Catalyzing early ovarian cancer detection: Platelet RNA-based precision screening by Eunyong Ahn, Se Ik Kim, Sungmin Park, Sarah Kim, Hyejin Lee, Yeochan Kim, Sangick Park, Suyeon Lee, Dong Won Hwang, Heeyeon Kim, HyunA Jo, Untack Cho, Juwon Lee, Cheol Lee, TaeJin Ahn, Yong-Sang Song

“…Here, we proposed our two-step method for assessing the existence of pelvic mass either located at ovaries or uterus with more than 99% specificity by utilizing exon-exon junction features with a sampling invariant normalization technique; then next our model finds the malignancy of detected mass with more than 99% negative predictive value for ovarian cancer to practically assist clinicians’ further investigation via combined features of exon-exon junctions, and hematology parameters. …”
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Atrial Natriuretic Peptide at Discharge as a Predictive Marker for Early Rehospitalization in Patients With Heart Failure With Preserved Ejection Fraction by Junichi Ohno, Kyung‐Duk Min, Isamu Sunayama, Yuki Matsumoto, Aika Daimon, Eri Manabe, Makiko Oboshi, Kohei Azuma, Masataka Sugahara, Akiyo Eguchi, Yoshiro Naito, Masanori Asakura, Masaharu Ishihara

“…This was confirmed in Cox models using log‐transformed standardized ANP (hazard ratio [HR] per SD, 2.01 [95% CI, 1.34–3.02]; P=0.0008) whereas discharge BNP levels showed weaker predictive value. Discharge ANP remained a significant predictor even after adjusting for age, body mass index, or estimated glomerular filtration ratio, whereas discharge BNP did not. …”
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Construction of a predictive model for cerebral small vessel disease MRI burden based on β2-microglobulin and lipoprotein(a) by Xiaoyan LI, Hongge JI, Tingting WANG, Yingying LI, Xijing ZHA, Bin LI, Dan JIANG

“…Objective To construct a predictive model for cerebral small vessel disease (CSVD) MRI burden based on β2-microglobulin (β2-MG) and lipoprotein(a) [Lp(a)], analyze its predictive value, and validate the model. MethodsA total of 138 CSVD patients admitted to Anhui No.2 Provincial People’s Hospital from February 2023 to August 2024 were enrolled. …”
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Prediction of infected pancreatic necrosis in patients with acute necrotizing pancreatitis based on ensemble machine learning model by Zefang Sun, Yan Fu, Jiarong Li, Baiqi Liu, Xiaoyue Hong, Chiayen Lin, Dingcheng Shen, Caihong Ning, Lu Chen, Xiaoping Yi, Gengwen Huang

“…Conclusion The EL model demonstrates superior predictive efficiency for IPN compared to the LR model, offering greater predictive value and potential clinical benefits. Furthermore, the EL model shows stable performance across different stages of IPN onset, enabling clinicians to make timely adjustments to treatment strategies and ultimately improve patient outcomes. …”
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Development of an electrocardiographic prediction model for outflow tract idiopathic premature ventricular contraction with decreased left ventricular ejection fraction by Pinliang Liao, Xiaolian Cai, Wen Zhang, Min Ou, Heling Ren, Maoqin Shu

“…Decision curve analysis (DCA) assessed clinical applicability, and net reclassification improvement (NRI) along with integrated discrimination improvement (IDI) indices were calculated to assess additional predictive value compared with traditional PVC burden. …”
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Statistical analysis and machine learning of TMS-induced MEPs for predicting poststroke motor impairment and performance by Chun-Ren Phang, Shintaro Uehara, Sachiko Kodera, Akiko Yuasa, Shin Kitamura, Yohei Otaka, Akimasa Hirata

