Validation of multiplex PCR for the diagnosis of acute bacterial meningitis in culture negative cerebrospinal fluid by Sérgio Monteiro de Almeida, Libera Maria Dalla Costa, Christian Siebra, Lavinia Nery Villa Stangler Arend, Keite da Silva Nogueira

“…This group demonstrated high specificity, positive predictive value, and efficiency. Conclusions: Multiplex PCR for CSF can improve the speed and accuracy of acute bacterial meningitis diagnosis in a clinical setting as a complement to classical immunological and bacteriological assays in CSF. …”
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Scoring Systems to Predict Survival or Neurological Recovery after Out-of-hospital Cardiac Arrest by Rishi Naik, Indrajeet Mandal, Diana A Gorog

“…NULL-PLEASE and CAST are recommended as the best scores to predict mortality and neurological outcome, respectively, due to the extent of external validation, ease of use and high predictive value of the variables. Whether use of these scores can lead to more cost-effective service delivery remains unclear.…”
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Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks by Nightingale Health Biobank Collaborative Group

“…Lastly, we assessed the incremental predictive value of metabolomic scores over existing clinical risk scores for multiple diseases and found modest improvements in discrimination for several diseases whose clinical utility, while promising, remains to be determined.…”
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MASSIVE TUMOR BURDEN IN HODGKIN’S LYMPHOMA AS A PROGNOSTIC FACTOR IN YOUNG ADULTS by A. P. Karitsky

“…The aim of the study was the assessment of tumor burden’s components (a mediastinum/thoracic ratio – MTR, peripheral bulky disease, and number of involved lymph nodes) in young adults with Hodgkin’s lymphoma and the analysis of their predictive value. Data on 87 patients aged from 19 till 29 years (median 24 ± 4 years) are submitted. …”
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ВОЗМОЖНОСТИ РАННЕЙ ДИАГНОСТИКИ ОСТРОГО ИНФАРКТА МИОКАРДА С ПОМОЩЬЮ БЕЛКА, СВЯЗЫВАЮЩЕГО ЖИРНЫЕ КИСЛОТЫ. РОССИЙСКОЕ МНОГОЦЕНТРОВОЕ ИССЛЕДОВАНИЕ ИСПОЛИН... by А. И. Мартынов, М. И. Воевода, Г. П. Арутюнов, В. А. Кокорин, А. А. Спасский, А. А. Михайлов

“…On results of the multicentre study ISPOLIN, which included 1049 patients in 17 cities of the Russian Federation, the new domestic express-test for the qualitative determination of cardiac fatty acid binding protein, has more sensitivity, accuracy and predictive value compared with the test of the troponin I in the first 12 h of AMI and can be recommended for wide application in practice.…”
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Early Neonatal Mortality (< 24 h) in Ecuador: A Population-Based Study on the Impact of Apgar Score, Gestational Age, Birth Weight, Delivery Type, and Healthcare Level by Iván Dueñas-Espín, María Alejandra Montaluisa, Andrea Aguilar-Molina, Fernando Aguinaga, Luciana Armijos-Acurio, Ruth Jimbo-Sotomayor, Ángela León Cáceres, María F. Rivadeneira, Silvana Rivera-Guerra, Xavier Sánchez, Betzabé Tello

“…These findings underscore the importance of Apgar evaluation in neonates and suggest a predictive value of the score for early neonatal mortality.…”
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Relative importance of temporal and location features in predicting smoking events by Han Yang, Hang Yu, Michael Kotlyar, Sheena R. Dufresne, Serguei V. S. Pakhomov

“…This study examined the predictive value of temporal and spatial features available from smartphones. …”
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Proinflammatory Cytokines in Pneumonias of Various Genesis by A. M. Golubev, T. V. Smelaya, V. V. Moroz, M. A. Golubev, Ye. P., Veligan, L. A. Marsova, M. V. Sharshavykh, N. M. Lazareva

“…Measurement of proinflammatory cytokines in critically ill patients with pneumonia is of diagnostic and predictive value. Key words: pneumonia, cytokines.…”
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Aggregate index of systemic inflammation as a novel prognostic biomarker in Chinese patients with acute decompensated heart failure: a population-based real-world study by Lin Hu, Yangjie Deng, Chuanjin Liu, Yinghao Kuang, Xinfang Huang, Jinyan Zhang, Wanfen Huang, Yafei Jian, Guobo Xie, Yang Zou, Shuhua Zhang

