Value of C⁃reactive protein/albumin ratio，pancreatic stone protein combined with interleukin⁃12 on prediction of offline extubation outcomes of patients with mechanical ventilation... by HOU Hongmei，PENG Feng，XIAO Yun

“…Objective To explore the predictive value of the ratio of C ⁃ reactive protein to albumin（CRP/ALB），pancreatic stone protein（PSP），and interleukin⁃12（IL⁃12）for the outcome of offline extubation in patients withmechanical ventilation in severe pneumonia，in order to guide clinical decision⁃making and enhance weaning success rates. …”
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A Multicenter Retrospective Study Predicting Early Noninvasive Ventilation Failure in Patients With Acute Hypoxic Respiratory Failure by Xiaoyi Liu, Hui Liu, Lijuan Chen, Xiangde Zheng, Hui Ran, Lili Chen, Rui Zhou, Yufeng Wang

“…ABSTRACT Background Volume OXygenation (VOX) index has good efficacy in predicting the failure of high‐flow nasal cannula therapy. However, its predictive value for treatment failure in patients receiving noninvasive ventilation (NIV) remains uncertain. …”
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GPD1L as a potential biomarker associated with Treg cell infiltration and lipid metabolism in clear cell renal cell carcinoma by Ming Yang, Dejiang Pang, Chuhui Gong, Kangping Song, Hongbo Ma, Yu Yang, Shujin Guo, Liqiong Wang

“…The expression of GPD1L in ccRCC cell lines and tissue samples was verified by western blotting, real time qPCR and immunohistochemistry. The predictive value of GPD1L was evaluated by survival analysis, ROC curve and Cox regression analysis. …”
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Radiomic-based models are able to predict the pathologic response to different neoadjuvant chemotherapy regimens in patients with gastric and gastroesophageal cancer: a cohort stud... by Annamaria Agnes, Luca Boldrini, Federica Perillo, Huong Elena Tran, Maria Gabriella Brizi, Riccardo Ricci, Jacopo Lenkowicz, Claudio Votta, Alberto Biondi, Riccardo Manfredi, Vincenzo Valentini, Domenico M. D’Ugo, Roberto Persiani

“…Radiomic models (in the entire case series and according to NAC regimens) were evaluated using the receiver operating characteristic area under the curve (AUC), sensitivity, and negative predictive value (NPV). Results The study included 77 patients undergoing NAC and subsequent tumor resection. …”
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Relationship between quantitative parameters of contrast⁃enhanced ultrasound and EMT⁃related markers and prognosis in patients with liver metastasis of colorectal cancer by CHEN Xi*，SUN Gaixia，WANG Likun，WU Xueliang

“…<b>Objective</b> To investigate the relationship between quantitative analysis of contrast-enhanced ultrasound（CEUS） and epithelial mesenchymal transition（EMT） related markers in patients with colorectal cancer liver metastasis（CRLM），and the predictive value of CEUS for the prognosis of patients. …”
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Predictive Models Using Machine Learning to Identify Fetal Growth Restriction in Patients With Preeclampsia: Development and Evaluation Study by Qing Hua, Fengchun Yang, Yadan Zhou, Fenglian Shi, Xiaoyan You, Jing Guo, Li Li

“…ML models were constructed to evaluate the predictive value of maternal parameter changes on preeclampsia combined with FGR. …”
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Using the ORACLE Risk Score to Assess Hemorrhagic Risk in Patients with Acute Coronary Syndrome and Atrial Fibrillation by V. A. Brazhnik, L. O. Minushkina, A. D. Erlikh, E. D. Kosmacheva, M. A. Chichkova, N. R. Khasanov, D. A. Zateyshchikov

“…The ORACLE risk score had the greatest prognostic value (area under the ROC curve 0.874±0.0416, sensitivity 82.7%, specificity 79.1%). The predictive value of the HAS-BLED risk score was slightly lower (area under the ROC curve 0.710±0.0360, sensitivity 63.2%, specificity 56.8%). …”
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External validation of SYNTAX score II in a real-world cohort undergoing coronary artery bypass grafting by Philipp Angleitner, Hannes Abfalterer, Alexandra Kaider, Emely Manville, Martin Bichler, Michael Graber, Leo Pölzl, Daniel Zimpfer, Sigrid Sandner, Nikolaos Bonaros

“…SYNTAX Score II, EuroSCORE II, the logistic EuroSCORE, and ACEF Score offer comparable predictive value towards 4-year mortality.…”
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Association between different dimensions of the C-reactive protein-triglyceride-glucose index and future cardiovascular disease risk in individuals with cardiovascular-kidney-metab... by Jintao Chen, Liying Yan, Lei He, Weixue Wang

“…Longitudinal monitoring of CTI changes over time can help early identification of high CVD risk in this population, and its predictive value is significantly superior to that of the TyG index. …”
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Biomarkers (NLR, PLR, SII) for Frequent COPD Exacerbations: Diagnostic and Clinical Management Implications in a Retrospective Study by Fu Y, Wang Y, Wang Y, Mou T, He X, Wang J, Xiong A, Qing B, Wu D, Li G

