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141
Comprehensive treatment of the macular edema in patients with retinal vein occlusion and hemostasis system disturbances
Published 2019-01-01“…<br> <br> <b>Key words:</b> retinal vein occlusion, macular edema, hemostasis, vascular endothelial growth factor, VEGF, lupus anticoagulant.<br> <b>For citation:</b> Shelkovnikova T.V., Takhchidi Kh.P., Vavin G.V. et al. …”
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142
Pancreatic Cancer: What the Oncologist Can Offer for Palliation
Published 2002-01-01“…Some novel biological agents, including angiogenesis inhibitors, matrix metalloproteinase inhibitors, antisense compounds, inhibitors of cell signalling such as epidermal growth factor and vascular endothelial growth factor, and inhibitors of oncogene activation, are undergoing phase II and III trials in patients with pancreatic cancer. …”
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143
Tracking Tumor Cells in Lymphatics in a Mice Xenograft Model by Magnetic Resonance Imaging
Published 2012-11-01“…Histologic findings confirmed the in vivo MRI results and revealed lymphangiogenesis, angiogenesis, infiltration of macrophages, and expression of vascular endothelial growth factor C in tumor and draining lymph nodes as well. …”
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144
Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians
Published 2012-01-01“…By the early 1990s, it had become clear that the recently discovered “vascular endothelial growth factor” (VEGF) was a powerful mediator of angiogenesis. …”
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145
PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
Published 2012-01-01“…PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. …”
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146
Rosuvastatin, Sildenafil and Their Combination in Monocrotaline-Induced Pulmonary Hypertension in Rat
Published 2014-09-01“…Right ventricular pressure, right ventricle mass and three biomarkers were evaluated after 21 days: brain natriuretic peptide, high-density lipoprotein cholesterol and vascular endothelial growth factor. The present study demonstrates that administration of hydrophilic statin with sildenafil results in reduction of pulmonary vascular remodeling and right ventricular pressure. …”
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147
Antivascular Endothelial Growth Factor Agents for Neovascular Age-Related Macular Degeneration
Published 2012-01-01“…Age-related macular degeneration (AMD) is the leading cause of severe visual loss and blindness over the age of 50 in developed countries. Vascular endothelial growth factor (VEGF) is considered as a critical molecule in the pathogenesis of choroidal neovascularization (CNV), which characterizes the neovascular AMD. …”
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148
Melittin: A Natural Component of Honeybee Venom as a Potential Anti-Cancer Therapy
Published 2023-12-01“…It interacts with various biological signalling pathways which suppress tumour cells, notably, the Hypoxia-Inducible Factor-1, Vascular Endothelial Growth Factor and the Nuclear Factor Kappa B pathways. …”
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149
BIOMARKERS, NEOANGIOGENESIS AND GROWTH FACTORS IN PANCREATIC CANCER
Published 2019-09-01“…The proangiogenic signaling molecule – vascular endothelial growth factor (VEGF) and its receptors play a central role in tumor angiogenesis. …”
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150
Release of Copper / Magnesium Ions from Hydroxyapatite-Based Fiber Scaffolds Hasten Bone Healing and Regeneration
Published 2024-09-01“…A low amount of Mg and Cu ions could improve vascular endothelial growth factor (VEGF) and angiogenesis around bone, thus can hasten bone healing and regeneration. …”
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151
Interleukin-1β Expression Is Required for Lysophosphatidic Acid-Induced Lymphangiogenesis in Human Umbilical Vein Endothelial Cells
Published 2011-01-01“…Previous studies indicated that LPA upregulates vascular endothelial growth factor- (VEGF-) C and lymphatic marker expressions in HUVECs. …”
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152
Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway
Published 2025-02-01“…Subsequently, our study verified the target-regulatory relationship between miR-126 and vascular endothelial growth factor (VEGF) in human umbilical vein endothelial cells (HUVECs) by using the “TargetScan” website and dual-luciferase reporter assay. …”
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153
A Review of Age-related Macular Degeneration and Current Concepts in Management
Published 2024-12-01“…Pharmacological interventions, particularly anti-vascular endothelial growth factor (anti-VEGF) agents, are extensively reviewed as the mainstay of treatment for wet AMD. …”
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154
VEGF Spliced Variants: Possible Role of Anti-Angiogenesis Therapy
Published 2012-01-01“…Among these tumour types, clear cell renal cell carcinomas (RCCs) are the most vascularized tumours due to mutations of the von Hippel Lindau gene resulting in HIF-1 alpha stabilisation and overexpression of Vascular Endothelial Growth Factor (VEGF). Surgical nephrectomy remains the most efficient curative treatment for patients with noninvasive disease, while VEGF targeting has resulted in varying degrees of success for treating metastatic disease. …”
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155
Combined Application of Bevacizumab and Mitomycin C or Bevacizumab and 5-Fluorouracil in Experimental Glaucoma Filtration Surgery
Published 2018-01-01“…The inhibitory effect of combined BVZ and 5-Fu in retinal pigment epithelial cells on vascular endothelial growth factor (VEGF) levels was demonstrated through in vitro experiments. …”
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156
Switching to faricimab from the current anti-VEGF therapy: evidence-based expert recommendations
Published 2025-01-01“…Dual inhibition of the angiopoietin (Ang)/Tie and vascular endothelial growth factor (VEGF) signalling pathways in patients with retinal diseases, such as neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DME), may induce greater vascular stability and contribute to increased treatment efficacy and durability compared with treatments that only target the VEGF pathway. …”
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157
Suppression of Human Tenon Fibroblast Cell Proliferation by Lentivirus-Mediated VEGF Small Hairpin RNA
Published 2017-01-01“…The functions of vascular endothelial growth factor (VEGF) in scar formation after trabeculectomy were investigated in a human Tenon fibroblast cell line from glaucoma patients using lentivirus-mediated VEGF shRNA. …”
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158
Early growth response 1 transcription factor and its context-dependent functions in glioblastoma
Published 2024-08-01“…Early growth response 1 regulatory roles extend to angiogenesis, cell adhesion, and resistance to chemotherapy, notably influencing pathways like hypoxia-inducible factor 1 and vascular endothelial growth factor A. Early growth response 1 can also induce cell adhesion, migration, chemoresistance against temozolomide, stemness, and self-renewal in glioblastoma cells. …”
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159
Conditioned medium derived from mesenchymal stem cells and spinal cord injury: A review of the current therapeutic capacities
Published 2025-06-01“…CM encompasses neuroprotective growth factors and cytokines, such as stem cell factor (SCF), vascular endothelial growth factor (VEGF), and glial cell line-derived neurotrophic factor (GDNF). …”
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160
Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications
Published 2010-01-01“…Experimental and clinical evidences show that vascular endothelial growth factor is a key signal in promoting angiogenesis. …”
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