Development and validation of the VAE-NT index: a novel biomechanical parameter for distinguishing subclinical corneal abnormalities by Lanting Yang, Lanting Yang, Lanting Yang, Hui Xu, Hui Xu, Honghu Jiang, Jingyin Zhu, Shihao Chen, Shihao Chen

“…The validity, reliability, and predictive value of the index were further assessed using the validation dataset. …”
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Prognostic impact of extranodal disease on PET/CT in follicular lymphoma: results from a validation study with ECOG 2408 by Frederique St-Pierre, Stephen M. Broski, Zequn Sun, Masha Kocherginsky, Betsy LaPlant, Matthew J. Maurer, Andrew Quon, Lucia Baratto, Hatice Savas, Lale Kostakoglu, Jane N. Winter, Thomas E. Witzig, Brad Kahl, Andrew M. Evens, Leo I. Gordon

“…PET factors with a significant impact on survival outcomes were combined with significant FL International Prognostic Index 2 (FLIPI-2) factors to evaluate the predictive value of a PET-based prognostic index. Presence of ≥2 EN sites and skin/soft tissue involvement on PET were validated as predictors of overall survival. …”
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Identification of Intermediate- to High-Risk Papillary Thyroid Carcinoma Patients Who May Be Safely Managed without the Performance of Delayed Stimulated Thyroglobulin Measurements... by Kyung-Hee Kim, Min-Hee Kim, Ye-Jee Lim, Ihn Suk Lee, Ja-Seong Bae, Dong-Jun Lim, Ki Hyun Baek, Jong Min Lee, Moo-Il Kang, Bong-Yun Cha

“…The combination of ablative Tg less than 2.9 ng/mL with pre- and postoperative independent risk factors for detectable sTg increased the negative predictive value for detectable sTg up to 98.5%. Conclusions. …”
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Combination of nucleated red blood cells and inflammatory biomarkers (PCT and CRP) for predicting sepsis and septic shock in children by Kaibin Pu, Kaibin Pu, Kaibin Pu, Chunyi Wang, Jie Cheng, Jie Cheng, Jie Cheng, Dapeng Chen, Liping Tan, Liping Tan, Liping Tan, Jihong Tan, Jihong Tan, Jihong Tan, Hongdong Li, Hongdong Li, Hongdong Li

“…This study aimed to investigate the clinical characteristics of children with sepsis and septic shock, with emphasis to evaluate the predictive value of C-reactive protein (CRP), procalcitonin (PCT), and nucleated red blood cell (NRBC) count in pediatric sepsis and septic shock patients.MethodsWe included a total of 121 children, including 80 with sepsis and 41 with septic shock, who were admitted to the Children’s Hospital of Chongqing Medical University between January 2021 and June 2024.ResultsNo significant differences in sex, age, weight, or basic diseases were observed between the sepsis and septic shock groups (P > 0.05). …”
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Diagnostic value of full blood count derived systemic inflammatory biomarkers in malaria infection by Joseph Boachie, Derrick Ahiable, Leticia Awonbiistemi Ajabuin, Richard Amissah, Abigail Asmah-Brown, Safianu Apalebilah, Ama Gyasiwaah Owusu-Poku, Henrietta Eshun, Patrick Adu, Joel Karikari Nyarkoh

“…A receiver operator characteristic (ROC) curve analysis showed that NLR (AUC = 0.937) had an excellent diagnostic and predictive value, with sensitivity of 86.7 % and specificity of 92.0 %. …”
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The proteinuria selectivity index value predicts the remission of IgA nephropathy: a retrospective cohort study by Ryunosuke Mitsuno, Takashin Nakayama, Wataru Ito, Tomomi Maruki, Ran Nakamichi, Keika Adachi, Norifumi Yoshimoto, Akihito Hishikawa, Aika Hagiwara, Shintaro Yamaguchi, Toshiaki Monkawa, Jun Yoshino, Akinori Hashiguchi, Tatsuhiko Azegami, Kaori Hayashi

“…The proteinuria selectivity index (PSI) has been used to assess the prognosis in nephrotic syndrome, but its predictive value in patients with IgAN remains unclear. …”
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Point-of-Care Urine Metabolomics Test to Diagnose Colorectal Cancers in Low- and Middle-Income Countries: A Pilot Controlled Trial in Southwestern Nigeria by Adeleye A. Adeomi, Olusegun I. Alatise, David Wishart, Scott MacKay, Olalekan Olasehinde, Funmilola Wuraola, Adewale Adisa, Tajudeen Mohammed, Adewale Aderounmu, Omolade Adefolabi Betiku, Oluwatosin Zainab Omoyiola, Adeoluwa Oluwaseyi Adeleye, Samson Oluwagbemiga Ogunleye, Olusegun Joshua Babatunde, Oluwabusayomi Roseline Ademakinwa, Israel Adeyemi Owoade, Jacob Mobolaji, Cristina Olcese, Rivka Kahn, Naqiya Rahil Choonawala, Grace Fitzgerald, H. Dean Hosgood, T. Peter Kingham

