Rising prevalence of Plasmodium falciparum Artemisinin partial resistance mutations in Ethiopia by Bokretsion G. Brhane, Abebe A. Fola, Helen Nigussie, Alec Leonetti, Moges Kassa, Henok Hailgiorgis, Yonas Wuletaw, Adugna Abera, Hussein Mohammed, Heven Sime, Abeba G/Tsadik, Gudissa Assefa, Hiwot Solomon, Geremew Tasew, Getachew Tollera, Mesay Hailu, Jonathan J. Juliano, Ashenafi Assefa, Jonathan B. Parr, Jeffrey A. Bailey

“…Additionally, polymorphisms associated with resistance to partner drugs, including those in crt, mdr1, dhps, and dhfr genes, are nearly fixed. Most samples (87.2%) consist of monogenomic infections (COI = 1), and mutant parasites show high local genetic relatedness at the health facility level, suggesting clonal transmission. …”
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