Development and validation of a nomogram model for sleep disorders in patients with recurrent implantation failure based on physiological and lifestyle factors by You Zhang, Ningxin Qin, Jing Hu, Jie Bai, Mengjia Pan, Yan Xu, Xin Huang, Ke Wang, Ke Wang

“…The predictors include both physiological indicators and daily lifestyle habits, demonstrating significant predictive value and clinical application efficiency. It can be used for early identification of potential sleep disorders in RIF patients, providing certain reference significance for clinical work.…”
Get full text

Membrane transporter genes predict chemoradiotherapy response in patients with cervical cancer by Natália Gregório Custódio, Fábio Ribeiro Queiroz, Angelo Borges de Melo Neto, Brenda Martins Cavalcante, Laurence Rodrigues do Amaral, Telma Maria Rossi de Figueiredo Franco, Matheus de Souza Gomes, Vasco Ariston de Carvalho Azevedo, Letícia da Conceição Braga, Paulo Guilherme de Oliveira Salles, Wander de Jesus Jeremias

“…Conclusion: Our results strongly suggest the presence of a candidate gene signature comprising ATP1B3 and SLCO1B3 that holds predictive value for chemoradiotherapy response in cervical cancer.…”
Get full text

Early Postoperative Increase in Transforming Growth Factor Beta-1 Predicts Microvascular Flap Loss in Reconstructive Surgery: A Prospective Cohort Study by Rihards Peteris Rocans, Janis Zarins, Evita Bine, Insana Mahauri, Renars Deksnis, Margarita Citovica, Simona Donina, Sabine Gravelsina, Anda Vilmane, Santa Rasa-Dzelzkaleja, Olegs Sabelnikovs, Biruta Mamaja

“…We aimed to investigate the predictive value of postoperative changes in transforming growth factor beta-1 (TGF-β1) for microvascular flap complications. …”
Get full text

Developing an electronic surprise question to predict end-of-life prognosis in a prospective cohort study of acute hospital admissions by Baldev Singh, Nisha Kumari-Dewat, Adam Ryder, Vijay Klaire, Hannah Jennens, Kamran Ahmed, Mona Sidhu, Ananth Viswanath, Emma Parry

“…For the GSFSQ-No classification, the mortality odds ratio was 12.4 (11.4–13.5) (p<0.001) vs GSFSQ-Yes (c-statistic 0.72 (0.70–0.73), p<0.001; accuracy, positive and negative predictive values 81.2%, 83.6%, 83.6%, respectively). Had the tool been utilised at the time of admission, the potential to reduce possibly avoidable subsequent hospital admissions, death-in-hospital and bed days was significant (p<0.001). …”
Get full text

Assessment of Long-Read Sequencing-Based Congenital Adrenal Hyperplasia Genotyping Assay for Newborns in Fujian, China by Xudong Wang, Xingxiu Lu, Faming Zheng, Kun Lin, Minjuan Liao, Yi Dong, Tiantian Chen, Ying He, Mei Lu, Jing Chen, Yanfang Li, Yulin Zhou

“…Finally, 66 neonates were diagnosed with CAH, with a positive predictive value of 28.82%. Based on this data, the overall prevalence of CAH in Fujian was estimated to be 1:26,883. …”
Get full text

Risk factors of bone metastasis in lung adenocarcinoma by Zhongnian Cao, Rong Zheng, Jing Li, Xuejuan Wang, Chao Ding, Fan Zhang, Jianhua Geng, Zhengmao Wei, Rong Fan

“…A receiver operating characteristic curve was used to verify the predictive value of the regression model, and the area under the curve was 0.912 (P < 0.001). …”
Get full text

Foreword

“…“Comparative Analysis of Historic Grade 1 Korean Textbooks at the Moscow Institute of Oriental Studies” contrasts materials from pre- and post-liberation periods, highlighting differences in pedagogy, orthography, and linguistic content, and underscoring their historical and educational value. Editors and Editorial Board invite the regular and new readers to engage with the content, to question, challenge, and reflect. …”
Get full text

Quality and content evaluation of thyroid eye disease treatment information on TikTok and Bilibili by Haisheng Wang, Huahong Zhang, Jiamin Cao, Feng Zhang, Wei Xiong

“…Quality, reliability, and educational value were assessed using the Global Quality Score (GQS), modified DISCERN (mDISCERN), Patient Education Materials Assessment Tool (PEMAT), and Journal of the American Medical Association (JAMA) benchmark criteria. …”
Get full text

Validating social media data reliability for cultural ecosystem services mapping in data-scarce GIAHS: A mixed-methods approach in hani rice Terraces by Luying Yang, Yanbo Li, Xiaoyan Wei

“…The results show that: (1) Among the places identified as possessing CESs via questionnaire method, 90 % of places with aesthetic value (AV), 90 % of places with cultural heritage value (CHV), 91 % places with cultural diversity value (CDV), and 80 % of places with scientific &amp; educational value (SEV) were also identified using social media data. …”
Get full text

Lessons from the Frontline: A Phenomenological Study into Faculty Members’ Experiences with Challenges of Remote Online Exams in Medical Sciences Universities by Mostafa Hadavinejad, Mahdieh Azin, Asieh Fatemidokht, Jalal Hassanshahi, Afsaneh Amiri Khorasani, Foad Iranmanesh

“…While online assessments can improve logistical efficiency and reduce certain stressors, ongoing concerns about academic integrity, technical preparedness, and educational value persist. Addressing these issues requires investment in reliable infrastructure, comprehensive faculty training, and innovative valid assessment methods.…”
Get full text

Association of Inflammatory and Metabolic Markers with Mortality in Patients with Postoperative Femur Fractures in the Intensive Care Unit by Metin Kilinc, Enes Çelik, Ibrahim Demir, Semih Aydemir, Hakan Akelma

