Marburg virus reaches Rwanda: how close are we to a vaccine solution? by Olivier Sibomana, Clyde Moono Hakayuwa, Jildas Munyantore

“…Marburg virus disease (MVD) is a highly virulent and often fatal disease caused by the Marburg virus, a member of the Filoviridae family, closely related to the Ebola virus. …”
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Case report: A novel de novo germline loss-of-function mutation in the STAT1 transactivation domain in two Chinese siblings, with the elder sibling presenting with multifocal Bacil... by Qin Ying Lim, Qin Ying Lim, Daniel Leung, Crystal K. Lam, Xingtian Yang, Kai N. Cheong, Kai N. Cheong, Andrew K. H. Yik, Jing Yang, Koon-Wing Chan, Pamela P. W. Lee, Pamela P. W. Lee, Pamela P. W. Lee, Pamela P. W. Lee, Miyuki Tsumura, Elaine Y. L. Au, Jaime S. Rosa Duque, Jaime S. Rosa Duque, Jaime S. Rosa Duque, Satoshi Okada, Yu Lung Lau, Yu Lung Lau, Yu Lung Lau

“…Individuals with autosomal dominant STAT1 deficiency are more susceptible to intracellular bacteria, the hallmark of which is Mendelian susceptibility to mycobacterial diseases (MSMDs) that are associated with increased risks of invasive disease by weakly virulent mycobacteria. We report a novel de novo heterozygous missense mutation in exon 23 of the STAT1 gene (NM_007315.4):c.2129C>T(p.Ser710Phe) (S710F), located in the transactivation domain (TAD) for two Chinese siblings, whereby the index patient presented with multifocal osteomyelitis after Bacillus Calmette–Guerin (BCG) vaccine, while the younger sibling was spared the infection, as BCG vaccination was withheld at birth. …”
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Lornoxicam Side Effects May Lead to Surgical Mismanagement, in Case of Postoperative Intra-Abdominal Collection: A Case Report and Literature Review by Mohammad Bukhetan Alharbi

“…We initially suspected infection caused by a highly virulent type of bacteria and planned to perform percutaneous drainage. …”
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Drug Target Identification and Prioritization for Treatment of Ovine Foot Rot: An In Silico Approach by Abhishek Acharya, Lalit C. Garg

“…Ovine foot rot is an infection of the feet of sheep, mainly caused by Dichelobacter nodosus. In its virulent form, it is highly contagious and debilitating, causing significant losses in the form of decline in wool growth and quality and poor fertility. …”
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Progress in Oral Vaccination against Tuberculosis in Its Main Wildlife Reservoir in Iberia, the Eurasian Wild Boar by Beatriz Beltrán-Beck, Cristina Ballesteros, Joaquín Vicente, José de la Fuente, Christian Gortázar

“…Oral vaccination with BCG in captive wild boar has shown to be safe with significant levels of protection against challenge with virulent M. bovis. An oral vaccination with a new heat-killed M. bovis vaccine conferred a protection similar to BCG. …”
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Phytosynthesized Nanoparticles as Novel Antifungal Agent for Sustainable Agriculture: A Mechanistic Approach, Current Advances, and Future Directions by Javeria Parveen, Tahira Sultana, Abeer Kazmi, Khafsa Malik, Abd Ullah, Amir Ali, Bushra Qayyum, Naveed Iqbal Raja, Zia-ur-Rehman Mashwani, Saif Ur Rehman

“…Due to rapidly changing environmental conditions, virulent pathogens have arisen continuously that invades the crops and badly affects their yield and quality of the cash crops which results in economic losses. …”
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Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes by Wanyi Huang, Wei He, Yue Huang, Yongping Tang, Ming Chen, Lianbei Sun, Zuwei Yang, Tianyi Hou, Huimin Liu, Haoyu Chen, Tianpeng Wang, Na Li, Yaqiong Guo, Lihua Xiao, Yaoyu Feng

“…Deletion of the MEDLE genes significantly reduces the growth and pathogenicity of a virulent strain in mice. Co-infection of two fluorescence-tagged C. hominis subtypes produces bicolored oocysts, supporting the conclusion that mixed subtype infections can lead to genetic recombination. …”
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Sero-epidemiology of the rhodococcus equi in horses in eastern kazakhstan by Kassymov Yerken, Ali Uslu, Otarbayev Bauyrzhan, Zafer Sayin, Aslı Balevi, Ismagulov Yerbol, Ilgekbayeva Gulnaz D, Aysegul Ilban, Osman Erganis

“…<p> <b>Materials and Methods:</b> Sera were collected from 311 horses in 3 regions (Zhambyl, Almaty, East Kazakhstan) across the eastern regions of Kazakhstan between September and November 2021 and the presence of antibodies against virulent R. equi was detected by enzyme-linked immunosorbent assay (ELISA).…”
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Isolation, identification, and pathogenicity tests of pathogenic bacterial associated with black body syndrome in white barramundi Lates calcarifer B. by Akmal Izwar, Sri Nuryati, Rahman, Rini Purnomowati

