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401
Emergency response for recently isolated Foot and Mouth Disease virus type A Africa in Egypt 2022
Published 2025-02-01“…Abstract Foot and mouth disease (FMD) is a highly contagious viral infection affecting cloven-hoofed ruminants, leading to significant economic losses. …”
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402
Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice
Published 2015-01-01“…Clinical studies have indicated that disease is primarily associated with recurrent HSK following reactivation of a latent viral infection of the trigeminal ganglia. One of the key factors that limit inflammation of the cornea is the expression of Fas ligand (FasL). …”
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403
The high-density lipoprotein binding protein HDLBP is an unusual RNA-binding protein with multiple roles in cancer and disease
Published 2024-12-01“…In this review, we give an overview of some of the functions of the protein as well as introduce its impact on different kinds of cancer, its connection to lipid metabolism and its role in viral infection. We also aim at addressing the possible use of HDLBP as a drug target or biomarker and discuss its future implications.…”
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404
Dynamical Behaviour and Chaotic Phenomena of HIV Infection through Fractional Calculus
Published 2022-01-01“…In this research work, the dynamics of HIV via fractional calculus to conceptualize the intricate phenomena of this viral infection has been formulated and conceptualized. …”
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405
Contribution of Gut Bacteria to Liver Pathobiology
Published 2010-01-01“…In the setting of tissue injury, whereby the liver is otherwise damaged (e.g., viral infection, toxin exposure, ischemic tissue damage, etc.), these same immune cell populations and their interactions with the infiltrating gut bacteria likely contribute to and promote these pathologies. …”
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406
Clinical profile of dengue encephalopathy: A series of twelve cases and a profile of other complications
Published 2025-01-01“…Dengue fever is a mosquito borne viral infection caused by a Flavivirus with four serotypes named DENV 1 to 4, is becoming a significant public health hazard. …”
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407
Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target?
Published 2010-01-01“…The antiretroviral activity of some of these proteins is overtaken by the action of HIV-1 Viral Infectivity Factor (Vif) protein. Since the discovery of APOBEC3G (A3G) as an antiviral factor, many advances have been made to understand its mechanism of action in the cell and how Vif acts in order to counteract its activity. …”
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408
Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor: Implications for Studying Immune Prophylaxis and Therapy during Pregnancy
Published 2012-01-01“…Using an intravenous antihepatitis B-specific immune globulin preparation as an example, we show that this transport results in neutralizing activity in the mother and the newborn that would potentially be prophylactic against hepatitis B viral infection. These preliminary data lay the groundwork for introducing pregnant guinea pigs as an appropriate model for the evaluation of antibody therapies and advancing the health of women and neonates.…”
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409
lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3
Published 2025-01-01“…Analysis of RNA expression data from in vitro experiments and clinical samples demonstrates reduced NORAD upon viral infection. Additionally, evolutionary conservation analysis suggests that this regulatory function of NORAD is restricted to humans, potentially owing to the introduction of an Alu element in hominoids. …”
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410
Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures
Published 2025-02-01“…Cognitive impairment is one of the many symptoms reported by individuals suffering from long-COVID and other post-viral infection disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). …”
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411
A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression
Published 2015-06-01“…PKR is a sensor protein that recognizes evading viruses and induces apoptosis to eliminate infected cells. Like viral infection, nc886 silencing activates PKR and induces apoptosis. …”
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412
Microblog burst topic diffusion prediction algorithm based on the users and node scale
Published 2013-08-01“…Currently microblog topic diffusion and prediction is still in its infancy. The viral infection model, the message propagation model and topic propagation model were deeply studied and a topic diffusion model was proposed based on fans relationship, user activity and influence. …”
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413
Recent advances in the science of human milk oligosaccharides
Published 2025-01-01“…Approximately 200 varieties of HMOs have been characterized.Although HMOs are not utilized as an energy source by infants, they have important protective functions, including pathogenic bacteria and viral infection inhibitors and immune modulators, among other functions, and HMOs stimulate brain-nerve development. …”
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414
A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin
Published 2013-01-01“…Amoxicillin could act directly, inducing the reactivation of a viral infection (HHV 6 and EBV) with symptoms similar to DRESS syndrome or by reducing the patients’ ability to detoxify the body from substances chronically taken. …”
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415
Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy
Published 2025-01-01“…Our results show that the MBP preferentially associates with cholesterol-rich membranes, and we find that cholesterol depletion significantly reduces viral infectivity. Furthermore, we observe that the disulfide bridge stabilizes the MBP’s interaction with the membrane, suggesting a structural role in viral entry. …”
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416
Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda
Published 2025-02-01“…These studies identify developmental regulation of the homeostatic IFN-λ response, which is present in the neonatal intestine from birth, stimulated independent of microbiota, and preemptively protects IECs from viral infection. This intrinsically programmed antiviral response in early life is particularly important due to the absence of a robust microbiota or protective immune memory at birth, when the risk of enteric infection is high.…”
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417
Synergistic Effect of Hyperglycemia and Suppression on Adult Mouse Islet Beta Cell Replication
Published 2012-01-01“…At 54 hours after viral infection, protein content in cultured targeting islets was 22% of that in freshly isolated islets. …”
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418
Discovery of a heparan sulfate binding domain in monkeypox virus H3 as an anti-poxviral drug target combining AI and MD simulations
Published 2025-01-01“…Targeting this domain, we designed a protein inhibitor, which disrupted the H3-HS interaction, inhibited viral infection in vitro and viral replication in vivo, offering a promising antiviral candidate. …”
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419
Application of in vitro and in vivo models in the study of food allergy
Published 2018-12-01“…We also introduced zebrafish, a promising model organism for investigating immunity though lacking direct applications in food allergy to date, and focused on traumatic inflammation, bacterial infection and viral infection models. In addition, we also summarized the clinical diagnostic research methods for food allergy. …”
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420
Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity
Published 2010-01-01“…IFN is a major effector of innate antiviral immunity and is naturally produced in response to viral infection when viral pathogen-associated molecular patterns (PAMPs) are recognized as nonself and are bound by cellular pathogen recognition receptors (PRRs), including Toll-like receptors (TLRs) and the RIG-I-like receptors (RLRs). …”
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