Prognostic and functional role of PPAR-alpha and SNP receptor (Leu162Val) in acute coronary syndrome: a potential novel target by Abdullah Abdulsattar Raeef, Hassan H. Al-Saeed, Sami Mekhlif Mishlish

“…ROC analysis identified CK-MB, and hs-CRP as optimal biomarkers for ACS diagnosis; PPARα showed good predictive value. The study also found that the dominant genotype (CC) represented a small percentage of the patient samples while the homozygotes (CG) and the recessive (GG) represented the highest percentage, unlike the healthy group. …”
Get full text

MODERN APPROACHES TO CLINICAL AND LABORATORY DIAGNOSTICS OF RHEUMATOID ARTHRITIS EARLY ONSET by D. G. Rekalov, S. Y. Dotsenko, A. V. Kylinich

“…It was shown prognostic value of the main serological markers of RA, and the predictive value for early detection of antibodies to the circulating peptide as a marker of the severity of bone-destructive changes in patients with certain clinical manifestations. …”
Get full text

Analysis of peripheral blood variables in evaluation and prediction of adverse outcomes with hypertensive disorders of pregnancy by Yingdi Jiang, Lu Dai, Jiang Lin, Yanjie Zhou

“…The ROC curves demonstrated that combining GA with NT-proBNP, LDH, and PDW provided stronger predictive value for adverse outcomes. Furthermore, the nomogram's calibration curve indicated excellent model calibration. …”
Get full text

Establishment of a Generalizable Industrial Crop Model for Microwave Extraction of Unsaturated Fatty Acids by Junyi Chen, Didi Lu, Shiqiang Chen, Song Liu, Yaqiu Zhang, Conghong Zhan

“…The stability and accuracy of the model were verified by the orthogonal experiment of UFA extraction from rice, and the correlation coefficient between the predicted value and the actual value of the orthogonal experiment was 0.9998. …”
Get full text

Value of Contrast-Enhanced Ultrasound in Adjusting the Classification of Chinese-TIRADS 4 Nodules by Hong Cheng, Shuang-Shuang Zhuo, Xin Rong, Ting-Yue Qi, Hong-Guang Sun, Xiao Xiao, Wen Zhang, Hai-Yan Cao, Lin-Hai Zhu, Lei Wang

“…The sensitivity, specificity, accuracy, and positive and negative predictive values of the C-TIRADS classification for the diagnosis of thyroid nodule malignancy before the adjustment based on the CEUS results were 83.6%, 63.8%, 74.4%, 72.7%, and 77.1%, respectively, and these values were 91.0%, 82.8%, 87.2%, 85.9%, and 88.9%, respectively, after the adjustment. …”
Get full text

FAM111B and FANCD2, a dual expression signature, defines a distinct phenotype of pancreatic cancer by Fang Wei, Wanying Li, Ting Zhou, Lijuan Feng, Xianglin Yuan, Lihong Zhang

“…Results Our results indicate that expression of FAM111B and FANCD2 is correlated in human PC tissues and comprises a dual expression signature with predictive value for the prognosis of PC. Using information in public databases, we confirmed the oncogenic relevance of FAM111B and FANCD2 in PC and identified a positive correlation between FAM111B, FANCD2, TP53 and KRAS.FAM111B and FANCD2 jointly regulate ferroptosis, mitotic nuclear division, and nuclear division pathways. …”
Get full text

Performance measures of the medical priority dispatch system in an urban basic life support system by Vittorio Nicoletta, Maxime Robitaille-Fortin, Valérie Bélanger, Éric Mercier, Jessica Harrisson

“…We assessed system performance using sensitivity, specificity, overtriage, undertriage, predictive values, and accuracy. Statistical analyses included chi-square tests for priority consistency and pairwise t-tests for performance changes over time. …”
Get full text

Predictive role of cystatin C and increased proteinuria in early assessment of acute renal toxicity in patient poisoned by nephrotoxic drugs and poisons by Esam Mohammed Abdallah Ali, Emad Ahmad Mohamad Yousef, Maha Abd El-Hamed Helal, Mohammed Hamdi Mohammed, Meray Medhat Shokry Zaghary, Marwa Ahmed Hasb Elnabi

“…Cystatin C had the highest predictive value (AUC = 0.993), while proteinuria ACR and day 2 serum creatinine showed significant predictive capabilities (AUCs of 0.805 and 0.873, respectively). …”
Get full text

Prospects of application of artificial neural networks for forecasting of cargo transportation volume in transport systems by D. T. Yakupov, O. N. Rozhko

“…The neural network model consists of a hidden layer of neurons with a sigmoidal activation function and an output neuron with a linear activation function, the input values of the dynamic time series, and the predicted value is removed from the output. For a more objective assessment of the prospects of the ANN application, the results of the forecast are presented in comparison with the results obtained in predicting the method of exponential smoothing.Results. …”
Get full text

Global, regional, and national burden of knee osteoarthritis: findings from the Global Burden of Disease study 2021 and projections to 2045 by Yi Ouyang, Miaomiao Dai

“…Notably, the case number of these metrics were predicted to keeping increasing, with predicted values of 658,088,384.48 (322,110,040.98–994,066,727.98), 47,256,502.97 (23,440,017.7–71,072,988.23) and 20,517,479.78 (10,056,930.68–30,978,028.88), respectively. …”
Get full text