“…P. stutzeri L01 and V. harveyi were the most virulent bacteria with a bacterial density of 107 CFU/mL. …”
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Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection. by Tanner M Johanns, James M Ertelt, Jared H Rowe, Sing Sing Way

“…The pathogenesis of persistent infection is dictated by the balance between opposing immune activation and suppression signals. Herein, virulent Salmonella was used to explore the role and potential importance of Foxp3-expressing regulatory T cells in dictating the natural progression of persistent bacterial infection. …”
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Dystopia, surveillance and the spaces of social control in Jenni Fagan’s The Panopticon (2012) by Claire Wrobel

“…Although the text explicitly reappropriates the Panopticon designed by Jeremy Bentham (1748-1832), an invention itself riven by the tension between utopia and dystopia, and echoes Michel Foucault’s strategic reading in Discipline and Punish (1975), the virulent critique it levels at the welfare state echoes some of the central issues to be found in George Orwell's attack on totalitarian states, particularly those related to memory and language. …”
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Hugo Chavez : le renouveau du populisme vénézuélien ? by Olivier Folz

“…Ex-putschist and uncontested leader of the disadvantaged sectors, he built his victory at the presidential elections of 1998 by using a virulent speech towards the parties and the past political community. …”
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The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection by Sareh Bagheri-Josheghani, Bita Bakhshi, Shahin Najar-peerayeh

“…Nowadays, nanovaccine is considered as an evolving method in the field of vaccination to induce immunity in the human body against various diseases, including bacterial or viral diseases as well as virulent tumors. Nanovaccines are more efficient than traditional vaccines since they could potentially induce both humoral and cellular immune reactions. …”
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Le peuple est-il soluble dans la constitution ? Leçons tunisiennes by Jean-Philippe Bras

“…Also, the day after their election, members of the Constituent Assembly were faced with virulent debates on the scope and duration of the mandate entrusted to them by the voting people, who expressed their fear of having the revolution confiscated by poll winners (mainly members of the Islamic party Ennahda), who had not been, far from it, major players in the revolutionary moment. …”
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Le Conseil Métropolitain pour l’Opportunité Éducative (METCO) à Boston : intégration raciale et libéralisme de banlieue, 1966-1996 by Sarah Harakat

“…While existing historiography has focused on white opposition to transportation strategies used to promote racial integration, the history of the suburbs which chose busing to diversify their schools remains to be written.In this sense, Boston presents a valuable case study in the 1970s, since it saw both the most virulent anti-busing urban revolt in the United States, and the expansion of the METCO busing program, now recognized as a national model of racial integration. …”
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De l’utopie socialiste au réalisme chrétien by Isabelle Richet

“…While a majority of Protestants and their clergy opposed Franklin Roosevelt from a conservative position, the theologian Reinhold Niebuhr developed a virulent left‑wing criticism of his policies, before finally rallying to his support at the end of the decade. …”
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The Natural History of Pancreatic Cancer in Manitoba: A Population Based Study by Jack Martin, Brian H Weinerman

“…Adenocarcinoma of the pancreas is a virulent malignancy. A retrospective study was undertaken to determine the natural history of the disease in Manitoba, and to examine which facets of the disease might predict survival. …”
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The Symptom and Genetic Diversity of Cassava Brown Streak Viruses Infecting Cassava in East Africa by I. U. Mohammed, M. M. Abarshi, B. Muli, R. J. Hillocks, M. N. Maruthi

“…These results were further confirmed by the mechanical inoculation of 13 herbaceous hosts in which the virulent isolates caused plant death in Nicotiana clevelandii and N. benthamiana whereas the milder isolates did not. …”
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Effectiveness and Cost-Benefit of an Influenza Vaccination Program for Health Care Workers by Annalee Yassi, Joel Kettner, Greg Hammond, Mary Cheang, Myrna McGill

“…Absenteeism among high risk hospital workers was increased by 35% (P=0.001) during the virulent influenza epidemic of 1987–88. Benefits, measured as the value of sick time avoided, compared with costs, including materials, occupational nursing staff time, employee time during vaccination, and time lost due to adverse reactions, revealed a net benefit of $39.23 per vaccinated employee. …”
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Polyarticular Septic Arthritis Caused by Haemophilus Influenzae in an Asplenic Patient: A Case Report by Roberto Desarden, Roya Caloia

“…Introduction: Prevalence of serious infections from Haemophilus influenzae has diminished over the last few decades because of immunizations against the most virulent serotype. However, over the last few years a handful of septic arthritis cases secondary to H influenzae have been documented. …”
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