Comparison of [99mTc]Tc-FAPI SPECT/CT and [18F]FDG PET/CT as predictive biomarkers for immunotherapy response in gastrointestinal cancer by Yu Zhang, Hong Chen, Dajia Lin, Zhiyi Lin, Jiyun Shi, Hannan Gao, Chenshen Huang, Fangqing Xue, Fan Wang, Wenxin Chen

“…For diagnostic accuracy in a total of 253 lesions in 78 patients, compared with [18F]FDG PET/CT, [99mTc]Tc-FAPI SPECT/CT demonstrated a higher sensitivity (100% [15 of 15 lesions] vs. 20% [3 of 15]; P < 0.001), accuracy (100% [48 of 48 lesions] vs. 75% [36 of 48];P < 0.001), and negative predictive value (100% [33 of 33 lesions] vs. 69% [36 of 48 lesions]; P = 0 0.001) in detecting peritoneal spread, and a higher sensitivity (85% [17 of 20 lesions] vs. 50% [10 of 20]; P = 0.041) in detecting liver metastases. …”
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Development and validation of a multidisciplinary risk assessment scale for immune checkpoint inhibitor-associated myocarditis by Yanan DAI, Yuan LIU, Yuchen XU, Qingqing CAI, Yan WANG, Yuhong ZHOU, Leilei CHENG, Junbo GE

“…The association between pretictive risk stratifications and actual assessment results was assessed using the Cox proportional hazards regression model. The predictive value of the scale for ICI-associated myocarditis was evaluated using receiver operating characteristic (ROC) curve. …”
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The novel triglyceride‒glucose-weighted adjusted waist index as a supplementary diagnostic tool for heart failure: evidence of improved reclassification beyond traditional TyG-rela... by Yuqin Fan, Dan Ye, Kebin Zhou, Lu Cai, Longhui Yu

“…However, further validation in large-scale prospective cohorts is warranted to confirm its long-term predictive value and generalizability across diverse populations. …”
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PLAGL2 as a prognostic biomarker and an EMT-promoting factor in PDAC by Yan-Hui Yang, Hao Wang, Zhe-Hua Xing, Qian-Qian Bai, Wei-Feng Liu, Da-Huan Li, Chi Zhang, Shu-Min Zhang, Fang-Fei Liu, Yu-Bo Liu, Hua Fan

“…We subsequently examined the expression of PLAGL2 via immunohistochemistry and PCR in PDAC tumor tissue samples from our hospital, explored the relationships between PLAGL2 expression and clinical features, and evaluated the predictive value of PLAGL2 for the survival of PDAC patients. we investigated the effect of PLAGL2 on the epithelial‒mesenchymal transition (EMT) process by examining its association with the expression of EMT-related proteins. …”
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Define a good prognosis of RNF43 codon 659-mutated and concomitant genomic signatures in CRC: an analysis of the cBioPortal database by Feng Wang, Li Lin, Zhongkang Li, Lei Qin, Shuai Zhang, Xueqing Hu, Yunbo Zhao, Yingying Huang

“…All mutation data were filtered by the 1021-panel (Geneplus-Beijing, China), and the processed data were used to analyze the predictive value of RNF43-mutated to OS and concomitant co-mutations. …”
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Redefining the role of IL-18 in post-surgical recovery and sepsis: a key mediator of inflammation resolution by Ioanna Papatheodorou, Gabriela Blažková, Veronika Bosáková, Zuzana Tomášiková, Erin Spearing, Robin Klieber, Pavel Ostašov, Julie Štíchová, Martina Dvončová, Alexandra Mýtniková, Jan Emmer, Kamila Bendíčková, Tomáš Tomáš, Vladimír Šrámek, Petros Kolovos, Monika Holubová, Martin Helán, Marcela Vlková, Jan Frič, Marcela Hortová-Kohoutková

“…Finally, TNF-α/IL-18 ratio showed a high predictive value of clinical severity in septic patients. …”
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Right ventricular dysfunction for prediction of long‐term recovery in de novo HFrEF : a PROLONG‐II substudy by Aiste Monika Jakstaite, Johanna Mueller‐Leisse, Henrike A.K. Hillmann, Stephan Hohmann, Jörg Eiringhaus, Udo Bavendiek, Tibor Kempf, Christian Veltmann, Johann Bauersachs, David Duncker, D. Berliner

