Noncanonical calcium binding motif controls folding of HopQ1, a Pseudomonas syringae type III secretion effector, in a pH-dependent manner by Fabian Giska, Wojciech Rymaszewski, Malgorzata Lichocka, Marcin Piechocki, Jakub Kwiatkowski, Jarosław Poznański, Magdalena Górecka, Magdalena Krzymowska

“…Abstract Virulence of many gram-negative bacteria relies upon delivery of type three effectors into host cells. …”
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Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in Candida glabrata. by Taiga Miyazaki, Hironobu Nakayama, Yohsuke Nagayoshi, Hiroshi Kakeya, Shigeru Kohno

“…We also uncovered the attenuated virulence of the C. glabrata Δire1 mutant in a mouse model of disseminated candidiasis. …”
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IDENTIFICATION OF THE CTX-M GENE IN KLEBSIELLA PNEUMONIAE PRODUCING ESBLS IN UTI PATIENTS AT A PRIVATE HOSPITAL IN PURWOKERTO, BANYUMAS REGENCY, CENTRAL JAVA - CROSS SECTIONAL STUD... by Anang Kurniawan, Joko Setyono, Dwi Utami Anjarawati

“…Background: The CTX-M gene in ESBLs-producing Klebsiella pneumoniae is associated with virulence factors and encodes for antibiotic resistance. …”
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Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition by Mary E. Peek, Abhinav Bhatnagar, Nael A. McCarty, Susu M. Zughaier

“…P. aeruginosa produces a major siderophore known as pyoverdine, found to be important for bacterial virulence and biofilm development. We report that pyoverdine did not bind to NGAL, as measured by tryptophan fluorescence quenching, while enterobactin bound to NGAL effectively causing a strong response. …”
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Functional genomic insights into Floricoccus penangensis ML061-4 isolated from leaf surface of Assam tea by Patthanasak Rungsirivanich, Elvina Parlindungan, Jennifer Mahony, Witsanu Supandee, Narumol Thongwai, Douwe van Sinderen

“…The ML061-4 genome was evaluated for genes associated with complex carbohydrate metabolism, bacterial adhesion, virulence factors, pathogenicity, bacteriophages, antiviral defence systems as well as toxin- and antibiotic-resistance associated genes, and genes involved in toxin production, secondary metabolite biosynthesis and xenobiotics biodegradation. …”
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Genomic and Drug Resistance Profile of Bovine Multidrug-Resistant <i>Escherichia coli</i> Isolated in Kazakhstan by Pavel G. Alexyuk, Andrey P. Bogoyavlenskiy, Yergali S. Moldakhanov, Kuralay S. Akanova, Adolat N. Manakbayeva, Timur Kerimov, Vladimir E. Berezin, Madina S. Alexyuk

“…It may also be a source for future comparative studies of the virulence and drug resistance of <i>E. coli</i> isolates.…”
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Pooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform. by Darach Miller, Adam Dziulko, Sasha Levy

“…In particular, viral-host PPI networks can be used to further our understanding of the molecular mechanisms of tissue specificity, host range, and virulence. At higher scales, viral-host PPI screening could also be used to screen for small-molecule antivirals that interfere with essential viral-host interactions, or to explore how the PPI networks between interacting viral and host genomes co-evolve. …”
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Predominant Dissemination of PVL-Negative CC89 MRSA with SCCmec Type II in Children with Impetigo in Japan by H. Kikuta, M. Shibata, S. Nakata, T. Yamanaka, H. Sakata, K. Akizawa, K. Kobayashi

“…Furthermore, molecular epidemiological analysis and virulence gene analysis were performed. Results. Of the 136 S. aureus isolates, 122 (89.7%) were MSSA and 14 (10.3%) were MRSA. …”
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First detection of recombinant variant of African swine fever virus in the Russian Federation (brief communication) by A. S. Igolkin, R. S. Chernyshev, N. G. Zinyakov, E. O. Morozova, A. R. Shotin, K. N. Gruzdev, I. A. Chvala, A. Mazloum

“…Zhao et al. reported on high virulence of the virus related variants as revealed by the challenge tests in domestic pigs. …”
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Novel mitochondrial-targeted alkyl chains act as fungal specific inhibitors of C. neoformans by Elizabeth S. M. Edrich, Luke Young, John Spencer, Andrew McGown, Anthony L. Moore, Campbell W. Gourlay

“…For example, C. neoformans possesses an Alternative Oxidase enzyme (Aox) that has been implicated in stress resistance and virulence that may represent a viable antifungal target. …”
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Saturated Transposon Analysis in Yeast as a one-step method to quantify the fitness effects of gene disruptions on a genome-wide scale. by Enzo Kingma, Floor Dolsma, Leila Iñigo de la Cruz, Liedewij Laan

