Estimating the Burden of False Positives and Implementation Costs From Adding Multiple Single Cancer Tests or a Single Multi‐Cancer Test to Standard‐Of‐Care Screening by Sarina Madhavan, Allan Hackshaw, Earl Hubbell, Ellen T. Chang, Anuraag Kansal, Christina A. Clarke

“…Results Compared with MCED‐10, SCED‐10 detected 1.4× more cancers (412 vs. 298), but had 188× more diagnostic investigations in cancer‐free people (93,289 vs. 497), lower efficiency (positive predictive value: 0.44% vs. 38%; number needed to screen: 2062 vs. 334), 3.4× the cost ($329 M vs. $98 M), and 150× higher cumulative burden of false positives per annual round of screening (18 vs. 0.12). …”
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Prognostic Value of Albumin-to-Fibrinogen Ratio for 28-Day Mortality among Patients with Sepsis from Various Infection Sites by Shuai Li, Yawei Shen, Bowen Chang, Nan Wang

“…The quadruple index, which included the APACHE II score, lactic acid, septic shock, and AFR, showed a more accurate predictive value for septic patients than the APACHE II score, lactic acid, septic shock, and AFR alone, with an AUC of 0.922, and specificity and sensitivity of 86.9% and 83.6%, respectively. …”
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Identification and validation of ubiquitination-related genes for predicting cervical cancer outcome by Ge Jin, Xiaomei Fan, Xiaoliang Liang, Honghong Dai, Jun Wang

“…The validated risk model demonstrates strong predictive value for patient survival. These findings provide crucial insights into the role of ubiquitination in CC pathogenesis and offer valuable targets for advancing future research and therapeutic strategies.…”
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Prediagnostic self-rated health and survival in women diagnosed with cancer in the Norwegian Women and Health Study: a prospective cohort study by Tonje Braaten, Kristin Benjaminsen Borch, Geir Fagerjord Lorem, Ida Løken Killie

“…Objectives Self-rated health (SRH) is a well-established predictor of all-cause mortality. However, its predictive value in patients with cancer remains unclear. …”
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Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure by Heping Xu, Jinyuan Xie, Huan Niu, Xiongwei Cai, Ping He

“…K‒M survival analysis and Boruta analysis were employed to evaluate the predictive value of the TyG-BMI. Subgroup analyses considered the effects of age, sex, ethnicity, and comorbidities. …”
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Evaluation of novel candidate variations and their interactions related to bipolar disorders: Analysis of GWAS data by Acikel C, Aydin Son Y, Celik C, Gul H

“…The validity of these methods was evaluated using true classification rate, recall (sensitivity), precision (positive predictive value), and F-measure. Results: Random forests, naïve Bayes, and k-nearest neighbors identified 16, 13, and ten candidate SNPs, respectively. …”
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Speckle-tracking echocardiography in the early diagnosis of heart failure after ST-segment elevation myocardial infarction by V. E. Oleinikov, A. V. Golubeva, V. A. Galimskaya, Yu. A. Barmenkova, E. A. Shigotarova, А. V. Babina

“…These values less than 12,5% (AUR =0,830 (95% CI (0,749; 0,911), p=0,001) and 13% (AUR =0,759 (95% CI (0,664; 0,855), p=0,001) is associated with HFmrEF The Twist had the highest predictive value in relation to HFrEF — 4,2° (AUR =0,998 (95% CI (0,993; 0,100), p=0,001).Conclusion. …”
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Clinical prediction model for MODY type diabetes mellitus in children by D. N. Laptev, E. A. Sechko, E. M. Romanenkova, I. A. Eremina, O. B. Bezlepkina, V. A. Peterkova, N. G. Mokrysheva

“…The performance (quality) assessment of the NN was carried out on a test sample (the area under the ROC (receiver operating characteristics) curve reached 0.97). The positive predictive value of PCPR was achieved at a cut-off value of 0.40 (predicted probability of MODY diabetes 40%). …”
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Diagnostic Performance of Infrared Thermography, Quantitative Sudomotor Axonal Reflex Testing, and 3-Phase Bone Scintigraphy for Complex Regional Pain Syndrome Diagnosis: A Retrosp... by Noh C, Lee J, Choi HY, Park E, Shin YS, Hong B, Ko Y, Oh C, Lee SY

“…The three positive results exhibited the highest specificity (0.933) and positive predictive value (0.917).Conclusion: Among the three laboratory tests for CRPS, infrared thermography was the most useful. …”
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Non-invasive screening for liver fibrosis by acoustic radiation force impulse in patients with ciliopathies by Johanna Bresch, Jens König, Martin Konrad, Sabine Kollmann, Mareike Dahmer-Heath, Hauke Sebastian Heinzow, Michael Praktiknjo, Jonel Trebicka, Carsten Bergmann, Hartmut H-J Schmidt, Bernhard Schlevogt

“…Normal GGT excluded ARFI-defined F4 fibrosis (negative predictive value 100%). Gene variants in PKHD1, TMEM67, and TULP3 were primarily detected in our patients with liver fibrosis whereas NPHP1 and HNF1B were not associated with increased liver stiffness. …”
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ΔSUVmax adds prognostic value to early response assessment during the first-line treatment of classical Hodgkin lymphoma: a retrospective cohort study by László Imre Pinczés, Dávid Tóthfalusi, Boglárka Dobó, Sándor Barna, Bence Farkas, Ildikó Garai, Árpád Illés, Zsófia Miltényi