“…We assessed validity of the test using sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV), and prespecified a specificity of 50% with a goal of ≥80% sensitivity to estimate the potential of the test to half the referrals to colonoscopy. …”
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Pre-treatment monocytic myeloid-derived suppressor cells as predictive biomarkers for immune checkpoint inhibitor response in clear cell renal cell carcinoma by Yiming Jin, Yiming Jin, Hisamitsu Ide, Hisamitsu Ide, Masayoshi Nagata, Takuro Kobayashi, Takuro Kobayashi, Jun Lu, Yoshihiro Ikehata, Yoshihiro Ikehata, Fumitaka Shimizu, Yan Lu, Shigeo Horie, Shigeo Horie, Shigeo Horie

“…Multivariable logistic regression was used to evaluate their predictive value. The primary outcome was objective response (CR/PR) based on RECIST 1.1.ResultsAmong 47 clinical and laboratory variables with an area under the curve (AUC) greater than 0.6, elastic net regression identified 7 key predictors of immunotherapy response. …”
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Cystic Fibrosis Newborn Screening: A Systematic Review-Driven Consensus Guideline from the United States Cystic Fibrosis Foundation by Meghan E. McGarry, Karen S. Raraigh, Philip Farrell, Faith Shropshire, Karey Padding, Cambrey White, M. Christine Dorley, Steven Hicks, Clement L. Ren, Kathryn Tullis, Debra Freedenberg, Q. Eileen Wafford, Sarah E. Hempstead, Marissa A. Taylor, Albert Faro, Marci K. Sontag, Susanna A. McColley

“…Systematic reviews were used to develop seven recommendations for newborn screening program practices to improve timeliness, sensitivity, and equity in diagnosing infants with CF: (1) The CF Foundation recommends the use of a floating immunoreactive trypsinogen (IRT) cutoff over a fixed IRT cutoff; (2) The CF Foundation recommends using a very high IRT referral strategy in CF newborn screening programs whose variant panel does not include all CF-causing variants in CFTR2 or does not have a variant panel that achieves at least 95% sensitivity in all ancestral groups within the state; (3) The CF Foundation recommends that CF newborn screening algorithms should not limit <i>CFTR</i> variant detection to the F508del variant or variants included in the American College of Medical Genetics-23 panel; (4) The CF Foundation recommends that CF newborn screening programs screen for all CF-causing <i>CFTR</i> variants in CFTR2; (5) The CF Foundation recommends conducting <i>CFTR</i> variant screening twice weekly or more frequently as resources allow; (6) The CF Foundation recommends the inclusion of a <i>CFTR</i> sequencing tier following IRT and <i>CFTR</i> variant panel testing to improve the specificity and positive predictive value of CF newborn screening; (7) The CF Foundation recommends that both the primary care provider and the CF specialist be notified of abnormal newborn screening results. …”
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Left heart function and strain for predicting change in hemoglobin levels in pediatric kidney transplantation recipients by Shufan Yue, Fei Xiao, Rui Fan, Wei Li, Donghong Liu, Fengjuan Yao, Hong Lin, Chenglin Wu, Longshan Liu, Changxi Wang, Jun Li, Cuiling Li, Cuiling Li

“…LVMI and changes in LVEF and LAEVI have predictive value in absence of Hb increase in pediatric KTx recipients.…”
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Triglyceride-glucose index as a predictor of one-year mortality in non-diabetic acute ischemic stroke by Shengyuan Wang, Xianjia Ning, Xianjia Ning, Xianjia Ning, Xianjia Ning, Jun Tu, Jun Tu, Jun Tu, Jinghua Wang, Jinghua Wang, Jinghua Wang, Jinghua Wang, Yu Zhao

“…Multivariate logistic regression and subgroup analyses were conducted to assess the predictive value of the TyG index for these outcomes.ResultsAmong the study population, 5.9% died within one year. …”
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Development and validation of a nomogram model for sleep disorders in patients with recurrent implantation failure based on physiological and lifestyle factors by You Zhang, Ningxin Qin, Jing Hu, Jie Bai, Mengjia Pan, Yan Xu, Xin Huang, Ke Wang, Ke Wang

“…The predictors include both physiological indicators and daily lifestyle habits, demonstrating significant predictive value and clinical application efficiency. It can be used for early identification of potential sleep disorders in RIF patients, providing certain reference significance for clinical work.…”
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Early Postoperative Increase in Transforming Growth Factor Beta-1 Predicts Microvascular Flap Loss in Reconstructive Surgery: A Prospective Cohort Study by Rihards Peteris Rocans, Janis Zarins, Evita Bine, Insana Mahauri, Renars Deksnis, Margarita Citovica, Simona Donina, Sabine Gravelsina, Anda Vilmane, Santa Rasa-Dzelzkaleja, Olegs Sabelnikovs, Biruta Mamaja

