Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes by Tobias Brünger, Alina Ivaniuk, Eduardo Pérez-Palma, Ludovica Montanucci, Stacey Cohen, Lacey Smith, Shridhar Parthasarathy, Ingo Helbig, Michael Nothnagel, Patrick May, Dennis Lal

“…For the gene family of voltage-gated sodium channels, where variants and expert-curated clinical phenotypes are available, we also assess whether phenotype patterns of multiple disorders for each gene are conserved across variant positions within the gene family. …”
Get full text

Taking a look at your speech: identifying diagnostic status and negative symptoms of psychosis using convolutional neural networks by Gleb Melshin, Anthony DiMaggio, Nadia Zeramdini, Michael MacKinley, Lena Palaniyappan, Alban Voppel

“…Modified ResNet-18 convolutional neural networks (CNNs) performed three classification tasks; (1) schizophrenia-spectrum vs healthy controls, within 179 clinically-rated patients, (2) individuals with more severe vs less severe negative symptom burden, and (3) clinically obvious vs subtle blunted affect. …”
Get full text

Influence of exercise interventions on functional movement screen scores in athletes: a systematic review and meta-analysis by Ali Asghar Maleki, Seyed Hamed Mousavi, Mohamad Ali Biabangard, Hooman Minoonejad

“…Abstract The functional movement screen (FMS) is a widely recognized tool for evaluating movement patterns and identifying potential injury risks in athletes. …”
Get full text

Laboratory Analysis of Soil Physicochemical Properties Based on Agricultural Fertilizer Input Requirement Application: A Case of Haramaya University, Ethiopia by Turyasingura, Benson, Chavula, Petros, Mohammed, Yasin, Eliyas, Abdi Alic, Girmac , Tesfasilassie, Sadeso, Kumale, Shentema, Solomon, Abebed, Aschalew, Katel, Shambhu, Timsina, Sandipa

“…Exchangeable calcium ranged 4.99 cmol (+)/kg to 18.34 cmol (+)/kg with a mean of 12.02 cmol (+)/kg which is rated as high. The potassium value of (0.05, 0.82 meq/100gm), 0.06 meq/100gm and (0.13, 0.46 meq/100gm) of soil respectively. …”
Get full text

Clinical features of patients with dysthymia in a large cohort of Han Chinese women with recurrent major depression. by Wenqing Wu, Zhoubing Wang, Yan Wei, Guanghua Zhang, Shenxun Shi, Jingfang Gao, Youhui Li, Ming Tao, Kerang Zhang, Xumei Wang, Chengge Gao, Lijun Yang, Kan Li, Jianguo Shi, Gang Wang, Lanfen Liu, Jinbei Zhang, Bo Du, Guoqing Jiang, Jianhua Shen, Ying Liu, Wei Liang, Jing Sun, Jian Hu, Tiebang Liu, Xueyi Wang, Guodong Miao, Huaqing Meng, Yi Li, Chunmei Hu, Yi Li, Guoping Huang, Gongying Li, Baowei Ha, Hong Deng, Qiyi Mei, Hui Zhong, Shugui Gao, Hong Sang, Yutang Zhang, Xiang Fang, Fengyu Yu, Donglin Yang, Tieqiao Liu, Yunchun Chen, Xiaohong Hong, Wenyuan Wu, Guibing Chen, Min Cai, Yan Song, Jiyang Pan, Jicheng Dong, Runde Pan, Wei Zhang, Zhenming Shen, Zhengrong Liu, Danhua Gu, Xiaoping Wang, Xiaojuan Liu, Qiwen Zhang, Yihan Li, Yiping Chen, Kenneth S Kendler, Jonathan Flint, Zhen Zhang

“…<h4>Conclusions</h4>There are increased rates of stressful life events in MDD with dysthymia, but the impact of life events on susceptibility to dysthymia with MDD differs from that seen for MDD alone. …”
Get full text

