Considerations for determining warm-water coral reef tipping points by P. Pearce-Kelly, A. H. Altieri, J. F. Bruno, C. E. Cornwall, M. McField, A. I. Muñiz-Castillo, J. Rocha, R. O. Setter, C. Sheppard, R. M. Roman-Cuesta, C. Yesson

“…A fuller assessment of interacting stressors is likely to further lower the tipping point thresholds in most cases. Uncertainties around tipping points for such crucially important ecosystems underline the imperative of robust assessment and, in the case of knowledge gaps, employing a precautionary principle favouring lower-range tipping point values.…”
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Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study by Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, Klara A. Visser, Carina.M.E. Hansen, Renske van der Meer, C. Tji Gan, Hester van der Vaart, Onno W. Akkerman, Willie N. Steenhuis, Marieke Verkleij, Harry G.M. Heijerman, Erik A.M. Verschuuren

“…Background: Elexacaftor/Tezacaftor/Ivacaftor (ETI) for people with CF (PwCF) after lung transplantation (LTx) has been restrained due to uncertainties regarding efficacy and drug interactions. …”
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Global decadal measurements of methanol, ethene, ethyne, and HCN from the Cross-track Infrared Sounder by K. C. Wells, D. B. Millet, J. F. Brewer, V. H. Payne, K. E. Cady-Pereira, R. Pernak, S. Kulawik, S. Kulawik, C. Vigouroux, N. Jones, E. Mahieu, M. Makarova, T. Nagahama, I. Ortega, M. Palm, K. Strong, M. Schneider, D. Smale, R. Sussmann, M. Zhou

“…Initial comparisons of the CrIS observations to predicted VOC distributions from the GEOS-Chem chemical transport model point to large uncertainties in our current<span id="page696"/> understanding of the atmospheric ethene budget as well as to underestimated HCN, ethyne, and methanol sources.…”
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A Quantitative Particle-Based Approach for the Geometallurgical Assessment of Tailings Deposits by Rosie Blannin, Max Frenzel, Raimon Tolosana-Delgado, Kai Bachmann, Alexandra Gomez Escobar, Lucas Pereira, Jens Gutzmer

“…The spatial distributions of processing-relevant particle properties throughout the tailings deposit were predicted with corresponding uncertainties. There are clear systematic trends in the spatial distributions of different particle types, resulting from the sedimentary-style deposition of the tailings. …”
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Seasonal air concentration variability, gas–particle partitioning, precipitation scavenging, and air–water equilibrium of organophosphate esters in southern Canada by Y. Li, F. Zhan, C. Shunthirasingham, Y. D. Lei, J. Oh, J. Oh, A. Ben Chaaben, Z. Lu, K. Lee, F. A. P. C. Gobas, H. Hung, F. Wania, F. Wania

“…Although beset by large uncertainties, air–water equilibrium calculations suggest net deposition of gaseous OPEs from the atmosphere to the Salish Sea and the St. …”
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Exacerbation of diabetes due to F. Nucleatum LPS-induced SGLT2 overexpression in the renal proximal tubular epithelial cells by Aiko Seki, Koichiro Kajiwara, Jumpei Teramachi, Masahiko Egusa, Takuya Miyawaki, Yoshihiko Sawa

“…Abstract Background Diabetes treatments by the control of sodium-glucose cotransporter 2 (SGLT2) is commonly conducted while there are still uncertainties about the mechanisms for the SGLT2 overexpression in kidneys with diabetes. …”
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A comparative assessment of grey water footprint estimation methods in paddy fields by Mahsa Naderi, Abdullah Darzi-Naftchali, Fatemeh Karandish, Hadi Razaghian, Jiří Šimůnek

“…Reliable estimation of the gray water footprint (GWF), a key indicator for assessing freshwater pollution, remains limited due to uncertainties in estimating leaching-runoff fractions and other assumptions in conventional methods. …”
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HIDRA3: a deep-learning model for multipoint ensemble sea level forecasting in the presence of tide gauge sensor failures by M. Rus, M. Rus, H. Mihanović, M. Ličer, M. Ličer, M. Kristan

“…The new architecture brings several benefits: (i) it improves training at locations with scarce historical SSH data, (ii) it enables predictions even at locations with sensor failures, and (iii) it reliably estimates prediction uncertainties. HIDRA3 is evaluated by jointly training on 11 tide gauge locations along the Adriatic. …”
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Aligning strategic and participatory approaches to agri‐environment scheme design and implementation to enhance nature recovery outcomes by D. J. Baker, C. Nye, R. Wheeler, C. Masquelier, A. Binner, K. J. Gaston, M. S. Heard, M. Lobley, D. Smith, I. M. D. Maclean

“…Strategic spatial targeting must also be carried out with the implementation phase in mind, accounting for socio‐economic opportunities and barriers to engagement and acknowledging that uncertainties around farm‐scale implementation mean plans must be adaptable. …”
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Cost-effectiveness analysis for implementation of smoking cessation strategies at primary health care settings in Tamil Nadu. by Vasantha Mahalingam, Ramesh Kumar Santhanakrishnan, Muniyandi Malaisamy, Karthick Chelvanayagam, Kavi Mathiyazhagan, Adhin Bhaskar, Karikalan Nagarajan, Jerard Maria Selvam, Surendran Veeraiah, Kavitha Rajsekar, Kirti Tyagi, Ponnuraja Chinnaiyan

