Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…WWP1 overexpression in AML confers a proliferative advantage to leukemic blasts (abnormal immature white blood cells) and counteracts apoptotic cell death and differentiation. …”
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Alternative psychopharmacologic treatments for pediatric catatonia: a retrospective analysis by Joshua R. Smith, Joshua R. Smith, Isaac Baldwin, Tasia York, Carina Anderson, Trey McGonigle, Simon Vandekar, Lee Wachtel, James Luccarelli, James Luccarelli

“…A retrospective clinical global impressions-improvement (CGI-I) score was assigned by four authors.Results102 pediatric patients diagnosed with catatonia were identified, and 31 met criteria for the study. 20 (65%) were white, 6 (19%) were Black, 4 (13%) were Hispanic, and 1 (3%) were Indian. …”
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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

“…Additional MOG binding of antibodies does not affect peripheral biodistribution but alters brain distribution to white matter localization and less neuronal internalization. …”
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Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections by Ryosuke Yamamura, Yu Nagayoshi, Kayo Nishiguchi, Hitomi Kaneko, Keiichi Yamamoto, Koki Matsushita, Miho Shimamura, Akihiro Kunisawa, Korin Sakakida, Takeshi Chujo, Masataka Adachi, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masashi Mukoyama, Kazuhito Tomizawa

“…Lastly, clinical studies using urine samples from febrile patients revealed significantly elevated levels of m2A during bacterial infections, and these values did not correlate with inflammation severity markers, such as white blood count (WBC) and C-reactive protein (CRP). …”
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Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

“…Abstract Recombinant human growth hormone (rhGH) therapy is the primary treatment for children born small for gestational age (SGA) who fail to show spontaneous catch-up growth by two or four years. While its effects on white adipose tissue are well-documented, this pilot study aimed to investigate its impact on the lipidome and the thermogenic and endocrine activities of brown adipose tissue (BAT) in SGA children following rhGH treatment. …”
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Testing of Retail Cheese, Butter, Ice Cream, and Other Dairy Products for Highly Pathogenic Avian Influenza in the US by David L. Suarez, Iryna V. Goraichuk, Lindsay Killmaster, Erica Spackman, Nicole J. Clausen, Tristan J. Colonius, Cynthia L. Leonard, Monica L. Metz

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SNP2-Lys-C markers inheritance, genes expression, and the resistance of second-generation Catfish Clarias gariepinus against Aeromonas hydrophila infection by Yudha Hanggara, Alimuddin Alimuddin, Dinar Tri Soelistyowati Tri Soelistyowati, Sri Nuryati

“…The survival of G2 seed correlates with the white blood cell and lysozyme activity, along with an increase in phagocytic activity peaking on the seventh day post-challenge. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

“…For brain volumes, higher FGCRS was associated with greater log-transformed white matter hyperintensities, smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes. …”
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Large-scale analysis highlights obesity as a risk factor for chronic, non-communicable inflammatory diseases by Sadegh Mousavi, Katja Bieber, Henner Zirpel, Artem Vorobyev, Henning Olbrich, Cristian Papara, Cristian Papara, David A. De Luca, David A. De Luca, Diamant Thaci, Enno Schmidt, Gabriele Riemekasten, Peter Lamprecht, Matthias Laudes, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Ralf J. Ludwig, Ralf J. Ludwig

“…In race-stratified analysis, overweight and obesity were linked to a higher risk for seven CIDs in White individuals and to one CID in “Black or African American” individuals.ConclusionOverweight and obesity increase the risk for the majority of CIDs in a sex- and race-specific manner.…”
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Clusterin induced by OPC phagocytosis blocks IL-9 secretion to inhibit myelination in a model of Alzheimer's disease by Rebecca M. Beiter, Tula P. Raghavan, Olivia Suchocki, Hannah E. Ennerfelt, Courtney R. Rivet-Noor, Andrea R. Merchak, Jennifer L. Phillips, Tim Bathe, John R. Lukens, Stefan Prokop, Jeffrey L. Dupree, Alban Gaultier

“…Background: Variants in the CLUSTERIN gene have been identified as a risk factor for late-onset Alzheimer's disease and are linked to decreased white matter integrity in healthy adults. However, the specific role for clusterin in myelin maintenance in the context of Alzheimer's disease remains unclear. …”
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Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis by Cinzia Femiano, Francesca Trojsi, Giuseppina Caiazzo, Mattia Siciliano, Carla Passaniti, Antonio Russo, Alvino Bisecco, Mario Cirillo, Maria Rosaria Monsurrò, Fabrizio Esposito, Gioacchino Tedeschi, Gabriella Santangelo

“…Self-rated Apathy Evaluation Scale (AES) scores and self-rated apathy T-scores of the Frontal Systems Behavior (FrSBe) scale were found inversely correlated to FA measures (p<.05, TFCE corrected) in widespread white matter (WM) areas, including several associative fiber tracts in the frontal, temporal, and parietal lobes. …”
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Consecutive prediction of adverse maternal outcomes of preeclampsia, using the PIERS-ML and fullPIERS models: A multicountry prospective observational study. by Guiyou Yang, Tünde Montgomery-Csobán, Wessel Ganzevoort, Sanne J Gordijn, Kimberley Kavanagh, Paul Murray, Laura A Magee, Henk Groen, Peter von Dadelszen