“…Yufen Fu,1– 3 Yuxin Wang,1,4 Yujiao Wang,1,4 Ting Mou,1,4 Xiang He,2,4 Junyi Wang,2,4 Anying Xiong,2,4 Bomiao Qing,2,4 Dehong Wu,2,4 Guoping Li1,2,4 1Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People’s Republic of China; 2Laboratory of Allergy and Precision Medicine, Chengdu Institute of Respiratory Health, the Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Longchang People’s Hospital, Neijiang, 642150, People’s Republic of China; 4Department of Pulmonary Medicine, Chengdu Third People’s Hospital branch of National Clinical Research Center for Respiratory Disease, Affiliated Hospital of Chongqing Medical University, Chengdu, 610031, People’s Republic of ChinaCorrespondence: Guoping Li, Email lzlgp@163.comObjective: To evaluate the diagnostic and predictive value of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) for frequent exacerbations of chronic obstructive pulmonary disease (AECOPD), and to develop a risk stratification scoring system to optimize clinical management in resource-limited healthcare settings.Patients and Methods: This retrospective observational study enrolled 16,849 AECOPD patients, categorized into frequent exacerbators (≥ 2 exacerbations/year, n=3,488) and non-frequent exacerbators (< 2 exacerbations/year, n=13,361). …”
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Detection of urinary levels of matrix metalloproteinase-7 and tumor necrosis factor-like weak inducer of apoptosis in patients with IgA nephropathy and values in predicting disease... by Ma Yong-duo, Wang Cong, Li Hai-xiang, Wu Huan

“…ObjectiveTo explore the expressions of urinary matrix metalloproteinase-7 （MMP-7） and tumor necrosis factor-like weak inducer of apoptosis （TWEAK） in patients with IgA nephropathy （IgAN） and examine its predictive value.MethodsFrom January 2018 to March 2021，115 IgAN patients and 50 normal subjects （control group） were selected.Based upon the progress of IgAN，115 cases of IgAN patients were divided into two groups of IgAN progressive （<italic>n</italic>=42） and IgAN non-progressive （<italic>n</italic>=73）.According to the IgAN Oxford classification criteria，they were assigned into two groups of MEST-C≥3 （<italic>n</italic>=45） and MEST-C&lt;3 （<italic>n</italic>=70）.The levels of urinary MMP-7 and TWEAK were compared between two groups.Multivariate Logistic regression was utilized for analyzing the risk factors of IgAN progression.Receiver operating characteristic （ROC） curve was plotted for examining the values of urinary MMP-7 and TWEAK levels in predicting IgAN progression.ResultsThe levels of urinary MMP-7 （15.72±7.85 <italic>vs</italic> 6.92±0.53 ng/mL） and TWEAK were significantly higher in IgAN progressive group than those in IgAN non-progressive group ［（958.47±42.60） <italic>vs</italic> （206.73±15.18）ng/mL，<italic>P</italic>&lt;0.001］.The levels of urinary MMP-7 ［（23.92±9.27） <italic>vs</italic> （18.15±8.36） ng/mL］ and TWEAK ［（1408.70±71.15） <italic>vs</italic> （1036.28±50.72） ng/mL］ were significantly higher in MEST-C≥3 score group than those in MEST-C&lt;3 score group （<italic>P</italic>&lt;0.001）.Multivariate Logistic regression analysis indicated that elevated levels of MMP-7 ［<italic>OR</italic>=2.986 95%<italic>CI</italic>（2.146，-8.513）］ and TWEAK ［<italic>OR</italic>=3.370 95%<italic>CI</italic>（2.752，-10.118）］ were the risk factors affecting the progression of IgAN.Receiver operating characteristic （ROC） curve indicated that the area under the curve （AUC） of MMP-7 and TWEAK in predicting IgAN progression was 0.948 （95% <italic>CI </italic>0.885-0.997） with a sensitivity of 97.5% and a specificity of 85.0%.Correlation analysis indicated that the urinary levels of MMP-7 and TWEAK were significantly positively correlated with M，E，S and T （<italic>P</italic>&lt;0.001）.ConclusionThe elevated urinary levels of MMP-7 and TWEAK are the risk factors affecting the progression of IgAN.Both may be used as biological indicators for predicting the progression of IgAN.…”
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Association of triglyceride-glucose index and estimated glucose disposal rate with outcomes in patients with acute myocardial infarction: Cumulative effect and mediation analysis. by Yazhao Sun, Pei Sun, Dongsheng Liu

“…Additionally, the net reclassification index (NRI) and integrated discrimination improvement (IDI) were computed to assess the incremental predictive value of TyG index + METS-IR beyond traditional risk factors. …”
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Lipid-Metabolism-Related Gene Signature Predicts Prognosis and Immune Microenvironment Alterations in Endometrial Cancer by Zhangxin Wu, Yufei Nie, Deshui Kong, Lixiang Xue, Tianhui He, Kuaile Zhang, Jie Zhang, Chunliang Shang, Hongyan Guo

