6‐Nitrodopamine potentiates catecholamine‐induced contractions of human isolated vas deferens by Antonio Tiago Lima, Sami Jabbour, José Britto‐Júnior, Demétrio Martinho Ramos deCarvalho, Adriano Fregonesi, Fernanda V. Mariano, Valéria Barbosa deSouza, Andre Almeida Schenka, Edson Antunes, Gilberto De Nucci

“…Catecholamine basal release was evaluated by LC–MS/MS and expression of tyrosine hydroxylase by both immunohistochemistry (IC) and fluorescence in‐situ hybridization (FISH). …”
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Study on SHP2 Conformational Transition and Structural Characterization of Its High-Potency Allosteric Inhibitors by Molecular Dynamics Simulations Combined with Machine Learning by Baerlike Wujieti, Mingtian Hao, Erxia Liu, Luqi Zhou, Huanchao Wang, Yu Zhang, Wei Cui, Bozhen Chen

“…The src-homology 2 domain-containing phosphatase 2 (SHP2) is a human cytoplasmic protein tyrosine phosphatase that plays a crucial role in cellular signal transduction. …”
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Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization by Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M. Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie

“…Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation. …”
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Alterations in the social-conditioned place preference and density of dopaminergic neurons in the ventral tegmental area in Clsnt2-KO mice by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, K. E. Uldanova, E. A. Chuyko, V. A. Naprimerov, T. V. Lipina, T. G. Amstislavskaya, S. Ya. Amstislavsky

“…At the same time, an increased number of DA and possibly GABA neurons labeled with antibodies against the type 2 dopamine receptor as well as against tyrosine hydroxylase were detected in the VTA of the Clstn2-KO mice. …”
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Roles of Alkaloids from Medicinal Plants in the Management of Diabetes Mellitus by Bikash Adhikari

“…., alkaloids, show antidiabetic activity through the inhibition of enzymes (α-amylase, α-glucosidase, aldose reductase, dipeptidyl peptidase-IV, and protein tyrosine phosphatase-1B); inhibition of advanced glycation end products; increment of insulin secretion and its sensitivity; enhancement of glucose uptake; and their antioxidant ability. …”
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Desmosomes In Vivo by David Garrod

“…Protein kinase C downregulates hyperadhesion and there is preliminary evidence that it may also be regulated by tyrosine kinases. Downregulation of desmosomes in vivo may occur by internalisation of whole desmosomes rather than disassembly. …”
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THE IMPORTANCE OF DIET THERAPY IN THE TREATMENT OF PHENYLKETONURIA: A CASE REPORT by Nikolina Gaćina, Jerko Vučak

“…It is caused by the impossibility of converting the essential amino acid phenylalanine into tyrosine, most often due to insufficient production or a complete lack of the enzyme phenylalanine hydroxylase due to a mutation in its gene. …”
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A case of pityriasis rubra pilaris secondary to ponatinib by Ariana Nateghi, Florence Lagacé-Thomassin, Julie Desrochers

“…Ponatinib, a tyrosine kinase inhibitor used for chronic myeloid leukemia and acute lymphoblastic leukemia, can cause rare cutaneous side effects. …”
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Treatment approaches in advanced penile cancer: targeted therapies and immunotherapy by David J. Benjamin, Robert C. Hsu

“…Several ongoing trials involving immune checkpoint inhibitors, tyrosine kinase inhibitors, and antibody drug conjugates are attempting to identify additional therapies.…”
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Tailored Therapy in Lung Cancer by George Rakovich, Lise Tremblay

“…Advances in molecular biology have made possible the development of drugs against specific molecular targets on cancer cells, most notably the tyrosine kinase inhibitors. The relevant literature and current practice guidelines are discussed. …”
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New Strategies and In Vivo Monitoring Methods for Stem Cell-Based Anticancer Therapies by Ping Wang, Aitor Aguirre

“…Despite significant advances in recent years, such as the introduction of targeted therapies such as receptor tyrosine kinase inhibitors and immunotherapy, current approaches are insufficient to stop the advance of the disease and many cancer types remain largely intractable. …”
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Molecular-genetic bases of plumage coloring in chicken by A. V. Makarova, O. V. Mitrofanova, A. B. Vakhrameev, N. V. Dementeva

“…The basis for the formation of melanin is the aromatic amino acid tyrosine. The process of melano-genesis involves many loci, part of the complex expression of plumage color genes. …”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances by Jiaojiao Zheng, Siying Wang, Lei Xia, Zhen Sun, Kui Ming Chan, René Bernards, Wenxin Qin, Jinhong Chen, Qiang Xia, Haojie Jin

“…At present, the primary therapeutic approaches for advanced HCC are tyrosine kinase inhibitors (TKI), immune checkpoint inhibitors (ICI), and combination regimens. …”
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Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion by Glen J. Weiss, Agnes K. Liman, Jeffrey Allen, Philip Y. Cheung, Rajesh N. Kukunoor

“…One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. …”
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Thyroid Mutations and Implications for Clinical Treatment by Emily S. Zhang, Joseph Scharpf

“…DTCs can have BRAF-like or RAS-like pathways of driver mutations with strong genotype–phenotype correlations, which are targetable through multikinase and tyrosine kinase inhibitors. Case studies illustrate how molecular profiling can guide clinical decisions and enhance treatment outcomes. …”
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Chronic Eosinophilic Leukemia Presenting as Cardiac Failure by Nii Boi-Doku Pepra-Ameyaw, William Kwasi Ghunney, Eugene Baafi Ampofo, Edeghonghon Olayemi

“…Good symptomatic control was achieved using hydroxyurea after which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor. Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.…”
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The Role of Decorin in Autoimmune and Inflammatory Diseases by Yuanji Dong, Jixin Zhong, Lingli Dong

“…Decorin is involved in an extensive signaling network and can interact with other extracellular matrix components, growth factors, receptor tyrosine kinases, and various proteases. Decorin has been shown to be involved in wound repair, cell cycle, angiogenesis, tumor metastasis, and autophagy. …”
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Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, follo... by G. Menardi, A. Castellino, C. Castellino, M. E. Bersia, E. Grande, G. Fraternali, M. Massaia, C. Fruttero

“…Post-Bruton’s tyrosine kinase inhibitor failure, the prognosis remains unfavorable. …”
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The transcriptional regulation effects of histidine, isoleucine and glutamate on free exopolysaccharide biosynthesis of Streptococcus thermophilus 937 by Yunchao Wa, Yunchao Wa, Xia Zhao, Xia Zhao, Chenchen Zhang, Chenchen Zhang, Hengxian Qu, Hengxian Qu, Dawei Chen, Dawei Chen, Xia Chen, Xia Chen, Yujun Huang, Yujun Huang, Ruixia Gu, Ruixia Gu

“…The upregulation of transcript levels of genes related to phenylalanine/tyrosine/tryptophan/histidine/ valine/leucine/isoleucine synthesis was caused by the increase in isoleucine concentrations.DiscussionThis indicates that 3 amino acids have different mechanisms for enhancing the biosynthesis of f-EPS in S. thermophilus 937.…”
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“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer by ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin

“…They divided it into four molecular subtypes and proposing corresponding precision treatment strategies: canonical luminal subtype (SNF1), sensitive to endocrine therapy; immunogenic subtype (SNF2), amenable to immunotherapy; proliferative subtype (SNF3), treatable by CDK4/6 inhibitors; and receptor tyrosine kinase-driven subtype (SNF4), targetable with tyrosine kinase inhibitors. …”
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