“…<h4>Methods and findings</h4>This multicountry prospective study used data of 8,843 women (32% white, 30% black, and 26% Asian) with a median age of 31 years. …”
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Association of T3/T4 ratio with inflammatory indicators and all-cause mortality in stroke survivors by Sheng Zhang, Zhongzhou Su, Xianqiang Wen

“…Pearson correlation analysis was used to analyze the correlation between T3/T4 ratio and white blood cell (WBC), Neutrophil-to-Lymphocyte Ratio (NLR), systemic immune-inflammation index (SII) and neutrophil percentage-to-albumin ratio (NPAR). …”
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Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center st... by Shuhei Suzuki, Yoshiyuki Nagumo, Kosuke Kojo, Atsushi Ikeda, Bunpei Isoda, Akane Yamaguchi, Kozaburo Tanuma, Satoshi Nitta, Masanobu Shiga, Takashi Kawahara, Shuya Kandori, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Hiroyuki Nishiyama

“…Sensitivity, specificity, and accuracy rates were calculated based on PDD or white light (WL) findings and pathologic diagnosis. …”
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Investigating the association of traditional and non-traditional tobacco product use with subclinical and clinical cardiovascular disease: The Cross-Cohort Collaboration- Tobacco w... by Erfan Tasdighi, Kunal K. Jha, Zeina A. Dardari, Ngozi Osuji, Tanuja Rajan, Ellen Boakye, Michael E. Hall, Carlos J. Rodriguez, Andrew C. Stokes, Omar El Shahawy, Emelia J. Benjamin, Aruni Bhatnagar, Andrew P. DeFilippis, Michael J. Blaha

“…The total number of participants in the pooled cohort is 322782 (mean age: 59.7 ± 11.8 years) of which 76% are women. White individuals make up the majority (73.1%), although there is good representation of other race and ethnicity groups including African American (15.6%) and Hispanic/Latino individuals (6.4%). …”
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The long-term impact of childhood sexual assault on depression and self-reported mental and physical health by Oluwasegun Akinyemi, Temitope Ogundare, Mojisola Fasokun, Fadeke Ogunyankin, Nkemdirim Ugochukwu, Walia Ajisafe, Seun Ikugbayigbe, Oluebubechukwu Eze, Kakra Hughes, Miriam Michael

“…Sampling weights ensured national representativeness, and robust standard errors accounted for clustering by state.ResultsIn a matched cohort of 15,150 individuals with CSA and 15,150 controls, the CSA group had an average age of 50.3 ± 16.3 years, with most being White (69.3%) and female (76.7%). CSA was significantly associated with an increased risk of depression diagnosis, with a 22.1 percentage-point increase for those with one CSA experience (ATE = 0.221, 95% CI: 0.192–0.250, p &lt; 0.001) and a 24.4 percentage-point increase for those with multiple CSA experiences (ATE = 0.244, 95% CI: 0.222–0.266, p &lt; 0.001). …”
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Evidence linking phthalate exposure to alterations of hematologic parameters in Chinese children: A cross-sectional study by Mei-Ting Wei, Ying Wen, Zhu-Xia Zhang, Xiu-Ju Liu, Feng-Xiang Wei, Wei-Qiang Liu, Li Zhou, Ding-Yan Chen, Yao Yao

“…Nine phthalate metabolites (mPAEs) and four hematologic parameters (white blood cell [WBC] count, red blood cell [RBC] count, hemoglobin [Hb], and platelet [PLT] count) were measured at the same time. …”
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Using photovoice to define “community” in substance use disorder research engaging service users, providers, and policymakers by McGladrey Margaret L, Marisa Booty, Ramona Olvera, Peter Balvanz, Hilary L. Surratt, Shannon Matthews, Susannah Stitzer, Owusua Yamoah, Sylvia Ellison, Kevin Campbell, Amy Farmer, Bethany Gealy, Mike Greenwell, Felicia Harris, Amy Kuntz, Sara Szelagowski, Alexandrea Shouse, Carrie B. Oser

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Study for the Effect on Structure and Properties of Highland Barley Proteins During Stir-frying by HUANG Liang-liang, JIANG Kang-hui, LI Qi, YANG Jie, HU Yun, LI Liang

“…After frying, the protein free sulfhydryl group and disulfide bond in both black and white highland barley were significantly changed (P < 0.05), which increased by 0.04 μmol/g, 0.43 μmol/g, 0.23 μmol/g and 0.31 μmol/g, respectively. …”
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Morphological Comparisons of Adult Worker Bees Developed in Chinese and Italian Honey Bee Combs by Shunhua Yang, Hui Li, Pingqing Wu, Dan Yue, Yulong Guo, Wenzheng Zhao, Kun Dong

“…Additionally, the average body weights of 6-day-old worker bee larvae, white-eyed pupae, adult worker bees, and honey stomachs containing sucrose solution were significantly higher in the treatment group than in the control group. …”
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