Transcriptomic Response in Pseudomonas aeruginosa towards Treatment with a Kaempferol Isolated from Melastoma malabathricum Linn Leaves by Mourouge Saadi Alwash, Wan Syaidatul Aqma, Wan Yaacob Ahmad, Nazlina Ibrahim

“…The results also revealed that KF decreased the expression of a broad range of virulence factors associated with LPS biosynthesis, iron homeostasis, cytotoxic pigment pyocyanin production, and motility and adhesion that are representative of an acute P. aeruginosa infection profile. …”
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Characterization and genome analysis of a novel phage BP15 infecting Vibrio parahaemolyticus by Te-Ken Hsu, Yi-Yin Chen, Shiao-Wen Li, Hui-Yu Shih, Hsin-Yiu Chou, Jeff Chia-Kai Hsu, Han-Ching Wang, Li-Li Chen

“…Phage BP15 possessed a circular double-stranded DNA of 59,584 bp with a G + C content of 46.7% and lacked tRNA genes, virulence genes, and lysogeny genes. These findings highlight the promising potential of phage BP15 as a biocontrol agent against Vibrio parahaemolyticus in Taiwan.…”
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Novel silver nanoparticle-based biomaterials for combating Klebsiella pneumoniae biofilms by Eslam Elashkar, Rihaf Alfaraj, Ola M. El-Borady, Mahmoud M. Amer, Abdelazeem M. Algammal, Azza S. El-Demerdash

“…BackgroundKlebsiella pneumoniae is a significant nosocomial pathogen that has developed resistance to multiple antibiotics, often forming biofilms that enhance its virulence. This study investigated the efficacy of a novel nanoformulation, AgNPs@chitosan-NaF, in combating K. pneumoniae biofilms.MethodsAntimicrobial susceptibility testing was performed to assess the antibiotic resistance profile of K. pneumoniae isolates. …”
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Preliminary In Vitro Evaluation of the Probiotic Potential of the Bacteriocinogenic Strain Enterococcus lactis PMD74 Isolated from Ezine Cheese by Başar Uymaz Tezel

“…Among the four genes tested, E. lactis PMD74 was observed to be positive for three virulence determinants, ace, sprE, and gelE, and negative for esp. …”
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Genomic Landscape Reveals Chromosomally-Mediated Antimicrobial Resistome and Virulome of a High-Risk International Clone II Acinetobacter baumannii AB073 from Thailand by Rattiya Cheewapat, Jadsadaporn Redkimned, Sirikran Lekuthai, Thawatchai Kitti, Kannipa Tasanapak, Aunchalee Thanwisai, Sutthirat Sitthisak, Thanet Sornda, Hathaichanok Impheng, Sudarat Onsurathum, Udomluk Leungtongkam, Supaporn Lamlertthon, Siriwat Kucharoenphaibul, Jintana Wongwigkarn, Pantira Singkum, Pattrarat Chanchaithong, Rapee Thummeepak

“…Moreover, this isolate also carried multiple genes associated with the ability of iron uptake, biofilm formation, immune invasion, virulence regulations, and serum resistance. In addition, the genomic epidemiological study showed that AB073-like strains were successful pathogens widespread in various geographic locations and clinical sources. …”
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Leptospira and Inflammation by C. F. Gonçalves-de-Albuquerque, P. Burth, A. R. Silva, M. Younes-Ibrahim, H. C. Castro-Faria-Neto, M. V. Castro-Faria

“…The recent sequencing of the Leptospira genome has increased our knowledge about this pathogen. Although the virulence factors, molecular targets, mechanisms of inflammation, and signaling pathways triggered by leptospiral antigens have been studied, some questions are still unanswered. …”
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Effect of Bacillus subtilis JZXJ-7, a Strain Isolated from Shrimp Paste, on Colonic Function and Microbial Community in Mice Infected with Vibrio parahaemolyticus by ZHOU Kui, WANG Rundong, GONG Mengxue, MOU Jingyuan, DENG Yijia, LI Xuepeng, ZHANG Yuhao, LI Jianrong

“…Totally 28 male C57BL/6J mice were randomly divided into four groups: a Vp infection model group (infected with the standard virulence strain ATCC33847), two JZXJ-7 intervention groups (administered at low (106 CFU) and high (108 CFU) doses by gavage), and a control group. …”
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Proteomic insights into dual-species biofilm formation of E. coli and E. faecalis on urinary catheters by Kidon Sung, Miseon Park, Ohgew Kweon, Angel Paredes, Alena Savenka, Saeed A Khan

“…Both E. coli and E. faecalis displayed significant downregulation of virulence-associated proteins when coexisting in dual-species biofilms. …”
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Proline isomerization modulates the bacterial IsdB/hemoglobin interaction: an atomic force spectroscopy study by Francesca Pancrazi, Omar De Bei, Francesco Lavecchia di Tocco, Marialaura Marchetti, Barbara Campanini, Salvatore Cannistraro, Stefano Bettati, Anna Rita Bizzarri