“…Linear regression, logistic regression, and Receiver Operating Characteristic (ROC) analyses were performed to determine the predictive value of these markers for ICU mortality. <i>Results</i>: The mean age of the patients was 76.3 ± 9.6 years, and 52.1% were female. …”
Get full text

Construction of a predictive model for cerebral small vessel disease MRI burden based on β2-microglobulin and lipoprotein(a) by Xiaoyan LI, Hongge JI, Tingting WANG, Yingying LI, Xijing ZHA, Bin LI, Dan JIANG

“…Objective To construct a predictive model for cerebral small vessel disease (CSVD) MRI burden based on β2-microglobulin (β2-MG) and lipoprotein(a) [Lp(a)], analyze its predictive value, and validate the model. MethodsA total of 138 CSVD patients admitted to Anhui No.2 Provincial People’s Hospital from February 2023 to August 2024 were enrolled. …”
Get full text

Comparing the Diagnostic Efficacy of Different Calcitonin Stimulation Tests for Sporadic Medullary Thyroid Carcinoma: Calcium Gluconate vs. Calcium Chloride by Jovan Ilic, Katarina Tausanovic, Goran Zoric, Milan Jovanovic, Matija Buzejic, Sara Ivanis, Milan Parezanovic, Milan Marinkovic, Nemanja Karamarkovic, Ana Petakov, Vladan Zivaljevic

“…Lower thresholds (388.4 pg/mL for CG and 431.5 pg/mL for CC) improved sensitivity (≥76.9%) and negative predictive value (>91%). <b>Conclusions:</b> Calcium stimulation testing improves MTC detection in patients with moderate bCt elevation. …”
Get full text

Preoperative imaging and intraoperative navigation of the parathyroid glands neoplasms in primary hyperparathyroidism by K. Yu. Slashchuk, M. V. Degtyarev, P. O. Rumyantsev, A. K. Eremkina, N. V. Tarbaeva, D. G. Beltsevich, I. V. Kim, G. A. Melnicthhenko, N. G. Mokrysheva

“…As a result of the analysis of the diagnostic accuracy, for a combination of ultrasound and SPECT/CT with augmented contrast enhanced CT, the overall accuracy in visualizing of parathyroid glands was 99 % (95 % confidence interval (CI): 97–100), diagnostic specificity 77 % (95 % CI: 54–100), sensitivity 100 % (95 % CI: 98–100), the predictive value of positive and negative results was 98 % (95 % CI: 97–100) and 100 % (95 % CI: 98–100) respectively.Conclusion. …”
Get full text

Validation of an Automated High-Throughput Multiplex Real-Time PCR Assay for Detection of Enteric Protozoa by Rachel Lau, Jason Kwan, Kimberley Marks-Beaubrun, Ruben Cudiamat, Min Qun Ellen Chen, Krista Orejana, Filip Ralevski, Andrea K. Boggild

“…<b>Results</b>: Among 461 unpreserved fecal specimens, sensitivity, specificity, positive predictive and negative predictive values of the enteric multiplex for fresh specimens were as follows: 93%, 98.3%, 85.1%, 99.3% for Bh; 100% for all measures in <i>Cryptosporidium</i> and Cc; 100%, 99.3%, 88.5%, 100% for Df; 33.3%, 100%, 100%, 99.6% for Eh; and 100%, 98.9%, 68.8%, 100% for Gl, respectively. …”
Get full text

Development of an electrocardiographic prediction model for outflow tract idiopathic premature ventricular contraction with decreased left ventricular ejection fraction by Pinliang Liao, Xiaolian Cai, Wen Zhang, Min Ou, Heling Ren, Maoqin Shu

“…Decision curve analysis (DCA) assessed clinical applicability, and net reclassification improvement (NRI) along with integrated discrimination improvement (IDI) indices were calculated to assess additional predictive value compared with traditional PVC burden. …”
Get full text

Improving prediction accuracy of hospital arrival vital signs using a multi-output machine learning model: a retrospective study of JSAS-registry data by Yasuyuki Kawai, Koji Yamamoto, Keisuke Tsuruta, Keita Miyazaki, Hideki Asai, Hidetada Fukushima

“…Model performance was assessed by comparing the predicted values with the actual hospital arrival measurements using mean absolute error, R² score, residual standard deviation, and Spearman’s correlation coefficient. …”
Get full text

A predictive model for WHO/ISUP pathologic grading of renal clear cell carcinoma based on CT radiomics: a multicenter study by Chunying Wu, Yuzhen Xi, Juanjuan Hu, Guodong Li, Xu Wang, Xiaofei Jiao, Zhongxiang Ding, Weiying Sun

“…Abstract Objective This study aims to evaluate the predictive value of CT radiomics combined with clinical-imaging features for the WHO/ISUP pathological grade of clear cell renal cell carcinoma(ccRCC). …”
Get full text

Effect of GLP-1 Receptor Agonists (Liraglutide) on Glycemic Parameters and Circulating miRNA Expression in Type 2 Diabetes Mellitus by Aqeel Meer AL-ZAMILY

“…ROC analysis showed strong diagnostic performance for miRNA-146a (AUC = 0.869) and miRNA-222 (AUC = 0.816), with moderate predictive value for miRNA-21 (AUC = 0.709). Conclusion: Liraglutide displayed significant glycemic control in patients with T2DM. …”
Get full text

Distribution of variants of the <i>TNFA</i> gene regulatory sites among Russian women of Caucasian origin with leiomyoma by V. I. Konenkov, A. V. Shevchenko, V. F. Prokofiev, E. G. Koroleva

“…The diagnostic specificity of this index was 100%, and the predictive value of this quotient reached 13.3, thus implying a 99.9% probability of a correct prediction. …”
Get full text