An Exosomal mRNA Urine Test for Detection and Risk Stratification of Human Kidney Transplant Rejection by Rania El Fekih, Kurt Franzen, James Hurley, Brian C. Haynes, Tamara Merhej, Areej Alghamdi, Elliot Hallmark, Shuran Xing, Sonia Kumar, John Choi, Zhabiz Solhjou, Christa Deban, Anis Saad, Ahmad Halawi, Nour Younis, Katherine Cashman, Maribel Dagher, Siawosh K. Eskandari, Soltan Al Chaar, Helmut Rennke, Astrid Weins, Reza Abdi, Anil Chandraker, James F. Markmann, Kassem Safa, Leonardo V. Riella, Matt McFaul, Chris Ventura, Alexandre V. Vlassov, Richard Formica, Camila Macedo, Johan Skog, Jamil R. Azzi

“…Results: Four mRNAs (IL32, B2M, CXCL11, and PGK1) performed well in distinguishing biopsies with rejection or significant inflammation from those without inflammation, achieving 94% sensitivity, 62% positive predictive value, and 52% specificity. Patients who tested positive by the signature but negative by biopsy were nearly twice as likely to experience adverse outcomes in the 5-year follow-up period, including subsequent rejection, thereby showing the limitations of kidney biopsies and the prognostic potential of molecular signatures. …”
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Statistical analysis and machine learning of TMS-induced MEPs for predicting poststroke motor impairment and performance by Chun-Ren Phang, Shintaro Uehara, Sachiko Kodera, Akiko Yuasa, Shin Kitamura, Yohei Otaka, Akimasa Hirata

“…This study aimed to evaluate the predictive value of inter-trial correlation (ITC), a novel metric reflecting waveform consistency, along with MEP amplitude and resting motor threshold (rMT), in estimating post-stroke motor outcomes. …”
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Prognostic value of myocardial bridging versus non-obstructive CAD: a long-term follow-up study by Zengfa Huang, Beibei Cao, Yang Yang, Yi Ding, Xinyu Du, Wanpeng Wang, Mei Li, Zuoqin Li, Xi Wang, Xu Zhao, Xiang Wang

“…Abstract We aim to investigate if myocardial bridging (MB) provides predictive value beyond its association with non-obstructive coronary artery disease (CAD) burden in a long-term follow-up and multicenter study. …”
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CYLD as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration by Jingya Xu, Jingya Xu, Zhonghua Dong, Zhaodong Li, Xuan Wang, Xuan Wang

“…Single-cell transcriptomic analysis demonstrated that CYLD exhibited the strongest correlation with the transition from MI to HF; using random forest modelling, we validated its predictive value in this context.DiscussionIn conclusion, our study identified CYLD as a critical regulator of the transition from MI to HF. …”
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Clinical impact of combined assessment of myocardial inflammation and fibrosis using myocardial biopsy in patients with dilated cardiomyopathy: a multicentre, retrospective cohort... by Toshihisa Anzai, Yasuo Sugano, Tetsuro Yokokawa, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Kazufumi Nakamura, Hiromitsu Kanamori, Michiaki Hiroe, Kaoru Dohi, Takafumi Nakayama, Keiko Ohta Ogo, Kinta Hatakeyama, Yoshihiro Seo, Kyoko Imanaka-Yoshida

“…Here, we investigated the combined prognostic value of these two factors, as evaluated using myocardial biopsy samples.Methods This retrospective and multicentre study included patients with DCM—defined as LVEF of ≤45% and left diastolic diameter of >112% of predicted value, without evidence of secondary or ischaemic cardiomyopathy. …”
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Association between FIB-4 index and lower extremity arterial disease in MASLD patients: a cross-sectional study by Chunxia Zhang, Yuchen Ying, Yuanhui Ru, Ziliang Wu, Yumeng Tian, Pingping Shen, Shiyuan Cao, Jing Zhang, Ri Liu

