Lysine methyltransferase 2D deficiency drives complete response to pembrolizumab in PD-L1-High cholangiocarcinoma: a case report and review of literature by Xiaofang Li, Xiaofang Li, Liao Wang, Liao Wang, Shuang Li, Shuang Li

“…Conventional biomarkers like PD-L1 expression show limited predictive value, creating an urgent need for novel therapeutic targets in this aggressive malignancy.Case presentationWe describe a stage IV ICC patient with PD-L1 positivity and a somatic KMT2D mutation (p.R5303C) who attained sustained complete remission after pembrolizumab treatment, despite developing severe multi-organ immune-related adverse events (irAEs) including hepatitis, pneumonitis, and thrombocytopenia. …”
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Combined preoperative platelet-albumin ratio and cancer inflammation prognostic index predicts prognosis in colorectal cancer: a retrospective study by Kuan Wang, Kejin Li, Ziyi Zhang, Xiangyue Zeng, Zhimin Wu, Boxiang Zhang, Yipeng Pan, Lucy Yue Lau, Zeliang Zhao, Yi Chen

“…In this study, we investigated the predictive value of two easy-to-measure preoperative markers, platelet-to-albumin ratio (PAR) and cancer inflammation prognostic index (CIPI), in postoperative survival of patients with CRC. …”
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Brief Communication: Maternal Plasma Autoantibodies Screening in Fetal Down Syndrome by Karol Charkiewicz, Monika Zbucka-Kretowska, Joanna Goscik, Slawomir Wolczynski, Adam Lemancewicz, Piotr Laudanski

“…The second step was to create a classifier of Down syndrome pregnancy, which includes 14 antibodies. The predictive value of the classifier (specificity and sensitivity) is 100%, classification errors, 0%, cross-validation errors, 0%. …”
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Impact of the “L” score from the RENAL nephrometry score on RAPN surgical outcomes in medial versus lateral renal tumors by Yasuhiro Numata, Hiroki Ito, Seiichiro Honda, Kota Kobayashi, Ryosuke Jikuya, Tomoyuki Tatenuma, Go Noguchi, Daiki Ueno, Mitsuru Komeya, Yusuke Ito, Kentaro Muraoka, Kazuki Kobayashi, Hisashi Hasumi, Kazuhide Makiyama

“…In conclusion, significance of the “L” score on surgical outcomes differs between medial and lateral tumors and it is strongly associated with outcomes in medial tumors, whereas its predictive value in lateral tumors is less marked. The RENAL nephrometry score lacks differentiation between medial and lateral tumors; therefore, surgeons should interpret “L” scores with caution.…”
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Clinicopathological and Survival Outcomes of Well-Differentiated Thyroid Carcinoma Undergoing Dedifferentiation: A Retrospective Study from FUSCC by Ben Ma, Weibo Xu, Wenjun Wei, Duo Wen, Zhongwu Lu, Shuwen Yang, Tongzhen Chen, Yulong Wang, Yu Wang, Qinghai Ji

“…Harrell index of concordance (C-index) and Akaike information criterion (AIC) were calculated to compare the predictive value for prognosis among several prognostic classification systems. …”
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Ablation Lesion Assessment with MRI by Lluís Mont, Ivo Roca-Luque, Till F Althoff

“…With a negative predictive value close to 100% it can reliably rule out pulmonary vein reconnection non-invasively and thus may avoid unnecessary invasive repeat procedures where a pulmonary vein isolation only approach is pursued. …”
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Utility of ultrasound examination in the diagnosis of laryngeal and hypopharyngeal cancers by G. F. Allakhverdieva, G. T. Sinyukova, T. Yu. Danzanova, E. V. Kovaleva, О. A. Saprina, E. A. Gudilina

“…US examination demonstrated a sensitivity of 94.1 %, accuracy of 91.9 %, efficacy of 47.0 %, and positive predictive value of 97.5 %. Specificity was not evaluated since we had no negative results.Conclusion. …”
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Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer’s Disease by Elena Salobrar-Garcia, Rosa de Hoz, Blanca Rojas, Ana I. Ramirez, Juan J. Salazar, Raquel Yubero, Pedro Gil, Alberto Triviño, José M. Ramirez

“…The PTs with the greatest predictive value are the higher spatial frequencies in CS and tritan unspecific errors in CP. …”
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Association between obesity indicators and retinopathy in US adults: NHANES 2005–2008 by Chuan-Xi Wang, Miao Kuang, Miao Kuang, Jing-Jing Hou, Si-Yu Lin, Sheng-Zhen Liu, Ning Bao, Zheng-Xuan Jiang

“…ROC curves showed that WWI had the highest predictive value for retinopathy.ConclusionOverall, increased levels of these obesity indicators increase the likelihood of developing retinopathy.…”
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Copeptin: Limited Usefulness in Early Stroke Differentiation? by Johannes von Recum, Julia Searle, Anna Slagman, Jörn Ole Vollert, Matthias Endres, Martin Möckel, Martin Ebinger

“…The diagnostic accuracy of copeptin for IS was 63% with a sensitivity of 80% and a positive predictive value of 64%. Conclusion. In this cohort of patients copeptin-levels within 4.5 hours of symptom onset were higher in patients with IS compared to TIA but the broad range of values in stroke-mimics limits diagnostic accuracy. …”
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A nomogram for predicting non-curative resection in patients with early gastric cancer based on white light imaging by Mengyu Cao, Linlin Ren, Congcong Min, Zeyuan Diao, Hao Chen, Hua Liu, Xiaoyu Li, Jiahui Xu, Zibin Tian, Tao Mao