Toxicokinetics, tissue distribution, and toxic potency of PFOS alternative OBS in adult zebrafish (Danio rerio) based on flow-through exposure system by Yilong Zou, Yu Zhou, Xianglian Wang, Guiqing Gao, Gang Chen, Zhanmeng Liu, Mi Deng, Xueping Huang, Yongming Wu

“…Our findings indicate that OBS accumulated rapidly in zebrafish, with log kinetic bioconcentration factor (logBCFk) values ranging from 2.48 to 2.70 and slow elimination rates (ke = 0.0490–0.0643 d−1). The blood, liver, and muscle were responsible for over 50 % of the total body burden of OBS, with tissue concentrations decreasing in the following order: blood > liver > intestine > gills > gonad > brain > muscle, suggesting a tissue-specific accumulation pattern. …”
Get full text

An interpretable XAI deep EEG model for schizophrenia diagnosis using feature selection and attention mechanisms by Ahmad Almadhor, Stephen Ojo, Thomas I. Nathaniel, Shtwai Alsubai, Abdullah Alharthi, Abdullah Al Hejaili, Gabriel Avelino Sampedro

“…The study proposes a novel automated technique for diagnosing Schizophrenia based on electroencephalogram (EEG) sensor data, aiming to enhance interpretability and prediction performance.MethodsThis research utilizes Deep Learning (DL) models, including the Deep Neural Network (DNN), Bi-Directional Long Short-Term Memory-Gated Recurrent Unit (BiLSTM- GRU), and BiLSTM with Attention, for the detection of Schizophrenia based on EEG data. …”
Get full text

Outpatient Testing for HIV in Italy, 2018–2023—Preliminary Data by Claudio Galli, Vincenza Regine, Anna Caraglia, Francesca Centrone, Maria Chironna, Gianluca Cruschelli, Massimo Farinella, Valentina Annachiara Orlando, Chiara Pasqualini, Monia Puglia, Lucia Pugliese, Laura Rancilio, Lara Tavoschi, Fabio Voller, Barbara Suligoi

“…We started a research project aimed at assessing testing rates for HIV infection among Italian outpatients in 2018–2023. …”
Get full text

Eruptive modes and hiatus of volcanism at West Mata seamount, NE Lau basin: 1996–2012 by Robert W. Embley, Susan G. Merle, Edward T. Baker, Kenna H. Rubin, John E. Lupton, Joseph A. Resing, Robert P. Dziak, Marvin D. Lilley, William W. Chadwick Jr., T. Shank, Ron Greene, Sharon L. Walker, Joseph Haxel, Eric Olson, Tamara Baumberger

“…Based on the historical eruption rates calculated using the bathymetric differencing technique, the volcano could be as young as several thousand years.…”
Get full text

Negative Regulation of <i>GmNAC35</i> by miR164 Enhances Drought Tolerance in Soybean by Wentao Hu, Man Zhang, Jie Lu, Miaomiao Zhang, Reqing He, Youlin Zhu, Dong Wang, Liyun Jiang

“…Conversely, <i>GmNAC35</i> showed an inverse pattern, indicating negative regulation by miR164. …”
Get full text

Multi-Objective Optimization of Off-Grid E-Bikes Charging Stations Powered by PhotoVoltaics by Fabio Corti, Gabriele Maria Lozito, Davide Astolfi, Salvatore Dello Iacono, Antony Vasile, Marco Pasetti, Alberto Reatti, Alessandra Flammini

“…A Genetic Algorithm is employed to determine the most appropriate rated power of the installed PhotoVoltaic (PV) systems and of the energy storage, by incorporating statistical methods to estimate the daily number of e-bikes requiring charging, hence making the optimization process more reflective of actual usage patterns. …”
Get full text

An integrated high-resolution bathymetric model for the Danube Delta system by L. Alaerts, L. Alaerts, J. Lambrechts, N. R. Randresihaja, N. R. Randresihaja, L. Vandenbulcke, O. Gourgue, E. Hanert, E. Hanert, M. Grégoire

“…These error rates are comparable to those observed in bathymetry interpolation in rivers with similar source datasets. …”
Get full text