“…Abstract Aims To analyse the predictive value of advanced markers of right ventricular (RV) function and RV‐pulmonary arterial (PA) coupling in forecasting long‐term left ventricular (LV) improvement in de novo heart failure with reduced ejection fraction (HFrEF). …”
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Altered albumin/neutrophil to lymphocyte ratio are associated with all-cause and cardiovascular mortality for advanced cardiovascular-kidney-metabolic syndrome by Xiaoshuang Yin, Jinmei Zou, Jing Yang

“…RCS analysis indicated an L-shaped link between ANLR and both ACM and CVM, both before and after PSM (all Pnon-linearity &lt; 0.001). The predictive value of ANLR, NLR, and ALB for CVM and ACM in individuals with advanced CKM syndrome demonstrated that ANLR and NLR exhibited comparable predictive capabilities for both ACM and CVM, outperforming ALB. …”
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Optimasi Convolutional Neural Network Untuk Deteksi Covid-19 pada X-ray Thorax Berbasis Dropout by I Gede Totok Suryawan, I Putu Agus Eka Darma Udayana

“…It proved that when this system was tested with COVID-19 thorax x-ray public database data, the classifier that used this architecture could achieve an accuracy rate of 95.20% followed by precision and recall value reaching 94.80% and 94.80%. respectively and last but not least F-score of 95.18% and Negative Predictive value of 95.60%  It could also save training time up to 62% compared to other deep learning architectures. …”
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Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children. by Ezio Bonifacio, Andreas Beyerlein, Markus Hippich, Christiane Winkler, Kendra Vehik, Michael N Weedon, Michael Laimighofer, Andrew T Hattersley, Jan Krumsiek, Brigitte I Frohnert, Andrea K Steck, William A Hagopian, Jeffrey P Krischer, Åke Lernmark, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Beena Akolkar, Richard A Oram, Stephen S Rich, Anette-G Ziegler, TEDDY Study Group

“…The risk (positive predictive value) for developing multiple islet autoantibodies (pre-symptomatic type 1 diabetes) and type 1 diabetes was determined in 4,543 children who had no first-degree relatives with type 1 diabetes and either a heterozygous HLA DR3 and DR4-DQ8 risk genotype or a homozygous DR4-DQ8 genotype, and in 3,498 of these children in whom genetic scores were calculated from 41 single nucleotide polymorphisms. …”
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Targeting AKR1B1 inhibits metabolic reprogramming to reverse systemic therapy resistance in hepatocellular carcinoma by Qi Wang, Juan Liu, Ming Yang, Jun Zhou, Yaxuan Li, Jingjing Zheng, Hao Jia, Shuhua Yue, Yinpeng Le, Yuxin Su, Wenrui Ma, Ni An, Yunfang Wang, Jiahong Dong

“…The secretory nature of AKR1B1 not only underscores its predictive value but also facilitates the intercellular transmission of drug resistance. …”
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Prognostic impact of type 2 diabetes mellitus and coronary microvascular dysfunction in patients undergoing rotational atherectomy during PCI by Lijun Feng, Yuxuan Zhang, Chenyun Zhang, Zining Chen, Jingnan Pan, Zhiling Gao, Delong Chen, Abuduwufuer Yidilisi, Jiacheng Fang, Yiyue Zheng, Tingting Mei, Jiantao Liu, Jianping Xiang, Jinlong Zhang, Changling Li, Jifang Cheng, Jian’an Wang, Jun jiang, Jian’an Wang

“…Abstract Background The combined predictive value of type 2 diabetes mellitus (T2DM) and coronary microvascular dysfunction (CMD) in rotational atherectomy (RA) patients during the PCI remains unclear. …”
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Diagnostic accuracy of CADe-assisted reading versus clinician reading for polyp detection in colon capsule endoscopy: a multicentre prospective study by Ian Io Lei, Nicolas Parsons, Cristiana Huhulea, Hagen Wenzek, Elizabeth White, Pablo Laiz, Charlie Noble, Alexander Robertson, Anastasios Koulaouzidis, Ramesh Arasaradnam

“…The per-polyp sub-analysis evaluated 1,803 polyps, examining sensitivity, positive predictive value and the impact of different factors on AI-assisted accuracy performance. …”
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Integrated machine learning identifies disulfidptosis-related and ferroptosis-related genes to evaluate survival prognosis and treatment efficacy in kidney renal clear cell carcino... by Yuan Xiang, Zijian Zhou, Tong Mu, Shunyao Zhang, Lei Xie, Yajie Zhou, Wenxiong Zhang, Liuxiang Fu