“…This study aimed to evaluate the predictive value of inter-trial correlation (ITC), a novel metric reflecting waveform consistency, along with MEP amplitude and resting motor threshold (rMT), in estimating post-stroke motor outcomes. …”
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CYLD as a key regulator of myocardial infarction-to-heart failure transition revealed by multi-omics integration by Jingya Xu, Jingya Xu, Zhonghua Dong, Zhaodong Li, Xuan Wang, Xuan Wang

“…Single-cell transcriptomic analysis demonstrated that CYLD exhibited the strongest correlation with the transition from MI to HF; using random forest modelling, we validated its predictive value in this context.DiscussionIn conclusion, our study identified CYLD as a critical regulator of the transition from MI to HF. …”
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Effect of GLP-1 Receptor Agonists (Liraglutide) on Glycemic Parameters and Circulating miRNA Expression in Type 2 Diabetes Mellitus by Aqeel Meer AL-ZAMILY

“…ROC analysis showed strong diagnostic performance for miRNA-146a (AUC = 0.869) and miRNA-222 (AUC = 0.816), with moderate predictive value for miRNA-21 (AUC = 0.709). Conclusion: Liraglutide displayed significant glycemic control in patients with T2DM. …”
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Effector-Memory γδ T Lymphocytes Predict CMV Disease After the Withdrawal of Prophylaxis in Kidney Transplant Recipients by Yoann Abadie, Jonathan Visentin, Jonathan Visentin, Elodie Wojciechowski, Manon Charrier, Julie Déchanet-Merville, Isabelle Garrigue, Patrick Blanco, Patrick Blanco, Pierre Merville, Pierre Merville, Hannah Kaminski, Hannah Kaminski, Lionel Couzi, Lionel Couzi

“…While no significant association was found in the overall cohort, in R⁺ patients, a count >4.65/mm³ was associated with a 97.7% positive predictive value for protection against CMV disease. Multivariate analysis confirmed its independent association with disease-free survival [HR: 0.27 (95% CI: 0.09–0.85), p = 0.0252]. …”
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Distribution of variants of the <i>TNFA</i> gene regulatory sites among Russian women of Caucasian origin with leiomyoma by V. I. Konenkov, A. V. Shevchenko, V. F. Prokofiev, E. G. Koroleva

“…The diagnostic specificity of this index was 100%, and the predictive value of this quotient reached 13.3, thus implying a 99.9% probability of a correct prediction. …”
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Rapid and actionable nasal-swab screening supports antimicrobial stewardship in patients with pneumonia: a prospective study by Siyao Chen, Yuanyuan Xiao, Caixia Tan, Juan Zhou, Ting Liu, Sisi Zhang, Yiran Hu, Yang Liu, Ming Zheng, Letao Chen, Xinghui Gao, Yi-Wei Tang, Fred C. Tenover, Anhua Wu, Chunhui Li

“…Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) nasal screening by polymerase chain reaction (PCR) is a rapid diagnostic tool with a high negative predictive value for pneumonia caused by MRSA. MRSA remains an important emerging pathogen in China and at present, there is little published data on the effect of rapid MRSA test results on antibiotic utilization for pneumonia. …”
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Evaluation of the Human Immunodeficiency Virus viral load surveillance system, national perspective in Tanzania: A descriptive cross-sectional study by Peter Richard Torokaa, Loveness John Urio, Ambwene Mwakalobo, Alex Sifaeli Magesa, James Njoroge Allan, David John Osima, Focus Medard Shao, Joseph Mziray, Yulitha Barnabas, Agricola Joachim, Mtebe Majigo

“…The system's sensitivity was 84.4%, with a predictive value positive (PVP) of 52% and a national data accuracy of 97%. …”
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A nomogram for predicting malnutrition risk in patients with chronic heart failure and correlation study between GHRL, MSTN, CRP, Hs-CRP by Yuling Zha, Chengshuai Liu, Yuping Zhou, Miao Kong, Jinlei Liu, Lu Jing, Hailati Gulimila