“…The nomogram based on these features showed good predictive value for NCR, with an area under the curve (AUC) of 0.8095 (95% CI: 0.7538–0.8651) in the training set and 0.7567 (95% CI: 0.6427–0.8707) in the validation set. …”
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A Selective Chromogenic Medium for Detecting Meropenem-Resistant <i>Pseudomonas aeruginosa</i> in Respiratory Samples by Carmen Cintora Mairal, Guillermo Martín-Gutiérrez, Ángel Rodríguez-Villodres, José Miguel Cisneros, José Antonio Lepe, José Manuel Ortiz de la Rosa

“…<b>Results</b>: The selective medium demonstrated excellent sensitivity (average 98.7%) and specificity (average 90%) across bacterial concentrations ranging from 1 × 10⁴ to 1 × 10⁸ CFU/mL, and a high negative predictive value (average 99.2%) compared to the broth microdilution (BMD) method. …”
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Irisin: An influential perspective on the protective effect of metformin on aortic and cardiac aging in rats by Ozgur Baris, Gulcin Gacar, Burak Acar, Feride Ipek Komsuoglu Celikyurt, Yusufhan Yazir, Tijen Utkan

“…It regulates energy metabolism, fat tissue and glucose metabolism. The predictive value of irisin for the effects of metformin on cardiac and aortic aging in an aged rat model was evaluated by quantitative and histological confirmation. …”
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Construction of immune-related risk signature for uveal melanoma by Zhaotian Zhang, Yao Ni, Genghang Chen, Yantao Wei, Manjuan Peng, Shaochong Zhang

“…The Kaplan–Meier analyses found for these patients in the high-risk group had a poor survival rate than those in the low-risk group. The predictive value and stability were confirmed by the receiver operative characteristics curves. …”
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Continuous beta-2 microglobulin–based clearance highlights superiority of high-Dose HDF over high-flux HD in predicting outcomes by Bernard Canaud, Andrew Davenport, Marion Morena-Carrere, Mailis Amico, Nicolas Molinari, Jean-Paul Cristol

“…Moreover, eCDCß2M demonstrated superior predictive value for mortality risk compared to Kt/V. These findings support eCDCß2M as a meaningful and physiologically relevant measure of dialysis efficiency and adequacy. …”
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Muscle thickness from amplitude mode ultrasound and clinical outcomes in patients with cancer by Rodrigo Albert Baracho Rüegg, Jarson P. Costa-Pereira, Amanda de Sousa Rebouças, Agnes Denise de Lima Bezerra, Nithaela Alves Bennemann, Jadson Gomes Xavier, Ana Paula Trussardi Fayh

“…Each millimeter increase in BMT reduced 30-day mortality risk by 9% (95% CI 0.85–0.96) and 6-month mortality risk by 6% (95% CI 0.91–0.98). TMT had no predictive value. BMT measured by A-mode ultrasound is a predictor of poor survival in cancer, highlighting its value as a bedside tool for early risk identification and timely interventions. …”
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Troponin, NT-proBNP and postoperative atrial fibrillation in a prospective cohort undergoing coronary artery bypass surgery by Amelie H. Ohlrogge, Ferdinand Seum, Korbinian Ruhland, Francisco M. Ojeda, Christin S. Börschel, Simon Pecha, Stefan Blankenberg, Tanja Zeller, Renate B. Schnabel

“…The existing evidence on the predictive value of preoperative high-sensitive Troponin and NT-proBNP concentration for the onset of postoperative atrial fibrillation (POAF) is inconsistent. …”
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Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults by Yiwei Peng, Yiwei Peng, Yiwei Peng, Yiwei Peng, Ling Li, Ling Li, Ling Li, Minqi Li, Minqi Li, Minqi Li, Jie Wang, Jie Wang, Jie Wang, Tianyao Long, Tianyao Long, Tianyao Long, Tianyao Long, Liuyangyi Zheng, Liuyangyi Zheng, Liuyangyi Zheng, Liuyangyi Zheng, Xuan Tan, Xuan Tan, Xuan Tan, Xuan Tan, Xiuqin Hong, Xiuqin Hong, Xiuqin Hong, Xiuqin Hong

“…ROC curve analysis showed that TyG-WC has higher predictive value for HTH compared to other variables (AUC = 0.676, 95%CI: 0.655–0.696, P = 0.010). …”
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Correlating Quantitative Fecal Immunochemical Test Results with Neoplastic Findings on Colonoscopy in a Population-Based Colorectal Cancer Screening Program: A Prospective Study by Neal Shahidi, Laura Gentile, Lovedeep Gondara, Jeremy Hamm, Colleen E. McGahan, Robert Enns, Jennifer Telford

“…The Canadian Partnership Against Cancer (CPAC) recommends a fecal immunochemical test- (FIT-) positive predictive value (PPV) for all adenomas of ≥50%. We sought to assess FIT performance among average-risk participants of the British Columbia Colon Screening Program (BCCSP). …”
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Differences in hematocrit-to-plasma albumin ratio as a predictor of severe maternal morbidity in hypertensive disorders of pregnancy: a retrospective cohort study by Yihua Ni, Liying Zhong, Huale Zhang, Xiaoyan Xiu

“…Multivariate logistic regression, threshold effect analysis, and receiver operating characteristic (ROC) curve evaluation were used to assess the predictive value of HCT-ALB and other clinical indicators. …”
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