“…The nomogram with risk score demonstrated significant predictive value than nomogram without the risk score. …”
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Predictive Significance of the Monocyte-to-High-Density Lipoprotein Cholesterol Ratio in Post-Percutaneous Coronary Intervention Contrast-Induced Nephropathy Among Patients with Co... by Lin A, Peng Y, Shao J, Chen L, Lin Y

“…The study used regression analyses to investigate the relationship between MHR and CIN rate and postoperative mortality, and demonstrated the cumulative incidence of postoperative fatal events in the three groups of patients by Kaplan-Meier curves, and also analyzed the predictive value of MHR and other inflammatory indicators on the risk of CIN by using receiver operating characteristic (ROC) curves.Results: Compared to Group 1, Groups 2 and 3 had a higher incidence of CIN, higher mortality, and longer hospital stays (P &lt; 0.001). …”
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DDAH1 Promotes Cisplatin Chemoresistance in Patients with Locally Advanced Nasopharyngeal Carcinoma via the EGFR‐JAK2‐STAT3 Pathway by Jin‐Hao Yang, Li Yuan, Qiu‐Yan Chen, Kai‐Qi Lan, Liang‐Ji Li, Yu‐Chen Li, Xiao‐Yun Li, Xue‐Song Sun, Lin‐Quan Tang, Sai‐Lan Liu, Hai‐Qiang Mai

“…To explore the regulatory mechanism and biological function of DDAH1 in cisplatin chemoresistance, NPC cell lines are subjected to overexpression and knockdown of DDAH1 in vitro, with findings further corroborated by in vivo chemosensitivity assays. The predictive value of DDAH1 expression is evaluated for survival and resistance to cisplatin‐based IC in a cohort of 339 patients with LANPC. …”
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Association between various insulin resistance surrogates and gallstone disease based on national health and nutrition examination survey by Rui Gong, Yuchen Ding, Kaiqi Yang, Xiaodie Meng, Xiujing Sun

“…The present study was designed to investigate the correlation between these novel IR surrogates and the risk of developing GSD and to explore the index with the best predictive value. We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey 2017-March 2020. …”
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Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome by Valeria Pergola, Dan-Alexandru Cozac, Maria Teresa Savo, Saima Mushtaq, Raffaella Motta, Roberto Pedrinelli, Pasquale Perrone-Filardi, Gianfranco Sinagra, Morena De Amicis, Maria Vittoria Chiaruttini, Gabriele Cordoni, Giulia Lorenzoni, Giuseppe Tarantini, Gino Gerosa, Dario Gregori, Giorgio De Conti, Domenico Corrado, Gianluca Pontone

“…Multivariate Cox models evaluated the predictive value of severe MAC alongside other significant variables. …”
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Association of Soluble Immune Checkpoint Molecules PD1 and 4‐1BB With CTLA‐4Ig Treatment Response in Early Rheumatoid Arthritis by Tilia Selldén, Kristina Lend, Jon Lampa, Merete Lund Hetland, Mikkel Østergaard, Tillmann Uhlig, Dan Nordström, Kim Hørslev‐Petersen, Björn Gudbjörnsson, Gerdur Gröndal, Inger Gjertsson, Ronald vanVollenhoven, Cristina Maglio, Kerstin Andersson, Anna‐Karin Hultgård Ekwall, Anna‐Carin Lundell, Anna Rudin

“…Furthermore, baseline levels of sPD1 or s4‐1BB together with proportions of PD1+ T follicular helper (TFh) cells predicted treatment response to CTLA‐4Ig with MTX after 48 weeks, achieving 90% and 100% positive predictive value, respectively. Conclusion High plasma levels of sPD1 and s4‐1BB are associated with good response to CTLA‐4Ig with MTX therapy in patients with eRA. …”
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Prognostic Value and Correlation Between WT1 Overexpression and NPM1 Mutation in Patients with Acute Myeloblastic Leukemia by LL Girshova, IG Budaeva, EG Ovsyannikova, SO Kuzin, DV Motorin, RSh Badaev, DB Zammoeva, VV Ivanov, KV Bogdanov, OS Pisotskaya, YuV Mirolyubova, TS Nikulina, YuA Alekseeva, AYu Zaritskii

“…The research showed the predictive value of a lower limit level of WT1 on day 28 of treatment (100 per 104 copies ABL), and for the first time, the importance of the early assessment WT1 expression reduction on day 14 of induction therapy.…”
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