“…To assess the robustness of the findings, one-way sensitivity analysis and probabilistic sensitivity analysis were performed which aims to explore and address the uncertainties associated with the outcomes.<h4>Results</h4>The cost of the current strategy (CS) was higher (₹359 or $4.28 million) when compared with PS1 (₹327 or $3.90 million) and PS3 (₹327 or $3.90 million) strategies. …”
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Source rock characterization of the Dingo Claystone, Barrow Sub-basin, Australia – Influence of contamination on geochemical analyses by Ummi Fayyadhah Binti Haji Talipudin, Mohamed Ragab Shalaby

“…To improve the accuracy of thermal maturity estimations, only samples with S2 greater than 1 were considered due to potential issues with peak integration and uncertainties of Tmax determination in samples with lower S2 values. …”
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Alkali Effect on Alkali-Surfactant-Polymer (ASP) Flooding Enhanced Oil Recovery Performance: Two Large-Scale Field Tests’ Evidence by Chen Sun, Hu Guo, Yiqiang Li, Guipu Jiang, Ruicheng Ma

“…This paper confirms that under Daqing Oilfield reservoir conditions, it is the alkali difference that caused the performance difference of these two tests, although some minor uncertainties exist. WASP is better than the SASP providing the same conditions . …”
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Modeling future sediment retention service in the Bagh-e-Shadi Forest protected area using InVEST and the ACCESS-ESM1-5 climate model by Sharif Joorabian Shooshtari, Tahereh Ardakani, Hadise Beik Khormizi

“…Additionally, this study focused on sensitivity analysis to individually assess model parameter uncertainties and highlighted the calibration process. …”
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A multi-stakeholder collaborative approach to awareness, education and support needed in the haemophilia gene therapy patient journey – a report on insights from a European patient... by O’Mahony Brian, Fletcher Simon, Baarslag Manuel, Khair Kate, Breederveld Daan, Jansen Nathalie, Pembroke Luke, Pinachyan Karen, Sivasubramaniyam Sujan

“…Gene therapy should be presented as one of a range of treatment options; understanding its risks, uncertainties and benefits is key to managing expectations and minimising treatment remorse. …”
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Cost-Benefit Analysis of Genetic Testing as a Prenatal Diagnostic Tool for Thalassemia: A Single-Center Study From Central Thailand by Malasai K, Jittikoon J, Udomsinprasert W, Talungchit P, Youngkong S, Sangroongruangsri S, Mahasirimongkol S, Chaikledkaew U

“…Both one-way and probabilistic sensitivity analyses were conducted to account for uncertainties in the parameters used.Results: The results revealed that adhering to the standard screening program with genetic testing resulted in a cost-savings of approximately 490 USD per prevented thalassemia case. …”
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Evaluation of Delay Characteristics at A 4- Legged Signalised Intersection for Improvement in The Level of Service. A Case Study of Jinja Road Intersection. by Babirye, Joanitor

“…Hence a micro- simulation model such as VISSIM was used to assess the performance, level of service of Jinja road intersection in order to minimize the uncertainties of increased; control delays, queue lengths experienced during peak hours. …”
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Assessment of Satellite-Derived FAPAR Products With Different Spatial Resolutions for Gross Primary Productivity Estimation by Xiyu Zhang, Huaan Jin, Wei Zhao, Gaofei Yin, Xinyao Xie, Jianrong Fan

“…However, most of the existing FAPAR products with moderate to coarse spatial resolutions introduce uncertainties in GPP estimations across heterogeneous landscapes. …”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…However, we encountered challenges that complicated pleural infection interpretation, including: (i) uncertainties regarding microbial pathogenicity and the impact of prior antibiotic therapy on diagnostic performance; (ii) lack of a clinical diagnostic gold-standard for molecular performance comparisons; (iii) potential microbial contamination during specimen collection or processing; and (iv) difficulties distinguishing background microbial noise from true microbial signal in low-biomass specimens. …”
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After neonatal care, what next? A qualitative study of mothers’ post-discharge experiences after premature birth in Kenya by Justinah Maluni, Dorothy Oluoch, Sassy Molyneux, Mwanamvua Boga, Caroline Jones, Florence Murila, Mike English, Sue Ziebland, Lisa Hinton

“…For mothers of premature babies, the transition home from hospital is marked by challenges and uncertainties. This study explored the post-discharge experiences of mothers of premature babies with the aim of identifying their needs and suggests strategies to strengthen and support their discharge preparation to care for their premature baby at home, and to and reduce mortality and readmission rates. …”
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Evaluation of mechanical and thermal performance of jute and coconut fiber-reinforced epoxy composites with rice husk ash for wall insulation applications by Md. Ahtesham Akhter, Dipayan Mondal, Arup Kumar Debnath, Md. Ashraful Islam, Md. Sanaul Rabbi

“…However, the combined uncertainties of mechanical properties (tensile and flexural) are estimated at 4.57 % and 4.93 %, respectively, while estimated at 5.67 % for thermal conductivity measurement. …”
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