“…We aimed to investigate the predictive value of postoperative changes in transforming growth factor beta-1 (TGF-β1) for microvascular flap complications. …”
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Assessment of Long-Read Sequencing-Based Congenital Adrenal Hyperplasia Genotyping Assay for Newborns in Fujian, China by Xudong Wang, Xingxiu Lu, Faming Zheng, Kun Lin, Minjuan Liao, Yi Dong, Tiantian Chen, Ying He, Mei Lu, Jing Chen, Yanfang Li, Yulin Zhou

“…Finally, 66 neonates were diagnosed with CAH, with a positive predictive value of 28.82%. Based on this data, the overall prevalence of CAH in Fujian was estimated to be 1:26,883. …”
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Risk factors of bone metastasis in lung adenocarcinoma by Zhongnian Cao, Rong Zheng, Jing Li, Xuejuan Wang, Chao Ding, Fan Zhang, Jianhua Geng, Zhengmao Wei, Rong Fan

“…A receiver operating characteristic curve was used to verify the predictive value of the regression model, and the area under the curve was 0.912 (P < 0.001). …”
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Japanese experience of newborn screening for lysosomal storage diseases and adrenoleukodystrophy by Takanori Onuki, Makiko Tajika, Yohei Sugiyama, Masaru Shimura, Keiko Ichimoto, Toju Tanaka, Hiromi Nyuzuki, Motomichi Kosuga, Ohsuke Migita, Tetsuya Ito, Hideo Sasai, Ryosuke Bo, Junpei Hamada, Takashi Hamazaki, Norio Sakai, Takahito Inoue, Kimitoshi Nakamura, Torayuki Okuyama, Kei Murayama

“…In contrast, the positive predictive value was low and false-positive rates was elevated, particularly for PD, MPS II, and ALD, have been attributed to pseudodeficiency alleles and methodological differences. …”
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The Combined Prognostic Value of 18F‐FDG PET/CT Metabolic Parameters of Immune Organs and Hematological Immune‐Related Markers in Patients With Locally Advanced Cervical Cancer by Yi Li, Xin Wang, Yuanlin Li, Wanhu Li, Defeng Liu, Longxiang Guo, Xiuli Liu, Zhichao Li, Ao Liu, Minghuan Li

“…Conclusion The nomograms based on metabolic parameters of immune organs and hematological immune‐related markers demonstrated high predictive value for patients with LACC undergoing CCRT. …”
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Mechanism and Predictive Role of NUB1 Protein in Oestrogen Receptor Pathway of FEC-Treated Breast Cancer Patients by Maria Arshad, Amira Raudhah Abdullah, Fuad Ismail, Francesco Pezzella, Azyani Yahaya, Geok-Chin Tan, Suet Lin Chia, Md Salzihan Md Salleh, Noraidatulakma Abdullah, Ka-Liong Tan

“…This study investigated NUB1’s predictive value in FEC treatment and its mechanistic interaction with the oestrogen receptor (ER) in BC. …”
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Retroflex tongue as a non-invasive neurological marker of functional severity in older adults with ischemic stroke: a retrospective observational study by Yung-Sheng Huang, Yung-Sheng Huang, Hen-Hong Chang, Hen-Hong Chang, Hen-Hong Chang, John Y. Chiang, John Y. Chiang, Po-Chi Hsu, Po-Chi Hsu, Lun-Chien Lo, Lun-Chien Lo, Lun-Chien Lo

“…Retroflex tongue (RT) and tongue deviation (TD) are observable signs of cranial nerve dysfunction; however, their comparative predictive value for stroke severity remains unclear.MethodsIn this retrospective observational study, 308 older adults (mean age: 69.1 years) hospitalized with ischemic stroke were enrolled. …”
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Using sputum and tongue swab specimens for in-home point-of-care targeted universal testing for tuberculosis of household contacts: an acceptability and feasibility analysis by Adam Penn-Nicholson, Andrew Medina-Marino, Charl Bezuidenhout, Gesine Meyer-Rath, Lawrence Long, Matthew P Fox, Grant Theron, Morten Ruhwald, Brooke Nichols, Sharon Olifant, Kuhle Fiphaza, Maria Pieruccini, Bernard Fourie

“…This study assessed the acceptability of in-home targeted universal TB testing (TUTT) using GeneXpert MTB/RIF Ultra at point-of-care (POC) during household contact investigations (HCIs) and the feasibility of using sputum and tongue swab specimens.Methods The TB Home Study sought to evaluate the predictive value of different specimen types for use as a household-level triage test for TB. …”
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