“…Moreover, in predicting 30-day mortality among ADHF patients, the AISI demonstrated significantly superior predictive value compared to white blood cell count, neutrophil count, monocyte count, and lymphocyte count (Area under the curve=0.77; all DeLong tests P &lt;0.05), with an optimal threshold of 925.44.DiscussionThis population-based retrospective cohort study demonstrated the predictive value of AISI for short-term outcomes in Chinese ADHF patients. …”
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Association Between Neutrophil Percentage to-Albumin Ratio, Neutrophil to-Lymphocyte Ratio, Platelet-to Lymphocyte Ratio and in-Hospital Mortality in Elder Patients with Bloodstrea... by Yu Z, Liu C, Gong M, Zhang P, Pei C, Liu X, Han X, Zhu P, Xu G, Du Y

“…This study aimed to investigate the association and the predictive value of NPAR, NLR and PLR with in-hospital mortality.Methods: This study included older patients with BSI who were hospitalized in a large healthcare center in Beijing from December 2011 to January 2024. …”
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Assessment of Circulating Tumor Cells in Colorectal Cancer as an Adjunctive Non-invasive Diagnostic Method by Saskia Aziza Nursyirwan, Murdani Abdullah, Andri Sanityoso Sulaiman, Ikhwan Rinaldi, Dadang Makmun, Marcellus Simadibrata, Dimas Ramadhian Noor, Agustinus Wiraatmadja, Wifanto Saditya Jeo, Nur Rahadiani, Diah Rini Handjari, Hamzah Shatri

“…The diagnostic analysis of CTC for detecting CRC (compared to polyps) using a CTC cutoff point of >1.5 cells/mL suggested sensitivity, specificity, and positive predictive value (PPV) of 50%, 88.89%, and 93.94%. Additionally, the negative predictive value (NPV), as well as the positive and negative likelihood ratio (PLR and NLR) were 34.04%, 4.5, and 0.56, respectively. …”
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Utility of photoacoustic patterns in intra-operative margin assessment of breast cancer post neoadjuvant chemotherapy by Yonggeng Goh, Ghayathri Balasundaram, Hui Min Tan, Thomas Choudary Putti, Renzhe Bi, Mikael Hartman, Shaik Ahmad Buhari, Celene Wei Qi Ng, Su Ann Lui, Serene Si Ning Goh, Wei Qi Leong, Eric Fang, Swee Tian Quek, Malini Olivo

“…Results: US-PA imaging demonstrated a high diagnostic accuracy of 89.0 %, with a sensitivity and negative predictive value (NPV) of 100 %, specificity of 86.9 %, and positive predictive value (PPV) of 59.4 %. …”
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The role of ultrasound-guided tru-cut biopsy in ovarian cancer: a systematic review of its safety, adequacy, and accuracy with meta-analysis of diagnostic performance by Munachiso Iheme Ndukwe, Matteo Pavone, Dominik Habes, Nicolo Bizzarri, Martin Stepan, Petra Bretová, Floriana Mascilini, Dominik Karasek, Denisa Pohankova, Akaninyene Ubom, Jana Marie Havigerova, Jiri Haviger, Igor Sirak

“…Diagnostic accuracy was assessed in 13 studies, revealing a mean diagnostic accuracy of 95.54% (95% CI: 93.19– 97.89%) and a median of 97.48%.In the meta-analysis of 10 studies, pooled sensitivity was 98.6%, specificity 41.9%, positive predictive value (PPV) 99.0%, and negative predictive value (NPV) 47.2%, with high heterogeneity observed in specificity and NPV estimates. …”
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Glutathione peroxidase 4 as a potential biomarker for atrial fibrosis and recurrence of atrial fibrillation by Tong Liu, MD, Dong-tao Zhou, ME, Fang Liu, MD, De-yong Long, MD, Yang Yang, MD, Meng-meng Li, MD, Xin Zhao, MD, Chang-yi Li, MD, Wei Wang, MD, Chen-xi Jiang, MD, Ri-Bo Tang, MD