“…The Fibrosis-4 (FIB-4) index, a non-invasive marker of liver fibrosis, may have predictive value for LEAD in patients with MASLD. This study aimed to explore the association between FIB-4 and LEAD in a cohort of patients with MASLD. …”
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Primary care patients presenting with unexpected weight loss in Australian general practices: replication of a diagnostic accuracy study by Brian D Nicholson, Jo-Anne Manski-Nankervis, Alex Lee, Meena Rafiq, Jon Emery, Barbara Hunter, Craig Nelson, Damien McCarthy, Brent Venning, George Fishman, Lucas de Mendonça, Sophie Chima, Deborah Daly, Chris Kearney, Fong Seng Lim, Javiera Martinez-Gutierrez

“…Objective We calculate positive predictive values (PPVs) of patients presenting with unexpected weight loss (UWL) being diagnosed with cancer within 6 months, using data from a population of Australian primary care patients to replicate results from a previous UK study.Design A diagnostic accuracy study involving calculation of the PPV for any cancer using retrospective data from routinely collected electronic healthcare records. …”
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Integrative speckle-tracking echocardiography for the early detection and prediction of cancer therapy–related cardiac dysfunction by Shuo Qiu, Yuxin Zhang, Ying Hou, Songhao Chen, Huihui Yu, Han Li, Lianbi Zhao, Xiaofang Zhang, Xi Zhang, Jiahan Liu, Changyang Xing, Yunyou Duan, Lijun Yuan

“…The relative changes of GLS, LASr, GWI at T1 were identified as predictors of CTRCD, with improved predictive value when combined together. Conclusion Not only the GLS, but also the LASr and myocardial work indices were significantly impaired just after one cycle therapy of anthracycline. …”
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Hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict prognosis in patients with atrial fibrillation and acute coronary syndrome or undergoing percutaneous coronary in... by Yijing Xin, Yimeng Wang, Yuyuan Shu, Hanyang Liang, Yanmin Yang

“…Adding the HALP score into the GRACE model or CHA2DS2-VASc model significantly increased the original predictive value on MACEs or all-cause death. Conclusions High HALP was associated with a reduced risk of MACEs risk in patients with AF and ACS or undergoing PCI. …”
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Clinical and dynamic circulating cytokines profile features of long-term progression-free survival benefit to immune checkpoint inhibitors in advanced non–small cell lung cancer by Jia-Yi Deng, Ming Gao, Xue Fan, Hong-Hong Yan, Wei-Chi Luo, Ming-Yi Yang, Xiao-Rong Yang, Zhi-Hong Chen, Chong-Rui Xu, Qing Zhou

“…Methods Advanced NSCLC patients receiving first-line ICIs monotherapy at Guangdong Lung Cancer Institute between December 2017 and August 2022 were identified. Predictive value of different characteristics was evaluated in LTPFS (PFS ≥ 24 months) compared with short-term PFS (STPFS, PFS ≤ 3 months). …”
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Development and validation of a nomogram model for sleep disorders in patients with recurrent implantation failure based on physiological and lifestyle factors by You Zhang, Ningxin Qin, Jing Hu, Jie Bai, Mengjia Pan, Yan Xu, Xin Huang, Ke Wang, Ke Wang

“…The predictors include both physiological indicators and daily lifestyle habits, demonstrating significant predictive value and clinical application efficiency. It can be used for early identification of potential sleep disorders in RIF patients, providing certain reference significance for clinical work.…”
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Membrane transporter genes predict chemoradiotherapy response in patients with cervical cancer by Natália Gregório Custódio, Fábio Ribeiro Queiroz, Angelo Borges de Melo Neto, Brenda Martins Cavalcante, Laurence Rodrigues do Amaral, Telma Maria Rossi de Figueiredo Franco, Matheus de Souza Gomes, Vasco Ariston de Carvalho Azevedo, Letícia da Conceição Braga, Paulo Guilherme de Oliveira Salles, Wander de Jesus Jeremias

“…Conclusion: Our results strongly suggest the presence of a candidate gene signature comprising ATP1B3 and SLCO1B3 that holds predictive value for chemoradiotherapy response in cervical cancer.…”
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Early Postoperative Increase in Transforming Growth Factor Beta-1 Predicts Microvascular Flap Loss in Reconstructive Surgery: A Prospective Cohort Study by Rihards Peteris Rocans, Janis Zarins, Evita Bine, Insana Mahauri, Renars Deksnis, Margarita Citovica, Simona Donina, Sabine Gravelsina, Anda Vilmane, Santa Rasa-Dzelzkaleja, Olegs Sabelnikovs, Biruta Mamaja

