the highest rate (10.1% [95% CI 4.9–18.2]) found in children aged 5 years and younger. …”
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A mobile app to improve adherence to colorectal cancer screening and post polypectomy surveillance guidelines by María A. Casas, Francisco Schlottmann, Leandro Steinberg, Xavier Bessa, Anna Serradesanferm, Angels Pozo, Sonia Torres, Antoni Castells, Francesc Balaguer, Jaume Grau, Lisandro Pereyra, María Pellisé

“…The app was increasingly and repeatedly used by professionals during the study period (72% retention rate). Among screening consultations, 2,082 (68.2%) patients were classified as average risk, suggesting the use of fecal occult blood test (FOBT) instead of colonoscopy. …”
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The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis by Shaoyu Zheng, Zexuan Zhou, Guangzhou Du, Qingzi Chen, Shaoqi Chen, Jianqun Lin, Shijian Hu, Weijin Zhang, Kedi Zheng, Jinghua Zhuang, Meigan Huang, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Marco Matucci-Cerinic, Daniel E. Furst, Yukai Wang

“…Sonographic ILD was detected in 76 patients who underwent LUS examination. The concordance rate between two modalities was 83.33% (Kappa value = 0.64, 95% CI 0.50–0.78). …”
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Analysis of HBV infection characteristics and OBI prevalence in pregnant women: a focus on HBcAb + alone or in combination with HBeAb + subgroups in Northwest China by Yun Xie, Ru Kang, Xiaoyue Cheng, Dan Li, Qi Wang, Jiao Li, Xuan Guo, Wenhui Gao, Xin He, Liutong Jiang, Gaili Meng

“…Despite a decline in HBsAg positivity, HBV remains moderately prevalent, the persistently high HBV susceptibility rate (31.07%) underscores an urgent need for targeted vaccination efforts among women of childbearing age in Northwest China.…”
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Strata pressure behavior law and regional-level intelligent early warning for high-intensity mining in extended working faces of medium-thick coal seams in Yuheng mining area by Feng CUI, Cheng ZONG, Xingping LAI, Tao XIE, Yunhu BAI, Yi ZHANG, Chong JIA, Hao WANG, Zhong LUO, Hao LIU

“…High-intensity mining and extended working faces have significantly modified strata pressure manifestation patterns and triggered spatiotemporal evolution of mining-induced pressure. …”
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Prevalence, microbiology, and antimicrobial susceptibility profile of bacterial skin and soft tissue infections in pediatric patients with malignancies at a referral teaching hospi... by Seyed Reza Abdipour Mehrian, Fatemeh Noushadi, Yaser Pourasghar, Armina Farkarian, Elahe Meftah, Fatemeh Homayounifar, Ali Amanati

“…However, it is important to acknowledge that this study was conducted at a single center and the high rate of culture-negative results suggests that non-bacterial etiologies or prior antibiotic use may play a significant role. …”
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Amivantamab versus standard therapies among patients with advanced non-small cell lung cancer and epidermal growth factor receptor exon 20 insertion mutations after platinum-based... by Lan Shen, Guangyuan Hu, Yan Wang, Jing Zhao, Xin Li, Jianmin Zhuo, Grace Kah Mun Low, Shun Lu

“…Effectiveness comparison, including real-world progression-free survival (rwPFS), real-world time to next therapy (rwTTNT) and real-world objective response rate (rwORR) was conducted between CHRYSALIS patients and the EC. …”
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The effect of photodynamic therapy on the wound process dynamics in patients with purulent hand diseases by J. L. Chepurnaya, G. G. Melkonyan, N. T. Gul’muradova, A. A. Sorokin

“…Photodynamic therapy was performed on the second postsurgical day by a laser apparatus “Atkus-2” (wave length 661 nm) with a gel form of the chlorinseries photosensitizer photoditazin in the form of an application at the rate of 1 g ml per 3–5 cm2 of the wound surface. …”
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Probabilistic seasonal dengue forecasting in Vietnam: A modelling study using superensembles. by Felipe J Colón-González, Leonardo Soares Bastos, Barbara Hofmann, Alison Hopkin, Quillon Harpham, Tom Crocker, Rosanna Amato, Iacopo Ferrario, Francesca Moschini, Samuel James, Sajni Malde, Eleanor Ainscoe, Vu Sinh Nam, Dang Quang Tan, Nguyen Duc Khoa, Mark Harrison, Gina Tsarouchi, Darren Lumbroso, Oliver J Brady, Rachel Lowe

“…As a climate-sensitive disease, environmental conditions and past patterns of dengue can be used to make predictions about future outbreak risk. …”
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