“…Objective: This study aimed to evaluate the predictive value of GPX4 for AF recurrence after ablation and the relationship between atrial fibrosis and ferroptosis. …”
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Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery by Katherine F. Melink, Natalja L. Stanski, Emily Gorrell, Jeffrey A. Alten, Kevin A. Pettit, Stuart L. Goldstein, Huaiyu Zang, Nicholas J. Ollberding, Rajit K. Basu, Shina Menon, Megan SooHoo, Katja M. Gist

“…Patients who were cRAI positive were younger, had higher surgical complexity, a higher mortality rate, and longer intensive care unit length of stay. cRAI predicted the composite outcome with an optimism‐corrected area under the receiver operating characteristic curve of 0.82, sensitivity of 0.81 (95% CI, 0.73–0.87), specificity of 0.75 (95% CI, 0.70–0.80), and negative predictive value of 0.91 (95% CI, 0.87–0.94). Incorporating urine neutrophil gelatinase–associated lipocalin improved predictive performance, with an area under the receiver operating characteristic curve of 0.84, sensitivity of 0.84 (95% CI, 0.77–0.90), specificity of 0.79 (95% CI, 0.74–0.83), and negative predictive value of 0.93 (95% CI, 0.90–0.96). …”
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Role of functional mapping on Gallium-68 perfusion positron emission tomography and computed tomographic imaging (PET/CT) to assess the risk of long-term radiation-induced lung tox... by François Lucia, David Bourhis, Frédérique Blanc-Béguin, Gaëlle Goasduff, Mohamed Hamya, Simon Hennebicq, Maëlle Mauguen, Romain Floch, Margaux Geier, Ulrike Schick, Maëlys Consigny, Olivier Pradier, Grégoire Le Gal, Pierre-Yves Salaun, Vincent Bourbonne, Pierre-Yves Le Roux

“…Discussion: The predictive value of PET perfusion-based functional parameters outperforms the standard CT-based dose-volume parameters for the risk of grade ≥2 long-term RILT.…”
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NINJ1 and MMP9: potential biomarkers for intracranial atherosclerosis plaque vulnerability by Xiao-lian Wei, Xiao-lian Wei, Xin Da, Yu-ge Zhang, Yu-ge Zhang, Zi-ang Li, Bing-jie Liu, Bing-jie Liu, Rui-fang Yan, Hua Zhong, Bin Yuan, Bin Yuan

“…Background and objectiveTo utilize high-resolution vessel wall imaging (HR-VWI) to identify the characteristic features of culprit plaques in intracranial atherosclerotic stenosis (ICAS) vessels and evaluate the predictive value of serum nerve injury-induced protein 1 (NINJ1) and matrix metalloproteinase 9 (MMP9) for the vulnerability of intracranial atherosclerotic plaques.MethodsThis study included symptomatic intracranial atherosclerotic stenosis (sICAS) patients who underwent high-resolution vessel wall imaging (HR-VWI) and healthy individuals. …”
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Body roundness index, visceral adiposity index, and metabolic score for visceral fat in predicting new-onset atrial fibrillation: a UK Biobank cohort study by Yi ZHENG, Lei LIU, Xinyu ZHENG, Tong LIU, Xiaoping LI

“…C-index analyses were conducted to evaluate the predictive value of BRI, VAI, and METS-VF for new-onset AF. …”
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Unveiling the predictive synergy of red cell distribution width and peak morning home systolic blood pressure: a dual biomarker approach for cognitive risk stratification in hypert... by Yimin Shu, Jie Chen, Yanjin Song, Wuhong Wang

“…AimThis study aims to evaluate the predictive value of combining red cell distribution width (RDW) and peak morning home systolic blood pressure (SBP) for post-stroke cognitive impairment (PSCI) in hypertensive patients with minor stroke.MethodsA prospective cohort study enrolled 430 patients, randomly stratified into training (n = 301) and validation (n = 129) cohorts. …”
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Evaluation of Lymphocyte-to-Monocyte Ratio and Mean Platelet Volume-to-Platelet Ratio in Rhegmatogenous Retinal Detachment by Xuan Xiao, Jiayi Song, Lin Ye, Wen Zuo, Hongxia Yang, Changzheng Chen, Hongmei Zheng, Ting Chen

“…Purpose. To assess the predictive value of inflammatory blood biomarkers in rhegmatogenous retinal detachment (RRD) patients and its correlation with proliferative retinopathy (PVR) grade. …”
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