“…The presence of a ΔSUVmax > 88% after 2 cycles of therapy was associated with longer PFS (P = 0.013 [HR, 5.21]), with a negative predictive value exceeding the DS. The combination of ΔSUVmax with DS further stratified PET-negative patients: the 5-year PFS of low-risk and high-risk patients were 92.1% and 79.1%, respectively (P = 0.047 [HR, 2.87]). …”
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Perioperative hemodynamic parameters monitored by three noninvasive technologies in children with congenital heart disease: A prospective study by Xiaoyu Xiong, Feng Xu, Wei Qiu, Shaojun Li, Chengjun Liu

“…Except for LVEF, eight parameters (VISmax [maximum VIS], VISmea [mean VIS], uCImea [mean uCI], uCImin [minimum uCI], eCImea [mean eCI], eCImin [minimum eCI], SVRImea [mean SVRI], and SVRImin [minimum SVRI]) showed predictive value for any AE (p < 0.05). VISmea, uCImea, and eCImea demonstrated the highest accuracy and linear associations (AUROC > 0.9, p = 0.00). …”
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Machine learning algorithms for risk factor selection with application to 60-day sepsis morbidity risk for a geriatric hip fracture cohort by Zhe Xu, Ruguo Zhang, Qiuhan Chen, Guoxuan Peng, Shanpeng Luo, Chen Liu, Ling Zeng, Jin Deng

“…The calibration and DCA results indicated that the model had good predictive value. The RCS revealed a linear relationship between age, BMI, hemoglobin and sepsis incidence (p > 0.05). …”
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EVALUATION OF COST-EFFECTIVENESS OF PLATELET REACTIVITY ANALYSIS USING THE VERIFYNOW P2Y12 ASSAY IN PATIENTS AFTER ACUTE CORONARY SYNDROME by A. V. Rudakova, N. V. Lomakin

“…The costs for one additional year of life as compared with the combination of clopidogrel plus aspirin were 376.5 and 373.2 thousand rubles, respectively, the costs for one additional quality adjusted life year (QALY) were 433.8 and 509.8 thousand rubles, respectively. The total predictive value of costs per 1 patient with ACS using the test was 32% lower than in the routine use of ticagrelor in all patients.Conclusion. …”
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Enhancing TB case detection: experience in offering upfront Xpert MTB/RIF testing to pediatric presumptive TB and DR TB cases for early rapid diagnosis of drug sensitive and drug r... by Neeraj Raizada, Kuldeep Singh Sachdeva, Sreenivas Achuthan Nair, Shubhangi Kulsange, Radhey Shayam Gupta, Rahul Thakur, Malik Parmar, Christen Gray, Ranjani Ramachandran, Bhavin Vadera, Shobha Ekka, Shikha Dhawan, Ameet Babre, Mayank Ghedia, Umesh Alavadi, Puneet Dewan, Mini Khetrapal, Ashwini Khanna, Catharina Boehme, Chinnambedu Nainarappan Paramsivan

“…Upfront Xpert MTB/RIF testing of presumptive PTB and presumptive DR-TB cases resulted in diagnosis of 79 and 12 rifampicin resistance cases, respectively. Positive predictive value (PPV) for rifampicin resistance detection was high (98%, CI 90.1-99.9), with no statistically significant variation with respect to past history of treatment.…”
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Follow-up of gestational trophoblastic disease/neoplasia via quantification of circulating nucleic acids of placental origin using C19MC microRNAs, hypermethylated , and sequences by Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta, Filip Hron

“…MiR-520a-5p had the best performance to detect patients with active disease (a positive predictive value of 100% at a null false positive ratio (FPR)). …”
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Assessing effectiveness of drought tolerance indices in selecting grape (Vitis vinifera) under induced drought stress conditions by JAI PRAKASH, AMULYA S, M K VERMA, SANJAY K SINGH, C BHARADWAJ, MADHUBALA THAKRE, CHAVLESH KUMAR, YOGESH BABU C J

“…Correlations (P<0.001) highlighted the predictive value of specific indices, like the drought resistance index (DI), mean relative performance (MRP), stress tolerance index (STI) and relative efficiency index (REI) for drought tolerance. …”
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Venous thromboembolism in patients undergoing unilateral partial pulmonary resection during hospitalization: a single-center retrospective study by Huaimin Liang, Xiaoning Li, Zhengliang Wei

“…Symptomatic thrombotic complications in hospitalized patients following surgery predominantly present as pulmonary embolism (PE). 4. The predictive value of the Caprini score for assessing the risk of venous thrombosis following unilateral partial lung resection in patients with benign lung tumors or early-stage lung cancer appears to be limited.…”
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Utilization of artificial intelligence to triage patients with delayed follow-up of probably benign breast ultrasound findings by Tali Amir, Kristen Coffey, Jeffrey S Reiner, Varadan Sevilimedu, Victoria L Mango

“…Koios DS had a sensitivity of 100% (2/2; 95% confidence interval [CI], 16% to 100%), specificity of 70% (154/219; 95% CI, 64% to 76%), negative predictive value of 100% (154/154; 95% CI, 98% to 100%), and false-positive rate of 30% (65/219; 95% CI, 24% to 36%). …”
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Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia by Pervin Hancı, Esra Temel, Furkan Bilir, Bilkay Serez Kaya

“…This study aims to evaluate the predictive value of the LAR compared to Pneumonia Severity Index (PSI), Confusion, urea, respiratory rate, blood pressure, 65 years or older (CURB-65), and quick-Sequential Organ Failure Assessment (q-SOFA) scores in determining the need for ICU admission and mortality among hospitalized patients with CAP. …”
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