Peripheral blood markers predict prognosis and irAEs of stage IV driver gene-negative lung adenocarcinoma treated with ICIs by Yu Li, Lei Cao, Lei Liu, Yawen Ding, Feng Cao

“…Additionally, we assessed the predictive value of peripheral blood markers for irAEs using logistic regression models.ResultsThe 1-, 3-, and 5-year PFS rates for the cohort of 102 patients were recorded at 35.3%, 3.9%, and 0%, respectively; similarly, the OS rates at these time points were observed to be 66.7%, 8.8%, and 2.9%. …”
Get full text

Comparative analysis of 16 baseline obesity and lipid-related indices for cardiovascular disease risk prediction in adults with cardiovascular-kidney-metabolic syndrome stages 0–3:... by Yilin Pan, Beibei Du, Long Feng, Jingru Bi

“…Abstract Objective In the context of the newly defined cardiovascular-kidney-metabolic (CKM) syndrome, this study aimed to systematically compare the predictive value of 16 different obesity- and lipid-related indices for new-onset cardiovascular disease (CVD) in a population with CKM stages 0–3. …”
Get full text

EFFECT IMBALANCE AQUEOUS BODY FLUIDS, AND RENAL DYSFUNCTION, CARDIOVASCULAR SURVIVAL IN PATIENTS AFTER AN ACUTE CORONARY SYNDROME, MYOCARDIAL REVASCULARIZATION by E. S. Levitskaya, M. M. Batiushin, E. O. Golovinova, V. V. Gul’chenko, A. V. Khripun

“…The study demonstrated the predictive value to stratify cardiovascular disease risk, not only the presence of albuminuria, but its level and value of GFR less than 60 mL/min/1,73m2. …”
Get full text

Evaluating breast cancer screening performance without registries using medico-administrative data by Emilien Jemelen, Francisco Orchard, William Madie, Bernard Valentin, Josine Belin, Enora Laas, Guillaume Jeannerod, Pierre Mares, Sandrine Katsahian, Agathe Guilloux

“…Key performance indicators for digital mammography include sensitivity (SE), positive predictive value (PPV), interval cancer rate (ICR) and cancer detection rate (CDR). …”
Get full text

Comparative Study on Total Organic Carbon Content Logging Prediction Method Based on Machine Learning by TANG Shengshou, YANG Bin, JIN Jiulong, LIU Hongrui, DAI Xingyu, PU Jincheng

“…The analysis of the practical application effect showed that the conventional Δlog R method had poor accuracy in calculating the total organic carbon content and could not achieve the expected effect. The predicted value of the XGBoost prediction model is in the best agreement with the measured value and has the highest reliability. …”
Get full text

The role of molecular diagnostics in the choice of therapy for biliary tract cancers by N. V. Mitiushkina, E. N. Imyanitov

“…Although a significant part of the above-mentioned disorders can be detected by traditional molecular biological approaches such as PCR, IHC, FISH and Sanger sequencing, a comprehensive analysis of all molecular markers of predictive value in biliary tract tumors is difficult to perform without the help of next-generation sequencing (NGS). …”
Get full text

Prospective validation of an artificial intelligence assessment in a cohort of applicants seeking financial compensation for asbestosis (PROSBEST) by Illaa Smesseim, Kevin B. W. Groot Lipman, Stefano Trebeschi, Martijn M. Stuiver, Renaud Tissier, Jacobus A. Burgers, Cornedine J. de Gooijer

“…Secondary objectives included evaluating specificity, accuracy, predictive values, area under the curve of the receiver operating characteristic (ROC-AUC), area under the precision-recall curve (PR-AUC), and interobserver variability. …”
Get full text

Construction and validation of a prognostic prediction model for osteosarcoma in children based on the SEER database by ZHANG Lei, LI Yuwan, WU Yindan, XU Zhi, SHAO Jinfu

“…The calibration curve showed that the predicted values were highly consistent with the observed values. …”
Get full text

External validation of precisebreast, a digital prognostic test for predicting breast cancer recurrence, in an early-stage cohort from the Netherlands by Pieter J. Westenend, Claudia Meurs, Gerardo Fernandez, Marcel Prastawa, Abishek Sainath Madduri, Aaron Feliz, Juan Carlos Mejias, Alexander Shtabsky, Xiaozhu Zhang, Brandon Veremis, Rebecca DeAngel, Michael J. Donovan

“…Model performance was assessed by AUC/C-index, hazard ratios, sensitivity, specificity, and negative and positive predictive values (NPV and PPV, respectively). Results PDxBR showed prognostic accuracy in this external cohort (AUC/C-index 0.71, 95% CI: 0.66–0.75). …”
Get full text

Identification and validation of ubiquitination-related genes for predicting cervical cancer outcome by Ge Jin, Xiaomei Fan, Xiaoliang Liang, Honghong Dai, Jun Wang

“…The validated risk model demonstrates strong predictive value for patient survival. These findings provide crucial insights into the role of ubiquitination in CC pathogenesis and offer valuable targets for advancing future research and therapeutic strategies.…”
Get full text