Biomechanical evaluation of novel construct for stabilizing subcapital femoral neck fractures: a synthetic bone model by Anjan R. Shah, Miguel A. Diaz, Douglas L. Cerynik, Blake Schultz

“…Abstract Background High complication rates continue to be reported for femoral neck fractures, where moderate to severe shortening has been associated with pain and inferior functional outcomes. …”
Get full text

Preoperative Bowel Preparation in Minimally Invasive and Vaginal Gynecologic Surgery by Michail Diakosavvas, Nikolaos Thomakos, Alexandros Psarris, Zacharias Fasoulakis, Marianna Theodora, Dimitrios Haidopoulos, Alexandros Rodolakis

“…Taking into consideration the fact that in most gynecologic cases there is minimal probability of bowel intraluminal entry and, thus, low surgical site infection rates, most scientific societies have issued guidelines against the use of any bowel preparation regimen before laparoscopic or vaginal surgery. …”
Get full text

Copper and Temperature Interactions Induce Differential Physiological and Metal Exclusion Responses in the Model Brown Macroalga <i>Ectocarpus</i> by Alex Santillán-Sarmiento, Paula S. M. Celis-Plá, A. John Moody, Claudio A. Saez, Murray T. Brown

“…In this study, we exposed the model brown seaweed <i>Ectocarpus</i> to different Cu concentrations (0, 0.8, 1.6, and 3.2 μM) at two different temperatures (15 and 25 °C). Relative growth rates decreased at 25 °C for the two highest Cu concentrations after 8 days of exposure, but a contrasting pattern was observed in the photosynthetic maximum quantum yield (<i>F_v</i>/<i>F_m</i>) and photosynthetic efficiency (<i>α</i>), where reductions were observed at 15 °C for the same Cu concentrations. …”
Get full text

Systemic Immunomodulatory Therapy in Uveitis Related to Beh&amp;ccedil;et&amp;rsquo;s Disease: A 10-year Profile by Almeida M, Ferreira AM, Araújo JR, Figueira L

“…The median treatment duration was 63.5 months, significantly reducing relapse rates from 2 ± 2.0 to 1 ± 1.2 per year (p &lt; 0.001). …”
Get full text

Antimicrobial Resistance Profile and Biofilm Formation of <i>Listeria monocytogenes</i> Isolated from Meat by Joana Paiva, Vanessa Silva, Patrícia Poeta, Cristina Saraiva

“…Introduction: <i>Listeria monocytogenes</i> is the causative agent of listeriosis, a serious infectious disease with one of the highest case fatality rates among foodborne diseases affecting humans. …”
Get full text

Treatment for Paget’s disease: surgical approaches by E. Yu. Fetisova, A. D. Zikiryakhodzhaev, N. N. Volchenko

“…Breast cancer (BC) ranks first in the pattern of female malignancies (20.7 %) and remains the top cancer among women. …”
Get full text

Socioeconomic inequalities in non-communicable diseases prevalence in India: disparities between self-reported diagnoses and standardized measures. by Sukumar Vellakkal, Sukumar Vellakkal, S V Subramanian, Christopher Millett, Sanjay Basu, David Stuckler, Shah Ebrahim

“…<h4>Methods</h4>We calculated age-adjusted prevalence rates of common NCDs from the Study on Global Ageing and Adult Health, a nationally representative cross-sectional survey. …”
Get full text

Ten-year outcomes of IMRT with chemotherapy versus IMRT alone for stage II–IVa nasopharyngeal carcinoma: a retrospective study by Xiao-li Wang, Da-qing Sun, Hui Yang, Yang Li, Xiu-feng Li, Xiao-long Chang, Xiang-di Meng, Ya-nan Zhang, Yun-xiang Zhang, Fu-rong Hao, Jian-wen Li

“…The 10-year OS, PFS, LRFS, and DMFS rates were 66.6%, 75.3%, 91.9%, and 81.2%, respectively. …”
Get full text