“…For example, TIS has been used to identify essential genes of Saccharomyces cerevisiae, screen for antibiotic resistance genes in Klebsiella pneumoniae and determine the set of genes required for virulence of Mycobacterium tuberculosis. While providing valuable insights, these applications of TIS focus on (conditional) gene essentiality and neglect possibly interesting but subtle differences in the importance of genes for fitness. …”
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Challenges and prospects for developing genetic resistance in common wheat against stem rust in Western Siberia by V. N. Kelbin, E. S. Skolotneva, E. A. Salina

“…To achieve adequate genetic control of the disease, an integral approach is important, incorporating both data on sources of resistance and relevant information on pathogenic populations existing in the region, their race composition and dynamics of virulence genes. The analysis of experimental data on field screening of bread wheat varieties from the CIMMYT nursery germplasm for stem rust resistance in the Omsk and Novosibirsk regions, together with laboratory testing of infection samples on the international set of wheat differential lines, suggests that a separate “Asian” population of Puccinia graminis f. sp. tritici exists in Western Siberia and the Altai Territory. …”
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African swine fever clinical scoring system by M. E. Vlasov, V. M. Balyshev, A. D. Sereda

“…The study of twelve ASFV strains of various virulence revealed that acute and subacute ASF produce the maximum clinical scores ranged from 13 to 22, chronic form gives 6–18 points, subclinical form is scored 0–8.…”
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Targeting quorum sensing for manipulation of commensal microbiota by Zachary Ziegert, Matthew Dietz, Max Hill, Marjais McBride, Elizabeth Painter, Mikael H. Elias, Christopher Staley

“…Extensive work using simple systems and single strains of bacteria have revealed a role for QS in the regulation of virulence factors and biofilm formation; however, less is known about QS dynamics among communities, especially in vivo. …”
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Pathogenicity and transmissibility of North American triple reassortant swine influenza A viruses in ferrets. by Subrata Barman, Petr S Krylov, Thomas P Fabrizio, John Franks, Jasmine C Turner, Patrick Seiler, David Wang, Jerold E Rehg, Gene A Erickson, Marie Gramer, Robert G Webster, Richard J Webby

“…Therefore, understanding of these viruses' pathogenicity and transmissibility may help to identify determinants of virulence of the 2009 H1N1 pandemic viruses and to elucidate potential human health threats posed by the TRS viruses. …”
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Fungal-Host Interaction: Curcumin Modulates Proteolytic Enzyme Activity of Candida albicans and Inflammatory Host Response In Vitro by Emily Chen, Bruna Benso, Dalia Seleem, Luiz Eduardo Nunes Ferreira, Silvana Pasetto, Vanessa Pardi, Ramiro Mendonça Murata

“…Thus, this study evaluated the modulatory effects of curcumin on major virulence factors associated with the pathogenicity of C. albicans. …”
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Characterization of Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Hospitalized Patients in Palestine by Regeen Handal, Lulu Qunibi, Ibrahim Sahouri, Maha Juhari, Rula Dawodi, Hiyam Marzouqa, Musa Hindiyeh

“…The ompA biofilm-producing virulence gene was detected in all isolates. Finally, Multilocus Sequence Typing (MLST) of 13 isolates revealed that more than one strain of A. baumannii was circulating in Palestinian hospitals as results revealed that 7 isolates were of ST208, 2 isolates ST218, 1 isolate ST231, 1 isolate ST348, and 2 new Sequence Types. …”
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INHIBITION OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) BIOFILM: THE ESSENTIAL ROLE AND POTENTIAL USAGE OF BACTERIOCINS by Tati Febrianti, Conny Riana Tjampakasari

“…Biofilm, as one of the virulence factors of MRSA, can result in the failure of antibiotic therapy. …”
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Prospects for the use of <i>Bacillus anthracis</i> toxin in cancer therapy by A. P. Rodionov, S. V. Ivanova, E. A. Artemeva, L. A. Melnikova

“…Lethal factor is the main virulence factor of the anthrax pathogen, which is a zinc-dependent metalloprotease, the substrate for which is intracellular MAPK signaling pathways widely present in cancer cells. …”
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Disseminated Candida lusitaniae: Nosocomial Acquisition Secondary to an Indwelling Urinary Catheter by Ali Raja, Julia Park

“…This particular fungal agent is especially difficult to treat due to its multiple virulence factors. Additionally, the use of indwelling urinary catheters should only occur when proper indications are present and should be promptly discontinued when their placement is no longer necessary.…”
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