“…The nomogram developed in this study demonstrated robust predictive value for identifying malnutrition in this population. …”
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Association between international normalized ratio-to-albumin ratio and mortality in critically ill patients with gastrointestinal bleeding: a retrospective MIMIC-IV database study by Xingyi Yang, Shasha Ying, Lihong Lv, Yishu Ji, Jiaqian Ying, Huyan Ke

“…Abstract Background While the international normalized ratio-to-albumin ratio (PTAR) is an established independent prognostic indicator for various diseases, its predictive value for clinical outcomes in critically ill patients with acute gastrointestinal bleeding (GIB) has not been systematically evaluated. …”
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Integrative speckle-tracking echocardiography for the early detection and prediction of cancer therapy–related cardiac dysfunction by Shuo Qiu, Yuxin Zhang, Ying Hou, Songhao Chen, Huihui Yu, Han Li, Lianbi Zhao, Xiaofang Zhang, Xi Zhang, Jiahan Liu, Changyang Xing, Yunyou Duan, Lijun Yuan

“…The relative changes of GLS, LASr, GWI at T1 were identified as predictors of CTRCD, with improved predictive value when combined together. Conclusion Not only the GLS, but also the LASr and myocardial work indices were significantly impaired just after one cycle therapy of anthracycline. …”
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Serum cytokine levels in children with community-acquired pneumonia caused by different respiratory pathogens by Yuanhui Duan, Yuexu Ou, Jieling Li, Xiaoming Gan, Jie Cao

“…Abstract Background Our study aims to investigate the levels of serum cytokines in children with community-acquired pneumonia (CAP) caused by different respiratory pathogens, and evaluate the predictive value of cytokines levels for severe pneumonia. …”
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Association of Heart Rate Variability with the Psychosocial Stress Level in Men 41-44 Years Old Living in Moscow by O. M. Drapkina, V. B. Rozanov, A. V. Kontsevaya, O. Yu. Isaykina, G. A. Muromtseva, M. B. Kotova, E. S. Akarachkova

“…The results of correlation and multiple regression analysis confirmed that these HRV indicators are statistically significantly associated not only with PS, but also with other indicators (age, waist / hip ratio, diastolic blood pressure). However, their predictive value turned out to be low, and the proportion of the explained variance of HRV indices ranged from 2.5 to 13.1%.Conclusion. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

“…The five identified sepsis-related genes have predictive value in assessing sepsis risk. Insights into the interactions between key genes and immune cell populations may contribute to improved clinical management of sepsis.Keywords: GEO, immune cell infiltration, key genes, nomogram, sepsis…”
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Clinical and dynamic circulating cytokines profile features of long-term progression-free survival benefit to immune checkpoint inhibitors in advanced non–small cell lung cancer by Jia-Yi Deng, Ming Gao, Xue Fan, Hong-Hong Yan, Wei-Chi Luo, Ming-Yi Yang, Xiao-Rong Yang, Zhi-Hong Chen, Chong-Rui Xu, Qing Zhou

“…Methods Advanced NSCLC patients receiving first-line ICIs monotherapy at Guangdong Lung Cancer Institute between December 2017 and August 2022 were identified. Predictive value of different characteristics was evaluated in LTPFS (PFS ≥ 24 months) compared with short-term PFS (STPFS, PFS ≤ 3 months). …”
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Metabolic syndrome with mortality and major adverse cardiovascular events in an elderly population by Shailendra Kumar Karn, Fang Zhao, Yawei Xu, Yi Zhang, Chunlai Zeng, Imran Ibrahim Shaikh, Shekhar Singh, Yuling Feng, Yuling Feng

“…Among the individual components of MS, the combination of central obesity, hypertension, and hyperglycemia (ABD+BP+GLU) showed the strongest predictive value for MACE (HR 3.001, 95% CI 1.640–5.492, p&lt;0.001).ConclusionsMS is an independent predictor of MACE in elderly populations, with central obesity, hypertension, and hyperglycemia being the most critical risk factors. …”
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