“…Results: Multivariate analysis indicated that the prognostic model had robust predictive value, with AUCs of 0.701, 0.746, and 0.790 for 1-, 3-, and 5-year overall survival predictions. …”
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Serum FGF23 and DPP4 Levels as Biomarkers for Coronary Artery Disease Severity in Type 2 Diabetic Patients with Coronary Heart Disease by Zhong X, Liang Z, Liao H, Zhan Y, Li G, Wu H, Li J

“…Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive value of these biomarkers.Results: Serum levels of FGF23 and DPP4 were significantly higher in the T2DM+CHD group than in the T2DM-only group (P< 0.05), and increased progressively with the severity of CAD (P< 0.05). …”
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PREDICTIVE RELEVANCE OF DIFFERENT CLINICAL AND LABORATORY FINDINGS FOR HIGHER MORTALITY IN PATIENTS WITH COVID-19 IN A SINGLE CENTER COHORT: NEUTROPHIL/ LYMPHOCYTE RATIO, HIGH CR... by Oğuz Evlice, Fatih Kuş, Özlem Arık, Murat Bektaş

“…Therefore, we aimed to evaluate the predictive value of different clinical and laboratory parameters in disease severity and mortality in patients with COVID-19. …”
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Long-term prognosis of left ventricular re-remodeling after surgery of ischemic cardiomyopathy: the potential of tomographic radionuclide ventriculography by V. V. Shipulin, A. I. Mishkina, M. O. Gulya, Yu. V. Varlamova, S. L. Andreev, A. S. Pryakhin, V. M. Shipulin, K. V. Zavadovsky

“…Univariate regression showed that ΔLVEF (odds ratio (OR), 0,88; confidence interval (CI), 0,8; 0,97; p=0.008), ΔLVPSD (OR, 1,13; CI, 1,03; 1,25; p=0,005), and coronary stenosis &gt;75% (OR, 4,25; CI, 1,57; 11,48; p=0,001) had a predictive value. According to the ROC-analysis, the sensitivity, specificity, and AUC were 87%, 64% and 0,727 for ΔLVPSD (threshold &gt;-1); 84%, 46% and 0,691 for coronary stenosis &gt;75% &gt;75% (threshold &gt;2); 65%, 82% and 0,674 for ΔLVEF (threshold ≤4), respectively. …”
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Evaluative performance of TyG-ABSI versus traditional indices in relation to cardiovascular disease and mortality: evidence from the U.S. NHANES by Xin Zheng, Wenjing Zhang, Feng Yang, Leigang Wang, Bing Yu, Bin Liang

“…This study aims to explore the association between TyG-ABSI and cardiovascular events in individuals with MetS and compare its predictive value with the traditional TyG index in this specific population. …”
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Analysis of Risk Factors and Development of a Predictive Model for Delirium in ICU Patients: Construction, Validation, and Clinical Implications by Li X, Zhang W, Wang T, Qiu Z, Sun X, Qu W, Zhang G

“…Xia Li,1,&amp;ast; Weisong Zhang,2,3,&amp;ast; Tao Wang,4 Zhengfeng Qiu,1 Xuan Sun,1 Wenhao Qu,1 Guopei Zhang1 1Department of Intensive Care Unit, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, 224000, People’s Republic of China; 2Department of Thoracic Surgery, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, 224000, People’s Republic of China; 3Medical School of Nantong University, Nantong, 226007, People’s Republic of China; 4Department of Anesthesiology, Affiliated Hospital 6 of Nantong University, Yancheng Third People’s Hospital, Yancheng, 224000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Guopei Zhang, Email zhangicu@163.comObjective: To analyze the influencing factors contributing to the occurrence of delirium in patients within the Intensive Care Unit (ICU) and to construct a prediction model for delirium in critically ill patients, subsequently verifying its predictive value.Methods: A prospective study was conducted involving 641 patients admitted between January 2023 and June 2024. …”
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Preoperative prediction of non-invasive follicular thyroid neoplasm with papillary-like nuclear features: a Canadian single-Centre experience by Vincent Larouche, Marc Philippe Pusztaszeri, Sabin Filimon, Richard Payne, Michael Hier, Michael Tamilia

“…NIFTP nodules were smaller (Mean size 22.97 mm +/− 12.3 vs 25.88 mm +/− 11.2 for non-NIFTP, p = 0.0448) and more often solid than non-NIFTP (93.2% (41/44) vs 74.8% (119/159) for non-NIFTP, p = 0.0067). 2017 ACR TIRADS nodule category of 1–4 on ultrasound had a negative predictive value and a sensitivity of 100% for NIFTP. ROC Curve Analysis demonstrated that a preoperative thyroglobulin level of 31.3 mcg/L had a sensitivity of 75% and a specificity of 62.5% to differentiate NIFTP from non-NIFTP cancers. …”
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Aneuploidy screening in women of advanced age in the public healthcare setting of a low- to middle- income country – an observational cohort study by L Geerts, N Du Toit, M Schoeman

“…In the SA public sector, DS screening and confirmatory genetic testing are fully state subsidised for women of advanced maternal age (AMA) but, owing to the low positive predictive value of AMA-based screening, ultrasound-based screening is also offered. …”
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