“…We aimed to investigate the predictive value of postoperative changes in transforming growth factor beta-1 (TGF-β1) for microvascular flap complications. …”
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Developing an electronic surprise question to predict end-of-life prognosis in a prospective cohort study of acute hospital admissions by Baldev Singh, Nisha Kumari-Dewat, Adam Ryder, Vijay Klaire, Hannah Jennens, Kamran Ahmed, Mona Sidhu, Ananth Viswanath, Emma Parry

“…For the GSFSQ-No classification, the mortality odds ratio was 12.4 (11.4–13.5) (p<0.001) vs GSFSQ-Yes (c-statistic 0.72 (0.70–0.73), p<0.001; accuracy, positive and negative predictive values 81.2%, 83.6%, 83.6%, respectively). Had the tool been utilised at the time of admission, the potential to reduce possibly avoidable subsequent hospital admissions, death-in-hospital and bed days was significant (p<0.001). …”
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Assessment of Long-Read Sequencing-Based Congenital Adrenal Hyperplasia Genotyping Assay for Newborns in Fujian, China by Xudong Wang, Xingxiu Lu, Faming Zheng, Kun Lin, Minjuan Liao, Yi Dong, Tiantian Chen, Ying He, Mei Lu, Jing Chen, Yanfang Li, Yulin Zhou

“…Finally, 66 neonates were diagnosed with CAH, with a positive predictive value of 28.82%. Based on this data, the overall prevalence of CAH in Fujian was estimated to be 1:26,883. …”
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Risk factors of bone metastasis in lung adenocarcinoma by Zhongnian Cao, Rong Zheng, Jing Li, Xuejuan Wang, Chao Ding, Fan Zhang, Jianhua Geng, Zhengmao Wei, Rong Fan

“…A receiver operating characteristic curve was used to verify the predictive value of the regression model, and the area under the curve was 0.912 (P < 0.001). …”
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Foreword

“…“Comparative Analysis of Historic Grade 1 Korean Textbooks at the Moscow Institute of Oriental Studies” contrasts materials from pre- and post-liberation periods, highlighting differences in pedagogy, orthography, and linguistic content, and underscoring their historical and educational value. Editors and Editorial Board invite the regular and new readers to engage with the content, to question, challenge, and reflect. …”
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Quality and content evaluation of thyroid eye disease treatment information on TikTok and Bilibili by Haisheng Wang, Huahong Zhang, Jiamin Cao, Feng Zhang, Wei Xiong

“…Quality, reliability, and educational value were assessed using the Global Quality Score (GQS), modified DISCERN (mDISCERN), Patient Education Materials Assessment Tool (PEMAT), and Journal of the American Medical Association (JAMA) benchmark criteria. …”
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Validating social media data reliability for cultural ecosystem services mapping in data-scarce GIAHS: A mixed-methods approach in hani rice Terraces by Luying Yang, Yanbo Li, Xiaoyan Wei

“…The results show that: (1) Among the places identified as possessing CESs via questionnaire method, 90 % of places with aesthetic value (AV), 90 % of places with cultural heritage value (CHV), 91 % places with cultural diversity value (CDV), and 80 % of places with scientific &amp; educational value (SEV) were also identified using social media data. …”
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Lessons from the Frontline: A Phenomenological Study into Faculty Members’ Experiences with Challenges of Remote Online Exams in Medical Sciences Universities by Mostafa Hadavinejad, Mahdieh Azin, Asieh Fatemidokht, Jalal Hassanshahi, Afsaneh Amiri Khorasani, Foad Iranmanesh

“…While online assessments can improve logistical efficiency and reduce certain stressors, ongoing concerns about academic integrity, technical preparedness, and educational value persist. Addressing these issues requires investment in reliable infrastructure, comprehensive faculty training, and innovative valid assessment methods.…”
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