“…Abstract Iron surface determinant B (IsdB), a Staphylococcus aureus (SA) surface protein involved in both heme iron acquisition from host hemoglobin (Hb) and bacterial adhesion, is a proven virulence factor that can be targeted for the design of antibacterial molecules or vaccines. …”
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Recurrent Herpes Zoster Ophthalmicus Preceded by Anabolic Steroids and High-Dose L-Arginine by Stephen A. LoBue, Adam Goldman, Richard A. Giovane, Stacy M. Carlson, Michael Bivona, Sinan Albear, Thomas D. LoBue

“…In vitro L-arginine supplementation has been associated with the proliferation and virulence of a variety of herpes viruses. Anabolic steroids have also been demonstrated by various studies to negatively affect cell-mediated immunity necessary to prevent viral infection. …”
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Validation of <i>Monilinia fructicola</i> Putative Effector Genes in Different Host Peach (<i>Prunus persica</i>) Cultivars and Defense Response Investigation by Lucia Landi, Annamaria Lucrezia D’Ortenzio, Sarah Mojela Makau, Rita Milvia De Miccolis Angelini, Gianfranco Romanazzi

“…<i>M. fructicola</i> putative virulence factors have been predicted by genome investigations. …”
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The prevalence of motility-related genes within the human oral microbiota by Sofia T. Rocha, Dhara D. Shah, Qiyun Zhu, Abhishek Shrivastava

“…A comprehensive phylogenetic analysis was conducted for all components of the rotary T9SS, a machinery responsible for secreting various enzymes, virulence factors, and enabling bacterial gliding motility. …”
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Investigation of Enterotoxigenic Coagulase-negative Staphylococci Isolated from Local and Imported Dairy Products; a Microbiological Study by Niyaz Sirwan Ali, Huner Hiwa Arif

“…Coagulase negative staphylococci (CNS) have been recorded as a conveying vector for virulence genes and have been implicated in some cases of food poisoning. …”
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ANALYSIS OF CHANGES IN AFRICAN SWINE FEVER VIRUS GENETIC STRUCTURE AND BIOLOGICAL PROPERTIES DURING ADAPTATION TO CONTINUOUS CELL CULTURE by Ali Mazloum, N. G. Zinyakov, A. S. Pershin, I. V. Shevchenko, I. Yu. Zhukov, D. N. Fedoseyeva, D. V. Sharypova, A. S. Igolkin, N. N. Vlasova

“…In particular, no virus genes directly associated with pig virulence have been identifed. Identifcation of such genes will enable preparation of deletion mutant ASF virus strains as well as development and testing of pilot safe vaccines based on the said virus strains. …”
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Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview by Jaroslav Mysak, Stepan Podzimek, Pavla Sommerova, Yelena Lyuya-Mi, Jirina Bartova, Tatjana Janatova, Jarmila Prochazkova, Jana Duskova

“…This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens—Porphyromonas gingivalis. …”
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Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model by Haruki Arévalo-Romero, Isaura Meza, Gabriela Vallejo-Flores, Ezequiel M. Fuentes-Pananá

“…Gastric cancer is the third cause of cancer death worldwide and infection by Helicobacter pylori (H. pylori) is considered the most important risk factor, mainly by the activity of its virulence factor CagA. H. pylori/CagA-induced chronic inflammation triggers a series of gastric lesions of increased severity, starting with gastritis and ending with cancer. …”
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Infectious bursal disease virus: identification of the novel genetic group and reassortant viruses by L. O. Scherbakova, Ye. V. Ovchinnikova, T. N. Zybina, S. N. Kolosov, N. G. Zinyakov, Z. B. Nikonova, D. B. Andreychuk, I. A. Chvala

“…Pathogenicity studies of the three IBDV isolates showed that the most virulent was an isolate having two genome segments characteristic of the highly virulent virus. …”
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Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? by Laura E. Carreto-Binaghi, Esmeralda Juárez, Silvia Guzmán-Beltrán, María Teresa Herrera, Martha Torres, Alejandro Alejandre, José Arturo Martínez-Orozco, Eduardo Becerril-Vargas, Yolanda Gonzalez

“…Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. …”
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A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis. by Erika Kroll, Carlos Bayon, Jason Rudd, Victoria J Armer, Anjana Magaji-Umashankar, Ryan Ames, Martin Urban, Neil A Brown, Kim Hammond-Kosack

“…Encouragingly, the restricted growth and highly reduced virulence phenotypes observed for ΔFgknr4 were replicated upon deletion of the orthologous gene in the wheat fungal pathogen Zymoseptoria tritici. …”
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Analysis and Characterization of the Immunogenicity of Rhoptry Protein 18 by Masoud Foroutan, Amir Karimipour-Saryazdi, Ali Dalir Ghaffari, Hamidreza Majidiani, Arezo Arzani Birgani, Elaheh Karimzadeh-Soureshjani, Shahrzad Soltani, Hany M Elsheikha

“…Rhoptry protein 18 (ROP18) is a key virulence factor secreted into host cells during the invasion of Toxoplasma gondii ( T. gondii ) and plays an important role in the pathogenesis of infection. …”
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